LeishMANIAdb
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Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein, putative
Species:
Leishmania major
UniProt:
Q4QGI4_LEIMA
TriTrypDb:
LmjF.12.1020 , LMJLV39_000018600 , LMJSD75_120013500
Length:
536

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 155
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 59, no: 9
NetGPI no yes: 0, no: 68
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 8
GO:0005929 cilium 4 69
GO:0016020 membrane 2 31
GO:0042995 cell projection 2 69
GO:0043226 organelle 2 69
GO:0043227 membrane-bounded organelle 3 69
GO:0110165 cellular anatomical entity 1 69
GO:0120025 plasma membrane bounded cell projection 3 69

Expansion

Sequence features

Q4QGI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0004672 protein kinase activity 3 4
GO:0004674 protein serine/threonine kinase activity 4 4
GO:0016301 kinase activity 4 4
GO:0016740 transferase activity 2 4
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 4
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 4
GO:0140096 catalytic activity, acting on a protein 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.494
CLV_NRD_NRD_1 6 8 PF00675 0.565
CLV_PCSK_KEX2_1 6 8 PF00082 0.565
CLV_PCSK_SKI1_1 159 163 PF00082 0.473
CLV_PCSK_SKI1_1 167 171 PF00082 0.249
CLV_PCSK_SKI1_1 185 189 PF00082 0.214
CLV_PCSK_SKI1_1 254 258 PF00082 0.368
CLV_PCSK_SKI1_1 326 330 PF00082 0.332
CLV_PCSK_SKI1_1 374 378 PF00082 0.393
CLV_PCSK_SKI1_1 395 399 PF00082 0.381
CLV_PCSK_SKI1_1 7 11 PF00082 0.669
DEG_APCC_DBOX_1 470 478 PF00400 0.255
DOC_CYCLIN_RxL_1 185 196 PF00134 0.490
DOC_CYCLIN_RxL_1 3 13 PF00134 0.515
DOC_MAPK_gen_1 395 405 PF00069 0.234
DOC_MAPK_MEF2A_6 203 212 PF00069 0.331
DOC_MAPK_MEF2A_6 492 500 PF00069 0.423
DOC_PP1_RVXF_1 108 115 PF00149 0.281
DOC_USP7_MATH_1 76 80 PF00917 0.442
DOC_USP7_MATH_2 223 229 PF00917 0.409
DOC_USP7_MATH_2 295 301 PF00917 0.253
DOC_WW_Pin1_4 522 527 PF00397 0.714
DOC_WW_Pin1_4 528 533 PF00397 0.668
LIG_14-3-3_CanoR_1 203 208 PF00244 0.439
LIG_14-3-3_CanoR_1 345 352 PF00244 0.468
LIG_14-3-3_CanoR_1 395 401 PF00244 0.562
LIG_14-3-3_CanoR_1 43 48 PF00244 0.497
LIG_14-3-3_CanoR_1 444 453 PF00244 0.443
LIG_14-3-3_CanoR_1 516 520 PF00244 0.642
LIG_BIR_II_1 1 5 PF00653 0.697
LIG_Clathr_ClatBox_1 207 211 PF01394 0.371
LIG_Clathr_ClatBox_1 497 501 PF01394 0.276
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.529
LIG_DLG_GKlike_1 203 210 PF00625 0.217
LIG_FHA_1 168 174 PF00498 0.387
LIG_FHA_1 203 209 PF00498 0.354
LIG_FHA_1 217 223 PF00498 0.344
LIG_FHA_1 232 238 PF00498 0.289
LIG_FHA_1 280 286 PF00498 0.362
LIG_FHA_1 304 310 PF00498 0.530
LIG_FHA_1 352 358 PF00498 0.320
LIG_FHA_1 42 48 PF00498 0.557
LIG_FHA_1 424 430 PF00498 0.358
LIG_FHA_2 121 127 PF00498 0.419
LIG_FHA_2 160 166 PF00498 0.454
LIG_FHA_2 255 261 PF00498 0.398
LIG_FHA_2 327 333 PF00498 0.400
LIG_FHA_2 63 69 PF00498 0.449
LIG_FHA_2 92 98 PF00498 0.486
LIG_LIR_Gen_1 126 135 PF02991 0.355
LIG_LIR_Gen_1 175 183 PF02991 0.373
LIG_LIR_Gen_1 200 208 PF02991 0.308
LIG_LIR_Gen_1 225 232 PF02991 0.311
LIG_LIR_Gen_1 297 304 PF02991 0.375
LIG_LIR_Gen_1 441 448 PF02991 0.371
LIG_LIR_Gen_1 465 474 PF02991 0.463
LIG_LIR_Gen_1 71 80 PF02991 0.537
LIG_LIR_Nem_3 103 107 PF02991 0.519
LIG_LIR_Nem_3 126 131 PF02991 0.391
LIG_LIR_Nem_3 175 180 PF02991 0.438
LIG_LIR_Nem_3 200 204 PF02991 0.278
LIG_LIR_Nem_3 225 229 PF02991 0.354
LIG_LIR_Nem_3 71 75 PF02991 0.343
LIG_NRBOX 130 136 PF00104 0.368
LIG_PCNA_PIPBox_1 373 382 PF02747 0.322
LIG_PCNA_PIPBox_1 397 406 PF02747 0.303
LIG_SH2_SRC 380 383 PF00017 0.312
LIG_SH2_SRC 404 407 PF00017 0.366
LIG_SH2_STAT5 380 383 PF00017 0.393
LIG_SH2_STAT5 404 407 PF00017 0.293
LIG_SH3_3 93 99 PF00018 0.378
LIG_SUMO_SIM_anti_2 209 214 PF11976 0.460
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.350
LIG_SUMO_SIM_par_1 133 138 PF11976 0.270
LIG_SUMO_SIM_par_1 205 211 PF11976 0.423
LIG_SUMO_SIM_par_1 425 430 PF11976 0.328
LIG_TYR_ITIM 102 107 PF00017 0.528
LIG_UBA3_1 496 505 PF00899 0.282
LIG_WW_3 342 346 PF00397 0.248
MOD_CK1_1 172 178 PF00069 0.459
MOD_CK1_1 202 208 PF00069 0.360
MOD_CK1_1 228 234 PF00069 0.370
MOD_CK1_1 276 282 PF00069 0.342
MOD_CK1_1 300 306 PF00069 0.414
MOD_CK1_1 327 333 PF00069 0.288
MOD_CK1_1 351 357 PF00069 0.357
MOD_CK1_1 389 395 PF00069 0.305
MOD_CK1_1 419 425 PF00069 0.402
MOD_CK2_1 203 209 PF00069 0.450
MOD_CK2_1 254 260 PF00069 0.413
MOD_CK2_1 326 332 PF00069 0.398
MOD_CK2_1 91 97 PF00069 0.363
MOD_GlcNHglycan 120 123 PF01048 0.432
MOD_GlcNHglycan 139 142 PF01048 0.401
MOD_GlcNHglycan 144 147 PF01048 0.405
MOD_GlcNHglycan 193 196 PF01048 0.392
MOD_GlcNHglycan 242 245 PF01048 0.380
MOD_GlcNHglycan 25 28 PF01048 0.703
MOD_GlcNHglycan 266 269 PF01048 0.409
MOD_GlcNHglycan 290 293 PF01048 0.370
MOD_GlcNHglycan 314 317 PF01048 0.422
MOD_GlcNHglycan 338 341 PF01048 0.456
MOD_GlcNHglycan 362 365 PF01048 0.441
MOD_GlcNHglycan 386 389 PF01048 0.365
MOD_GlcNHglycan 410 413 PF01048 0.339
MOD_GlcNHglycan 434 437 PF01048 0.406
MOD_GlcNHglycan 446 449 PF01048 0.360
MOD_GlcNHglycan 457 461 PF01048 0.351
MOD_GlcNHglycan 465 469 PF01048 0.422
MOD_GSK3_1 120 127 PF00069 0.350
MOD_GSK3_1 133 140 PF00069 0.342
MOD_GSK3_1 144 151 PF00069 0.365
MOD_GSK3_1 199 206 PF00069 0.382
MOD_GSK3_1 224 231 PF00069 0.335
MOD_GSK3_1 248 255 PF00069 0.335
MOD_GSK3_1 272 279 PF00069 0.340
MOD_GSK3_1 32 39 PF00069 0.659
MOD_GSK3_1 320 327 PF00069 0.371
MOD_GSK3_1 344 351 PF00069 0.349
MOD_GSK3_1 416 423 PF00069 0.328
MOD_GSK3_1 440 447 PF00069 0.446
MOD_GSK3_1 514 521 PF00069 0.649
MOD_GSK3_1 522 529 PF00069 0.670
MOD_GSK3_1 87 94 PF00069 0.419
MOD_N-GLC_1 36 41 PF02516 0.559
MOD_N-GLC_1 86 91 PF02516 0.330
MOD_N-GLC_2 513 515 PF02516 0.571
MOD_NEK2_1 10 15 PF00069 0.557
MOD_NEK2_1 120 125 PF00069 0.325
MOD_NEK2_1 135 140 PF00069 0.344
MOD_NEK2_1 169 174 PF00069 0.291
MOD_NEK2_1 191 196 PF00069 0.424
MOD_NEK2_1 21 26 PF00069 0.453
MOD_NEK2_1 237 242 PF00069 0.332
MOD_NEK2_1 261 266 PF00069 0.376
MOD_NEK2_1 285 290 PF00069 0.432
MOD_NEK2_1 309 314 PF00069 0.436
MOD_NEK2_1 333 338 PF00069 0.370
MOD_NEK2_1 357 362 PF00069 0.357
MOD_NEK2_1 381 386 PF00069 0.426
MOD_NEK2_1 405 410 PF00069 0.505
MOD_NEK2_1 429 434 PF00069 0.499
MOD_NEK2_1 458 463 PF00069 0.421
MOD_NEK2_1 86 91 PF00069 0.394
MOD_NEK2_2 273 278 PF00069 0.441
MOD_PIKK_1 126 132 PF00454 0.440
MOD_PIKK_1 237 243 PF00454 0.368
MOD_PIKK_1 261 267 PF00454 0.428
MOD_PIKK_1 285 291 PF00454 0.466
MOD_PIKK_1 309 315 PF00454 0.404
MOD_PIKK_1 333 339 PF00454 0.498
MOD_PIKK_1 357 363 PF00454 0.440
MOD_PIKK_1 381 387 PF00454 0.436
MOD_PIKK_1 405 411 PF00454 0.349
MOD_PIKK_1 429 435 PF00454 0.442
MOD_PKA_1 62 68 PF00069 0.313
MOD_PKA_2 202 208 PF00069 0.366
MOD_PKA_2 344 350 PF00069 0.468
MOD_PKA_2 515 521 PF00069 0.680
MOD_PKB_1 157 165 PF00069 0.223
MOD_Plk_1 159 165 PF00069 0.266
MOD_Plk_1 199 205 PF00069 0.347
MOD_Plk_1 224 230 PF00069 0.299
MOD_Plk_1 440 446 PF00069 0.538
MOD_Plk_1 464 470 PF00069 0.490
MOD_Plk_1 86 92 PF00069 0.377
MOD_Plk_2-3 68 74 PF00069 0.441
MOD_Plk_4 172 178 PF00069 0.287
MOD_Plk_4 203 209 PF00069 0.302
MOD_ProDKin_1 522 528 PF00069 0.715
MOD_SUMO_rev_2 251 256 PF00179 0.248
MOD_SUMO_rev_2 323 328 PF00179 0.250
MOD_SUMO_rev_2 347 352 PF00179 0.250
MOD_SUMO_rev_2 59 65 PF00179 0.271
TRG_DiLeu_BaLyEn_6 115 120 PF01217 0.533
TRG_ENDOCYTIC_2 104 107 PF00928 0.536
TRG_ER_diArg_1 156 159 PF00400 0.243
TRG_ER_diArg_1 470 473 PF00400 0.291
TRG_ER_diArg_1 5 7 PF00400 0.559
TRG_NES_CRM1_1 252 262 PF08389 0.402
TRG_NES_CRM1_1 324 334 PF08389 0.246
TRG_NES_CRM1_1 348 358 PF08389 0.245
TRG_NES_CRM1_1 372 382 PF08389 0.239
TRG_Pf-PMV_PEXEL_1 233 238 PF00026 0.418
TRG_Pf-PMV_PEXEL_1 281 286 PF00026 0.234
TRG_Pf-PMV_PEXEL_1 305 310 PF00026 0.242
TRG_Pf-PMV_PEXEL_1 353 358 PF00026 0.466
TRG_Pf-PMV_PEXEL_1 425 430 PF00026 0.455
TRG_Pf-PMV_PEXEL_1 444 449 PF00026 0.519
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.336

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 29% 84%
A0A0N1I661 Leptomonas seymouri 38% 94%
A0A0N1I7S5 Leptomonas seymouri 35% 100%
A0A0N1II82 Leptomonas seymouri 27% 78%
A0A0S4IHI7 Bodo saltans 29% 69%
A0A0S4IJN2 Bodo saltans 29% 80%
A0A0S4ILC9 Bodo saltans 38% 97%
A0A0S4IN27 Bodo saltans 42% 99%
A0A0S4IQE4 Bodo saltans 26% 95%
A0A0S4ISU4 Bodo saltans 38% 81%
A0A0S4IT62 Bodo saltans 37% 72%
A0A0S4IU23 Bodo saltans 29% 91%
A0A0S4IU73 Bodo saltans 38% 100%
A0A0S4IV96 Bodo saltans 37% 88%
A0A0S4IVQ8 Bodo saltans 34% 89%
A0A0S4IW93 Bodo saltans 28% 88%
A0A0S4IY44 Bodo saltans 27% 80%
A0A0S4J014 Bodo saltans 29% 75%
A0A0S4J206 Bodo saltans 36% 87%
A0A0S4J2H8 Bodo saltans 28% 92%
A0A0S4J4L7 Bodo saltans 27% 73%
A0A0S4J5A0 Bodo saltans 37% 94%
A0A0S4J954 Bodo saltans 24% 72%
A0A0S4JAQ6 Bodo saltans 26% 100%
A0A0S4JAS1 Bodo saltans 38% 85%
A0A0S4JB95 Bodo saltans 23% 88%
A0A0S4JBV9 Bodo saltans 30% 100%
A0A0S4JD35 Bodo saltans 29% 90%
A0A0S4JDS1 Bodo saltans 26% 100%
A0A0S4JDT0 Bodo saltans 36% 81%
A0A0S4JEK1 Bodo saltans 25% 100%
A0A0S4JFY5 Bodo saltans 33% 100%
A0A0S4JL29 Bodo saltans 34% 100%
A0A0S4JQZ0 Bodo saltans 26% 71%
A0A0S4JS89 Bodo saltans 27% 100%
A0A0S4JTM6 Bodo saltans 33% 73%
A0A0S4JTQ7 Bodo saltans 40% 100%
A0A0S4JU95 Bodo saltans 35% 71%
A0A0S4JVI0 Bodo saltans 27% 75%
A0A0S4KGV4 Bodo saltans 26% 99%
A0A0S4KH41 Bodo saltans 31% 77%
A0A0S4KJA7 Bodo saltans 25% 80%
A0A0S4KK37 Bodo saltans 31% 92%
A0A3Q8I9A6 Leishmania donovani 48% 100%
A0A3Q8IC27 Leishmania donovani 36% 100%
A0A3Q8IFC2 Leishmania donovani 32% 100%
A0A3S5H6M3 Leishmania donovani 52% 78%
A0A3S5H6M4 Leishmania donovani 58% 82%
A0A3S7WS66 Leishmania donovani 58% 81%
A4HBX3 Leishmania braziliensis 33% 100%
A4HVB0 Leishmania infantum 50% 100%
A4HZ93 Leishmania infantum 35% 100%
A4I6S3 Leishmania infantum 31% 100%
A7SFP1 Nematostella vectensis 26% 93%
B4LXW1 Drosophila virilis 23% 87%
D1GJ51 Leishmania infantum 54% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 70%
E9AGG2 Leishmania infantum 52% 81%
E9AGG5 Leishmania infantum 46% 100%
E9AGG7 Leishmania infantum 59% 85%
E9AGG9 Leishmania infantum 65% 99%
E9AGH0 Leishmania infantum 48% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 76%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 77%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 100%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 49% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
F4IUU1 Arabidopsis thaliana 26% 66%
F4JGB6 Arabidopsis thaliana 26% 66%
F4KHA2 Arabidopsis thaliana 24% 68%
O48851 Arabidopsis thaliana 26% 70%
O49325 Arabidopsis thaliana 24% 69%
O49328 Arabidopsis thaliana 22% 67%
O80809 Arabidopsis thaliana 29% 74%
Q1PEN0 Arabidopsis thaliana 23% 75%
Q25331 Leishmania major 47% 100%
Q4QC79 Leishmania major 36% 100%
Q4QGI0 Leishmania major 64% 98%
Q4QGI2 Leishmania major 88% 100%
Q4QGI6 Leishmania major 56% 98%
Q4QGI8 Leishmania major 89% 71%
Q4QGJ0 Leishmania major 53% 85%
Q4QGJ2 Leishmania major 51% 83%
Q4QGJ4 Leishmania major 47% 100%
Q4QGJ7 Leishmania major 47% 100%
Q4QGJ9 Leishmania major 57% 91%
Q4QGK0 Leishmania major 62% 94%
Q4QGK1 Leishmania major 53% 76%
Q4QGK2 Leishmania major 75% 96%
Q4QGK4 Leishmania major 50% 80%
Q4QGK6 Leishmania major 47% 100%
Q4QGK8 Leishmania major 73% 100%
Q4QGL2 Leishmania major 73% 100%
Q4QGL4 Leishmania major 52% 100%
Q4QGL8 Leishmania major 64% 88%
Q4QGM1 Leishmania major 88% 69%
Q5F4C4 Gallus gallus 27% 100%
Q7FZR1 Arabidopsis thaliana 24% 66%
Q80VQ1 Mus musculus 25% 100%
Q940E8 Zea mays 28% 87%
Q9BTT6 Homo sapiens 26% 100%
Q9C9H6 Arabidopsis thaliana 24% 68%
Q9LJW7 Arabidopsis thaliana 25% 75%
Q9LS79 Arabidopsis thaliana 24% 68%
Q9MA83 Arabidopsis thaliana 26% 68%
Q9SHI3 Arabidopsis thaliana 23% 74%
Q9SHI4 Arabidopsis thaliana 24% 71%
Q9SKK5 Arabidopsis thaliana 22% 80%
Q9SVN2 Arabidopsis thaliana 24% 67%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS