LeishMANIAdb
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Putative surface antigen protein 2

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein 2
Gene product:
surface antigen protein 2, putative
Species:
Leishmania major
UniProt:
Q4QGI6_LEIMA
TriTrypDb:
LmjF.12.0730 , LMJLV39_000019000 * , LMJSD75_120012800 * , LMJSD75_120012900 *
Length:
547

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 160
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 60, no: 7
NetGPI no yes: 0, no: 67
Cellular components
Term Name Level Count
GO:0005929 cilium 4 68
GO:0016020 membrane 2 32
GO:0042995 cell projection 2 68
GO:0043226 organelle 2 68
GO:0043227 membrane-bounded organelle 3 68
GO:0110165 cellular anatomical entity 1 68
GO:0120025 plasma membrane bounded cell projection 3 68
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGI6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI6

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 97 101 PF00656 0.310
CLV_NRD_NRD_1 6 8 PF00675 0.775
CLV_PCSK_KEX2_1 6 8 PF00082 0.775
CLV_PCSK_SKI1_1 7 11 PF00082 0.738
DEG_SCF_FBW7_2 475 480 PF00400 0.480
DEG_SPOP_SBC_1 455 459 PF00917 0.504
DOC_AGCK_PIF_2 69 74 PF00069 0.280
DOC_CYCLIN_RxL_1 3 13 PF00134 0.705
DOC_MAPK_gen_1 419 427 PF00069 0.319
DOC_MAPK_MEF2A_6 133 140 PF00069 0.313
DOC_MAPK_MEF2A_6 419 427 PF00069 0.495
DOC_PP1_RVXF_1 131 138 PF00149 0.228
DOC_USP7_MATH_1 299 303 PF00917 0.416
DOC_USP7_MATH_1 359 363 PF00917 0.423
DOC_USP7_MATH_1 523 527 PF00917 0.509
DOC_USP7_MATH_2 270 276 PF00917 0.398
DOC_USP7_MATH_2 390 396 PF00917 0.354
DOC_USP7_UBL2_3 512 516 PF12436 0.288
DOC_WW_Pin1_4 467 472 PF00397 0.642
DOC_WW_Pin1_4 473 478 PF00397 0.618
DOC_WW_Pin1_4 85 90 PF00397 0.471
LIG_14-3-3_CanoR_1 400 405 PF00244 0.428
LIG_14-3-3_CanoR_1 43 48 PF00244 0.359
LIG_14-3-3_CanoR_1 444 452 PF00244 0.588
LIG_Actin_WH2_2 152 167 PF00022 0.225
LIG_BIR_II_1 1 5 PF00653 0.683
LIG_BRCT_BRCA1_1 133 137 PF00533 0.238
LIG_BRCT_BRCA1_1 205 209 PF00533 0.435
LIG_BRCT_BRCA1_1 70 74 PF00533 0.432
LIG_Clathr_ClatBox_1 185 189 PF01394 0.284
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.432
LIG_FHA_1 146 152 PF00498 0.280
LIG_FHA_1 231 237 PF00498 0.384
LIG_FHA_1 42 48 PF00498 0.476
LIG_FHA_2 206 212 PF00498 0.310
LIG_FHA_2 278 284 PF00498 0.416
LIG_FHA_2 445 451 PF00498 0.610
LIG_FHA_2 455 461 PF00498 0.481
LIG_FHA_2 479 485 PF00498 0.559
LIG_FHA_2 63 69 PF00498 0.416
LIG_FHA_2 92 98 PF00498 0.406
LIG_LIR_Gen_1 103 112 PF02991 0.383
LIG_LIR_Gen_1 113 121 PF02991 0.436
LIG_LIR_Gen_1 134 145 PF02991 0.349
LIG_LIR_Gen_1 189 198 PF02991 0.359
LIG_LIR_Gen_1 206 217 PF02991 0.351
LIG_LIR_Gen_1 272 281 PF02991 0.297
LIG_LIR_Gen_1 392 399 PF02991 0.404
LIG_LIR_Gen_1 71 80 PF02991 0.458
LIG_LIR_Nem_3 103 107 PF02991 0.445
LIG_LIR_Nem_3 134 140 PF02991 0.354
LIG_LIR_Nem_3 189 193 PF02991 0.349
LIG_LIR_Nem_3 206 212 PF02991 0.305
LIG_LIR_Nem_3 374 380 PF02991 0.351
LIG_LIR_Nem_3 71 75 PF02991 0.362
LIG_PCNA_PIPBox_1 324 333 PF02747 0.229
LIG_PDZ_Class_2 542 547 PF00595 0.499
LIG_PTB_Apo_2 136 143 PF02174 0.210
LIG_PTB_Apo_2 184 191 PF02174 0.315
LIG_PTB_Phospho_1 136 142 PF10480 0.212
LIG_PTB_Phospho_1 184 190 PF10480 0.216
LIG_SH2_CRK 104 108 PF00017 0.472
LIG_SH2_CRK 142 146 PF00017 0.300
LIG_SH2_GRB2like 190 193 PF00017 0.271
LIG_SH2_NCK_1 142 146 PF00017 0.216
LIG_SH2_PTP2 190 193 PF00017 0.228
LIG_SH2_SRC 190 193 PF00017 0.275
LIG_SH2_STAT5 142 145 PF00017 0.230
LIG_SH2_STAT5 190 193 PF00017 0.307
LIG_SH2_STAT5 331 334 PF00017 0.310
LIG_SH2_STAT5 377 380 PF00017 0.407
LIG_SH2_STAT5 506 509 PF00017 0.499
LIG_SH3_3 449 455 PF00018 0.609
LIG_SH3_3 459 465 PF00018 0.630
LIG_SH3_3 93 99 PF00018 0.446
LIG_Sin3_3 531 538 PF02671 0.294
LIG_SUMO_SIM_anti_2 157 163 PF11976 0.295
LIG_SUMO_SIM_anti_2 181 187 PF11976 0.291
LIG_SUMO_SIM_anti_2 208 215 PF11976 0.233
LIG_SUMO_SIM_anti_2 254 259 PF11976 0.305
LIG_SUMO_SIM_anti_2 280 287 PF11976 0.335
LIG_SUMO_SIM_anti_2 301 307 PF11976 0.327
LIG_SUMO_SIM_anti_2 349 355 PF11976 0.373
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.376
LIG_SUMO_SIM_par_1 232 239 PF11976 0.427
LIG_TYR_ITIM 102 107 PF00017 0.471
LIG_TYR_ITIM 140 145 PF00017 0.302
LIG_TYR_ITIM 188 193 PF00017 0.271
LIG_UBA3_1 136 144 PF00899 0.213
LIG_UBA3_1 257 264 PF00899 0.237
LIG_UBA3_1 305 312 PF00899 0.315
LIG_UBA3_1 353 360 PF00899 0.257
MOD_CK1_1 131 137 PF00069 0.243
MOD_CK1_1 154 160 PF00069 0.366
MOD_CK1_1 178 184 PF00069 0.275
MOD_CK1_1 202 208 PF00069 0.366
MOD_CK1_1 226 232 PF00069 0.391
MOD_CK1_1 274 280 PF00069 0.336
MOD_CK1_1 298 304 PF00069 0.325
MOD_CK1_1 322 328 PF00069 0.304
MOD_CK1_1 346 352 PF00069 0.331
MOD_CK1_1 370 376 PF00069 0.403
MOD_CK2_1 444 450 PF00069 0.411
MOD_CK2_1 454 460 PF00069 0.661
MOD_CK2_1 478 484 PF00069 0.576
MOD_CK2_1 91 97 PF00069 0.450
MOD_GlcNHglycan 121 124 PF01048 0.680
MOD_GlcNHglycan 145 148 PF01048 0.565
MOD_GlcNHglycan 169 172 PF01048 0.475
MOD_GlcNHglycan 193 196 PF01048 0.545
MOD_GlcNHglycan 217 220 PF01048 0.594
MOD_GlcNHglycan 241 244 PF01048 0.553
MOD_GlcNHglycan 25 28 PF01048 0.739
MOD_GlcNHglycan 289 292 PF01048 0.580
MOD_GlcNHglycan 297 300 PF01048 0.539
MOD_GlcNHglycan 313 316 PF01048 0.535
MOD_GlcNHglycan 337 340 PF01048 0.564
MOD_GlcNHglycan 361 364 PF01048 0.603
MOD_GlcNHglycan 368 372 PF01048 0.603
MOD_GlcNHglycan 384 388 PF01048 0.561
MOD_GlcNHglycan 404 407 PF01048 0.529
MOD_GlcNHglycan 494 497 PF01048 0.673
MOD_GlcNHglycan 526 529 PF01048 0.483
MOD_GSK3_1 127 134 PF00069 0.327
MOD_GSK3_1 151 158 PF00069 0.340
MOD_GSK3_1 175 182 PF00069 0.265
MOD_GSK3_1 199 206 PF00069 0.351
MOD_GSK3_1 223 230 PF00069 0.379
MOD_GSK3_1 247 254 PF00069 0.393
MOD_GSK3_1 271 278 PF00069 0.338
MOD_GSK3_1 295 302 PF00069 0.336
MOD_GSK3_1 319 326 PF00069 0.332
MOD_GSK3_1 32 39 PF00069 0.564
MOD_GSK3_1 343 350 PF00069 0.340
MOD_GSK3_1 440 447 PF00069 0.564
MOD_GSK3_1 463 470 PF00069 0.603
MOD_GSK3_1 506 513 PF00069 0.496
MOD_GSK3_1 87 94 PF00069 0.375
MOD_N-GLC_1 100 105 PF02516 0.526
MOD_N-GLC_1 191 196 PF02516 0.460
MOD_N-GLC_1 260 265 PF02516 0.529
MOD_N-GLC_1 308 313 PF02516 0.500
MOD_NEK2_1 10 15 PF00069 0.617
MOD_NEK2_1 119 124 PF00069 0.383
MOD_NEK2_1 140 145 PF00069 0.315
MOD_NEK2_1 151 156 PF00069 0.296
MOD_NEK2_1 164 169 PF00069 0.261
MOD_NEK2_1 21 26 PF00069 0.543
MOD_NEK2_1 212 217 PF00069 0.411
MOD_NEK2_1 236 241 PF00069 0.436
MOD_NEK2_1 260 265 PF00069 0.340
MOD_NEK2_1 284 289 PF00069 0.357
MOD_NEK2_1 308 313 PF00069 0.366
MOD_NEK2_1 385 390 PF00069 0.386
MOD_PIKK_1 164 170 PF00454 0.337
MOD_PIKK_1 212 218 PF00454 0.311
MOD_PIKK_1 236 242 PF00454 0.359
MOD_PIKK_1 284 290 PF00454 0.447
MOD_PIKK_1 332 338 PF00454 0.348
MOD_PKA_1 62 68 PF00069 0.313
MOD_PKA_2 164 170 PF00069 0.359
MOD_PKA_2 443 449 PF00069 0.579
MOD_Plk_1 100 106 PF00069 0.354
MOD_Plk_1 271 277 PF00069 0.352
MOD_Plk_1 391 397 PF00069 0.450
MOD_Plk_1 510 516 PF00069 0.382
MOD_Plk_2-3 68 74 PF00069 0.434
MOD_Plk_4 131 137 PF00069 0.291
MOD_Plk_4 157 163 PF00069 0.345
MOD_Plk_4 181 187 PF00069 0.244
MOD_Plk_4 205 211 PF00069 0.374
MOD_Plk_4 253 259 PF00069 0.383
MOD_Plk_4 301 307 PF00069 0.283
MOD_Plk_4 349 355 PF00069 0.335
MOD_ProDKin_1 467 473 PF00069 0.641
MOD_ProDKin_1 85 91 PF00069 0.467
MOD_SUMO_rev_2 250 255 PF00179 0.238
MOD_SUMO_rev_2 504 513 PF00179 0.318
MOD_SUMO_rev_2 59 65 PF00179 0.284
TRG_ENDOCYTIC_2 104 107 PF00928 0.470
TRG_ENDOCYTIC_2 142 145 PF00928 0.272
TRG_ENDOCYTIC_2 190 193 PF00928 0.268
TRG_ENDOCYTIC_2 377 380 PF00928 0.413
TRG_ER_diArg_1 5 7 PF00400 0.728
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.658

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 29% 86%
A0A0N1I661 Leptomonas seymouri 39% 96%
A0A0S4IHI7 Bodo saltans 25% 71%
A0A0S4ILC9 Bodo saltans 42% 99%
A0A0S4ISU4 Bodo saltans 36% 83%
A0A0S4IT62 Bodo saltans 42% 74%
A0A0S4IVQ8 Bodo saltans 35% 91%
A0A0S4IW93 Bodo saltans 27% 90%
A0A0S4IWB9 Bodo saltans 29% 66%
A0A0S4IY44 Bodo saltans 26% 82%
A0A0S4J014 Bodo saltans 25% 76%
A0A0S4J2H8 Bodo saltans 27% 94%
A0A0S4J746 Bodo saltans 26% 78%
A0A0S4JAQ6 Bodo saltans 26% 100%
A0A0S4JAS1 Bodo saltans 32% 86%
A0A0S4JB95 Bodo saltans 25% 90%
A0A0S4JDT0 Bodo saltans 33% 83%
A0A0S4JL29 Bodo saltans 29% 100%
A0A0S4JNU2 Bodo saltans 40% 67%
A0A0S4JQZ0 Bodo saltans 24% 73%
A0A0S4JTM6 Bodo saltans 28% 74%
A0A0S4JTQ7 Bodo saltans 40% 100%
A0A0S4JVI0 Bodo saltans 28% 77%
A0A0S4KJA7 Bodo saltans 27% 82%
A0A0S4KK37 Bodo saltans 29% 94%
A0A3Q8I9A6 Leishmania donovani 47% 70%
A0A3Q8IC27 Leishmania donovani 32% 100%
A0A3S5H6M3 Leishmania donovani 55% 80%
A0A3S5H6M4 Leishmania donovani 50% 83%
A0A3S7WS66 Leishmania donovani 49% 83%
A4HBX3 Leishmania braziliensis 34% 100%
A4HVB0 Leishmania infantum 50% 100%
A4HZ93 Leishmania infantum 32% 100%
D1GJ51 Leishmania infantum 61% 100%
E9AGG2 Leishmania infantum 54% 82%
E9AGG5 Leishmania infantum 61% 100%
E9AGG7 Leishmania infantum 59% 87%
E9AGG9 Leishmania infantum 54% 100%
E9AGH0 Leishmania infantum 48% 69%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 77%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 45% 71%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 78%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 44% 74%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B1U5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
F4IUU1 Arabidopsis thaliana 23% 68%
F4JGB6 Arabidopsis thaliana 26% 67%
F4JTU7 Arabidopsis thaliana 24% 67%
F4KHA2 Arabidopsis thaliana 24% 69%
O48851 Arabidopsis thaliana 24% 71%
O80809 Arabidopsis thaliana 23% 76%
Q1PEN0 Arabidopsis thaliana 24% 76%
Q25331 Leishmania major 72% 100%
Q4QC79 Leishmania major 33% 100%
Q4QGI0 Leishmania major 61% 100%
Q4QGI2 Leishmania major 57% 100%
Q4QGI4 Leishmania major 56% 100%
Q4QGI8 Leishmania major 57% 72%
Q4QGJ0 Leishmania major 58% 87%
Q4QGJ2 Leishmania major 58% 84%
Q4QGJ4 Leishmania major 71% 100%
Q4QGJ6 Leishmania major 54% 100%
Q4QGJ7 Leishmania major 71% 100%
Q4QGJ9 Leishmania major 60% 93%
Q4QGK0 Leishmania major 61% 96%
Q4QGK1 Leishmania major 58% 78%
Q4QGK2 Leishmania major 51% 98%
Q4QGK4 Leishmania major 57% 82%
Q4QGK6 Leishmania major 72% 100%
Q4QGK8 Leishmania major 55% 100%
Q4QGL2 Leishmania major 55% 100%
Q4QGL4 Leishmania major 65% 100%
Q4QGL5 Leishmania major 51% 100%
Q4QGL8 Leishmania major 59% 90%
Q4QGM1 Leishmania major 57% 70%
Q7FZR1 Arabidopsis thaliana 21% 67%
Q9C9H6 Arabidopsis thaliana 22% 70%
Q9LJW7 Arabidopsis thaliana 24% 77%
Q9LS79 Arabidopsis thaliana 22% 70%
Q9SHI3 Arabidopsis thaliana 24% 75%
Q9SVN2 Arabidopsis thaliana 24% 68%
Q9ZU46 Arabidopsis thaliana 26% 76%
Q9ZUK7 Arabidopsis thaliana 22% 66%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS