Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QGI5_LEIMA

TriTrypDb:

LmjF.12.0995 , LMJLV39_120012700 , LMJSD75_120013200

Length:

558

Annotations

LeishMANIAdb annotations

This is a highly disordered Cys-rich prote8in with spurious hydrophobic segments. Very low conservation.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGI5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	279	283	PF00656	0.807
CLV_C14_Caspase3-7	309	313	PF00656	0.815
CLV_MEL_PAP_1	29	35	PF00089	0.467
CLV_NRD_NRD_1	156	158	PF00675	0.518
CLV_NRD_NRD_1	222	224	PF00675	0.646
CLV_NRD_NRD_1	272	274	PF00675	0.819
CLV_NRD_NRD_1	31	33	PF00675	0.474
CLV_NRD_NRD_1	542	544	PF00675	0.785
CLV_NRD_NRD_1	94	96	PF00675	0.507
CLV_PCSK_FUR_1	128	132	PF00082	0.521
CLV_PCSK_FUR_1	538	542	PF00082	0.794
CLV_PCSK_KEX2_1	130	132	PF00082	0.525
CLV_PCSK_KEX2_1	156	158	PF00082	0.518
CLV_PCSK_KEX2_1	221	223	PF00082	0.645
CLV_PCSK_KEX2_1	272	274	PF00082	0.819
CLV_PCSK_KEX2_1	31	33	PF00082	0.474
CLV_PCSK_KEX2_1	540	542	PF00082	0.795
CLV_PCSK_KEX2_1	94	96	PF00082	0.507
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.525
CLV_PCSK_PC7_1	536	542	PF00082	0.793
CLV_PCSK_SKI1_1	275	279	PF00082	0.806
DEG_Nend_UBRbox_4	1	3	PF02207	0.467
DEG_SPOP_SBC_1	177	181	PF00917	0.667
DOC_CDC14_PxL_1	263	271	PF14671	0.797
DOC_CKS1_1	133	138	PF01111	0.519
DOC_CYCLIN_yCln2_LP_2	167	173	PF00134	0.665
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.722
DOC_MAPK_gen_1	163	173	PF00069	0.671
DOC_MAPK_gen_1	31	37	PF00069	0.477
DOC_MAPK_gen_1	94	101	PF00069	0.497
DOC_MAPK_MEF2A_6	166	175	PF00069	0.665
DOC_MAPK_MEF2A_6	19	27	PF00069	0.403
DOC_MAPK_MEF2A_6	350	358	PF00069	0.720
DOC_MAPK_MEF2A_6	6	15	PF00069	0.447
DOC_MAPK_MEF2A_6	94	103	PF00069	0.497
DOC_PP2B_LxvP_1	167	170	PF13499	0.660
DOC_PP2B_LxvP_1	173	176	PF13499	0.606
DOC_PP2B_LxvP_1	316	319	PF13499	0.845
DOC_USP7_MATH_1	177	181	PF00917	0.667
DOC_USP7_MATH_1	262	266	PF00917	0.797
DOC_USP7_MATH_1	276	280	PF00917	0.558
DOC_USP7_MATH_1	323	327	PF00917	0.841
DOC_USP7_MATH_1	380	384	PF00917	0.789
DOC_USP7_MATH_1	465	469	PF00917	0.818
DOC_USP7_MATH_1	483	487	PF00917	0.820
DOC_USP7_MATH_1	73	77	PF00917	0.440
DOC_WW_Pin1_4	105	110	PF00397	0.473
DOC_WW_Pin1_4	132	137	PF00397	0.517
DOC_WW_Pin1_4	165	170	PF00397	0.667
DOC_WW_Pin1_4	190	195	PF00397	0.722
DOC_WW_Pin1_4	370	375	PF00397	0.797
DOC_WW_Pin1_4	420	425	PF00397	0.724
DOC_WW_Pin1_4	497	502	PF00397	0.849
DOC_WW_Pin1_4	94	99	PF00397	0.498
LIG_14-3-3_CanoR_1	19	24	PF00244	0.435
LIG_14-3-3_CanoR_1	288	296	PF00244	0.790
LIG_14-3-3_CanoR_1	444	450	PF00244	0.770
LIG_14-3-3_CanoR_1	499	508	PF00244	0.843
LIG_CtBP_PxDLS_1	424	428	PF00389	0.726
LIG_FHA_1	136	142	PF00498	0.520
LIG_FHA_1	177	183	PF00498	0.672
LIG_FHA_1	328	334	PF00498	0.855
LIG_FHA_1	371	377	PF00498	0.800
LIG_FHA_1	507	513	PF00498	0.658
LIG_FHA_1	528	534	PF00498	0.753
LIG_FHA_1	549	555	PF00498	0.644
LIG_FHA_2	240	246	PF00498	0.637
LIG_FHA_2	307	313	PF00498	0.810
LIG_FHA_2	421	427	PF00498	0.547
LIG_GBD_Chelix_1	480	488	PF00786	0.819
LIG_LIR_Apic_2	496	501	PF02991	0.848
LIG_LIR_Gen_1	100	109	PF02991	0.499
LIG_LIR_Gen_1	18	27	PF02991	0.437
LIG_LIR_Gen_1	383	392	PF02991	0.557
LIG_LIR_Nem_3	100	105	PF02991	0.495
LIG_LIR_Nem_3	18	23	PF02991	0.434
LIG_LIR_Nem_3	24	29	PF02991	0.428
LIG_LIR_Nem_3	383	387	PF02991	0.613
LIG_MYND_1	190	194	PF01753	0.641
LIG_OCRL_FandH_1	383	395	PF00620	0.726
LIG_PCNA_PIPBox_1	35	44	PF02747	0.485
LIG_SH2_CRK	30	34	PF00017	0.470
LIG_SH2_PTP2	10	13	PF00017	0.448
LIG_SH2_PTP2	14	17	PF00017	0.423
LIG_SH2_PTP2	20	23	PF00017	0.407
LIG_SH2_PTP2	26	29	PF00017	0.405
LIG_SH2_SRC	10	13	PF00017	0.448
LIG_SH2_STAT5	10	13	PF00017	0.448
LIG_SH2_STAT5	14	17	PF00017	0.423
LIG_SH2_STAT5	20	23	PF00017	0.407
LIG_SH2_STAT5	26	29	PF00017	0.405
LIG_SH2_STAT5	53	56	PF00017	0.482
LIG_SH3_2	186	191	PF14604	0.656
LIG_SH3_2	267	272	PF14604	0.801
LIG_SH3_3	116	122	PF00018	0.543
LIG_SH3_3	130	136	PF00018	0.482
LIG_SH3_3	183	189	PF00018	0.680
LIG_SH3_3	201	207	PF00018	0.616
LIG_SH3_3	264	270	PF00018	0.794
LIG_SH3_3	357	363	PF00018	0.702
LIG_SH3_3	371	377	PF00018	0.555
LIG_SH3_CIN85_PxpxPR_1	186	191	PF14604	0.656
LIG_SH3_CIN85_PxpxPR_1	544	549	PF14604	0.789
LIG_SH3_CIN85_PxpxPR_1	60	65	PF14604	0.466
LIG_Sin3_3	313	320	PF02671	0.834
LIG_SUMO_SIM_par_1	423	428	PF11976	0.724
LIG_WW_3	188	192	PF00397	0.652
MOD_CDK_SPK_2	497	502	PF00069	0.849
MOD_CK1_1	108	114	PF00069	0.485
MOD_CK1_1	180	186	PF00069	0.674
MOD_CK1_1	265	271	PF00069	0.797
MOD_CK1_1	289	295	PF00069	0.790
MOD_CK1_1	464	470	PF00069	0.818
MOD_CK1_1	500	506	PF00069	0.842
MOD_CK1_1	97	103	PF00069	0.494
MOD_CK2_1	239	245	PF00069	0.633
MOD_CMANNOS	78	81	PF00535	0.441
MOD_Cter_Amidation	128	131	PF01082	0.523
MOD_Cter_Amidation	538	541	PF01082	0.792
MOD_Cter_Amidation	92	95	PF01082	0.509
MOD_GlcNHglycan	182	185	PF01048	0.679
MOD_GlcNHglycan	288	291	PF01048	0.787
MOD_GlcNHglycan	292	295	PF01048	0.723
MOD_GlcNHglycan	324	328	PF01048	0.847
MOD_GlcNHglycan	38	41	PF01048	0.481
MOD_GlcNHglycan	396	399	PF01048	0.697
MOD_GlcNHglycan	429	432	PF01048	0.635
MOD_GlcNHglycan	463	466	PF01048	0.813
MOD_GlcNHglycan	467	470	PF01048	0.751
MOD_GlcNHglycan	485	488	PF01048	0.820
MOD_GlcNHglycan	502	505	PF01048	0.850
MOD_GlcNHglycan	511	515	PF01048	0.677
MOD_GSK3_1	103	110	PF00069	0.500
MOD_GSK3_1	15	22	PF00069	0.430
MOD_GSK3_1	176	183	PF00069	0.670
MOD_GSK3_1	235	242	PF00069	0.686
MOD_GSK3_1	247	254	PF00069	0.719
MOD_GSK3_1	286	293	PF00069	0.789
MOD_GSK3_1	323	330	PF00069	0.847
MOD_GSK3_1	368	375	PF00069	0.793
MOD_GSK3_1	461	468	PF00069	0.691
MOD_GSK3_1	506	513	PF00069	0.652
MOD_NEK2_1	103	108	PF00069	0.499
MOD_NEK2_1	171	176	PF00069	0.665
MOD_NEK2_1	425	430	PF00069	0.600
MOD_NEK2_2	276	281	PF00069	0.805
MOD_OFUCOSY	295	301	PF10250	0.795
MOD_PIKK_1	108	114	PF00454	0.514
MOD_PIKK_1	213	219	PF00454	0.656
MOD_PIKK_1	332	338	PF00454	0.833
MOD_PKA_2	211	217	PF00069	0.658
MOD_PKA_2	252	258	PF00069	0.800
MOD_PKA_2	290	296	PF00069	0.791
MOD_PKA_2	344	350	PF00069	0.746
MOD_PKA_2	465	471	PF00069	0.821
MOD_PKA_2	548	554	PF00069	0.662
MOD_PKB_1	273	281	PF00069	0.810
MOD_PKB_1	370	378	PF00069	0.800
MOD_Plk_1	323	329	PF00069	0.844
MOD_Plk_1	425	431	PF00069	0.714
MOD_Plk_1	510	516	PF00069	0.780
MOD_Plk_4	21	27	PF00069	0.435
MOD_Plk_4	73	79	PF00069	0.435
MOD_ProDKin_1	105	111	PF00069	0.474
MOD_ProDKin_1	132	138	PF00069	0.519
MOD_ProDKin_1	165	171	PF00069	0.668
MOD_ProDKin_1	190	196	PF00069	0.722
MOD_ProDKin_1	370	376	PF00069	0.798
MOD_ProDKin_1	420	426	PF00069	0.724
MOD_ProDKin_1	497	503	PF00069	0.849
MOD_ProDKin_1	94	100	PF00069	0.497
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.855
TRG_ENDOCYTIC_2	10	13	PF00928	0.448
TRG_ENDOCYTIC_2	14	17	PF00928	0.423
TRG_ENDOCYTIC_2	20	23	PF00928	0.407
TRG_ENDOCYTIC_2	26	29	PF00928	0.405
TRG_ENDOCYTIC_2	30	33	PF00928	0.417
TRG_ENDOCYTIC_2	53	56	PF00928	0.482
TRG_ER_diArg_1	221	223	PF00400	0.645
TRG_ER_diArg_1	234	237	PF00400	0.593
TRG_ER_diArg_1	272	275	PF00400	0.819
TRG_ER_diArg_1	30	32	PF00400	0.475
TRG_ER_diArg_1	538	541	PF00400	0.814
TRG_ER_diArg_1	542	544	PF00400	0.785
TRG_ER_diArg_1	94	96	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
Q4QGK9	Leishmania major	99%	100%
Q4QGL1	Leishmania major	99%	100%