LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2, putative
Species:
Leishmania major
UniProt:
Q4QGJ0_LEIMA
TriTrypDb:
LmjF.12.0850 , LMJLV39_000011100 , LMJLV39_000013400 * , LMJSD75_120013100 *
Length:
629

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 120
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 48, no: 7
NetGPI no yes: 0, no: 55
Cellular components
Term Name Level Count
GO:0005929 cilium 4 56
GO:0016020 membrane 2 30
GO:0042995 cell projection 2 56
GO:0043226 organelle 2 56
GO:0043227 membrane-bounded organelle 3 56
GO:0110165 cellular anatomical entity 1 56
GO:0120025 plasma membrane bounded cell projection 3 56
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGJ0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGJ0

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0019538 protein metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0004175 endopeptidase activity 4 1
GO:0004252 serine-type endopeptidase activity 5 1
GO:0005488 binding 1 1
GO:0008233 peptidase activity 3 1
GO:0008236 serine-type peptidase activity 4 1
GO:0016787 hydrolase activity 2 1
GO:0017171 serine hydrolase activity 3 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0140096 catalytic activity, acting on a protein 2 4
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.462
CLV_NRD_NRD_1 282 284 PF00675 0.469
CLV_NRD_NRD_1 6 8 PF00675 0.696
CLV_PCSK_KEX2_1 282 284 PF00082 0.457
CLV_PCSK_KEX2_1 6 8 PF00082 0.696
CLV_PCSK_SKI1_1 190 194 PF00082 0.654
CLV_PCSK_SKI1_1 228 232 PF00082 0.498
CLV_PCSK_SKI1_1 351 355 PF00082 0.469
CLV_PCSK_SKI1_1 7 11 PF00082 0.714
DEG_SCF_FBW7_1 520 527 PF00400 0.409
DEG_SCF_FBW7_2 557 562 PF00400 0.478
DEG_SPOP_SBC_1 475 479 PF00917 0.612
DEG_SPOP_SBC_1 490 494 PF00917 0.442
DEG_SPOP_SBC_1 505 509 PF00917 0.524
DEG_SPOP_SBC_1 524 528 PF00917 0.443
DEG_SPOP_SBC_1 537 541 PF00917 0.477
DOC_CKS1_1 521 526 PF01111 0.412
DOC_CYCLIN_RxL_1 105 115 PF00134 0.425
DOC_CYCLIN_RxL_1 3 13 PF00134 0.669
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.385
DOC_MAPK_gen_1 228 238 PF00069 0.263
DOC_MAPK_gen_1 240 249 PF00069 0.237
DOC_MAPK_gen_1 351 358 PF00069 0.376
DOC_MAPK_MEF2A_6 182 191 PF00069 0.232
DOC_MAPK_MEF2A_6 231 238 PF00069 0.389
DOC_MAPK_MEF2A_6 446 453 PF00069 0.428
DOC_MAPK_NFAT4_5 231 239 PF00069 0.224
DOC_PP1_RVXF_1 108 115 PF00149 0.314
DOC_PP1_RVXF_1 180 187 PF00149 0.390
DOC_USP7_MATH_1 373 377 PF00917 0.423
DOC_USP7_MATH_1 426 430 PF00917 0.371
DOC_USP7_MATH_1 605 609 PF00917 0.458
DOC_USP7_MATH_1 80 84 PF00917 0.449
DOC_USP7_MATH_2 175 181 PF00917 0.373
DOC_USP7_MATH_2 224 230 PF00917 0.405
DOC_USP7_MATH_2 320 326 PF00917 0.261
DOC_WW_Pin1_4 262 267 PF00397 0.247
DOC_WW_Pin1_4 520 525 PF00397 0.509
DOC_WW_Pin1_4 549 554 PF00397 0.619
DOC_WW_Pin1_4 555 560 PF00397 0.615
DOC_WW_Pin1_4 85 90 PF00397 0.457
LIG_14-3-3_CanoR_1 158 164 PF00244 0.411
LIG_14-3-3_CanoR_1 43 48 PF00244 0.351
LIG_Actin_WH2_2 201 216 PF00022 0.246
LIG_BIR_II_1 1 5 PF00653 0.653
LIG_BRCT_BRCA1_1 182 186 PF00533 0.464
LIG_deltaCOP1_diTrp_1 62 69 PF00928 0.426
LIG_FHA_1 208 214 PF00498 0.341
LIG_FHA_1 218 224 PF00498 0.357
LIG_FHA_1 352 358 PF00498 0.316
LIG_FHA_1 377 383 PF00498 0.354
LIG_FHA_1 42 48 PF00498 0.464
LIG_FHA_1 593 599 PF00498 0.499
LIG_FHA_2 122 128 PF00498 0.349
LIG_FHA_2 137 143 PF00498 0.237
LIG_FHA_2 204 210 PF00498 0.318
LIG_FHA_2 254 260 PF00498 0.438
LIG_FHA_2 301 307 PF00498 0.352
LIG_FHA_2 537 543 PF00498 0.475
LIG_FHA_2 561 567 PF00498 0.459
LIG_FHA_2 63 69 PF00498 0.401
LIG_FHA_2 92 98 PF00498 0.421
LIG_GSK3_LRP6_1 520 526 PF00069 0.408
LIG_LIR_Gen_1 113 121 PF02991 0.405
LIG_LIR_Gen_1 127 135 PF02991 0.337
LIG_LIR_Gen_1 152 159 PF02991 0.322
LIG_LIR_Gen_1 177 186 PF02991 0.349
LIG_LIR_Gen_1 232 243 PF02991 0.319
LIG_LIR_Gen_1 250 257 PF02991 0.335
LIG_LIR_Gen_1 297 305 PF02991 0.327
LIG_LIR_Gen_1 322 330 PF02991 0.290
LIG_LIR_Gen_1 370 378 PF02991 0.336
LIG_LIR_Gen_1 417 426 PF02991 0.441
LIG_LIR_Gen_1 71 80 PF02991 0.468
LIG_LIR_Nem_3 103 107 PF02991 0.442
LIG_LIR_Nem_3 127 132 PF02991 0.382
LIG_LIR_Nem_3 183 189 PF02991 0.305
LIG_LIR_Nem_3 232 238 PF02991 0.290
LIG_LIR_Nem_3 297 302 PF02991 0.401
LIG_LIR_Nem_3 370 374 PF02991 0.338
LIG_LIR_Nem_3 417 422 PF02991 0.405
LIG_LIR_Nem_3 71 75 PF02991 0.365
LIG_NRBOX 352 358 PF00104 0.361
LIG_PCNA_PIPBox_1 326 335 PF02747 0.216
LIG_PDZ_Class_2 624 629 PF00595 0.309
LIG_SH2_SRC 235 238 PF00017 0.376
LIG_SH2_STAT5 235 238 PF00017 0.317
LIG_SH2_STAT5 285 288 PF00017 0.271
LIG_SH2_STAT5 588 591 PF00017 0.507
LIG_SH2_STAT5 599 602 PF00017 0.552
LIG_SH3_3 267 273 PF00018 0.437
LIG_SH3_3 518 524 PF00018 0.409
LIG_SH3_3 541 547 PF00018 0.641
LIG_SH3_3 93 99 PF00018 0.461
LIG_Sin3_3 613 620 PF02671 0.286
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.377
LIG_SUMO_SIM_par_1 209 215 PF11976 0.408
LIG_SUMO_SIM_par_1 449 455 PF11976 0.465
LIG_TYR_ITIM 102 107 PF00017 0.398
LIG_TYR_ITIM 233 238 PF00017 0.360
LIG_UBA3_1 108 116 PF00899 0.218
LIG_UBA3_1 233 240 PF00899 0.212
MOD_CK1_1 152 158 PF00069 0.395
MOD_CK1_1 180 186 PF00069 0.339
MOD_CK1_1 203 209 PF00069 0.344
MOD_CK1_1 229 235 PF00069 0.320
MOD_CK1_1 241 247 PF00069 0.360
MOD_CK1_1 252 258 PF00069 0.316
MOD_CK1_1 277 283 PF00069 0.323
MOD_CK1_1 297 303 PF00069 0.336
MOD_CK1_1 325 331 PF00069 0.314
MOD_CK1_1 376 382 PF00069 0.373
MOD_CK1_1 385 391 PF00069 0.385
MOD_CK1_1 396 402 PF00069 0.381
MOD_CK1_1 414 420 PF00069 0.379
MOD_CK1_1 85 91 PF00069 0.341
MOD_CK2_1 127 133 PF00069 0.450
MOD_CK2_1 253 259 PF00069 0.410
MOD_CK2_1 536 542 PF00069 0.632
MOD_CK2_1 560 566 PF00069 0.628
MOD_CK2_1 91 97 PF00069 0.448
MOD_GlcNHglycan 121 124 PF01048 0.593
MOD_GlcNHglycan 170 173 PF01048 0.526
MOD_GlcNHglycan 194 197 PF01048 0.569
MOD_GlcNHglycan 243 246 PF01048 0.598
MOD_GlcNHglycan 25 28 PF01048 0.720
MOD_GlcNHglycan 290 294 PF01048 0.525
MOD_GlcNHglycan 315 318 PF01048 0.527
MOD_GlcNHglycan 347 350 PF01048 0.558
MOD_GlcNHglycan 363 366 PF01048 0.547
MOD_GlcNHglycan 370 374 PF01048 0.539
MOD_GlcNHglycan 382 385 PF01048 0.619
MOD_GlcNHglycan 387 390 PF01048 0.658
MOD_GlcNHglycan 395 398 PF01048 0.624
MOD_GlcNHglycan 410 414 PF01048 0.628
MOD_GlcNHglycan 419 422 PF01048 0.588
MOD_GlcNHglycan 608 611 PF01048 0.514
MOD_GlcNHglycan 84 87 PF01048 0.585
MOD_GSK3_1 121 128 PF00069 0.386
MOD_GSK3_1 134 141 PF00069 0.317
MOD_GSK3_1 145 152 PF00069 0.364
MOD_GSK3_1 176 183 PF00069 0.346
MOD_GSK3_1 200 207 PF00069 0.368
MOD_GSK3_1 249 256 PF00069 0.315
MOD_GSK3_1 258 265 PF00069 0.327
MOD_GSK3_1 273 280 PF00069 0.374
MOD_GSK3_1 291 298 PF00069 0.315
MOD_GSK3_1 32 39 PF00069 0.588
MOD_GSK3_1 369 376 PF00069 0.362
MOD_GSK3_1 396 403 PF00069 0.393
MOD_GSK3_1 411 418 PF00069 0.366
MOD_GSK3_1 466 473 PF00069 0.527
MOD_GSK3_1 474 481 PF00069 0.581
MOD_GSK3_1 485 492 PF00069 0.553
MOD_GSK3_1 493 500 PF00069 0.575
MOD_GSK3_1 504 511 PF00069 0.473
MOD_GSK3_1 515 522 PF00069 0.535
MOD_GSK3_1 523 530 PF00069 0.579
MOD_GSK3_1 545 552 PF00069 0.555
MOD_GSK3_1 588 595 PF00069 0.512
MOD_GSK3_1 87 94 PF00069 0.395
MOD_NEK2_1 10 15 PF00069 0.569
MOD_NEK2_1 112 117 PF00069 0.367
MOD_NEK2_1 119 124 PF00069 0.396
MOD_NEK2_1 145 150 PF00069 0.345
MOD_NEK2_1 170 175 PF00069 0.314
MOD_NEK2_1 192 197 PF00069 0.376
MOD_NEK2_1 21 26 PF00069 0.548
MOD_NEK2_1 236 241 PF00069 0.329
MOD_NEK2_1 310 315 PF00069 0.348
MOD_NEK2_1 332 337 PF00069 0.370
MOD_NEK2_1 358 363 PF00069 0.417
MOD_NEK2_1 380 385 PF00069 0.352
MOD_NEK2_1 411 416 PF00069 0.413
MOD_NEK2_1 424 429 PF00069 0.421
MOD_NEK2_2 426 431 PF00069 0.447
MOD_PIKK_1 351 357 PF00454 0.372
MOD_PKA_1 351 357 PF00069 0.231
MOD_PKA_2 157 163 PF00069 0.438
MOD_PKA_2 241 247 PF00069 0.311
MOD_Plk_1 176 182 PF00069 0.370
MOD_Plk_1 252 258 PF00069 0.355
MOD_Plk_1 358 364 PF00069 0.344
MOD_Plk_1 369 375 PF00069 0.422
MOD_Plk_1 592 598 PF00069 0.527
MOD_Plk_1 80 86 PF00069 0.305
MOD_Plk_2-3 209 215 PF00069 0.359
MOD_Plk_2-3 253 259 PF00069 0.269
MOD_Plk_2-3 68 74 PF00069 0.433
MOD_Plk_4 229 235 PF00069 0.387
MOD_Plk_4 358 364 PF00069 0.323
MOD_Plk_4 373 379 PF00069 0.318
MOD_ProDKin_1 262 268 PF00069 0.248
MOD_ProDKin_1 520 526 PF00069 0.511
MOD_ProDKin_1 549 555 PF00069 0.620
MOD_ProDKin_1 85 91 PF00069 0.453
MOD_SUMO_rev_2 441 447 PF00179 0.298
MOD_SUMO_rev_2 586 595 PF00179 0.333
TRG_DiLeu_BaEn_1 593 598 PF01217 0.356
TRG_ENDOCYTIC_2 104 107 PF00928 0.401
TRG_ENDOCYTIC_2 235 238 PF00928 0.330
TRG_ER_diArg_1 281 283 PF00400 0.267
TRG_ER_diArg_1 5 7 PF00400 0.620
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.567

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I661 Leptomonas seymouri 36% 100%
A0A0S4IHI7 Bodo saltans 28% 81%
A0A0S4ILC9 Bodo saltans 34% 100%
A0A0S4IM54 Bodo saltans 29% 70%
A0A0S4IRQ2 Bodo saltans 33% 74%
A0A0S4IT62 Bodo saltans 36% 85%
A0A0S4IU73 Bodo saltans 37% 100%
A0A0S4IU91 Bodo saltans 26% 71%
A0A0S4IV96 Bodo saltans 32% 100%
A0A0S4IW93 Bodo saltans 29% 100%
A0A0S4J2H8 Bodo saltans 26% 100%
A0A0S4J5A0 Bodo saltans 33% 100%
A0A0S4J954 Bodo saltans 27% 85%
A0A0S4JAQ6 Bodo saltans 27% 100%
A0A0S4JNU2 Bodo saltans 35% 77%
A0A0S4JTM6 Bodo saltans 28% 85%
A0A0S4JTQ7 Bodo saltans 36% 100%
A0A0S4KEC2 Bodo saltans 32% 71%
A0A0S4KF94 Bodo saltans 23% 72%
A0A0S4KGV4 Bodo saltans 25% 100%
A0A0S4KLL4 Bodo saltans 27% 67%
A0A1P8ATR9 Arabidopsis thaliana 22% 67%
A0A1X0ND37 Trypanosomatidae 25% 66%
A0A3Q8IC27 Leishmania donovani 33% 100%
A0A3S5H6M3 Leishmania donovani 80% 92%
A0A3S5H6M4 Leishmania donovani 61% 96%
A0A3S7WS66 Leishmania donovani 61% 96%
A4HBX3 Leishmania braziliensis 34% 100%
A4HZ93 Leishmania infantum 33% 100%
D1GJ51 Leishmania infantum 50% 99%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 83%
E9AGG2 Leishmania infantum 82% 95%
E9AGG5 Leishmania infantum 52% 100%
E9AGG7 Leishmania infantum 53% 100%
E9AGG9 Leishmania infantum 56% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 89%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 60% 90%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
F4J8G2 Arabidopsis thaliana 24% 72%
F4J9A8 Arabidopsis thaliana 23% 66%
F4JGB6 Arabidopsis thaliana 25% 78%
F4JTU7 Arabidopsis thaliana 23% 77%
F4K4T3 Arabidopsis thaliana 22% 66%
Q4QC79 Leishmania major 33% 100%
Q4QGI0 Leishmania major 65% 100%
Q4QGI2 Leishmania major 56% 100%
Q4QGI4 Leishmania major 53% 100%
Q4QGI6 Leishmania major 58% 100%
Q4QGI8 Leishmania major 54% 83%
Q4QGJ2 Leishmania major 66% 97%
Q4QGJ6 Leishmania major 51% 100%
Q4QGJ9 Leishmania major 64% 100%
Q4QGK0 Leishmania major 61% 100%
Q4QGK1 Leishmania major 93% 89%
Q4QGK2 Leishmania major 54% 100%
Q4QGK4 Leishmania major 55% 94%
Q4QGK8 Leishmania major 59% 100%
Q4QGL2 Leishmania major 58% 100%
Q4QGL5 Leishmania major 47% 100%
Q4QGL8 Leishmania major 51% 100%
Q4QGM1 Leishmania major 56% 81%
Q7FZR1 Arabidopsis thaliana 23% 78%
Q8RX63 Arabidopsis thaliana 23% 73%
Q9LJS0 Arabidopsis thaliana 23% 71%
Q9LJS2 Arabidopsis thaliana 22% 71%
Q9LS80 Arabidopsis thaliana 20% 75%
Q9SHI4 Arabidopsis thaliana 21% 83%
Q9SVM3 Arabidopsis thaliana 23% 75%
Q9SVN2 Arabidopsis thaliana 24% 79%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS