Putative NADH:flavin oxidoreductase/NADH oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Activating nitroreductase NTR2

Species:

Leishmania major

UniProt:

Q4QGH6_LEIMA

TriTrypDb:

LmjF.12.1130 , LMJLV39_120013400 , LMJSD75_120014100

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005829	cytosol	2	1

Expansion

Sequence features

Q4QGH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0010181	FMN binding	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0032553	ribonucleotide binding	3	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016657	oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	221	225	PF00656	0.566
CLV_C14_Caspase3-7	83	87	PF00656	0.493
CLV_NRD_NRD_1	267	269	PF00675	0.281
CLV_PCSK_KEX2_1	267	269	PF00082	0.201
CLV_PCSK_SKI1_1	13	17	PF00082	0.261
CLV_PCSK_SKI1_1	217	221	PF00082	0.335
CLV_PCSK_SKI1_1	268	272	PF00082	0.318
CLV_PCSK_SKI1_1	89	93	PF00082	0.325
DEG_COP1_1	37	44	PF00400	0.594
DOC_CYCLIN_RxL_1	214	224	PF00134	0.566
DOC_MAPK_gen_1	232	239	PF00069	0.547
DOC_MAPK_gen_1	267	274	PF00069	0.446
DOC_MAPK_MEF2A_6	232	239	PF00069	0.551
DOC_MAPK_MEF2A_6	53	60	PF00069	0.542
DOC_MAPK_NFAT4_5	53	61	PF00069	0.542
DOC_PP1_RVXF_1	265	272	PF00149	0.566
DOC_PP4_FxxP_1	279	282	PF00568	0.518
DOC_USP7_MATH_1	241	245	PF00917	0.519
DOC_USP7_MATH_1	373	377	PF00917	0.597
DOC_USP7_MATH_1	4	8	PF00917	0.553
DOC_WW_Pin1_4	237	242	PF00397	0.481
DOC_WW_Pin1_4	278	283	PF00397	0.446
DOC_WW_Pin1_4	371	376	PF00397	0.515
LIG_14-3-3_CanoR_1	111	115	PF00244	0.522
LIG_14-3-3_CanoR_1	143	149	PF00244	0.446
LIG_14-3-3_CanoR_1	53	57	PF00244	0.481
LIG_Actin_WH2_2	223	240	PF00022	0.460
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BRCT_BRCA1_1	22	26	PF00533	0.475
LIG_FHA_1	255	261	PF00498	0.495
LIG_FHA_1	323	329	PF00498	0.542
LIG_FHA_1	90	96	PF00498	0.535
LIG_FHA_2	351	357	PF00498	0.531
LIG_Integrin_RGD_1	276	278	PF01839	0.291
LIG_IRF3_LxIS_1	235	240	PF10401	0.477
LIG_LIR_Apic_2	147	153	PF02991	0.454
LIG_LIR_Apic_2	278	282	PF02991	0.518
LIG_LIR_Gen_1	163	172	PF02991	0.446
LIG_LIR_Gen_1	347	352	PF02991	0.497
LIG_LIR_Nem_3	163	167	PF02991	0.584
LIG_LIR_Nem_3	292	297	PF02991	0.484
LIG_LIR_Nem_3	347	351	PF02991	0.514
LIG_LIR_Nem_3	356	362	PF02991	0.454
LIG_LIR_Nem_3	86	91	PF02991	0.497
LIG_LYPXL_yS_3	362	365	PF13949	0.411
LIG_SH2_NCK_1	168	172	PF00017	0.503
LIG_SH2_PTP2	164	167	PF00017	0.477
LIG_SH2_STAP1	168	172	PF00017	0.503
LIG_SH2_STAP1	50	54	PF00017	0.463
LIG_SH2_STAP1	70	74	PF00017	0.360
LIG_SH2_STAT5	164	167	PF00017	0.546
LIG_SH2_STAT5	191	194	PF00017	0.481
LIG_SH2_STAT5	259	262	PF00017	0.528
LIG_SH2_STAT5	352	355	PF00017	0.441
LIG_SH3_3	24	30	PF00018	0.516
LIG_SH3_3	369	375	PF00018	0.599
LIG_TRAF2_1	157	160	PF00917	0.496
LIG_TRAF2_1	290	293	PF00917	0.583
LIG_WRC_WIRS_1	242	247	PF05994	0.590
LIG_WRC_WIRS_1	348	353	PF05994	0.313
LIG_WRC_WIRS_1	70	75	PF05994	0.535
MOD_CDC14_SPxK_1	281	284	PF00782	0.446
MOD_CDK_SPxK_1	278	284	PF00069	0.446
MOD_CK1_1	2	8	PF00069	0.477
MOD_CK2_1	350	356	PF00069	0.431
MOD_GlcNHglycan	1	4	PF01048	0.693
MOD_GlcNHglycan	127	130	PF01048	0.276
MOD_GlcNHglycan	314	317	PF01048	0.293
MOD_GlcNHglycan	375	378	PF01048	0.660
MOD_GSK3_1	109	116	PF00069	0.462
MOD_GSK3_1	198	205	PF00069	0.490
MOD_GSK3_1	237	244	PF00069	0.512
MOD_GSK3_1	347	354	PF00069	0.531
MOD_GSK3_1	48	55	PF00069	0.506
MOD_N-GLC_2	214	216	PF02516	0.277
MOD_NEK2_1	196	201	PF00069	0.477
MOD_NEK2_1	365	370	PF00069	0.448
MOD_PIKK_1	144	150	PF00454	0.452
MOD_PIKK_1	259	265	PF00454	0.584
MOD_PIKK_1	61	67	PF00454	0.493
MOD_PKA_1	89	95	PF00069	0.542
MOD_PKA_2	110	116	PF00069	0.566
MOD_PKA_2	52	58	PF00069	0.512
MOD_Plk_1	61	67	PF00069	0.460
MOD_Plk_4	160	166	PF00069	0.446
MOD_Plk_4	347	353	PF00069	0.548
MOD_ProDKin_1	237	243	PF00069	0.481
MOD_ProDKin_1	278	284	PF00069	0.446
MOD_ProDKin_1	371	377	PF00069	0.515
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.302
TRG_ENDOCYTIC_2	164	167	PF00928	0.483
TRG_ENDOCYTIC_2	294	297	PF00928	0.484
TRG_ENDOCYTIC_2	362	365	PF00928	0.512
TRG_ENDOCYTIC_2	70	73	PF00928	0.495
TRG_ER_diArg_1	215	218	PF00400	0.535
TRG_ER_diArg_1	267	269	PF00400	0.401
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2A2	Leptomonas seymouri	69%	100%
A0A0N0P2S0	Leptomonas seymouri	30%	100%
A0A0N1HZB3	Leptomonas seymouri	40%	68%
A0A0S4IVY9	Bodo saltans	32%	100%
A0A0S4IYW9	Bodo saltans	42%	100%
A0A0S4JST7	Bodo saltans	25%	68%
A0A1D8PPK1	Candida albicans (strain SC5314 / ATCC MYA-2876)	34%	95%
A0A1U8QTA2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	39%	99%
A0A1X0P653	Trypanosomatidae	46%	100%
A0A3Q8ICQ9	Leishmania donovani	93%	100%
A0A422NKC3	Trypanosoma rangeli	45%	100%
A0A482NAR8	Talaromyces variabilis	29%	95%
A2TBU0	Epichloe festucae var. lolii	35%	100%
A4H6Z3	Leishmania braziliensis	82%	100%
A4IQK7	Geobacillus thermodenitrificans (strain NG80-2)	31%	100%
A8C7R3	Claviceps fusiformis	33%	100%
B7HJE9	Bacillus cereus (strain B4264)	28%	100%
B7HNI1	Bacillus cereus (strain AH187)	28%	100%
B7ITF9	Bacillus cereus (strain G9842)	28%	100%
B8N8Q9	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	30%	93%
B8NWW6	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	38%	100%
B9FFD2	Oryza sativa subsp. japonica	42%	95%
B9FFD3	Oryza sativa subsp. japonica	40%	100%
B9FSC8	Oryza sativa subsp. japonica	39%	100%
B9IY25	Bacillus cereus (strain Q1)	28%	100%
C3L5F3	Bacillus anthracis (strain CDC 684 / NRRL 3495)	29%	100%
C3P7Z9	Bacillus anthracis (strain A0248)	29%	100%
C5D427	Geobacillus sp. (strain WCH70)	32%	100%
C5H429	Artemisia annua	38%	99%
E9AGH7	Leishmania infantum	93%	100%
E9AP13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
I1RV17	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	93%
M1W0Y0	Claviceps purpurea (strain 20.1)	35%	100%
O94467	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	97%
P0DI08	Arabidopsis thaliana	40%	100%
P0DI09	Arabidopsis thaliana	40%	100%
P0DN73	Streptococcus pyogenes serotype M5 (strain Manfredo)	26%	96%
P40952	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	33%	97%
P41816	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	96%
P43084	Candida albicans	34%	95%
P54524	Bacillus subtilis (strain 168)	32%	100%
P77258	Escherichia coli (strain K12)	39%	100%
Q02899	Saccharomyces pastorianus	34%	96%
Q03558	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	96%
Q09670	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q09671	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	98%
Q0E0C6	Oryza sativa subsp. japonica	38%	95%
Q4WZ70	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	37%	100%
Q5KXG9	Geobacillus kaustophilus (strain HTA426)	31%	100%
Q63CC9	Bacillus cereus (strain ZK / E33L)	30%	100%
Q69TH4	Oryza sativa subsp. japonica	40%	100%
Q69TH6	Oryza sativa subsp. japonica	41%	100%
Q69TH8	Oryza sativa subsp. japonica	38%	100%
Q69TI0	Oryza sativa subsp. japonica	41%	100%
Q69TI2	Oryza sativa subsp. japonica	39%	98%
Q6UEF0	Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)	28%	87%
Q6Z965	Oryza sativa subsp. japonica	41%	98%
Q6ZXC1	Claviceps purpurea	35%	100%
Q739N4	Bacillus cereus (strain ATCC 10987 / NRS 248)	28%	100%
Q81EF6	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	28%	100%
Q81RK6	Bacillus anthracis	29%	100%
Q84QK0	Oryza sativa subsp. japonica	40%	100%
Q8GYA3	Arabidopsis thaliana	36%	100%
Q8GYB8	Arabidopsis thaliana	40%	100%
Q8LAH7	Arabidopsis thaliana	40%	100%
Q9FEW9	Solanum lycopersicum	38%	97%
Q9FEX0	Solanum lycopersicum	34%	100%
Q9FUP0	Arabidopsis thaliana	39%	98%
Q9XG54	Solanum lycopersicum	38%	100%
V5BT91	Trypanosoma cruzi	44%	100%
W6Q2D7	Penicillium roqueforti (strain FM164)	39%	100%
W6Q9S9	Penicillium roqueforti (strain FM164)	39%	100%