SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania major

UniProt:

Q4QGH3_LEIMA

TriTrypDb:

LmjF.12.1160 , LMJLV39_120013700 , LMJSD75_120014400

Length:

947

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	5
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QGH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	3
GO:0006869	lipid transport	5	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0071702	organic substance transport	4	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	4
GO:0008289	lipid binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.712
CLV_C14_Caspase3-7	387	391	PF00656	0.745
CLV_C14_Caspase3-7	399	403	PF00656	0.619
CLV_C14_Caspase3-7	404	408	PF00656	0.632
CLV_C14_Caspase3-7	768	772	PF00656	0.833
CLV_C14_Caspase3-7	901	905	PF00656	0.662
CLV_NRD_NRD_1	163	165	PF00675	0.589
CLV_NRD_NRD_1	180	182	PF00675	0.410
CLV_NRD_NRD_1	281	283	PF00675	0.492
CLV_NRD_NRD_1	412	414	PF00675	0.584
CLV_NRD_NRD_1	426	428	PF00675	0.504
CLV_NRD_NRD_1	503	505	PF00675	0.358
CLV_PCSK_KEX2_1	163	165	PF00082	0.467
CLV_PCSK_KEX2_1	281	283	PF00082	0.492
CLV_PCSK_KEX2_1	412	414	PF00082	0.584
CLV_PCSK_KEX2_1	426	428	PF00082	0.508
CLV_PCSK_KEX2_1	913	915	PF00082	0.583
CLV_PCSK_PC1ET2_1	913	915	PF00082	0.583
CLV_PCSK_SKI1_1	170	174	PF00082	0.565
CLV_PCSK_SKI1_1	203	207	PF00082	0.611
CLV_PCSK_SKI1_1	326	330	PF00082	0.482
CLV_PCSK_SKI1_1	467	471	PF00082	0.471
CLV_PCSK_SKI1_1	484	488	PF00082	0.311
CLV_PCSK_SKI1_1	571	575	PF00082	0.380
CLV_PCSK_SKI1_1	631	635	PF00082	0.444
CLV_PCSK_SKI1_1	636	640	PF00082	0.379
CLV_PCSK_SKI1_1	675	679	PF00082	0.547
CLV_PCSK_SKI1_1	693	697	PF00082	0.452
CLV_PCSK_SKI1_1	914	918	PF00082	0.532
CLV_PCSK_SKI1_1	922	926	PF00082	0.441
CLV_PCSK_SKI1_1	933	937	PF00082	0.382
CLV_PCSK_SKI1_1	95	99	PF00082	0.451
DEG_APCC_DBOX_1	503	511	PF00400	0.556
DEG_APCC_DBOX_1	769	777	PF00400	0.825
DEG_MDM2_SWIB_1	7	15	PF02201	0.407
DEG_SCF_FBW7_1	738	743	PF00400	0.806
DEG_SPOP_SBC_1	357	361	PF00917	0.708
DEG_SPOP_SBC_1	882	886	PF00917	0.775
DOC_CDC14_PxL_1	638	646	PF14671	0.597
DOC_CKS1_1	737	742	PF01111	0.814
DOC_CYCLIN_yClb5_NLxxxL_5	922	928	PF00134	0.729
DOC_MAPK_DCC_7	770	778	PF00069	0.790
DOC_MAPK_gen_1	167	177	PF00069	0.767
DOC_MAPK_gen_1	181	187	PF00069	0.558
DOC_MAPK_gen_1	504	512	PF00069	0.675
DOC_MAPK_gen_1	922	930	PF00069	0.667
DOC_MAPK_MEF2A_6	615	623	PF00069	0.555
DOC_MAPK_MEF2A_6	770	778	PF00069	0.790
DOC_PP1_RVXF_1	314	321	PF00149	0.621
DOC_PP4_FxxP_1	668	671	PF00568	0.563
DOC_PP4_FxxP_1	795	798	PF00568	0.682
DOC_USP7_MATH_1	146	150	PF00917	0.750
DOC_USP7_MATH_1	232	236	PF00917	0.828
DOC_USP7_MATH_1	275	279	PF00917	0.717
DOC_USP7_MATH_1	289	293	PF00917	0.772
DOC_USP7_MATH_1	382	386	PF00917	0.700
DOC_USP7_MATH_1	543	547	PF00917	0.620
DOC_USP7_MATH_1	669	673	PF00917	0.629
DOC_USP7_MATH_1	722	726	PF00917	0.750
DOC_USP7_MATH_1	740	744	PF00917	0.807
DOC_USP7_MATH_1	816	820	PF00917	0.766
DOC_USP7_MATH_1	829	833	PF00917	0.798
DOC_USP7_MATH_1	876	880	PF00917	0.823
DOC_USP7_UBL2_3	233	237	PF12436	0.726
DOC_USP7_UBL2_3	925	929	PF12436	0.679
DOC_WW_Pin1_4	238	243	PF00397	0.704
DOC_WW_Pin1_4	330	335	PF00397	0.810
DOC_WW_Pin1_4	368	373	PF00397	0.798
DOC_WW_Pin1_4	66	71	PF00397	0.657
DOC_WW_Pin1_4	713	718	PF00397	0.775
DOC_WW_Pin1_4	736	741	PF00397	0.772
DOC_WW_Pin1_4	748	753	PF00397	0.704
DOC_WW_Pin1_4	821	826	PF00397	0.795
DOC_WW_Pin1_4	840	845	PF00397	0.837
DOC_WW_Pin1_4	87	92	PF00397	0.744
LIG_14-3-3_CanoR_1	281	285	PF00244	0.690
LIG_14-3-3_CanoR_1	373	381	PF00244	0.777
LIG_14-3-3_CanoR_1	419	428	PF00244	0.667
LIG_14-3-3_CanoR_1	451	456	PF00244	0.608
LIG_14-3-3_CanoR_1	544	551	PF00244	0.671
LIG_14-3-3_CanoR_1	571	577	PF00244	0.624
LIG_14-3-3_CanoR_1	636	644	PF00244	0.608
LIG_14-3-3_CanoR_1	855	862	PF00244	0.784
LIG_14-3-3_CanoR_1	914	924	PF00244	0.673
LIG_APCC_ABBA_1	654	659	PF00400	0.553
LIG_APCC_ABBA_1	661	666	PF00400	0.565
LIG_APCC_ABBAyCdc20_2	653	659	PF00400	0.553
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	148	152	PF00533	0.651
LIG_BRCT_BRCA1_1	165	169	PF00533	0.799
LIG_BRCT_BRCA1_1	249	253	PF00533	0.788
LIG_BRCT_BRCA1_1	354	358	PF00533	0.746
LIG_BRCT_BRCA1_1	482	486	PF00533	0.586
LIG_BRCT_BRCA1_1	566	570	PF00533	0.565
LIG_BRCT_BRCA1_1	605	609	PF00533	0.617
LIG_BRCT_BRCA1_1	68	72	PF00533	0.659
LIG_Clathr_ClatBox_1	121	125	PF01394	0.655
LIG_Clathr_ClatBox_1	590	594	PF01394	0.573
LIG_FHA_1	312	318	PF00498	0.663
LIG_FHA_1	376	382	PF00498	0.833
LIG_FHA_1	594	600	PF00498	0.575
LIG_FHA_1	606	612	PF00498	0.544
LIG_FHA_1	647	653	PF00498	0.572
LIG_FHA_1	748	754	PF00498	0.800
LIG_FHA_2	189	195	PF00498	0.672
LIG_FHA_2	265	271	PF00498	0.798
LIG_FHA_2	345	351	PF00498	0.713
LIG_FHA_2	397	403	PF00498	0.808
LIG_FHA_2	496	502	PF00498	0.669
LIG_LIR_Apic_2	106	110	PF02991	0.682
LIG_LIR_Apic_2	666	671	PF02991	0.569
LIG_LIR_Gen_1	130	137	PF02991	0.611
LIG_LIR_Gen_1	435	443	PF02991	0.583
LIG_LIR_Gen_1	450	459	PF02991	0.517
LIG_LIR_Gen_1	554	559	PF02991	0.536
LIG_LIR_Gen_1	649	657	PF02991	0.510
LIG_LIR_Gen_1	680	689	PF02991	0.738
LIG_LIR_Gen_1	69	80	PF02991	0.677
LIG_LIR_Nem_3	130	135	PF02991	0.591
LIG_LIR_Nem_3	149	155	PF02991	0.747
LIG_LIR_Nem_3	435	439	PF02991	0.602
LIG_LIR_Nem_3	450	455	PF02991	0.522
LIG_LIR_Nem_3	463	468	PF02991	0.589
LIG_LIR_Nem_3	554	558	PF02991	0.556
LIG_LIR_Nem_3	567	572	PF02991	0.501
LIG_LIR_Nem_3	575	579	PF02991	0.558
LIG_LIR_Nem_3	649	654	PF02991	0.508
LIG_LIR_Nem_3	680	684	PF02991	0.740
LIG_LIR_Nem_3	69	75	PF02991	0.703
LIG_MLH1_MIPbox_1	165	169	PF16413	0.799
LIG_MLH1_MIPbox_1	482	486	PF16413	0.586
LIG_MLH1_MIPbox_1	566	570	PF16413	0.565
LIG_MYND_1	844	848	PF01753	0.829
LIG_NRBOX	524	530	PF00104	0.652
LIG_NRBOX	923	929	PF00104	0.731
LIG_Pex14_2	481	485	PF04695	0.589
LIG_Pex14_2	7	11	PF04695	0.407
LIG_REV1ctd_RIR_1	166	174	PF16727	0.800
LIG_REV1ctd_RIR_1	567	575	PF16727	0.572
LIG_SH2_CRK	132	136	PF00017	0.681
LIG_SH2_CRK	576	580	PF00017	0.613
LIG_SH2_STAP1	468	472	PF00017	0.698
LIG_SH2_STAT5	186	189	PF00017	0.586
LIG_SH2_STAT5	576	579	PF00017	0.678
LIG_SH2_STAT5	655	658	PF00017	0.589
LIG_SH3_1	841	847	PF00018	0.836
LIG_SH3_3	236	242	PF00018	0.678
LIG_SH3_3	537	543	PF00018	0.563
LIG_SH3_3	819	825	PF00018	0.794
LIG_SH3_3	841	847	PF00018	0.836
LIG_SUMO_SIM_anti_2	496	504	PF11976	0.663
LIG_SUMO_SIM_par_1	119	125	PF11976	0.658
LIG_SUMO_SIM_par_1	589	594	PF11976	0.573
LIG_SUMO_SIM_par_1	774	779	PF11976	0.786
LIG_TYR_ITIM	574	579	PF00017	0.599
LIG_UBA3_1	455	460	PF00899	0.675
LIG_UBA3_1	499	505	PF00899	0.556
LIG_WRC_WIRS_1	478	483	PF05994	0.590
MOD_CDC14_SPxK_1	90	93	PF00782	0.794
MOD_CDK_SPK_2	368	373	PF00069	0.688
MOD_CDK_SPxK_1	736	742	PF00069	0.814
MOD_CDK_SPxK_1	87	93	PF00069	0.796
MOD_CDK_SPxxK_3	713	720	PF00069	0.790
MOD_CK1_1	147	153	PF00069	0.813
MOD_CK1_1	201	207	PF00069	0.699
MOD_CK1_1	222	228	PF00069	0.737
MOD_CK1_1	247	253	PF00069	0.743
MOD_CK1_1	271	277	PF00069	0.826
MOD_CK1_1	280	286	PF00069	0.750
MOD_CK1_1	292	298	PF00069	0.717
MOD_CK1_1	311	317	PF00069	0.679
MOD_CK1_1	338	344	PF00069	0.790
MOD_CK1_1	35	41	PF00069	0.698
MOD_CK1_1	385	391	PF00069	0.739
MOD_CK1_1	538	544	PF00069	0.574
MOD_CK1_1	705	711	PF00069	0.787
MOD_CK1_1	736	742	PF00069	0.763
MOD_CK1_1	744	750	PF00069	0.648
MOD_CK1_1	769	775	PF00069	0.702
MOD_CK1_1	782	788	PF00069	0.667
MOD_CK1_1	800	806	PF00069	0.754
MOD_CK1_1	809	815	PF00069	0.685
MOD_CK1_1	837	843	PF00069	0.756
MOD_CK1_1	857	863	PF00069	0.815
MOD_CK1_1	877	883	PF00069	0.621
MOD_CK1_1	908	914	PF00069	0.722
MOD_CK1_1	915	921	PF00069	0.673
MOD_CK2_1	188	194	PF00069	0.680
MOD_CK2_1	222	228	PF00069	0.757
MOD_CK2_1	264	270	PF00069	0.790
MOD_CK2_1	495	501	PF00069	0.664
MOD_GlcNHglycan	12	15	PF01048	0.437
MOD_GlcNHglycan	141	144	PF01048	0.538
MOD_GlcNHglycan	146	149	PF01048	0.525
MOD_GlcNHglycan	221	224	PF01048	0.562
MOD_GlcNHglycan	230	233	PF01048	0.567
MOD_GlcNHglycan	249	252	PF01048	0.401
MOD_GlcNHglycan	25	28	PF01048	0.458
MOD_GlcNHglycan	255	258	PF01048	0.536
MOD_GlcNHglycan	273	276	PF01048	0.469
MOD_GlcNHglycan	286	289	PF01048	0.503
MOD_GlcNHglycan	291	294	PF01048	0.451
MOD_GlcNHglycan	305	308	PF01048	0.489
MOD_GlcNHglycan	330	333	PF01048	0.524
MOD_GlcNHglycan	456	459	PF01048	0.399
MOD_GlcNHglycan	545	548	PF01048	0.379
MOD_GlcNHglycan	628	631	PF01048	0.462
MOD_GlcNHglycan	643	647	PF01048	0.389
MOD_GlcNHglycan	66	69	PF01048	0.554
MOD_GlcNHglycan	697	700	PF01048	0.563
MOD_GlcNHglycan	707	710	PF01048	0.518
MOD_GlcNHglycan	731	734	PF01048	0.556
MOD_GlcNHglycan	799	802	PF01048	0.591
MOD_GlcNHglycan	862	865	PF01048	0.605
MOD_GlcNHglycan	870	873	PF01048	0.554
MOD_GlcNHglycan	874	877	PF01048	0.530
MOD_GlcNHglycan	885	888	PF01048	0.461
MOD_GlcNHglycan	908	911	PF01048	0.524
MOD_GlcNHglycan	917	920	PF01048	0.471
MOD_GlcNHglycan	99	102	PF01048	0.370
MOD_GSK3_1	135	142	PF00069	0.752
MOD_GSK3_1	228	235	PF00069	0.754
MOD_GSK3_1	264	271	PF00069	0.744
MOD_GSK3_1	280	287	PF00069	0.667
MOD_GSK3_1	340	347	PF00069	0.755
MOD_GSK3_1	348	355	PF00069	0.742
MOD_GSK3_1	356	363	PF00069	0.691
MOD_GSK3_1	382	389	PF00069	0.826
MOD_GSK3_1	396	403	PF00069	0.648
MOD_GSK3_1	593	600	PF00069	0.573
MOD_GSK3_1	642	649	PF00069	0.542
MOD_GSK3_1	669	676	PF00069	0.615
MOD_GSK3_1	705	712	PF00069	0.740
MOD_GSK3_1	729	736	PF00069	0.763
MOD_GSK3_1	740	747	PF00069	0.646
MOD_GSK3_1	754	761	PF00069	0.647
MOD_GSK3_1	800	807	PF00069	0.805
MOD_GSK3_1	830	837	PF00069	0.805
MOD_GSK3_1	868	875	PF00069	0.821
MOD_GSK3_1	877	884	PF00069	0.727
MOD_GSK3_1	908	915	PF00069	0.715
MOD_GSK3_1	936	943	PF00069	0.804
MOD_GSK3_1	95	102	PF00069	0.602
MOD_N-GLC_1	188	193	PF02516	0.512
MOD_N-GLC_1	198	203	PF02516	0.587
MOD_N-GLC_1	268	273	PF02516	0.598
MOD_N-GLC_1	344	349	PF02516	0.618
MOD_N-GLC_1	816	821	PF02516	0.617
MOD_N-GLC_1	868	873	PF02516	0.600
MOD_N-GLC_1	895	900	PF02516	0.606
MOD_N-GLC_2	897	899	PF02516	0.464
MOD_NEK2_1	137	142	PF00069	0.677
MOD_NEK2_1	168	173	PF00069	0.800
MOD_NEK2_1	188	193	PF00069	0.480
MOD_NEK2_1	198	203	PF00069	0.645
MOD_NEK2_1	23	28	PF00069	0.647
MOD_NEK2_1	253	258	PF00069	0.789
MOD_NEK2_1	268	273	PF00069	0.660
MOD_NEK2_1	303	308	PF00069	0.779
MOD_NEK2_1	32	37	PF00069	0.648
MOD_NEK2_1	328	333	PF00069	0.705
MOD_NEK2_1	348	353	PF00069	0.692
MOD_NEK2_1	358	363	PF00069	0.738
MOD_NEK2_1	495	500	PF00069	0.618
MOD_NEK2_1	529	534	PF00069	0.589
MOD_NEK2_1	572	577	PF00069	0.603
MOD_NEK2_1	593	598	PF00069	0.540
MOD_NEK2_1	677	682	PF00069	0.607
MOD_NEK2_1	753	758	PF00069	0.753
MOD_NEK2_1	830	835	PF00069	0.806
MOD_NEK2_1	862	867	PF00069	0.676
MOD_NEK2_1	883	888	PF00069	0.811
MOD_NEK2_2	308	313	PF00069	0.719
MOD_OFUCOSY	894	899	PF10250	0.608
MOD_PIKK_1	529	535	PF00454	0.587
MOD_PIKK_1	733	739	PF00454	0.679
MOD_PIKK_1	834	840	PF00454	0.840
MOD_PK_1	912	918	PF00069	0.664
MOD_PKA_1	163	169	PF00069	0.661
MOD_PKA_1	912	918	PF00069	0.771
MOD_PKA_2	163	169	PF00069	0.740
MOD_PKA_2	280	286	PF00069	0.746
MOD_PKA_2	375	381	PF00069	0.786
MOD_PKA_2	543	549	PF00069	0.684
MOD_PKA_2	769	775	PF00069	0.802
MOD_PKA_2	854	860	PF00069	0.826
MOD_PKA_2	936	942	PF00069	0.802
MOD_Plk_1	188	194	PF00069	0.712
MOD_Plk_1	268	274	PF00069	0.806
MOD_Plk_1	344	350	PF00069	0.818
MOD_Plk_1	396	402	PF00069	0.768
MOD_Plk_1	593	599	PF00069	0.575
MOD_Plk_1	722	728	PF00069	0.729
MOD_Plk_1	857	863	PF00069	0.740
MOD_Plk_2-3	396	402	PF00069	0.811
MOD_Plk_4	103	109	PF00069	0.592
MOD_Plk_4	127	133	PF00069	0.590
MOD_Plk_4	188	194	PF00069	0.623
MOD_Plk_4	308	314	PF00069	0.749
MOD_Plk_4	44	50	PF00069	0.762
MOD_Plk_4	451	457	PF00069	0.608
MOD_Plk_4	477	483	PF00069	0.595
MOD_Plk_4	495	501	PF00069	0.595
MOD_Plk_4	564	570	PF00069	0.642
MOD_Plk_4	605	611	PF00069	0.645
MOD_Plk_4	669	675	PF00069	0.644
MOD_Plk_4	857	863	PF00069	0.832
MOD_ProDKin_1	238	244	PF00069	0.706
MOD_ProDKin_1	330	336	PF00069	0.814
MOD_ProDKin_1	368	374	PF00069	0.798
MOD_ProDKin_1	66	72	PF00069	0.659
MOD_ProDKin_1	713	719	PF00069	0.776
MOD_ProDKin_1	736	742	PF00069	0.774
MOD_ProDKin_1	748	754	PF00069	0.705
MOD_ProDKin_1	821	827	PF00069	0.795
MOD_ProDKin_1	840	846	PF00069	0.838
MOD_ProDKin_1	87	93	PF00069	0.742
MOD_SUMO_for_1	441	444	PF00179	0.652
MOD_SUMO_rev_2	159	169	PF00179	0.807
MOD_SUMO_rev_2	712	722	PF00179	0.788
TRG_DiLeu_BaLyEn_6	822	827	PF01217	0.681
TRG_ENDOCYTIC_2	132	135	PF00928	0.669
TRG_ENDOCYTIC_2	576	579	PF00928	0.608
TRG_ENDOCYTIC_2	9	12	PF00928	0.407
TRG_ER_diArg_1	426	428	PF00400	0.682
TRG_ER_diArg_1	684	687	PF00400	0.673
TRG_ER_diLys_1	944	947	PF00400	0.840
TRG_NLS_Bipartite_1	163	185	PF00514	0.625
TRG_Pf-PMV_PEXEL_1	326	330	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	724	728	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD4	Leptomonas seymouri	50%	100%
A0A3S7WS71	Leishmania donovani	88%	100%
E9AGI0	Leishmania infantum	88%	100%
E9AP16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%