N-ethylmaleimide reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

n-ethylmaleimide reductase-like protein

Species:

Leishmania major

UniProt:

Q4QGH5_LEIMA

TriTrypDb:

LmjF.12.1140 , LMJLV39_120013500 , LMJSD75_120014200

Length:

828

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QGH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	6
GO:0010181	FMN binding	4	6
GO:0016491	oxidoreductase activity	2	6
GO:0032553	ribonucleotide binding	3	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	227	231	PF00656	0.616
CLV_C14_Caspase3-7	391	395	PF00656	0.732
CLV_C14_Caspase3-7	633	637	PF00656	0.612
CLV_C14_Caspase3-7	688	692	PF00656	0.612
CLV_MEL_PAP_1	647	653	PF00089	0.362
CLV_NRD_NRD_1	298	300	PF00675	0.412
CLV_NRD_NRD_1	397	399	PF00675	0.786
CLV_NRD_NRD_1	460	462	PF00675	0.420
CLV_NRD_NRD_1	496	498	PF00675	0.362
CLV_NRD_NRD_1	609	611	PF00675	0.409
CLV_NRD_NRD_1	645	647	PF00675	0.412
CLV_NRD_NRD_1	678	680	PF00675	0.412
CLV_NRD_NRD_1	784	786	PF00675	0.652
CLV_PCSK_KEX2_1	298	300	PF00082	0.412
CLV_PCSK_KEX2_1	397	399	PF00082	0.786
CLV_PCSK_KEX2_1	460	462	PF00082	0.420
CLV_PCSK_KEX2_1	532	534	PF00082	0.352
CLV_PCSK_KEX2_1	644	646	PF00082	0.412
CLV_PCSK_KEX2_1	727	729	PF00082	0.437
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.337
CLV_PCSK_PC1ET2_1	727	729	PF00082	0.412
CLV_PCSK_SKI1_1	172	176	PF00082	0.412
CLV_PCSK_SKI1_1	223	227	PF00082	0.412
CLV_PCSK_SKI1_1	344	348	PF00082	0.412
CLV_PCSK_SKI1_1	497	501	PF00082	0.412
CLV_PCSK_SKI1_1	658	662	PF00082	0.412
CLV_PCSK_SKI1_1	704	708	PF00082	0.381
CLV_PCSK_SKI1_1	91	95	PF00082	0.412
CLV_Separin_Metazoa	564	568	PF03568	0.562
DEG_APCC_DBOX_1	222	230	PF00400	0.612
DEG_COP1_1	39	46	PF00400	0.612
DEG_SCF_FBW7_1	243	250	PF00400	0.612
DEG_SPOP_SBC_1	354	358	PF00917	0.393
DOC_ANK_TNKS_1	285	292	PF00023	0.612
DOC_CDC14_PxL_1	775	783	PF14671	0.397
DOC_CYCLIN_RxL_1	220	230	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	822	828	PF00134	0.639
DOC_MAPK_gen_1	221	228	PF00069	0.612
DOC_MAPK_gen_1	460	468	PF00069	0.612
DOC_MAPK_gen_1	572	581	PF00069	0.612
DOC_MAPK_gen_1	644	651	PF00069	0.612
DOC_MAPK_gen_1	679	686	PF00069	0.612
DOC_MAPK_MEF2A_6	572	581	PF00069	0.612
DOC_MAPK_MEF2A_6	644	651	PF00069	0.612
DOC_PP1_RVXF_1	271	278	PF00149	0.612
DOC_PP1_RVXF_1	570	576	PF00149	0.612
DOC_PP1_SILK_1	700	705	PF00149	0.487
DOC_PP2B_LxvP_1	822	825	PF13499	0.638
DOC_PP4_FxxP_1	378	381	PF00568	0.791
DOC_USP7_MATH_1	161	165	PF00917	0.590
DOC_USP7_MATH_1	170	174	PF00917	0.539
DOC_USP7_MATH_1	354	358	PF00917	0.551
DOC_USP7_MATH_1	687	691	PF00917	0.632
DOC_USP7_MATH_1	793	797	PF00917	0.678
DOC_USP7_MATH_1	805	809	PF00917	0.560
DOC_USP7_MATH_1	818	822	PF00917	0.494
DOC_USP7_UBL2_3	574	578	PF12436	0.562
DOC_USP7_UBL2_3	819	823	PF12436	0.542
DOC_WW_Pin1_4	113	118	PF00397	0.615
DOC_WW_Pin1_4	243	248	PF00397	0.612
DOC_WW_Pin1_4	28	33	PF00397	0.562
DOC_WW_Pin1_4	620	625	PF00397	0.637
DOC_WW_Pin1_4	649	654	PF00397	0.623
DOC_WW_Pin1_4	809	814	PF00397	0.670
LIG_14-3-3_CanoR_1	113	117	PF00244	0.612
LIG_14-3-3_CanoR_1	298	302	PF00244	0.617
LIG_14-3-3_CanoR_1	403	408	PF00244	0.674
LIG_14-3-3_CanoR_1	460	465	PF00244	0.636
LIG_14-3-3_CanoR_1	519	523	PF00244	0.562
LIG_14-3-3_CanoR_1	55	59	PF00244	0.612
LIG_14-3-3_CanoR_1	567	575	PF00244	0.562
LIG_Actin_WH2_2	561	576	PF00022	0.607
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_BRCT_BRCA1_1	273	277	PF00533	0.473
LIG_BRCT_BRCA1_1	356	360	PF00533	0.527
LIG_CaMK_CASK_1	294	299	PF00069	0.612
LIG_deltaCOP1_diTrp_1	294	301	PF00928	0.612
LIG_FHA_1	261	267	PF00498	0.612
LIG_FHA_1	498	504	PF00498	0.618
LIG_FHA_1	537	543	PF00498	0.595
LIG_FHA_1	61	67	PF00498	0.612
LIG_FHA_1	92	98	PF00498	0.612
LIG_FHA_2	161	167	PF00498	0.612
LIG_FHA_2	244	250	PF00498	0.637
LIG_FHA_2	310	316	PF00498	0.587
LIG_FHA_2	613	619	PF00498	0.612
LIG_FHA_2	661	667	PF00498	0.612
LIG_FHA_2	90	96	PF00498	0.537
LIG_Integrin_RGD_1	282	284	PF01839	0.412
LIG_LIR_Apic_2	377	381	PF02991	0.750
LIG_LIR_Apic_2	543	549	PF02991	0.537
LIG_LIR_Apic_2	691	697	PF02991	0.612
LIG_LIR_Gen_1	274	281	PF02991	0.462
LIG_LIR_Nem_3	274	280	PF02991	0.462
LIG_LIR_Nem_3	340	346	PF02991	0.612
LIG_LIR_Nem_3	364	370	PF02991	0.583
LIG_LIR_Nem_3	413	419	PF02991	0.545
LIG_LIR_Nem_3	463	467	PF02991	0.615
LIG_LIR_Nem_3	71	75	PF02991	0.463
LIG_LIR_Nem_3	772	778	PF02991	0.640
LIG_LIR_Nem_3	88	93	PF02991	0.618
LIG_LYPXL_yS_3	778	781	PF13949	0.376
LIG_MLH1_MIPbox_1	356	360	PF16413	0.492
LIG_REV1ctd_RIR_1	357	366	PF16727	0.559
LIG_RPA_C_Fungi	455	467	PF08784	0.497
LIG_RPA_C_Fungi	789	801	PF08784	0.510
LIG_SH2_CRK	464	468	PF00017	0.512
LIG_SH2_CRK	511	515	PF00017	0.497
LIG_SH2_CRK	546	550	PF00017	0.392
LIG_SH2_CRK	694	698	PF00017	0.477
LIG_SH2_PTP2	683	686	PF00017	0.462
LIG_SH2_SRC	77	80	PF00017	0.497
LIG_SH2_STAP1	10	14	PF00017	0.615
LIG_SH2_STAP1	458	462	PF00017	0.406
LIG_SH2_STAT3	265	268	PF00017	0.427
LIG_SH2_STAT5	10	13	PF00017	0.581
LIG_SH2_STAT5	197	200	PF00017	0.497
LIG_SH2_STAT5	265	268	PF00017	0.497
LIG_SH2_STAT5	311	314	PF00017	0.462
LIG_SH2_STAT5	367	370	PF00017	0.577
LIG_SH2_STAT5	416	419	PF00017	0.601
LIG_SH2_STAT5	481	484	PF00017	0.532
LIG_SH2_STAT5	511	514	PF00017	0.532
LIG_SH2_STAT5	580	583	PF00017	0.497
LIG_SH2_STAT5	603	606	PF00017	0.497
LIG_SH2_STAT5	683	686	PF00017	0.480
LIG_SH3_3	124	130	PF00018	0.523
LIG_SH3_3	16	22	PF00018	0.480
LIG_SH3_3	26	32	PF00018	0.392
LIG_SH3_3	333	339	PF00018	0.420
LIG_SH3_3	369	375	PF00018	0.608
LIG_SH3_3	416	422	PF00018	0.599
LIG_SH3_3	432	438	PF00018	0.497
LIG_SH3_3	756	762	PF00018	0.604
LIG_SUMO_SIM_par_1	224	230	PF11976	0.497
LIG_TRAF2_2	440	445	PF00917	0.497
LIG_TYR_ITIM	509	514	PF00017	0.497
LIG_TYR_ITIM	681	686	PF00017	0.497
LIG_WRC_WIRS_1	171	176	PF05994	0.392
LIG_WRC_WIRS_1	199	204	PF05994	0.497
LIG_WRC_WIRS_1	248	253	PF05994	0.497
MOD_CDK_SPxxK_3	28	35	PF00069	0.392
MOD_CDK_SPxxK_3	620	627	PF00069	0.501
MOD_CK1_1	31	37	PF00069	0.410
MOD_CK1_1	54	60	PF00069	0.497
MOD_CK2_1	160	166	PF00069	0.525
MOD_CK2_1	254	260	PF00069	0.462
MOD_CK2_1	718	724	PF00069	0.497
MOD_CK2_1	89	95	PF00069	0.392
MOD_Cter_Amidation	642	645	PF01082	0.497
MOD_DYRK1A_RPxSP_1	113	117	PF00069	0.501
MOD_GlcNHglycan	163	166	PF01048	0.460
MOD_GlcNHglycan	2	5	PF01048	0.766
MOD_GlcNHglycan	301	304	PF01048	0.450
MOD_GlcNHglycan	390	393	PF01048	0.700
MOD_GlcNHglycan	542	545	PF01048	0.444
MOD_GlcNHglycan	568	571	PF01048	0.497
MOD_GlcNHglycan	687	690	PF01048	0.497
MOD_GlcNHglycan	71	75	PF01048	0.487
MOD_GlcNHglycan	741	744	PF01048	0.252
MOD_GlcNHglycan	795	798	PF01048	0.698
MOD_GlcNHglycan	82	85	PF01048	0.497
MOD_GSK3_1	243	250	PF00069	0.523
MOD_GSK3_1	297	304	PF00069	0.329
MOD_GSK3_1	354	361	PF00069	0.548
MOD_GSK3_1	384	391	PF00069	0.733
MOD_GSK3_1	393	400	PF00069	0.635
MOD_GSK3_1	401	408	PF00069	0.577
MOD_GSK3_1	42	49	PF00069	0.392
MOD_GSK3_1	536	543	PF00069	0.458
MOD_GSK3_1	805	812	PF00069	0.616
MOD_N-GLC_1	118	123	PF02516	0.497
MOD_N-GLC_1	219	224	PF02516	0.497
MOD_N-GLC_1	524	529	PF02516	0.462
MOD_N-GLC_1	718	723	PF02516	0.497
MOD_NEK2_1	198	203	PF00069	0.497
MOD_NEK2_1	301	306	PF00069	0.287
MOD_NEK2_1	346	351	PF00069	0.287
MOD_NEK2_1	417	422	PF00069	0.531
MOD_NEK2_1	425	430	PF00069	0.307
MOD_NEK2_2	426	431	PF00069	0.497
MOD_NEK2_2	818	823	PF00069	0.539
MOD_PIKK_1	417	423	PF00454	0.594
MOD_PIKK_1	536	542	PF00454	0.392
MOD_PKA_1	397	403	PF00069	0.709
MOD_PKA_1	460	466	PF00069	0.497
MOD_PKA_1	497	503	PF00069	0.427
MOD_PKA_1	610	616	PF00069	0.497
MOD_PKA_2	112	118	PF00069	0.497
MOD_PKA_2	297	303	PF00069	0.504
MOD_PKA_2	361	367	PF00069	0.608
MOD_PKA_2	397	403	PF00069	0.812
MOD_PKA_2	460	466	PF00069	0.526
MOD_PKA_2	518	524	PF00069	0.427
MOD_PKA_2	54	60	PF00069	0.497
MOD_PKA_2	566	572	PF00069	0.427
MOD_PKA_2	793	799	PF00069	0.683
MOD_Plk_1	219	225	PF00069	0.497
MOD_Plk_1	354	360	PF00069	0.526
MOD_Plk_1	412	418	PF00069	0.469
MOD_Plk_1	718	724	PF00069	0.492
MOD_Plk_2-3	374	380	PF00069	0.718
MOD_Plk_2-3	718	724	PF00069	0.497
MOD_Plk_4	198	204	PF00069	0.502
MOD_Plk_4	301	307	PF00069	0.287
MOD_Plk_4	355	361	PF00069	0.597
MOD_Plk_4	477	483	PF00069	0.515
MOD_Plk_4	698	704	PF00069	0.392
MOD_Plk_4	763	769	PF00069	0.616
MOD_ProDKin_1	113	119	PF00069	0.501
MOD_ProDKin_1	243	249	PF00069	0.497
MOD_ProDKin_1	28	34	PF00069	0.427
MOD_ProDKin_1	620	626	PF00069	0.532
MOD_ProDKin_1	649	655	PF00069	0.512
MOD_ProDKin_1	809	815	PF00069	0.670
MOD_SUMO_rev_2	147	152	PF00179	0.497
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.497
TRG_DiLeu_BaLyEn_6	626	631	PF01217	0.497
TRG_ENDOCYTIC_2	10	13	PF00928	0.619
TRG_ENDOCYTIC_2	416	419	PF00928	0.636
TRG_ENDOCYTIC_2	464	467	PF00928	0.512
TRG_ENDOCYTIC_2	511	514	PF00928	0.497
TRG_ENDOCYTIC_2	683	686	PF00928	0.497
TRG_ENDOCYTIC_2	72	75	PF00928	0.497
TRG_ENDOCYTIC_2	778	781	PF00928	0.585
TRG_ER_diArg_1	221	224	PF00400	0.497
TRG_ER_diArg_1	297	299	PF00400	0.497
TRG_ER_diArg_1	397	399	PF00400	0.716
TRG_ER_diArg_1	440	443	PF00400	0.497
TRG_ER_diArg_1	627	630	PF00400	0.497
TRG_ER_diArg_1	644	646	PF00400	0.244
TRG_Pf-PMV_PEXEL_1	223	227	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.743
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.427
TRG_Pf-PMV_PEXEL_1	629	633	PF00026	0.497
TRG_Pf-PMV_PEXEL_1	91	95	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8C3	Leishmania donovani	94%	100%
A4H6Z4	Leishmania braziliensis	81%	95%
E9AGH8	Leishmania infantum	93%	100%
E9AP14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%