LeishMANIAdb
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Putative surface antigen protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative surface antigen protein
Gene product:
surface antigen protein, putative
Species:
Leishmania major
UniProt:
Q4QGI0_LEIMA
TriTrypDb:
LmjF.12.1090 , LMJLV39_000018900 * , LMJSD75_120013600 *
Length:
509

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 165
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 77, no: 17
NetGPI no yes: 0, no: 94
Cellular components
Term Name Level Count
GO:0005929 cilium 4 95
GO:0042995 cell projection 2 95
GO:0043226 organelle 2 95
GO:0043227 membrane-bounded organelle 3 95
GO:0110165 cellular anatomical entity 1 95
GO:0120025 plasma membrane bounded cell projection 3 95
GO:0016020 membrane 2 36
GO:0005886 plasma membrane 3 6

Expansion

Sequence features

Q4QGI0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGI0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.526
CLV_NRD_NRD_1 311 313 PF00675 0.245
CLV_NRD_NRD_1 359 361 PF00675 0.501
CLV_NRD_NRD_1 6 8 PF00675 0.718
CLV_PCSK_KEX2_1 311 313 PF00082 0.245
CLV_PCSK_KEX2_1 359 361 PF00082 0.501
CLV_PCSK_KEX2_1 6 8 PF00082 0.718
CLV_PCSK_SKI1_1 231 235 PF00082 0.489
CLV_PCSK_SKI1_1 351 355 PF00082 0.426
CLV_PCSK_SKI1_1 375 379 PF00082 0.469
CLV_PCSK_SKI1_1 399 403 PF00082 0.465
CLV_PCSK_SKI1_1 7 11 PF00082 0.702
DOC_AGCK_PIF_2 69 74 PF00069 0.306
DOC_CYCLIN_RxL_1 105 116 PF00134 0.315
DOC_CYCLIN_RxL_1 187 197 PF00134 0.536
DOC_CYCLIN_RxL_1 3 13 PF00134 0.712
DOC_CYCLIN_yClb5_NLxxxL_5 286 295 PF00134 0.448
DOC_CYCLIN_yClb5_NLxxxL_5 430 439 PF00134 0.505
DOC_MAPK_gen_1 469 477 PF00069 0.514
DOC_MAPK_MEF2A_6 469 477 PF00069 0.600
DOC_PP1_RVXF_1 108 115 PF00149 0.530
DOC_USP7_MATH_1 204 208 PF00917 0.492
DOC_USP7_MATH_1 274 278 PF00917 0.454
DOC_USP7_MATH_1 450 454 PF00917 0.416
DOC_USP7_MATH_2 175 181 PF00917 0.475
DOC_USP7_MATH_2 224 230 PF00917 0.521
DOC_WW_Pin1_4 494 499 PF00397 0.707
LIG_14-3-3_CanoR_1 359 367 PF00244 0.545
LIG_14-3-3_CanoR_1 43 48 PF00244 0.546
LIG_14-3-3_CanoR_1 493 498 PF00244 0.728
LIG_Actin_WH2_2 298 313 PF00022 0.273
LIG_Actin_WH2_2 346 361 PF00022 0.279
LIG_BIR_II_1 1 5 PF00653 0.716
LIG_BRCT_BRCA1_1 154 158 PF00533 0.365
LIG_BRCT_BRCA1_1 303 307 PF00533 0.402
LIG_BRCT_BRCA1_1 70 74 PF00533 0.547
LIG_BRCT_BRCA1_2 70 76 PF00533 0.243
LIG_deltaCOP1_diTrp_1 61 69 PF00928 0.567
LIG_FHA_1 183 189 PF00498 0.371
LIG_FHA_1 218 224 PF00498 0.423
LIG_FHA_1 281 287 PF00498 0.343
LIG_FHA_1 328 334 PF00498 0.346
LIG_FHA_1 401 407 PF00498 0.359
LIG_FHA_1 42 48 PF00498 0.454
LIG_FHA_2 122 128 PF00498 0.513
LIG_FHA_2 421 427 PF00498 0.436
LIG_FHA_2 63 69 PF00498 0.497
LIG_FHA_2 92 98 PF00498 0.536
LIG_LIR_Gen_1 113 122 PF02991 0.553
LIG_LIR_Gen_1 127 135 PF02991 0.428
LIG_LIR_Gen_1 177 184 PF02991 0.453
LIG_LIR_Gen_1 201 208 PF02991 0.394
LIG_LIR_Gen_1 226 233 PF02991 0.402
LIG_LIR_Gen_1 304 315 PF02991 0.328
LIG_LIR_Gen_1 441 450 PF02991 0.464
LIG_LIR_Gen_1 71 79 PF02991 0.562
LIG_LIR_Nem_3 103 107 PF02991 0.518
LIG_LIR_Nem_3 127 132 PF02991 0.450
LIG_LIR_Nem_3 304 310 PF02991 0.282
LIG_LIR_Nem_3 441 446 PF02991 0.390
LIG_LIR_Nem_3 71 75 PF02991 0.418
LIG_NRBOX 183 189 PF00104 0.238
LIG_PCNA_PIPBox_1 230 239 PF02747 0.448
LIG_SH2_CRK 384 388 PF00017 0.393
LIG_SH2_NCK_1 384 388 PF00017 0.250
LIG_SH2_STAT5 309 312 PF00017 0.322
LIG_SH2_STAT5 384 387 PF00017 0.504
LIG_SH3_3 93 99 PF00018 0.538
LIG_SUMO_SIM_anti_2 136 142 PF11976 0.426
LIG_SUMO_SIM_anti_2 327 333 PF11976 0.422
LIG_SUMO_SIM_anti_2 352 357 PF11976 0.520
LIG_SUMO_SIM_anti_2 376 381 PF11976 0.405
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.539
LIG_SUMO_SIM_par_1 473 479 PF11976 0.555
LIG_TYR_ITIM 102 107 PF00017 0.457
LIG_TYR_ITIM 382 387 PF00017 0.482
LIG_UBA3_1 379 386 PF00899 0.484
MOD_CK1_1 152 158 PF00069 0.448
MOD_CK1_1 180 186 PF00069 0.443
MOD_CK1_1 207 213 PF00069 0.386
MOD_CK1_1 229 235 PF00069 0.391
MOD_CK1_1 241 247 PF00069 0.372
MOD_CK1_1 276 282 PF00069 0.320
MOD_CK1_1 300 306 PF00069 0.301
MOD_CK1_1 324 330 PF00069 0.362
MOD_CK1_1 349 355 PF00069 0.381
MOD_CK1_1 373 379 PF00069 0.361
MOD_CK1_1 397 403 PF00069 0.399
MOD_CK1_1 420 426 PF00069 0.387
MOD_CK1_1 438 444 PF00069 0.416
MOD_CK2_1 127 133 PF00069 0.491
MOD_CK2_1 420 426 PF00069 0.355
MOD_CK2_1 91 97 PF00069 0.536
MOD_GlcNHglycan 145 148 PF01048 0.436
MOD_GlcNHglycan 170 173 PF01048 0.368
MOD_GlcNHglycan 194 197 PF01048 0.451
MOD_GlcNHglycan 243 246 PF01048 0.427
MOD_GlcNHglycan 25 28 PF01048 0.659
MOD_GlcNHglycan 267 270 PF01048 0.322
MOD_GlcNHglycan 315 318 PF01048 0.396
MOD_GlcNHglycan 339 342 PF01048 0.456
MOD_GlcNHglycan 363 366 PF01048 0.455
MOD_GlcNHglycan 387 390 PF01048 0.432
MOD_GlcNHglycan 411 414 PF01048 0.406
MOD_GlcNHglycan 419 422 PF01048 0.387
MOD_GlcNHglycan 423 426 PF01048 0.374
MOD_GlcNHglycan 435 438 PF01048 0.448
MOD_GlcNHglycan 443 446 PF01048 0.409
MOD_GlcNHglycan 84 87 PF01048 0.448
MOD_GSK3_1 121 128 PF00069 0.468
MOD_GSK3_1 145 152 PF00069 0.449
MOD_GSK3_1 166 173 PF00069 0.410
MOD_GSK3_1 176 183 PF00069 0.407
MOD_GSK3_1 207 214 PF00069 0.353
MOD_GSK3_1 225 232 PF00069 0.365
MOD_GSK3_1 273 280 PF00069 0.354
MOD_GSK3_1 297 304 PF00069 0.347
MOD_GSK3_1 32 39 PF00069 0.580
MOD_GSK3_1 321 328 PF00069 0.388
MOD_GSK3_1 354 361 PF00069 0.369
MOD_GSK3_1 393 400 PF00069 0.402
MOD_GSK3_1 417 424 PF00069 0.399
MOD_GSK3_1 435 442 PF00069 0.377
MOD_GSK3_1 493 500 PF00069 0.689
MOD_GSK3_1 87 94 PF00069 0.455
MOD_N-GLC_1 143 148 PF02516 0.439
MOD_N-GLC_1 238 243 PF02516 0.346
MOD_N-GLC_1 433 438 PF02516 0.345
MOD_N-GLC_1 77 82 PF02516 0.364
MOD_NEK2_1 10 15 PF00069 0.610
MOD_NEK2_1 121 126 PF00069 0.438
MOD_NEK2_1 192 197 PF00069 0.447
MOD_NEK2_1 21 26 PF00069 0.665
MOD_NEK2_1 211 216 PF00069 0.385
MOD_NEK2_1 262 267 PF00069 0.273
MOD_NEK2_1 286 291 PF00069 0.339
MOD_NEK2_1 310 315 PF00069 0.419
MOD_NEK2_1 334 339 PF00069 0.362
MOD_NEK2_1 358 363 PF00069 0.368
MOD_NEK2_1 382 387 PF00069 0.436
MOD_NEK2_1 406 411 PF00069 0.491
MOD_NEK2_1 435 440 PF00069 0.402
MOD_NEK2_1 448 453 PF00069 0.351
MOD_NEK2_2 450 455 PF00069 0.283
MOD_PIKK_1 262 268 PF00454 0.481
MOD_PIKK_1 334 340 PF00454 0.495
MOD_PIKK_1 358 364 PF00454 0.485
MOD_PIKK_1 406 412 PF00454 0.528
MOD_PKA_1 62 68 PF00069 0.345
MOD_PKA_2 310 316 PF00069 0.493
MOD_PKA_2 358 364 PF00069 0.492
MOD_Plk_1 176 182 PF00069 0.423
MOD_Plk_1 225 231 PF00069 0.415
MOD_Plk_1 238 244 PF00069 0.427
MOD_Plk_2-3 68 74 PF00069 0.513
MOD_Plk_4 136 142 PF00069 0.411
MOD_Plk_4 183 189 PF00069 0.406
MOD_Plk_4 232 238 PF00069 0.384
MOD_Plk_4 303 309 PF00069 0.315
MOD_Plk_4 327 333 PF00069 0.404
MOD_Plk_4 351 357 PF00069 0.362
MOD_Plk_4 375 381 PF00069 0.348
MOD_ProDKin_1 494 500 PF00069 0.709
MOD_SUMO_rev_2 59 65 PF00179 0.304
TRG_DiLeu_BaLyEn_6 253 258 PF01217 0.476
TRG_ENDOCYTIC_2 104 107 PF00928 0.462
TRG_ENDOCYTIC_2 384 387 PF00928 0.386
TRG_ER_diArg_1 310 312 PF00400 0.497
TRG_ER_diArg_1 358 360 PF00400 0.504
TRG_ER_diArg_1 5 7 PF00400 0.720
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.569

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I121 Leptomonas seymouri 27% 100%
A0A0N1I661 Leptomonas seymouri 39% 89%
A0A0N1I7S5 Leptomonas seymouri 36% 100%
A0A0N1II82 Leptomonas seymouri 30% 74%
A0A0S4IIK7 Bodo saltans 30% 100%
A0A0S4IJN2 Bodo saltans 28% 76%
A0A0S4ILC9 Bodo saltans 39% 92%
A0A0S4IN27 Bodo saltans 42% 94%
A0A0S4IQE4 Bodo saltans 26% 90%
A0A0S4IR61 Bodo saltans 29% 100%
A0A0S4ISU4 Bodo saltans 38% 77%
A0A0S4IT62 Bodo saltans 40% 69%
A0A0S4IU23 Bodo saltans 29% 86%
A0A0S4IU73 Bodo saltans 43% 100%
A0A0S4IV96 Bodo saltans 36% 84%
A0A0S4IVQ8 Bodo saltans 35% 85%
A0A0S4IW93 Bodo saltans 29% 84%
A0A0S4IY44 Bodo saltans 25% 76%
A0A0S4IZC7 Bodo saltans 29% 100%
A0A0S4J014 Bodo saltans 30% 71%
A0A0S4J206 Bodo saltans 37% 83%
A0A0S4J2H8 Bodo saltans 26% 87%
A0A0S4J3T7 Bodo saltans 34% 100%
A0A0S4J4L7 Bodo saltans 30% 69%
A0A0S4J5A0 Bodo saltans 39% 89%
A0A0S4J954 Bodo saltans 28% 69%
A0A0S4JAQ6 Bodo saltans 26% 99%
A0A0S4JAS1 Bodo saltans 35% 80%
A0A0S4JAW7 Bodo saltans 28% 100%
A0A0S4JB95 Bodo saltans 27% 84%
A0A0S4JBV9 Bodo saltans 30% 100%
A0A0S4JD35 Bodo saltans 32% 85%
A0A0S4JDS1 Bodo saltans 25% 96%
A0A0S4JDT0 Bodo saltans 35% 77%
A0A0S4JEK1 Bodo saltans 28% 100%
A0A0S4JFY5 Bodo saltans 34% 100%
A0A0S4JL29 Bodo saltans 34% 100%
A0A0S4JQW3 Bodo saltans 24% 100%
A0A0S4JQZ0 Bodo saltans 27% 68%
A0A0S4JS89 Bodo saltans 31% 100%
A0A0S4JTM6 Bodo saltans 36% 69%
A0A0S4JTQ7 Bodo saltans 40% 96%
A0A0S4JU95 Bodo saltans 36% 67%
A0A0S4JVI0 Bodo saltans 31% 72%
A0A0S4KGV4 Bodo saltans 26% 94%
A0A0S4KH41 Bodo saltans 33% 73%
A0A0S4KJA7 Bodo saltans 27% 76%
A0A0S4KK37 Bodo saltans 32% 87%
A0A3Q8I9A6 Leishmania donovani 54% 100%
A0A3Q8I9B4 Leishmania donovani 43% 100%
A0A3Q8I9D9 Leishmania donovani 44% 100%
A0A3Q8IC27 Leishmania donovani 36% 100%
A0A3S5H6L9 Leishmania donovani 45% 100%
A0A3S5H6M3 Leishmania donovani 58% 74%
A0A3S5H6M4 Leishmania donovani 59% 77%
A0A3S7WS66 Leishmania donovani 60% 77%
A4HBX3 Leishmania braziliensis 34% 100%
A4HVB0 Leishmania infantum 54% 100%
A4HZ93 Leishmania infantum 36% 100%
D1GJ51 Leishmania infantum 62% 100%
E8NHG9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 67%
E9AGG2 Leishmania infantum 58% 77%
E9AGG5 Leishmania infantum 47% 100%
E9AGG7 Leishmania infantum 57% 81%
E9AGG9 Leishmania infantum 79% 94%
E9AGH0 Leishmania infantum 49% 100%
E9ANZ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 72%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 53% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AP04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 55% 73%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 73% 99%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 57% 100%
E9AP08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
O02833 Papio hamadryas 23% 84%
O48851 Arabidopsis thaliana 26% 66%
O80809 Arabidopsis thaliana 26% 71%
P35858 Homo sapiens 22% 84%
Q1PEN0 Arabidopsis thaliana 23% 71%
Q25331 Leishmania major 60% 100%
Q4QC79 Leishmania major 32% 96%
Q4QGI2 Leishmania major 62% 91%
Q4QGI4 Leishmania major 64% 95%
Q4QGI6 Leishmania major 61% 93%
Q4QGI8 Leishmania major 62% 67%
Q4QGJ0 Leishmania major 65% 81%
Q4QGJ2 Leishmania major 58% 79%
Q4QGJ4 Leishmania major 59% 100%
Q4QGJ6 Leishmania major 63% 89%
Q4QGJ7 Leishmania major 60% 100%
Q4QGJ9 Leishmania major 57% 87%
Q4QGK0 Leishmania major 64% 89%
Q4QGK1 Leishmania major 63% 72%
Q4QGK2 Leishmania major 62% 91%
Q4QGK4 Leishmania major 58% 76%
Q4QGK6 Leishmania major 60% 100%
Q4QGK8 Leishmania major 64% 99%
Q4QGL2 Leishmania major 64% 99%
Q4QGL4 Leishmania major 63% 100%
Q4QGL5 Leishmania major 59% 93%
Q4QGL8 Leishmania major 64% 83%
Q80X72 Mus musculus 23% 88%
Q940E8 Zea mays 26% 83%
Q9CRC8 Mus musculus 25% 85%
Q9LJW7 Arabidopsis thaliana 26% 72%
Q9SHI3 Arabidopsis thaliana 24% 70%
Q9SHI4 Arabidopsis thaliana 24% 67%
Q9SKK5 Arabidopsis thaliana 22% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS