Putative surface antigen protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen protein, putative

Species:

Leishmania major

UniProt:

Q4QGI8_LEIMA

TriTrypDb:

LmjF.12.0740 , LmjF.12.0755 , LMJLV39_000011100 , LMJLV39_000018600 , LMJSD75_120012800 , LMJSD75_120013500

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 90

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 35, no: 7
NetGPI	no	yes: 0, no: 42

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	43
GO:0016020	membrane	2	28
GO:0042995	cell projection	2	43
GO:0043226	organelle	2	43
GO:0043227	membrane-bounded organelle	3	43
GO:0110165	cellular anatomical entity	1	43
GO:0120025	plasma membrane bounded cell projection	3	43
GO:0005886	plasma membrane	3	7

Expansion

Sequence features

Q4QGI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004672	protein kinase activity	3	3
GO:0004674	protein serine/threonine kinase activity	4	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.343
CLV_NRD_NRD_1	6	8	PF00675	0.761
CLV_PCSK_KEX2_1	6	8	PF00082	0.761
CLV_PCSK_SKI1_1	159	163	PF00082	0.604
CLV_PCSK_SKI1_1	167	171	PF00082	0.613
CLV_PCSK_SKI1_1	254	258	PF00082	0.474
CLV_PCSK_SKI1_1	326	330	PF00082	0.615
CLV_PCSK_SKI1_1	398	402	PF00082	0.585
CLV_PCSK_SKI1_1	419	423	PF00082	0.590
CLV_PCSK_SKI1_1	7	11	PF00082	0.722
DEG_APCC_DBOX_1	494	502	PF00400	0.433
DEG_SCF_FBW7_2	688	693	PF00400	0.490
DEG_SPOP_SBC_1	547	551	PF00917	0.633
DEG_SPOP_SBC_1	556	560	PF00917	0.590
DEG_SPOP_SBC_1	566	570	PF00917	0.550
DEG_SPOP_SBC_1	576	580	PF00917	0.596
DEG_SPOP_SBC_1	587	591	PF00917	0.450
DEG_SPOP_SBC_1	596	600	PF00917	0.443
DEG_SPOP_SBC_1	607	611	PF00917	0.530
DEG_SPOP_SBC_1	616	620	PF00917	0.596
DEG_SPOP_SBC_1	646	650	PF00917	0.633
DEG_SPOP_SBC_1	667	671	PF00917	0.501
DOC_CYCLIN_RxL_1	186	196	PF00134	0.322
DOC_CYCLIN_RxL_1	3	13	PF00134	0.635
DOC_MAPK_gen_1	419	429	PF00069	0.423
DOC_MAPK_MEF2A_6	130	139	PF00069	0.347
DOC_MAPK_MEF2A_6	203	212	PF00069	0.238
DOC_MAPK_MEF2A_6	517	524	PF00069	0.497
DOC_PP1_RVXF_1	108	115	PF00149	0.415
DOC_USP7_MATH_1	736	740	PF00917	0.443
DOC_USP7_MATH_1	76	80	PF00917	0.446
DOC_WW_Pin1_4	680	685	PF00397	0.661
DOC_WW_Pin1_4	686	691	PF00397	0.621
LIG_14-3-3_CanoR_1	159	164	PF00244	0.346
LIG_14-3-3_CanoR_1	203	208	PF00244	0.391
LIG_14-3-3_CanoR_1	419	425	PF00244	0.342
LIG_14-3-3_CanoR_1	43	48	PF00244	0.426
LIG_14-3-3_CanoR_1	468	477	PF00244	0.382
LIG_Actin_WH2_2	417	432	PF00022	0.231
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BRCT_BRCA1_1	135	139	PF00533	0.435
LIG_Clathr_ClatBox_1	207	211	PF01394	0.364
LIG_deltaCOP1_diTrp_1	176	183	PF00928	0.388
LIG_deltaCOP1_diTrp_1	61	69	PF00928	0.434
LIG_DLG_GKlike_1	203	210	PF00625	0.251
LIG_FHA_1	168	174	PF00498	0.361
LIG_FHA_1	203	209	PF00498	0.362
LIG_FHA_1	217	223	PF00498	0.377
LIG_FHA_1	232	238	PF00498	0.316
LIG_FHA_1	280	286	PF00498	0.357
LIG_FHA_1	304	310	PF00498	0.343
LIG_FHA_1	339	345	PF00498	0.318
LIG_FHA_1	352	358	PF00498	0.310
LIG_FHA_1	376	382	PF00498	0.357
LIG_FHA_1	42	48	PF00498	0.443
LIG_FHA_1	448	454	PF00498	0.362
LIG_FHA_1	541	547	PF00498	0.419
LIG_FHA_1	581	587	PF00498	0.408
LIG_FHA_1	601	607	PF00498	0.449
LIG_FHA_1	661	667	PF00498	0.539
LIG_FHA_1	724	730	PF00498	0.520
LIG_FHA_2	121	127	PF00498	0.358
LIG_FHA_2	255	261	PF00498	0.420
LIG_FHA_2	327	333	PF00498	0.404
LIG_FHA_2	63	69	PF00498	0.387
LIG_FHA_2	668	674	PF00498	0.503
LIG_FHA_2	692	698	PF00498	0.482
LIG_FHA_2	92	98	PF00498	0.442
LIG_LIR_Gen_1	126	135	PF02991	0.335
LIG_LIR_Gen_1	175	185	PF02991	0.375
LIG_LIR_Gen_1	200	208	PF02991	0.366
LIG_LIR_Gen_1	248	256	PF02991	0.326
LIG_LIR_Gen_1	465	472	PF02991	0.342
LIG_LIR_Gen_1	489	498	PF02991	0.431
LIG_LIR_Gen_1	71	80	PF02991	0.375
LIG_LIR_Nem_3	103	107	PF02991	0.449
LIG_LIR_Nem_3	126	131	PF02991	0.412
LIG_LIR_Nem_3	175	180	PF02991	0.381
LIG_LIR_Nem_3	200	204	PF02991	0.330
LIG_LIR_Nem_3	416	421	PF02991	0.253
LIG_LIR_Nem_3	71	75	PF02991	0.371
LIG_LIR_Nem_3	81	86	PF02991	0.349
LIG_NRBOX	130	136	PF00104	0.357
LIG_PCNA_PIPBox_1	397	406	PF02747	0.324
LIG_PDZ_Class_2	755	760	PF00595	0.298
LIG_Pex14_1	179	183	PF04695	0.228
LIG_SH2_SRC	404	407	PF00017	0.328
LIG_SH2_STAT5	404	407	PF00017	0.330
LIG_SH2_STAT5	428	431	PF00017	0.357
LIG_SH2_STAT5	719	722	PF00017	0.532
LIG_SH2_STAT5	730	733	PF00017	0.542
LIG_SH3_3	672	678	PF00018	0.624
LIG_SH3_3	93	99	PF00018	0.419
LIG_Sin3_3	744	751	PF02671	0.298
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.444
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.391
LIG_SUMO_SIM_par_1	133	138	PF11976	0.321
LIG_SUMO_SIM_par_1	205	211	PF11976	0.376
LIG_SUMO_SIM_par_1	449	454	PF11976	0.377
LIG_TYR_ITIM	102	107	PF00017	0.446
MOD_CK1_1	172	178	PF00069	0.367
MOD_CK1_1	202	208	PF00069	0.374
MOD_CK1_1	228	234	PF00069	0.363
MOD_CK1_1	248	254	PF00069	0.240
MOD_CK1_1	255	261	PF00069	0.320
MOD_CK1_1	276	282	PF00069	0.348
MOD_CK1_1	300	306	PF00069	0.379
MOD_CK1_1	327	333	PF00069	0.334
MOD_CK1_1	351	357	PF00069	0.347
MOD_CK1_1	372	378	PF00069	0.260
MOD_CK1_1	413	419	PF00069	0.338
MOD_CK1_1	443	449	PF00069	0.381
MOD_CK2_1	203	209	PF00069	0.267
MOD_CK2_1	254	260	PF00069	0.427
MOD_CK2_1	326	332	PF00069	0.431
MOD_CK2_1	667	673	PF00069	0.502
MOD_CK2_1	691	697	PF00069	0.487
MOD_CK2_1	91	97	PF00069	0.443
MOD_GlcNHglycan	120	123	PF01048	0.597
MOD_GlcNHglycan	139	142	PF01048	0.550
MOD_GlcNHglycan	144	147	PF01048	0.543
MOD_GlcNHglycan	193	196	PF01048	0.577
MOD_GlcNHglycan	242	245	PF01048	0.545
MOD_GlcNHglycan	247	250	PF01048	0.545
MOD_GlcNHglycan	25	28	PF01048	0.736
MOD_GlcNHglycan	266	269	PF01048	0.588
MOD_GlcNHglycan	290	293	PF01048	0.557
MOD_GlcNHglycan	314	317	PF01048	0.567
MOD_GlcNHglycan	338	341	PF01048	0.568
MOD_GlcNHglycan	362	365	PF01048	0.462
MOD_GlcNHglycan	386	389	PF01048	0.601
MOD_GlcNHglycan	410	413	PF01048	0.571
MOD_GlcNHglycan	434	437	PF01048	0.580
MOD_GlcNHglycan	458	461	PF01048	0.604
MOD_GlcNHglycan	470	473	PF01048	0.584
MOD_GlcNHglycan	481	485	PF01048	0.586
MOD_GlcNHglycan	489	493	PF01048	0.647
MOD_GlcNHglycan	707	710	PF01048	0.706
MOD_GlcNHglycan	739	742	PF01048	0.433
MOD_GSK3_1	120	127	PF00069	0.383
MOD_GSK3_1	133	140	PF00069	0.320
MOD_GSK3_1	144	151	PF00069	0.328
MOD_GSK3_1	199	206	PF00069	0.371
MOD_GSK3_1	224	231	PF00069	0.345
MOD_GSK3_1	248	255	PF00069	0.346
MOD_GSK3_1	272	279	PF00069	0.355
MOD_GSK3_1	32	39	PF00069	0.594
MOD_GSK3_1	320	327	PF00069	0.355
MOD_GSK3_1	344	351	PF00069	0.353
MOD_GSK3_1	392	399	PF00069	0.367
MOD_GSK3_1	440	447	PF00069	0.398
MOD_GSK3_1	464	471	PF00069	0.378
MOD_GSK3_1	537	544	PF00069	0.533
MOD_GSK3_1	545	552	PF00069	0.539
MOD_GSK3_1	555	562	PF00069	0.464
MOD_GSK3_1	565	572	PF00069	0.477
MOD_GSK3_1	575	582	PF00069	0.563
MOD_GSK3_1	585	592	PF00069	0.520
MOD_GSK3_1	595	602	PF00069	0.483
MOD_GSK3_1	605	612	PF00069	0.522
MOD_GSK3_1	615	622	PF00069	0.497
MOD_GSK3_1	623	630	PF00069	0.490
MOD_GSK3_1	636	643	PF00069	0.534
MOD_GSK3_1	645	652	PF00069	0.572
MOD_GSK3_1	655	662	PF00069	0.521
MOD_GSK3_1	665	672	PF00069	0.555
MOD_GSK3_1	676	683	PF00069	0.626
MOD_GSK3_1	719	726	PF00069	0.496
MOD_GSK3_1	87	94	PF00069	0.418
MOD_N-GLC_1	86	91	PF02516	0.508
MOD_NEK2_1	10	15	PF00069	0.642
MOD_NEK2_1	120	125	PF00069	0.350
MOD_NEK2_1	135	140	PF00069	0.330
MOD_NEK2_1	169	174	PF00069	0.301
MOD_NEK2_1	191	196	PF00069	0.380
MOD_NEK2_1	21	26	PF00069	0.536
MOD_NEK2_1	237	242	PF00069	0.415
MOD_NEK2_1	261	266	PF00069	0.382
MOD_NEK2_1	285	290	PF00069	0.378
MOD_NEK2_1	309	314	PF00069	0.387
MOD_NEK2_1	333	338	PF00069	0.349
MOD_NEK2_1	357	362	PF00069	0.407
MOD_NEK2_1	381	386	PF00069	0.417
MOD_NEK2_1	405	410	PF00069	0.390
MOD_NEK2_1	429	434	PF00069	0.431
MOD_NEK2_1	453	458	PF00069	0.351
MOD_NEK2_1	482	487	PF00069	0.383
MOD_NEK2_1	86	91	PF00069	0.354
MOD_NEK2_2	273	278	PF00069	0.254
MOD_PIKK_1	237	243	PF00454	0.431
MOD_PIKK_1	261	267	PF00454	0.327
MOD_PIKK_1	285	291	PF00454	0.408
MOD_PIKK_1	309	315	PF00454	0.374
MOD_PIKK_1	333	339	PF00454	0.399
MOD_PIKK_1	357	363	PF00454	0.349
MOD_PIKK_1	381	387	PF00454	0.456
MOD_PIKK_1	405	411	PF00454	0.386
MOD_PIKK_1	429	435	PF00454	0.437
MOD_PIKK_1	453	459	PF00454	0.467
MOD_PK_1	225	231	PF00069	0.237
MOD_PKA_1	62	68	PF00069	0.339
MOD_PKA_2	202	208	PF00069	0.343
MOD_PKB_1	157	165	PF00069	0.261
MOD_Plk_1	175	181	PF00069	0.369
MOD_Plk_1	199	205	PF00069	0.419
MOD_Plk_1	464	470	PF00069	0.393
MOD_Plk_1	488	494	PF00069	0.425
MOD_Plk_1	723	729	PF00069	0.501
MOD_Plk_1	86	92	PF00069	0.437
MOD_Plk_2-3	68	74	PF00069	0.389
MOD_Plk_4	203	209	PF00069	0.316
MOD_ProDKin_1	680	686	PF00069	0.661
MOD_SUMO_rev_2	248	256	PF00179	0.244
MOD_SUMO_rev_2	323	328	PF00179	0.266
MOD_SUMO_rev_2	347	352	PF00179	0.244
MOD_SUMO_rev_2	395	400	PF00179	0.255
MOD_SUMO_rev_2	59	65	PF00179	0.316
TRG_DiLeu_BaEn_1	724	729	PF01217	0.377
TRG_DiLeu_BaLyEn_6	115	120	PF01217	0.264
TRG_ENDOCYTIC_2	104	107	PF00928	0.450
TRG_ER_diArg_1	156	159	PF00400	0.466
TRG_ER_diArg_1	494	497	PF00400	0.324
TRG_ER_diArg_1	5	7	PF00400	0.713
TRG_NES_CRM1_1	252	262	PF08389	0.257
TRG_NES_CRM1_1	324	334	PF08389	0.256
TRG_NES_CRM1_1	348	358	PF08389	0.246
TRG_NES_CRM1_1	396	406	PF08389	0.264
TRG_Pf-PMV_PEXEL_1	233	238	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	281	286	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	305	310	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	377	382	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IH88	Bodo saltans	34%	68%
A0A0S4IIQ2	Bodo saltans	24%	70%
A0A0S4IRQ2	Bodo saltans	30%	89%
A0A0S4IT62	Bodo saltans	38%	100%
A0A0S4IU23	Bodo saltans	28%	100%
A0A0S4IVU4	Bodo saltans	27%	74%
A0A0S4IZD9	Bodo saltans	26%	68%
A0A0S4J014	Bodo saltans	26%	100%
A0A0S4J0Z0	Bodo saltans	25%	70%
A0A0S4J206	Bodo saltans	34%	100%
A0A0S4J5I5	Bodo saltans	26%	76%
A0A0S4J7H0	Bodo saltans	29%	76%
A0A0S4J954	Bodo saltans	25%	100%
A0A0S4JB95	Bodo saltans	23%	100%
A0A0S4JLC0	Bodo saltans	31%	73%
A0A0S4JMQ7	Bodo saltans	36%	75%
A0A0S4JNU2	Bodo saltans	35%	93%
A0A0S4JQZ4	Bodo saltans	31%	76%
A0A0S4JTM6	Bodo saltans	29%	100%
A0A0S4JV99	Bodo saltans	26%	72%
A0A0S4KEC2	Bodo saltans	36%	86%
A0A0S4KF94	Bodo saltans	26%	87%
A0A1X0ND37	Trypanosomatidae	23%	80%
A0A3Q8I9B4	Leishmania donovani	41%	100%
A0A3S5H6M3	Leishmania donovani	52%	100%
A0A3S5H6M4	Leishmania donovani	54%	100%
A0A3S7WS66	Leishmania donovani	54%	100%
A4HM88	Leishmania braziliensis	27%	100%
E8NHG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AGG2	Leishmania infantum	51%	100%
E9AGG7	Leishmania infantum	59%	100%
E9AGG9	Leishmania infantum	59%	100%
E9ANZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AP04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AP05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
F4J8G2	Arabidopsis thaliana	25%	87%
F4JTU7	Arabidopsis thaliana	24%	93%
O65440	Arabidopsis thaliana	22%	77%
O80809	Arabidopsis thaliana	22%	100%
P93194	Ipomoea nil	26%	69%
Q1PEN0	Arabidopsis thaliana	22%	100%
Q4QGI0	Leishmania major	62%	94%
Q4QGI2	Leishmania major	89%	100%
Q4QGI4	Leishmania major	89%	99%
Q4QGI6	Leishmania major	57%	100%
Q4QGJ0	Leishmania major	54%	100%
Q4QGJ2	Leishmania major	53%	100%
Q4QGJ9	Leishmania major	49%	100%
Q4QGK0	Leishmania major	52%	100%
Q4QGK1	Leishmania major	52%	100%
Q4QGK2	Leishmania major	75%	100%
Q4QGK4	Leishmania major	53%	100%
Q4QGK8	Leishmania major	62%	100%
Q4QGL2	Leishmania major	62%	100%
Q4QGL8	Leishmania major	65%	100%
Q4QGM1	Leishmania major	83%	98%
Q5MR23	Solanum pimpinellifolium	22%	88%
Q8LPB4	Daucus carota	22%	74%
Q8RX63	Arabidopsis thaliana	24%	88%
Q93YT3	Arabidopsis thaliana	26%	85%
Q9C699	Arabidopsis thaliana	26%	78%
Q9LJW7	Arabidopsis thaliana	24%	100%
Q9LRT1	Arabidopsis thaliana	26%	75%
Q9LY03	Arabidopsis thaliana	26%	79%
Q9LZV7	Arabidopsis thaliana	27%	79%
Q9M9X0	Arabidopsis thaliana	25%	88%
Q9SD62	Arabidopsis thaliana	24%	74%
Q9SVM3	Arabidopsis thaliana	24%	90%
Q9SVN2	Arabidopsis thaliana	24%	95%
Q9ZUI0	Arabidopsis thaliana	24%	78%