SMP-LTD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative integral membrane protein conserved region (DUF2404), putative

Species:

Leishmania major

UniProt:

Q4QGH2_LEIMA

TriTrypDb:

LmjF.12.1170 , LMJLV39_120013800 , LMJSD75_120014500

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QGH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006869	lipid transport	5	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0071702	organic substance transport	4	9

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0008289	lipid binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	628	632	PF00656	0.636
CLV_C14_Caspase3-7	718	722	PF00656	0.627
CLV_MEL_PAP_1	418	424	PF00089	0.366
CLV_NRD_NRD_1	194	196	PF00675	0.478
CLV_NRD_NRD_1	197	199	PF00675	0.487
CLV_NRD_NRD_1	272	274	PF00675	0.449
CLV_NRD_NRD_1	28	30	PF00675	0.400
CLV_NRD_NRD_1	300	302	PF00675	0.375
CLV_NRD_NRD_1	43	45	PF00675	0.363
CLV_NRD_NRD_1	456	458	PF00675	0.421
CLV_NRD_NRD_1	568	570	PF00675	0.632
CLV_NRD_NRD_1	722	724	PF00675	0.434
CLV_PCSK_FUR_1	195	199	PF00082	0.482
CLV_PCSK_KEX2_1	194	196	PF00082	0.478
CLV_PCSK_KEX2_1	197	199	PF00082	0.485
CLV_PCSK_KEX2_1	213	215	PF00082	0.273
CLV_PCSK_KEX2_1	272	274	PF00082	0.449
CLV_PCSK_KEX2_1	300	302	PF00082	0.375
CLV_PCSK_KEX2_1	568	570	PF00082	0.632
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.467
CLV_PCSK_SKI1_1	338	342	PF00082	0.348
CLV_PCSK_SKI1_1	503	507	PF00082	0.412
CLV_PCSK_SKI1_1	635	639	PF00082	0.446
CLV_PCSK_SKI1_1	85	89	PF00082	0.300
DEG_SPOP_SBC_1	396	400	PF00917	0.533
DOC_ANK_TNKS_1	274	281	PF00023	0.582
DOC_CKS1_1	311	316	PF01111	0.628
DOC_CKS1_1	596	601	PF01111	0.655
DOC_CKS1_1	655	660	PF01111	0.673
DOC_CYCLIN_RxL_1	300	313	PF00134	0.610
DOC_CYCLIN_RxL_1	500	509	PF00134	0.549
DOC_MAPK_DCC_7	427	436	PF00069	0.515
DOC_MAPK_gen_1	371	380	PF00069	0.578
DOC_MAPK_gen_1	427	436	PF00069	0.515
DOC_MAPK_HePTP_8	410	422	PF00069	0.506
DOC_MAPK_HePTP_8	424	436	PF00069	0.464
DOC_MAPK_MEF2A_6	158	165	PF00069	0.610
DOC_MAPK_MEF2A_6	289	297	PF00069	0.527
DOC_MAPK_MEF2A_6	371	380	PF00069	0.524
DOC_MAPK_MEF2A_6	413	422	PF00069	0.507
DOC_MAPK_MEF2A_6	427	436	PF00069	0.468
DOC_MAPK_NFAT4_5	158	166	PF00069	0.609
DOC_MAPK_NFAT4_5	373	381	PF00069	0.519
DOC_MAPK_NFAT4_5	413	421	PF00069	0.576
DOC_PP1_RVXF_1	336	342	PF00149	0.529
DOC_PP1_RVXF_1	417	423	PF00149	0.568
DOC_PP1_RVXF_1	468	474	PF00149	0.581
DOC_PP1_RVXF_1	501	508	PF00149	0.549
DOC_PP1_RVXF_1	67	74	PF00149	0.556
DOC_PP4_FxxP_1	518	521	PF00568	0.570
DOC_SPAK_OSR1_1	421	425	PF12202	0.536
DOC_SPAK_OSR1_1	448	452	PF12202	0.563
DOC_USP7_MATH_1	362	366	PF00917	0.606
DOC_USP7_MATH_1	396	400	PF00917	0.672
DOC_USP7_MATH_1	492	496	PF00917	0.560
DOC_USP7_MATH_1	545	549	PF00917	0.691
DOC_USP7_MATH_1	556	560	PF00917	0.770
DOC_USP7_MATH_1	606	610	PF00917	0.743
DOC_USP7_MATH_1	687	691	PF00917	0.646
DOC_USP7_MATH_1	694	698	PF00917	0.703
DOC_USP7_MATH_1	704	708	PF00917	0.656
DOC_USP7_MATH_1	711	715	PF00917	0.642
DOC_USP7_UBL2_3	356	360	PF12436	0.544
DOC_USP7_UBL2_3	41	45	PF12436	0.613
DOC_WW_Pin1_4	251	256	PF00397	0.639
DOC_WW_Pin1_4	310	315	PF00397	0.583
DOC_WW_Pin1_4	595	600	PF00397	0.719
DOC_WW_Pin1_4	654	659	PF00397	0.721
DOC_WW_Pin1_4	690	695	PF00397	0.737
DOC_WW_Pin1_4	700	705	PF00397	0.639
LIG_14-3-3_CanoR_1	139	148	PF00244	0.599
LIG_14-3-3_CanoR_1	200	210	PF00244	0.553
LIG_14-3-3_CanoR_1	29	35	PF00244	0.600
LIG_14-3-3_CanoR_1	345	350	PF00244	0.541
LIG_14-3-3_CanoR_1	363	369	PF00244	0.599
LIG_14-3-3_CanoR_1	421	425	PF00244	0.555
LIG_14-3-3_CanoR_1	557	566	PF00244	0.816
LIG_14-3-3_CanoR_1	639	643	PF00244	0.704
LIG_14-3-3_CanoR_1	668	675	PF00244	0.791
LIG_14-3-3_CanoR_1	686	692	PF00244	0.659
LIG_APCC_ABBA_1	161	166	PF00400	0.601
LIG_APCC_ABBA_1	504	509	PF00400	0.609
LIG_APCC_ABBAyCdc20_2	373	379	PF00400	0.594
LIG_APCC_ABBAyCdc20_2	503	509	PF00400	0.612
LIG_BIR_III_2	80	84	PF00653	0.446
LIG_BIR_III_4	561	565	PF00653	0.707
LIG_BRCT_BRCA1_1	670	674	PF00533	0.720
LIG_CaM_NSCaTE_8	306	313	PF13499	0.573
LIG_deltaCOP1_diTrp_1	516	523	PF00928	0.597
LIG_EH1_1	499	507	PF00400	0.605
LIG_eIF4E_1	500	506	PF01652	0.467
LIG_FHA_1	16	22	PF00498	0.472
LIG_FHA_1	29	35	PF00498	0.543
LIG_FHA_1	297	303	PF00498	0.553
LIG_FHA_1	472	478	PF00498	0.602
LIG_FHA_1	596	602	PF00498	0.771
LIG_FHA_1	90	96	PF00498	0.535
LIG_FHA_2	101	107	PF00498	0.634
LIG_FHA_2	185	191	PF00498	0.659
LIG_FHA_2	202	208	PF00498	0.602
LIG_FHA_2	346	352	PF00498	0.615
LIG_FHA_2	398	404	PF00498	0.588
LIG_FHA_2	716	722	PF00498	0.630
LIG_LIR_Apic_2	516	521	PF02991	0.557
LIG_LIR_Gen_1	18	28	PF02991	0.464
LIG_LIR_Gen_1	288	298	PF02991	0.534
LIG_LIR_Gen_1	304	314	PF02991	0.513
LIG_LIR_Gen_1	316	327	PF02991	0.563
LIG_LIR_Gen_1	330	340	PF02991	0.528
LIG_LIR_Gen_1	405	416	PF02991	0.524
LIG_LIR_Gen_1	48	57	PF02991	0.639
LIG_LIR_Gen_1	534	543	PF02991	0.766
LIG_LIR_Nem_3	142	148	PF02991	0.649
LIG_LIR_Nem_3	18	23	PF02991	0.378
LIG_LIR_Nem_3	288	293	PF02991	0.533
LIG_LIR_Nem_3	304	309	PF02991	0.499
LIG_LIR_Nem_3	316	322	PF02991	0.583
LIG_LIR_Nem_3	330	335	PF02991	0.537
LIG_LIR_Nem_3	405	411	PF02991	0.522
LIG_LIR_Nem_3	423	429	PF02991	0.560
LIG_LIR_Nem_3	48	52	PF02991	0.629
LIG_LIR_Nem_3	517	523	PF02991	0.672
LIG_LIR_Nem_3	534	539	PF02991	0.783
LIG_MYND_1	599	603	PF01753	0.714
LIG_NRBOX	348	354	PF00104	0.569
LIG_PCNA_yPIPBox_3	328	338	PF02747	0.543
LIG_SH2_CRK	11	15	PF00017	0.503
LIG_SH2_CRK	145	149	PF00017	0.636
LIG_SH2_NCK_1	536	540	PF00017	0.757
LIG_SH2_STAP1	536	540	PF00017	0.703
LIG_SH2_STAT5	263	266	PF00017	0.604
LIG_SH2_STAT5	500	503	PF00017	0.553
LIG_SH3_2	663	668	PF14604	0.751
LIG_SH3_3	390	396	PF00018	0.560
LIG_SH3_3	447	453	PF00018	0.499
LIG_SH3_3	461	467	PF00018	0.524
LIG_SH3_3	55	61	PF00018	0.618
LIG_SH3_3	593	599	PF00018	0.795
LIG_SH3_3	600	606	PF00018	0.775
LIG_SH3_3	612	618	PF00018	0.822
LIG_SH3_3	660	666	PF00018	0.725
LIG_TRAF2_1	204	207	PF00917	0.644
LIG_TRAF2_1	281	284	PF00917	0.607
LIG_TYR_ITIM	424	429	PF00017	0.528
LIG_TYR_ITSM	141	148	PF00017	0.653
LIG_TYR_ITSM	532	539	PF00017	0.638
LIG_UBA3_1	22	30	PF00899	0.464
LIG_UBA3_1	434	439	PF00899	0.571
LIG_UBA3_1	490	496	PF00899	0.624
LIG_WRC_WIRS_1	623	628	PF05994	0.829
LIG_WW_3	662	666	PF00397	0.735
MOD_CDK_SPxxK_3	595	602	PF00069	0.751
MOD_CK1_1	254	260	PF00069	0.685
MOD_CK1_1	266	272	PF00069	0.623
MOD_CK1_1	288	294	PF00069	0.572
MOD_CK1_1	33	39	PF00069	0.573
MOD_CK1_1	391	397	PF00069	0.551
MOD_CK1_1	572	578	PF00069	0.685
MOD_CK1_1	590	596	PF00069	0.822
MOD_CK1_1	609	615	PF00069	0.745
MOD_CK1_1	622	628	PF00069	0.719
MOD_CK1_1	653	659	PF00069	0.751
MOD_CK1_1	690	696	PF00069	0.731
MOD_CK1_1	716	722	PF00069	0.669
MOD_CK2_1	184	190	PF00069	0.652
MOD_CK2_1	201	207	PF00069	0.605
MOD_CK2_1	309	315	PF00069	0.652
MOD_CK2_1	545	551	PF00069	0.688
MOD_Cter_Amidation	270	273	PF01082	0.426
MOD_Cter_Amidation	721	724	PF01082	0.431
MOD_GlcNHglycan	256	259	PF01048	0.538
MOD_GlcNHglycan	265	268	PF01048	0.429
MOD_GlcNHglycan	528	534	PF01048	0.523
MOD_GlcNHglycan	589	592	PF01048	0.504
MOD_GlcNHglycan	608	611	PF01048	0.573
MOD_GlcNHglycan	619	622	PF01048	0.495
MOD_GlcNHglycan	652	655	PF01048	0.494
MOD_GlcNHglycan	671	674	PF01048	0.597
MOD_GlcNHglycan	696	699	PF01048	0.562
MOD_GlcNHglycan	706	709	PF01048	0.475
MOD_GlcNHglycan	715	718	PF01048	0.437
MOD_GSK3_1	126	133	PF00069	0.588
MOD_GSK3_1	250	257	PF00069	0.635
MOD_GSK3_1	262	269	PF00069	0.659
MOD_GSK3_1	309	316	PF00069	0.629
MOD_GSK3_1	341	348	PF00069	0.560
MOD_GSK3_1	391	398	PF00069	0.570
MOD_GSK3_1	492	499	PF00069	0.536
MOD_GSK3_1	545	552	PF00069	0.750
MOD_GSK3_1	569	576	PF00069	0.805
MOD_GSK3_1	590	597	PF00069	0.739
MOD_GSK3_1	606	613	PF00069	0.759
MOD_GSK3_1	633	640	PF00069	0.769
MOD_GSK3_1	650	657	PF00069	0.783
MOD_GSK3_1	690	697	PF00069	0.779
MOD_GSK3_1	700	707	PF00069	0.825
MOD_GSK3_1	711	718	PF00069	0.642
MOD_N-GLC_1	139	144	PF02516	0.450
MOD_N-GLC_1	391	396	PF02516	0.349
MOD_N-GLC_1	557	562	PF02516	0.570
MOD_N-GLC_1	573	578	PF02516	0.543
MOD_NEK2_1	256	261	PF00069	0.709
MOD_NEK2_1	309	314	PF00069	0.627
MOD_NEK2_1	341	346	PF00069	0.563
MOD_NEK2_1	35	40	PF00069	0.586
MOD_NEK2_1	494	499	PF00069	0.555
MOD_NEK2_1	637	642	PF00069	0.802
MOD_NEK2_1	643	648	PF00069	0.630
MOD_NEK2_1	669	674	PF00069	0.682
MOD_NEK2_1	675	680	PF00069	0.682
MOD_NEK2_1	88	93	PF00069	0.528
MOD_PIKK_1	126	132	PF00454	0.551
MOD_PIKK_1	471	477	PF00454	0.569
MOD_PK_1	30	36	PF00069	0.542
MOD_PKA_2	130	136	PF00069	0.599
MOD_PKA_2	193	199	PF00069	0.662
MOD_PKA_2	250	256	PF00069	0.669
MOD_PKA_2	28	34	PF00069	0.560
MOD_PKA_2	362	368	PF00069	0.604
MOD_PKA_2	420	426	PF00069	0.572
MOD_PKA_2	556	562	PF00069	0.780
MOD_PKA_2	638	644	PF00069	0.730
MOD_PKA_2	712	718	PF00069	0.657
MOD_PKB_1	137	145	PF00069	0.647
MOD_Plk_4	150	156	PF00069	0.582
MOD_Plk_4	16	22	PF00069	0.443
MOD_Plk_4	184	190	PF00069	0.516
MOD_Plk_4	30	36	PF00069	0.571
MOD_Plk_4	496	502	PF00069	0.544
MOD_Plk_4	638	644	PF00069	0.744
MOD_ProDKin_1	251	257	PF00069	0.639
MOD_ProDKin_1	310	316	PF00069	0.583
MOD_ProDKin_1	595	601	PF00069	0.720
MOD_ProDKin_1	654	660	PF00069	0.721
MOD_ProDKin_1	690	696	PF00069	0.737
MOD_ProDKin_1	700	706	PF00069	0.640
MOD_SUMO_for_1	62	65	PF00179	0.611
MOD_SUMO_rev_2	351	357	PF00179	0.604
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.531
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.652
TRG_ENDOCYTIC_2	11	14	PF00928	0.365
TRG_ENDOCYTIC_2	145	148	PF00928	0.633
TRG_ENDOCYTIC_2	426	429	PF00928	0.538
TRG_ENDOCYTIC_2	536	539	PF00928	0.761
TRG_ER_diArg_1	194	197	PF00400	0.687
TRG_ER_diArg_1	272	275	PF00400	0.647
TRG_ER_diArg_1	300	302	PF00400	0.614
TRG_ER_diArg_1	446	449	PF00400	0.481
TRG_NLS_Bipartite_1	29	45	PF00514	0.601
TRG_NLS_MonoExtC_3	40	45	PF00514	0.565
TRG_NLS_MonoExtN_4	356	362	PF00514	0.586
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	232	237	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN3	Leptomonas seymouri	65%	99%
A0A1X0NNZ4	Trypanosomatidae	42%	100%
A0A3S5H6M5	Leishmania donovani	88%	100%
A4H6Z6	Leishmania braziliensis	34%	100%
A4H6Z7	Leishmania braziliensis	70%	100%
C9ZI10	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AGI1	Leishmania infantum	88%	100%
E9AP17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
V5DG13	Trypanosoma cruzi	31%	100%