WW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGI3_LEIMA

TriTrypDb:

LmjF.12.0950

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 23
NetGPI	no	yes: 0, no: 24

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	318	322	PF00656	0.693
CLV_NRD_NRD_1	182	184	PF00675	0.575
CLV_NRD_NRD_1	260	262	PF00675	0.788
CLV_NRD_NRD_1	271	273	PF00675	0.683
CLV_NRD_NRD_1	348	350	PF00675	0.656
CLV_NRD_NRD_1	430	432	PF00675	0.528
CLV_PCSK_FUR_1	346	350	PF00082	0.604
CLV_PCSK_KEX2_1	182	184	PF00082	0.575
CLV_PCSK_KEX2_1	196	198	PF00082	0.624
CLV_PCSK_KEX2_1	260	262	PF00082	0.740
CLV_PCSK_KEX2_1	348	350	PF00082	0.653
CLV_PCSK_KEX2_1	429	431	PF00082	0.527
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.624
CLV_PCSK_SKI1_1	348	352	PF00082	0.651
CLV_Separin_Metazoa	179	183	PF03568	0.574
DEG_Nend_UBRbox_1	1	4	PF02207	0.435
DOC_CYCLIN_RxL_1	345	355	PF00134	0.658
DOC_MAPK_gen_1	272	280	PF00069	0.727
DOC_PP4_FxxP_1	101	104	PF00568	0.602
DOC_USP7_MATH_1	274	278	PF00917	0.710
DOC_USP7_MATH_1	379	383	PF00917	0.687
DOC_USP7_MATH_1	392	396	PF00917	0.682
DOC_WW_Pin1_4	14	19	PF00397	0.591
DOC_WW_Pin1_4	56	61	PF00397	0.576
LIG_14-3-3_CanoR_1	384	393	PF00244	0.748
LIG_14-3-3_CanoR_1	424	429	PF00244	0.545
LIG_BRCT_BRCA1_1	276	280	PF00533	0.706
LIG_Clathr_ClatBox_1	83	87	PF01394	0.531
LIG_deltaCOP1_diTrp_1	263	268	PF00928	0.653
LIG_EVH1_1	101	105	PF00568	0.605
LIG_FHA_1	196	202	PF00498	0.616
LIG_LIR_Apic_2	12	18	PF02991	0.590
LIG_LIR_Apic_2	203	208	PF02991	0.642
LIG_LIR_Apic_2	251	256	PF02991	0.644
LIG_LIR_Apic_2	46	50	PF02991	0.583
LIG_LIR_Apic_2	99	104	PF02991	0.606
LIG_LIR_Gen_1	189	200	PF02991	0.603
LIG_LIR_Gen_1	242	253	PF02991	0.600
LIG_LIR_Nem_3	135	141	PF02991	0.606
LIG_LIR_Nem_3	189	195	PF02991	0.633
LIG_LIR_Nem_3	242	248	PF02991	0.603
LIG_LIR_Nem_3	263	267	PF02991	0.655
LIG_LIR_Nem_3	311	317	PF02991	0.499
LIG_LIR_Nem_3	38	43	PF02991	0.597
LIG_PCNA_PIPBox_1	69	78	PF02747	0.683
LIG_PDZ_Wminus1_1	433	435	PF00595	0.531
LIG_Pex14_2	280	284	PF04695	0.747
LIG_SH2_CRK	245	249	PF00017	0.617
LIG_SH2_CRK	40	44	PF00017	0.600
LIG_SH2_NCK_1	245	249	PF00017	0.646
LIG_SH2_NCK_1	305	309	PF00017	0.753
LIG_SH2_NCK_1	317	321	PF00017	0.699
LIG_SH2_PTP2	253	256	PF00017	0.645
LIG_SH2_SRC	253	256	PF00017	0.664
LIG_SH2_SRC	317	320	PF00017	0.668
LIG_SH2_STAT3	163	166	PF00017	0.706
LIG_SH2_STAT3	23	26	PF00017	0.597
LIG_SH2_STAT5	23	26	PF00017	0.623
LIG_SH2_STAT5	253	256	PF00017	0.645
LIG_SH2_STAT5	47	50	PF00017	0.585
LIG_SH3_1	373	379	PF00018	0.733
LIG_SH3_3	139	145	PF00018	0.612
LIG_SH3_3	198	204	PF00018	0.628
LIG_SH3_3	295	301	PF00018	0.642
LIG_SH3_3	355	361	PF00018	0.674
LIG_SH3_3	373	379	PF00018	0.726
LIG_SH3_3	88	94	PF00018	0.601
LIG_SH3_3	99	105	PF00018	0.605
LIG_TRAF2_1	176	179	PF00917	0.649
LIG_TRAF2_1	18	21	PF00917	0.679
LIG_TRAF2_1	200	203	PF00917	0.733
LIG_WW_2	378	381	PF00397	0.809
MOD_CDC14_SPxK_1	59	62	PF00782	0.554
MOD_CDK_SPxK_1	56	62	PF00069	0.572
MOD_CK1_1	382	388	PF00069	0.799
MOD_CK2_1	111	117	PF00069	0.577
MOD_CK2_1	336	342	PF00069	0.545
MOD_CK2_1	405	411	PF00069	0.735
MOD_Cter_Amidation	258	261	PF01082	0.735
MOD_Cter_Amidation	270	273	PF01082	0.698
MOD_GlcNHglycan	269	272	PF01048	0.698
MOD_GlcNHglycan	353	357	PF01048	0.639
MOD_GlcNHglycan	358	361	PF01048	0.629
MOD_GlcNHglycan	37	40	PF01048	0.581
MOD_GlcNHglycan	381	384	PF01048	0.763
MOD_GlcNHglycan	387	390	PF01048	0.790
MOD_GlcNHglycan	394	397	PF01048	0.768
MOD_GSK3_1	352	359	PF00069	0.669
MOD_GSK3_1	52	59	PF00069	0.575
MOD_NEK2_1	267	272	PF00069	0.622
MOD_NEK2_1	351	356	PF00069	0.602
MOD_NEK2_1	52	57	PF00069	0.594
MOD_PKA_2	385	391	PF00069	0.751
MOD_Plk_1	111	117	PF00069	0.592
MOD_Plk_1	336	342	PF00069	0.517
MOD_Plk_2-3	405	411	PF00069	0.589
MOD_ProDKin_1	14	20	PF00069	0.590
MOD_ProDKin_1	56	62	PF00069	0.572
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.591
TRG_ENDOCYTIC_2	129	132	PF00928	0.580
TRG_ENDOCYTIC_2	245	248	PF00928	0.605
TRG_ENDOCYTIC_2	40	43	PF00928	0.599
TRG_ER_diArg_1	1	4	PF00400	0.600
TRG_ER_diArg_1	181	183	PF00400	0.583
TRG_ER_diArg_1	211	214	PF00400	0.726
TRG_ER_diArg_1	346	349	PF00400	0.599
TRG_ER_diArg_1	428	431	PF00400	0.530
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.580
TRG_Pf-PMV_PEXEL_1	348	353	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9T4	Leptomonas seymouri	79%	98%
A0A0S4IRN8	Bodo saltans	74%	100%
A0A1X0NP12	Trypanosomatidae	72%	100%
A0A381ME06	Leishmania infantum	94%	99%
A0A3Q8IHT5	Leishmania donovani	94%	99%
A0A3S7WS51	Leishmania donovani	94%	99%
A4H6Y7	Leishmania braziliensis	82%	99%
C9ZHZ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9AGG3	Leishmania infantum	94%	99%
E9AGG8	Leishmania infantum	94%	99%
E9AP06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
Q4QGI1	Leishmania major	97%	100%
Q4QGJ1	Leishmania major	100%	100%
Q4QGJ3	Leishmania major	98%	90%
Q4QGJ5	Leishmania major	98%	91%
Q4QGJ8	Leishmania major	99%	90%
Q4QGK3	Leishmania major	99%	74%
Q4QGK5	Leishmania major	99%	90%
Q4QGK7	Leishmania major	99%	90%
Q4QGL3	Leishmania major	99%	90%
Q4QGL6	Leishmania major	99%	95%
Q4QGM0	Leishmania major	99%	90%
V5BF60	Trypanosoma cruzi	73%	88%