LeishMANIAdb
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Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein, putative
Species:
Leishmania major
UniProt:
Q4QGI2_LEIMA
TriTrypDb:
LmjF.12.1040 , LMJLV39_000018600 * , LMJSD75_120013500 *
Length:
560

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 150
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 58, no: 13
NetGPI no yes: 0, no: 71
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 8
GO:0005929 cilium 4 72
GO:0016020 membrane 2 32
GO:0042995 cell projection 2 72
GO:0043226 organelle 2 72
GO:0043227 membrane-bounded organelle 3 72
GO:0110165 cellular anatomical entity 1 72
GO:0120025 plasma membrane bounded cell projection 3 72

Expansion

Sequence features

Q4QGI2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI2

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 123 127 PF00656 0.457
CLV_NRD_NRD_1 6 8 PF00675 0.574
CLV_PCSK_KEX2_1 6 8 PF00082 0.574
CLV_PCSK_SKI1_1 159 163 PF00082 0.224
CLV_PCSK_SKI1_1 167 171 PF00082 0.497
CLV_PCSK_SKI1_1 185 189 PF00082 0.328
CLV_PCSK_SKI1_1 254 258 PF00082 0.533
CLV_PCSK_SKI1_1 302 306 PF00082 0.268
CLV_PCSK_SKI1_1 350 354 PF00082 0.251
CLV_PCSK_SKI1_1 398 402 PF00082 0.511
CLV_PCSK_SKI1_1 419 423 PF00082 0.477
CLV_PCSK_SKI1_1 7 11 PF00082 0.693
DEG_APCC_DBOX_1 494 502 PF00400 0.255
DOC_CYCLIN_RxL_1 185 196 PF00134 0.463
DOC_CYCLIN_RxL_1 3 13 PF00134 0.704
DOC_MAPK_gen_1 419 429 PF00069 0.263
DOC_MAPK_MEF2A_6 203 212 PF00069 0.210
DOC_MAPK_MEF2A_6 516 524 PF00069 0.564
DOC_PP1_RVXF_1 108 115 PF00149 0.278
DOC_USP7_MATH_1 76 80 PF00917 0.400
DOC_USP7_MATH_2 223 229 PF00917 0.444
DOC_WW_Pin1_4 546 551 PF00397 0.735
DOC_WW_Pin1_4 552 557 PF00397 0.746
LIG_14-3-3_CanoR_1 203 208 PF00244 0.357
LIG_14-3-3_CanoR_1 419 425 PF00244 0.407
LIG_14-3-3_CanoR_1 43 48 PF00244 0.526
LIG_14-3-3_CanoR_1 468 477 PF00244 0.437
LIG_14-3-3_CanoR_1 540 544 PF00244 0.659
LIG_BIR_II_1 1 5 PF00653 0.618
LIG_Clathr_ClatBox_1 207 211 PF01394 0.202
LIG_Clathr_ClatBox_1 521 525 PF01394 0.296
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.476
LIG_DLG_GKlike_1 203 210 PF00625 0.220
LIG_FHA_1 168 174 PF00498 0.390
LIG_FHA_1 203 209 PF00498 0.328
LIG_FHA_1 217 223 PF00498 0.387
LIG_FHA_1 232 238 PF00498 0.261
LIG_FHA_1 280 286 PF00498 0.342
LIG_FHA_1 328 334 PF00498 0.224
LIG_FHA_1 376 382 PF00498 0.414
LIG_FHA_1 42 48 PF00498 0.553
LIG_FHA_1 448 454 PF00498 0.336
LIG_FHA_2 121 127 PF00498 0.467
LIG_FHA_2 160 166 PF00498 0.522
LIG_FHA_2 255 261 PF00498 0.489
LIG_FHA_2 303 309 PF00498 0.421
LIG_FHA_2 351 357 PF00498 0.237
LIG_FHA_2 63 69 PF00498 0.413
LIG_FHA_2 92 98 PF00498 0.438
LIG_LIR_Gen_1 126 135 PF02991 0.309
LIG_LIR_Gen_1 175 183 PF02991 0.345
LIG_LIR_Gen_1 200 208 PF02991 0.340
LIG_LIR_Gen_1 225 232 PF02991 0.315
LIG_LIR_Gen_1 465 472 PF02991 0.299
LIG_LIR_Gen_1 489 498 PF02991 0.403
LIG_LIR_Gen_1 71 80 PF02991 0.537
LIG_LIR_Nem_3 103 107 PF02991 0.470
LIG_LIR_Nem_3 126 131 PF02991 0.314
LIG_LIR_Nem_3 175 180 PF02991 0.392
LIG_LIR_Nem_3 200 204 PF02991 0.366
LIG_LIR_Nem_3 225 229 PF02991 0.412
LIG_LIR_Nem_3 71 75 PF02991 0.357
LIG_NRBOX 130 136 PF00104 0.210
LIG_PCNA_PIPBox_1 397 406 PF02747 0.327
LIG_PCNA_PIPBox_1 421 430 PF02747 0.293
LIG_SH2_SRC 404 407 PF00017 0.423
LIG_SH2_SRC 428 431 PF00017 0.306
LIG_SH2_STAT5 404 407 PF00017 0.299
LIG_SH2_STAT5 428 431 PF00017 0.290
LIG_SH3_3 93 99 PF00018 0.369
LIG_SUMO_SIM_anti_2 209 214 PF11976 0.435
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.346
LIG_SUMO_SIM_par_1 133 138 PF11976 0.204
LIG_SUMO_SIM_par_1 205 211 PF11976 0.366
LIG_SUMO_SIM_par_1 449 454 PF11976 0.361
LIG_TYR_ITIM 102 107 PF00017 0.548
LIG_UBA3_1 520 529 PF00899 0.336
MOD_CK1_1 172 178 PF00069 0.349
MOD_CK1_1 202 208 PF00069 0.401
MOD_CK1_1 228 234 PF00069 0.348
MOD_CK1_1 276 282 PF00069 0.357
MOD_CK1_1 324 330 PF00069 0.240
MOD_CK1_1 375 381 PF00069 0.308
MOD_CK1_1 413 419 PF00069 0.321
MOD_CK1_1 443 449 PF00069 0.352
MOD_CK2_1 203 209 PF00069 0.521
MOD_CK2_1 254 260 PF00069 0.510
MOD_CK2_1 302 308 PF00069 0.361
MOD_CK2_1 350 356 PF00069 0.245
MOD_CK2_1 91 97 PF00069 0.474
MOD_GlcNHglycan 120 123 PF01048 0.405
MOD_GlcNHglycan 139 142 PF01048 0.494
MOD_GlcNHglycan 144 147 PF01048 0.498
MOD_GlcNHglycan 193 196 PF01048 0.413
MOD_GlcNHglycan 242 245 PF01048 0.443
MOD_GlcNHglycan 25 28 PF01048 0.625
MOD_GlcNHglycan 266 269 PF01048 0.473
MOD_GlcNHglycan 290 293 PF01048 0.420
MOD_GlcNHglycan 314 317 PF01048 0.252
MOD_GlcNHglycan 338 341 PF01048 0.257
MOD_GlcNHglycan 362 365 PF01048 0.409
MOD_GlcNHglycan 386 389 PF01048 0.407
MOD_GlcNHglycan 410 413 PF01048 0.448
MOD_GlcNHglycan 434 437 PF01048 0.406
MOD_GlcNHglycan 458 461 PF01048 0.429
MOD_GlcNHglycan 470 473 PF01048 0.389
MOD_GlcNHglycan 481 485 PF01048 0.374
MOD_GlcNHglycan 489 493 PF01048 0.393
MOD_GSK3_1 120 127 PF00069 0.448
MOD_GSK3_1 133 140 PF00069 0.460
MOD_GSK3_1 144 151 PF00069 0.394
MOD_GSK3_1 199 206 PF00069 0.392
MOD_GSK3_1 224 231 PF00069 0.324
MOD_GSK3_1 248 255 PF00069 0.375
MOD_GSK3_1 296 303 PF00069 0.359
MOD_GSK3_1 32 39 PF00069 0.540
MOD_GSK3_1 320 327 PF00069 0.246
MOD_GSK3_1 344 351 PF00069 0.428
MOD_GSK3_1 368 375 PF00069 0.304
MOD_GSK3_1 440 447 PF00069 0.377
MOD_GSK3_1 464 471 PF00069 0.436
MOD_GSK3_1 538 545 PF00069 0.649
MOD_GSK3_1 546 553 PF00069 0.616
MOD_GSK3_1 87 94 PF00069 0.384
MOD_N-GLC_1 36 41 PF02516 0.528
MOD_N-GLC_1 86 91 PF02516 0.280
MOD_N-GLC_2 537 539 PF02516 0.459
MOD_NEK2_1 10 15 PF00069 0.568
MOD_NEK2_1 120 125 PF00069 0.378
MOD_NEK2_1 135 140 PF00069 0.469
MOD_NEK2_1 169 174 PF00069 0.295
MOD_NEK2_1 191 196 PF00069 0.399
MOD_NEK2_1 21 26 PF00069 0.506
MOD_NEK2_1 237 242 PF00069 0.334
MOD_NEK2_1 261 266 PF00069 0.502
MOD_NEK2_1 285 290 PF00069 0.399
MOD_NEK2_1 309 314 PF00069 0.247
MOD_NEK2_1 333 338 PF00069 0.238
MOD_NEK2_1 357 362 PF00069 0.363
MOD_NEK2_1 381 386 PF00069 0.396
MOD_NEK2_1 405 410 PF00069 0.325
MOD_NEK2_1 429 434 PF00069 0.383
MOD_NEK2_1 453 458 PF00069 0.412
MOD_NEK2_1 482 487 PF00069 0.388
MOD_NEK2_1 86 91 PF00069 0.283
MOD_NEK2_2 321 326 PF00069 0.238
MOD_PIKK_1 126 132 PF00454 0.429
MOD_PIKK_1 237 243 PF00454 0.363
MOD_PIKK_1 261 267 PF00454 0.573
MOD_PIKK_1 285 291 PF00454 0.500
MOD_PIKK_1 309 315 PF00454 0.249
MOD_PIKK_1 333 339 PF00454 0.241
MOD_PIKK_1 357 363 PF00454 0.561
MOD_PIKK_1 381 387 PF00454 0.502
MOD_PIKK_1 405 411 PF00454 0.483
MOD_PIKK_1 429 435 PF00454 0.456
MOD_PIKK_1 453 459 PF00454 0.537
MOD_PKA_1 62 68 PF00069 0.306
MOD_PKA_2 202 208 PF00069 0.432
MOD_PKA_2 539 545 PF00069 0.721
MOD_PKB_1 157 165 PF00069 0.221
MOD_Plk_1 159 165 PF00069 0.245
MOD_Plk_1 199 205 PF00069 0.358
MOD_Plk_1 224 230 PF00069 0.334
MOD_Plk_1 464 470 PF00069 0.364
MOD_Plk_1 488 494 PF00069 0.379
MOD_Plk_1 86 92 PF00069 0.377
MOD_Plk_2-3 68 74 PF00069 0.437
MOD_Plk_4 172 178 PF00069 0.340
MOD_Plk_4 203 209 PF00069 0.337
MOD_ProDKin_1 546 552 PF00069 0.736
MOD_SUMO_rev_2 251 256 PF00179 0.248
MOD_SUMO_rev_2 299 304 PF00179 0.436
MOD_SUMO_rev_2 347 352 PF00179 0.251
MOD_SUMO_rev_2 371 376 PF00179 0.250
MOD_SUMO_rev_2 59 65 PF00179 0.270
TRG_DiLeu_BaLyEn_6 115 120 PF01217 0.230
TRG_ENDOCYTIC_2 104 107 PF00928 0.548
TRG_ER_diArg_1 156 159 PF00400 0.243
TRG_ER_diArg_1 494 497 PF00400 0.303
TRG_ER_diArg_1 5 7 PF00400 0.568
TRG_NES_CRM1_1 252 262 PF08389 0.246
TRG_NES_CRM1_1 300 310 PF08389 0.387
TRG_NES_CRM1_1 348 358 PF08389 0.247
TRG_NES_CRM1_1 372 382 PF08389 0.562
TRG_NES_CRM1_1 396 406 PF08389 0.377
TRG_Pf-PMV_PEXEL_1 233 238 PF00026 0.246
TRG_Pf-PMV_PEXEL_1 281 286 PF00026 0.239
TRG_Pf-PMV_PEXEL_1 329 334 PF00026 0.227
TRG_Pf-PMV_PEXEL_1 377 382 PF00026 0.467
TRG_Pf-PMV_PEXEL_1 449 454 PF00026 0.246
TRG_Pf-PMV_PEXEL_1 468 473 PF00026 0.505
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.335

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 29% 88%
A0A0N1I121 Leptomonas seymouri 27% 100%
A0A0N1I661 Leptomonas seymouri 37% 98%
A0A0N1I7S5 Leptomonas seymouri 36% 100%
A0A0S4IHI7 Bodo saltans 29% 72%
A0A0S4IJN2 Bodo saltans 28% 83%
A0A0S4ILC9 Bodo saltans 38% 100%
A0A0S4IN27 Bodo saltans 41% 100%
A0A0S4IQE4 Bodo saltans 26% 99%
A0A0S4ISU4 Bodo saltans 34% 85%
A0A0S4IT62 Bodo saltans 37% 76%
A0A0S4IU23 Bodo saltans 28% 95%
A0A0S4IU73 Bodo saltans 36% 100%
A0A0S4IV96 Bodo saltans 36% 92%
A0A0S4IVQ8 Bodo saltans 33% 93%
A0A0S4IW93 Bodo saltans 26% 92%
A0A0S4IWB9 Bodo saltans 32% 68%
A0A0S4IY44 Bodo saltans 26% 84%
A0A0S4J014 Bodo saltans 29% 78%
A0A0S4J206 Bodo saltans 36% 91%
A0A0S4J2H8 Bodo saltans 27% 96%
A0A0S4J4L7 Bodo saltans 27% 76%
A0A0S4J5A0 Bodo saltans 38% 98%
A0A0S4J954 Bodo saltans 24% 76%
A0A0S4JAQ6 Bodo saltans 27% 100%
A0A0S4JAS1 Bodo saltans 35% 88%
A0A0S4JB95 Bodo saltans 24% 92%
A0A0S4JBV9 Bodo saltans 30% 100%
A0A0S4JD35 Bodo saltans 26% 94%
A0A0S4JDS1 Bodo saltans 25% 100%
A0A0S4JDT0 Bodo saltans 36% 85%
A0A0S4JEK1 Bodo saltans 25% 100%
A0A0S4JL29 Bodo saltans 32% 100%
A0A0S4JMF9 Bodo saltans 34% 100%
A0A0S4JN05 Bodo saltans 36% 67%
A0A0S4JNU2 Bodo saltans 42% 68%
A0A0S4JQZ0 Bodo saltans 25% 74%
A0A0S4JS89 Bodo saltans 30% 100%
A0A0S4JTM6 Bodo saltans 32% 76%
A0A0S4JTQ7 Bodo saltans 40% 100%
A0A0S4JU95 Bodo saltans 32% 74%
A0A0S4JVI0 Bodo saltans 27% 79%
A0A0S4KEG2 Bodo saltans 27% 67%
A0A0S4KGV4 Bodo saltans 26% 100%
A0A0S4KIR5 Bodo saltans 26% 67%
A0A0S4KJA7 Bodo saltans 26% 83%
A0A0S4KK37 Bodo saltans 29% 96%
A0A3Q8I9A6 Leishmania donovani 46% 100%
A0A3Q8I9D9 Leishmania donovani 43% 100%
A0A3Q8IC27 Leishmania donovani 35% 100%
A0A3Q8IFC2 Leishmania donovani 32% 100%
A0A3S5H6L9 Leishmania donovani 44% 100%
A0A3S5H6M3 Leishmania donovani 54% 82%
A0A3S5H6M4 Leishmania donovani 55% 85%
A0A3S7WS66 Leishmania donovani 55% 85%
A4HBX3 Leishmania braziliensis 34% 100%
A4HVB0 Leishmania infantum 49% 100%
A4HZ93 Leishmania infantum 35% 100%
A4I6S3 Leishmania infantum 31% 100%
B4JTV9 Drosophila grimshawi 26% 90%
B5DX45 Drosophila pseudoobscura pseudoobscura 24% 89%
D1GJ51 Leishmania infantum 54% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 73%
E9AGG2 Leishmania infantum 55% 84%
E9AGG5 Leishmania infantum 48% 100%
E9AGG7 Leishmania infantum 59% 89%
E9AGG9 Leishmania infantum 60% 100%
E9AGH0 Leishmania infantum 45% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 79%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 54% 80%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 52% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 48% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
F4IUU1 Arabidopsis thaliana 27% 69%
F4JGB6 Arabidopsis thaliana 24% 69%
F4JTU7 Arabidopsis thaliana 24% 69%
F4KHA2 Arabidopsis thaliana 23% 71%
O48851 Arabidopsis thaliana 26% 73%
O49325 Arabidopsis thaliana 23% 72%
O49328 Arabidopsis thaliana 22% 70%
O49879 Solanum lycopersicum 24% 66%
O80809 Arabidopsis thaliana 30% 78%
Q1PEN0 Arabidopsis thaliana 21% 78%
Q25331 Leishmania major 46% 100%
Q4QC79 Leishmania major 35% 100%
Q4QGI0 Leishmania major 62% 94%
Q4QGI4 Leishmania major 88% 100%
Q4QGI6 Leishmania major 57% 100%
Q4QGI8 Leishmania major 89% 74%
Q4QGJ0 Leishmania major 56% 89%
Q4QGJ2 Leishmania major 55% 86%
Q4QGJ4 Leishmania major 46% 100%
Q4QGJ7 Leishmania major 46% 100%
Q4QGJ9 Leishmania major 58% 95%
Q4QGK0 Leishmania major 61% 98%
Q4QGK1 Leishmania major 50% 80%
Q4QGK2 Leishmania major 77% 100%
Q4QGK4 Leishmania major 54% 84%
Q4QGK6 Leishmania major 46% 100%
Q4QGK8 Leishmania major 65% 100%
Q4QGL2 Leishmania major 65% 100%
Q4QGL4 Leishmania major 52% 100%
Q4QGL8 Leishmania major 60% 92%
Q4QGM1 Leishmania major 83% 72%
Q5M8G4 Xenopus tropicalis 27% 93%
Q6GPJ5 Xenopus laevis 25% 93%
Q7FZR1 Arabidopsis thaliana 25% 69%
Q940E8 Zea mays 28% 91%
Q9C9H6 Arabidopsis thaliana 25% 71%
Q9C9H7 Arabidopsis thaliana 24% 66%
Q9LJW7 Arabidopsis thaliana 24% 79%
Q9LS79 Arabidopsis thaliana 24% 71%
Q9LS80 Arabidopsis thaliana 22% 67%
Q9MA83 Arabidopsis thaliana 25% 71%
Q9SHI3 Arabidopsis thaliana 25% 77%
Q9SHI4 Arabidopsis thaliana 25% 74%
Q9SKK5 Arabidopsis thaliana 24% 83%
Q9SVM3 Arabidopsis thaliana 23% 66%
Q9SVN2 Arabidopsis thaliana 24% 70%
Q9ZUK7 Arabidopsis thaliana 26% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS