J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGH8_LEIMA

TriTrypDb:

LmjF.12.1110 , LMJLV39_120013100 , LMJSD75_120013800

Length:

733

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	2
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0035966	response to topologically incorrect protein	3	2
GO:0035967	cellular response to topologically incorrect protein	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050896	response to stimulus	1	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0051788	response to misfolded protein	4	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0070887	cellular response to chemical stimulus	3	2
GO:0071218	cellular response to misfolded protein	5	2
GO:0071310	cellular response to organic substance	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.621
CLV_C14_Caspase3-7	510	514	PF00656	0.594
CLV_C14_Caspase3-7	727	731	PF00656	0.573
CLV_NRD_NRD_1	109	111	PF00675	0.412
CLV_NRD_NRD_1	143	145	PF00675	0.368
CLV_NRD_NRD_1	216	218	PF00675	0.672
CLV_NRD_NRD_1	259	261	PF00675	0.496
CLV_NRD_NRD_1	393	395	PF00675	0.632
CLV_NRD_NRD_1	44	46	PF00675	0.476
CLV_PCSK_FUR_1	257	261	PF00082	0.488
CLV_PCSK_KEX2_1	105	107	PF00082	0.323
CLV_PCSK_KEX2_1	109	111	PF00082	0.329
CLV_PCSK_KEX2_1	142	144	PF00082	0.305
CLV_PCSK_KEX2_1	216	218	PF00082	0.672
CLV_PCSK_KEX2_1	259	261	PF00082	0.496
CLV_PCSK_KEX2_1	393	395	PF00082	0.632
CLV_PCSK_KEX2_1	44	46	PF00082	0.476
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.257
CLV_PCSK_SKI1_1	110	114	PF00082	0.341
CLV_PCSK_SKI1_1	473	477	PF00082	0.467
CLV_Separin_Metazoa	718	722	PF03568	0.528
DEG_Nend_UBRbox_4	1	3	PF02207	0.430
DEG_SPOP_SBC_1	679	683	PF00917	0.613
DOC_CDC14_PxL_1	1	9	PF14671	0.419
DOC_CKS1_1	21	26	PF01111	0.437
DOC_CYCLIN_RxL_1	105	118	PF00134	0.293
DOC_CYCLIN_RxL_1	88	96	PF00134	0.287
DOC_CYCLIN_yCln2_LP_2	50	56	PF00134	0.485
DOC_MAPK_gen_1	105	115	PF00069	0.332
DOC_MAPK_gen_1	383	391	PF00069	0.492
DOC_PP1_RVXF_1	109	116	PF00149	0.239
DOC_PP2B_LxvP_1	19	22	PF13499	0.444
DOC_PP4_FxxP_1	187	190	PF00568	0.611
DOC_PP4_FxxP_1	273	276	PF00568	0.597
DOC_USP7_MATH_1	153	157	PF00917	0.664
DOC_USP7_MATH_1	158	162	PF00917	0.617
DOC_USP7_MATH_1	22	26	PF00917	0.436
DOC_USP7_MATH_1	282	286	PF00917	0.599
DOC_USP7_MATH_1	305	309	PF00917	0.675
DOC_USP7_MATH_1	31	35	PF00917	0.457
DOC_USP7_MATH_1	37	41	PF00917	0.439
DOC_USP7_MATH_1	426	430	PF00917	0.604
DOC_USP7_MATH_1	594	598	PF00917	0.527
DOC_USP7_MATH_1	706	710	PF00917	0.622
DOC_WW_Pin1_4	156	161	PF00397	0.573
DOC_WW_Pin1_4	188	193	PF00397	0.589
DOC_WW_Pin1_4	20	25	PF00397	0.444
DOC_WW_Pin1_4	285	290	PF00397	0.634
DOC_WW_Pin1_4	49	54	PF00397	0.598
DOC_WW_Pin1_4	57	62	PF00397	0.492
DOC_WW_Pin1_4	584	589	PF00397	0.618
DOC_WW_Pin1_4	631	636	PF00397	0.556
DOC_WW_Pin1_4	671	676	PF00397	0.698
DOC_WW_Pin1_4	709	714	PF00397	0.620
DOC_WW_Pin1_4	74	79	PF00397	0.408
LIG_14-3-3_CanoR_1	265	273	PF00244	0.590
LIG_14-3-3_CanoR_1	304	310	PF00244	0.671
LIG_14-3-3_CanoR_1	411	420	PF00244	0.807
LIG_14-3-3_CanoR_1	702	706	PF00244	0.676
LIG_14-3-3_CanoR_1	721	726	PF00244	0.529
LIG_14-3-3_CanoR_1	88	94	PF00244	0.356
LIG_AP2alpha_2	542	544	PF02296	0.606
LIG_BRCT_BRCA1_1	292	296	PF00533	0.627
LIG_eIF4E_1	108	114	PF01652	0.305
LIG_eIF4E_1	385	391	PF01652	0.438
LIG_EVH1_2	13	17	PF00568	0.420
LIG_FHA_1	21	27	PF00498	0.445
LIG_FHA_1	235	241	PF00498	0.631
LIG_FHA_1	31	37	PF00498	0.465
LIG_FHA_1	420	426	PF00498	0.625
LIG_FHA_1	434	440	PF00498	0.527
LIG_FHA_1	613	619	PF00498	0.408
LIG_FHA_1	90	96	PF00498	0.371
LIG_FHA_2	195	201	PF00498	0.556
LIG_FHA_2	459	465	PF00498	0.691
LIG_FHA_2	713	719	PF00498	0.535
LIG_FHA_2	725	731	PF00498	0.481
LIG_FHA_2	75	81	PF00498	0.401
LIG_FHA_2	82	88	PF00498	0.342
LIG_Integrin_RGD_1	561	563	PF01839	0.592
LIG_LIR_Apic_2	272	276	PF02991	0.599
LIG_LIR_Nem_3	125	130	PF02991	0.265
LIG_LIR_Nem_3	293	299	PF02991	0.538
LIG_LIR_Nem_3	714	720	PF02991	0.563
LIG_LIR_Nem_3	87	93	PF02991	0.349
LIG_PROFILIN_1	278	284	PF00235	0.534
LIG_SH2_CRK	90	94	PF00017	0.351
LIG_SH2_SRC	134	137	PF00017	0.371
LIG_SH2_SRC	717	720	PF00017	0.530
LIG_SH2_STAP1	134	138	PF00017	0.305
LIG_SH2_STAP1	628	632	PF00017	0.511
LIG_SH2_STAT3	363	366	PF00017	0.605
LIG_SH2_STAT5	271	274	PF00017	0.533
LIG_SH2_STAT5	363	366	PF00017	0.605
LIG_SH2_STAT5	586	589	PF00017	0.667
LIG_SH2_STAT5	602	605	PF00017	0.440
LIG_SH2_STAT5	642	645	PF00017	0.494
LIG_SH3_3	161	167	PF00018	0.612
LIG_SH3_3	182	188	PF00018	0.642
LIG_SH3_3	273	279	PF00018	0.550
LIG_SH3_3	281	287	PF00018	0.600
LIG_SH3_3	52	58	PF00018	0.497
LIG_SH3_3	7	13	PF00018	0.445
LIG_TRAF2_1	197	200	PF00917	0.733
LIG_TRAF2_1	344	347	PF00917	0.607
LIG_TYR_ITSM	713	720	PF00017	0.532
LIG_WRC_WIRS_1	296	301	PF05994	0.531
LIG_WW_2	281	284	PF00397	0.551
MOD_CDK_SPK_2	631	636	PF00069	0.556
MOD_CDK_SPxxK_3	20	27	PF00069	0.441
MOD_CK1_1	156	162	PF00069	0.622
MOD_CK1_1	20	26	PF00069	0.492
MOD_CK1_1	245	251	PF00069	0.562
MOD_CK1_1	269	275	PF00069	0.657
MOD_CK1_1	285	291	PF00069	0.609
MOD_CK1_1	292	298	PF00069	0.668
MOD_CK1_1	314	320	PF00069	0.716
MOD_CK1_1	399	405	PF00069	0.641
MOD_CK1_1	40	46	PF00069	0.473
MOD_CK1_1	429	435	PF00069	0.576
MOD_CK1_1	449	455	PF00069	0.726
MOD_CK1_1	458	464	PF00069	0.544
MOD_CK1_1	631	637	PF00069	0.496
MOD_CK1_1	657	663	PF00069	0.636
MOD_CK1_1	678	684	PF00069	0.574
MOD_CK1_1	704	710	PF00069	0.648
MOD_CK1_1	712	718	PF00069	0.514
MOD_CK1_1	724	730	PF00069	0.587
MOD_CK2_1	194	200	PF00069	0.648
MOD_CK2_1	332	338	PF00069	0.739
MOD_CK2_1	458	464	PF00069	0.650
MOD_CK2_1	468	474	PF00069	0.449
MOD_CK2_1	594	600	PF00069	0.466
MOD_CK2_1	603	609	PF00069	0.438
MOD_CK2_1	646	652	PF00069	0.486
MOD_CK2_1	681	687	PF00069	0.791
MOD_CK2_1	712	718	PF00069	0.552
MOD_CK2_1	74	80	PF00069	0.413
MOD_GlcNHglycan	219	222	PF01048	0.733
MOD_GlcNHglycan	268	271	PF01048	0.720
MOD_GlcNHglycan	273	276	PF01048	0.597
MOD_GlcNHglycan	335	338	PF01048	0.567
MOD_GlcNHglycan	378	381	PF01048	0.563
MOD_GlcNHglycan	398	401	PF01048	0.659
MOD_GlcNHglycan	504	508	PF01048	0.796
MOD_GlcNHglycan	524	527	PF01048	0.506
MOD_GlcNHglycan	532	535	PF01048	0.562
MOD_GlcNHglycan	548	551	PF01048	0.552
MOD_GlcNHglycan	630	633	PF01048	0.628
MOD_GlcNHglycan	648	651	PF01048	0.511
MOD_GlcNHglycan	656	659	PF01048	0.506
MOD_GlcNHglycan	667	670	PF01048	0.534
MOD_GlcNHglycan	677	680	PF01048	0.585
MOD_GlcNHglycan	694	697	PF01048	0.669
MOD_GlcNHglycan	708	711	PF01048	0.564
MOD_GSK3_1	152	159	PF00069	0.647
MOD_GSK3_1	285	292	PF00069	0.814
MOD_GSK3_1	294	301	PF00069	0.581
MOD_GSK3_1	305	312	PF00069	0.593
MOD_GSK3_1	407	414	PF00069	0.611
MOD_GSK3_1	429	436	PF00069	0.596
MOD_GSK3_1	441	448	PF00069	0.623
MOD_GSK3_1	449	456	PF00069	0.641
MOD_GSK3_1	530	537	PF00069	0.666
MOD_GSK3_1	57	64	PF00069	0.548
MOD_GSK3_1	617	624	PF00069	0.500
MOD_GSK3_1	626	633	PF00069	0.516
MOD_GSK3_1	671	678	PF00069	0.744
MOD_GSK3_1	688	695	PF00069	0.695
MOD_GSK3_1	701	708	PF00069	0.564
MOD_GSK3_1	79	86	PF00069	0.381
MOD_N-GLC_1	240	245	PF02516	0.572
MOD_N-GLC_1	429	434	PF02516	0.608
MOD_N-GLC_2	244	246	PF02516	0.601
MOD_NEK2_1	17	22	PF00069	0.500
MOD_NEK2_1	202	207	PF00069	0.638
MOD_NEK2_1	291	296	PF00069	0.655
MOD_NEK2_1	331	336	PF00069	0.533
MOD_NEK2_1	446	451	PF00069	0.757
MOD_NEK2_1	530	535	PF00069	0.681
MOD_NEK2_1	603	608	PF00069	0.535
MOD_NEK2_1	643	648	PF00069	0.543
MOD_NEK2_1	705	710	PF00069	0.736
MOD_OFUCOSY	29	35	PF10250	0.460
MOD_PIKK_1	245	251	PF00454	0.492
MOD_PIKK_1	282	288	PF00454	0.579
MOD_PIKK_1	315	321	PF00454	0.549
MOD_PIKK_1	411	417	PF00454	0.612
MOD_PIKK_1	468	474	PF00454	0.425
MOD_PIKK_1	612	618	PF00454	0.404
MOD_PIKK_1	79	85	PF00454	0.375
MOD_PK_1	721	727	PF00069	0.552
MOD_PKA_2	305	311	PF00069	0.679
MOD_PKA_2	31	37	PF00069	0.487
MOD_PKA_2	314	320	PF00069	0.586
MOD_PKA_2	480	486	PF00069	0.495
MOD_PKA_2	534	540	PF00069	0.592
MOD_PKA_2	621	627	PF00069	0.613
MOD_PKA_2	701	707	PF00069	0.598
MOD_PKB_1	322	330	PF00069	0.585
MOD_PKB_1	409	417	PF00069	0.571
MOD_Plk_1	429	435	PF00069	0.551
MOD_Plk_1	483	489	PF00069	0.517
MOD_Plk_2-3	338	344	PF00069	0.703
MOD_Plk_2-3	553	559	PF00069	0.585
MOD_Plk_4	614	620	PF00069	0.524
MOD_Plk_4	712	718	PF00069	0.555
MOD_Plk_4	721	727	PF00069	0.522
MOD_ProDKin_1	156	162	PF00069	0.575
MOD_ProDKin_1	188	194	PF00069	0.586
MOD_ProDKin_1	20	26	PF00069	0.446
MOD_ProDKin_1	285	291	PF00069	0.633
MOD_ProDKin_1	49	55	PF00069	0.596
MOD_ProDKin_1	57	63	PF00069	0.494
MOD_ProDKin_1	584	590	PF00069	0.615
MOD_ProDKin_1	631	637	PF00069	0.555
MOD_ProDKin_1	671	677	PF00069	0.701
MOD_ProDKin_1	709	715	PF00069	0.621
MOD_ProDKin_1	74	80	PF00069	0.402
MOD_SUMO_for_1	344	347	PF00179	0.607
MOD_SUMO_rev_2	101	107	PF00179	0.338
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.510
TRG_ENDOCYTIC_2	717	720	PF00928	0.557
TRG_ENDOCYTIC_2	90	93	PF00928	0.355
TRG_ER_diArg_1	108	110	PF00400	0.325
TRG_ER_diArg_1	142	144	PF00400	0.331
TRG_ER_diArg_1	258	260	PF00400	0.484
TRG_ER_diArg_1	322	325	PF00400	0.582
TRG_ER_diArg_1	393	395	PF00400	0.665
TRG_ER_diArg_1	582	585	PF00400	0.589
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC79	Leptomonas seymouri	37%	100%
A0A3S7WS81	Leishmania donovani	83%	100%
A4H6Z1	Leishmania braziliensis	60%	100%
E9AGH2	Leishmania infantum	83%	100%
E9AP11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%