CSD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGH1_LEIMA

TriTrypDb:

LmjF.12.1180 , LMJLV39_120013900 , LMJSD75_120014600

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGH1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.709
CLV_C14_Caspase3-7	123	127	PF00656	0.701
CLV_C14_Caspase3-7	168	172	PF00656	0.579
CLV_C14_Caspase3-7	197	201	PF00656	0.634
CLV_C14_Caspase3-7	479	483	PF00656	0.583
CLV_C14_Caspase3-7	498	502	PF00656	0.738
CLV_C14_Caspase3-7	731	735	PF00656	0.570
CLV_C14_Caspase3-7	790	794	PF00656	0.479
CLV_NRD_NRD_1	164	166	PF00675	0.669
CLV_NRD_NRD_1	182	184	PF00675	0.600
CLV_NRD_NRD_1	191	193	PF00675	0.625
CLV_NRD_NRD_1	77	79	PF00675	0.746
CLV_NRD_NRD_1	822	824	PF00675	0.664
CLV_NRD_NRD_1	855	857	PF00675	0.610
CLV_PCSK_KEX2_1	164	166	PF00082	0.758
CLV_PCSK_KEX2_1	181	183	PF00082	0.587
CLV_PCSK_KEX2_1	190	192	PF00082	0.632
CLV_PCSK_KEX2_1	762	764	PF00082	0.459
CLV_PCSK_KEX2_1	77	79	PF00082	0.746
CLV_PCSK_KEX2_1	821	823	PF00082	0.667
CLV_PCSK_KEX2_1	857	859	PF00082	0.592
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.628
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.577
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.592
CLV_PCSK_SKI1_1	217	221	PF00082	0.601
CLV_PCSK_SKI1_1	445	449	PF00082	0.384
CLV_PCSK_SKI1_1	763	767	PF00082	0.530
CLV_PCSK_SKI1_1	78	82	PF00082	0.733
CLV_PCSK_SKI1_1	8	12	PF00082	0.513
CLV_PCSK_SKI1_1	857	861	PF00082	0.683
DEG_SCF_FBW7_1	545	552	PF00400	0.544
DEG_SPOP_SBC_1	549	553	PF00917	0.560
DEG_SPOP_SBC_1	679	683	PF00917	0.734
DEG_SPOP_SBC_1	702	706	PF00917	0.506
DOC_CYCLIN_RxL_1	75	83	PF00134	0.740
DOC_CYCLIN_yClb1_LxF_4	806	812	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	374	380	PF00134	0.727
DOC_CYCLIN_yCln2_LP_2	398	401	PF00134	0.544
DOC_MAPK_gen_1	762	771	PF00069	0.434
DOC_MAPK_MEF2A_6	632	641	PF00069	0.511
DOC_PP2B_LxvP_1	398	401	PF13499	0.544
DOC_PP2B_LxvP_1	639	642	PF13499	0.462
DOC_PP4_FxxP_1	422	425	PF00568	0.398
DOC_USP7_MATH_1	101	105	PF00917	0.697
DOC_USP7_MATH_1	261	265	PF00917	0.606
DOC_USP7_MATH_1	318	322	PF00917	0.707
DOC_USP7_MATH_1	323	327	PF00917	0.706
DOC_USP7_MATH_1	341	345	PF00917	0.514
DOC_USP7_MATH_1	358	362	PF00917	0.508
DOC_USP7_MATH_1	472	476	PF00917	0.654
DOC_USP7_MATH_1	500	504	PF00917	0.615
DOC_USP7_MATH_1	508	512	PF00917	0.558
DOC_USP7_MATH_1	64	68	PF00917	0.715
DOC_USP7_MATH_1	680	684	PF00917	0.691
DOC_USP7_MATH_1	701	705	PF00917	0.609
DOC_USP7_MATH_1	845	849	PF00917	0.732
DOC_USP7_UBL2_3	217	221	PF12436	0.538
DOC_USP7_UBL2_3	4	8	PF12436	0.630
DOC_USP7_UBL2_3	762	766	PF12436	0.532
DOC_WW_Pin1_4	133	138	PF00397	0.752
DOC_WW_Pin1_4	421	426	PF00397	0.520
DOC_WW_Pin1_4	474	479	PF00397	0.665
DOC_WW_Pin1_4	511	516	PF00397	0.656
DOC_WW_Pin1_4	545	550	PF00397	0.663
DOC_WW_Pin1_4	738	743	PF00397	0.627
LIG_14-3-3_CanoR_1	260	270	PF00244	0.594
LIG_14-3-3_CanoR_1	607	611	PF00244	0.462
LIG_14-3-3_CanoR_1	770	776	PF00244	0.507
LIG_Actin_WH2_2	439	456	PF00022	0.504
LIG_Actin_WH2_2	587	605	PF00022	0.553
LIG_APCC_ABBA_1	867	872	PF00400	0.670
LIG_CaM_IQ_9	226	242	PF13499	0.495
LIG_deltaCOP1_diTrp_1	644	652	PF00928	0.431
LIG_FHA_1	152	158	PF00498	0.656
LIG_FHA_1	305	311	PF00498	0.719
LIG_FHA_1	584	590	PF00498	0.541
LIG_FHA_1	711	717	PF00498	0.481
LIG_FHA_1	739	745	PF00498	0.590
LIG_FHA_1	87	93	PF00498	0.736
LIG_FHA_2	197	203	PF00498	0.728
LIG_FHA_2	389	395	PF00498	0.495
LIG_FHA_2	477	483	PF00498	0.552
LIG_FHA_2	496	502	PF00498	0.656
LIG_FHA_2	565	571	PF00498	0.603
LIG_FHA_2	788	794	PF00498	0.403
LIG_Integrin_isoDGR_2	622	624	PF01839	0.639
LIG_LIR_Apic_2	644	650	PF02991	0.532
LIG_LIR_Apic_2	661	667	PF02991	0.534
LIG_LIR_Gen_1	12	23	PF02991	0.517
LIG_LIR_Gen_1	442	451	PF02991	0.485
LIG_LIR_Nem_3	114	119	PF02991	0.604
LIG_LIR_Nem_3	12	18	PF02991	0.497
LIG_LIR_Nem_3	161	166	PF02991	0.658
LIG_LIR_Nem_3	431	436	PF02991	0.408
LIG_LIR_Nem_3	442	446	PF02991	0.486
LIG_LIR_Nem_3	514	520	PF02991	0.556
LIG_LIR_Nem_3	646	651	PF02991	0.433
LIG_LYPXL_yS_3	875	878	PF13949	0.675
LIG_PALB2_WD40_1	643	651	PF16756	0.532
LIG_Pex14_2	11	15	PF04695	0.500
LIG_Pex14_2	648	652	PF04695	0.429
LIG_PROFILIN_1	670	676	PF00235	0.534
LIG_SH2_CRK	664	668	PF00017	0.587
LIG_SH2_NCK_1	147	151	PF00017	0.668
LIG_SH2_SRC	747	750	PF00017	0.461
LIG_SH2_STAP1	747	751	PF00017	0.455
LIG_SH2_STAT3	243	246	PF00017	0.590
LIG_SH2_STAT5	147	150	PF00017	0.707
LIG_SH2_STAT5	407	410	PF00017	0.520
LIG_SH2_STAT5	452	455	PF00017	0.594
LIG_SH2_STAT5	712	715	PF00017	0.444
LIG_SH2_STAT5	727	730	PF00017	0.396
LIG_SH2_STAT5	784	787	PF00017	0.543
LIG_SH3_1	664	670	PF00018	0.703
LIG_SH3_3	251	257	PF00018	0.577
LIG_SH3_3	424	430	PF00018	0.442
LIG_SH3_3	455	461	PF00018	0.549
LIG_SH3_3	512	518	PF00018	0.572
LIG_SH3_3	559	565	PF00018	0.642
LIG_SH3_3	647	653	PF00018	0.441
LIG_SH3_3	664	670	PF00018	0.632
LIG_SH3_3	671	677	PF00018	0.652
LIG_SH3_3	695	701	PF00018	0.708
LIG_SUMO_SIM_anti_2	394	400	PF11976	0.455
LIG_TRAF2_1	568	571	PF00917	0.592
LIG_TRFH_1	147	151	PF08558	0.572
LIG_WW_1	144	147	PF00397	0.745
MOD_CK1_1	104	110	PF00069	0.661
MOD_CK1_1	136	142	PF00069	0.746
MOD_CK1_1	158	164	PF00069	0.623
MOD_CK1_1	476	482	PF00069	0.588
MOD_CK1_1	487	493	PF00069	0.790
MOD_CK1_1	511	517	PF00069	0.624
MOD_CK1_1	580	586	PF00069	0.549
MOD_CK1_1	681	687	PF00069	0.778
MOD_CK1_1	704	710	PF00069	0.617
MOD_CK1_1	733	739	PF00069	0.624
MOD_CK1_1	96	102	PF00069	0.656
MOD_CK2_1	196	202	PF00069	0.731
MOD_CK2_1	27	33	PF00069	0.539
MOD_CK2_1	388	394	PF00069	0.509
MOD_CK2_1	42	48	PF00069	0.609
MOD_CK2_1	564	570	PF00069	0.616
MOD_CK2_1	680	686	PF00069	0.690
MOD_CK2_1	691	697	PF00069	0.621
MOD_GlcNHglycan	158	161	PF01048	0.561
MOD_GlcNHglycan	173	176	PF01048	0.550
MOD_GlcNHglycan	202	205	PF01048	0.536
MOD_GlcNHglycan	243	246	PF01048	0.720
MOD_GlcNHglycan	264	267	PF01048	0.657
MOD_GlcNHglycan	321	324	PF01048	0.735
MOD_GlcNHglycan	325	328	PF01048	0.707
MOD_GlcNHglycan	360	363	PF01048	0.756
MOD_GlcNHglycan	366	369	PF01048	0.616
MOD_GlcNHglycan	454	457	PF01048	0.439
MOD_GlcNHglycan	486	489	PF01048	0.576
MOD_GlcNHglycan	509	513	PF01048	0.549
MOD_GlcNHglycan	54	57	PF01048	0.704
MOD_GlcNHglycan	583	586	PF01048	0.558
MOD_GlcNHglycan	66	69	PF01048	0.595
MOD_GlcNHglycan	660	663	PF01048	0.737
MOD_GlcNHglycan	683	686	PF01048	0.696
MOD_GlcNHglycan	693	696	PF01048	0.796
MOD_GlcNHglycan	734	738	PF01048	0.741
MOD_GlcNHglycan	82	85	PF01048	0.713
MOD_GlcNHglycan	833	836	PF01048	0.795
MOD_GlcNHglycan	847	850	PF01048	0.556
MOD_GlcNHglycan	95	98	PF01048	0.597
MOD_GSK3_1	132	139	PF00069	0.704
MOD_GSK3_1	151	158	PF00069	0.543
MOD_GSK3_1	196	203	PF00069	0.539
MOD_GSK3_1	23	30	PF00069	0.558
MOD_GSK3_1	234	241	PF00069	0.537
MOD_GSK3_1	291	298	PF00069	0.721
MOD_GSK3_1	300	307	PF00069	0.618
MOD_GSK3_1	319	326	PF00069	0.482
MOD_GSK3_1	358	365	PF00069	0.569
MOD_GSK3_1	43	50	PF00069	0.473
MOD_GSK3_1	435	442	PF00069	0.397
MOD_GSK3_1	472	479	PF00069	0.662
MOD_GSK3_1	484	491	PF00069	0.596
MOD_GSK3_1	545	552	PF00069	0.542
MOD_GSK3_1	560	567	PF00069	0.595
MOD_GSK3_1	577	584	PF00069	0.367
MOD_GSK3_1	606	613	PF00069	0.475
MOD_GSK3_1	703	710	PF00069	0.619
MOD_GSK3_1	771	778	PF00069	0.419
MOD_GSK3_1	92	99	PF00069	0.659
MOD_N-GLC_1	472	477	PF02516	0.625
MOD_N-GLC_1	64	69	PF02516	0.654
MOD_N-GLC_1	800	805	PF02516	0.559
MOD_NEK2_1	23	28	PF00069	0.662
MOD_NEK2_1	42	47	PF00069	0.467
MOD_NEK2_1	434	439	PF00069	0.426
MOD_NEK2_1	441	446	PF00069	0.359
MOD_NEK2_1	581	586	PF00069	0.545
MOD_NEK2_1	610	615	PF00069	0.446
MOD_NEK2_1	643	648	PF00069	0.454
MOD_NEK2_1	771	776	PF00069	0.579
MOD_PIKK_1	347	353	PF00454	0.622
MOD_PKA_2	152	158	PF00069	0.656
MOD_PKA_2	352	358	PF00069	0.563
MOD_PKA_2	560	566	PF00069	0.595
MOD_PKA_2	606	612	PF00069	0.578
MOD_PKA_2	710	716	PF00069	0.542
MOD_PKA_2	93	99	PF00069	0.692
MOD_Plk_1	508	514	PF00069	0.685
MOD_Plk_1	643	649	PF00069	0.407
MOD_Plk_1	800	806	PF00069	0.510
MOD_Plk_4	158	164	PF00069	0.641
MOD_Plk_4	577	583	PF00069	0.538
MOD_Plk_4	606	612	PF00069	0.533
MOD_Plk_4	643	649	PF00069	0.407
MOD_Plk_4	747	753	PF00069	0.437
MOD_Plk_4	784	790	PF00069	0.407
MOD_ProDKin_1	133	139	PF00069	0.753
MOD_ProDKin_1	421	427	PF00069	0.526
MOD_ProDKin_1	474	480	PF00069	0.667
MOD_ProDKin_1	511	517	PF00069	0.657
MOD_ProDKin_1	545	551	PF00069	0.667
MOD_ProDKin_1	738	744	PF00069	0.612
MOD_SUMO_for_1	31	34	PF00179	0.653
MOD_SUMO_rev_2	850	859	PF00179	0.754
TRG_DiLeu_BaEn_1	394	399	PF01217	0.455
TRG_DiLeu_BaEn_1	863	868	PF01217	0.664
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.718
TRG_DiLeu_BaLyEn_6	585	590	PF01217	0.472
TRG_DiLeu_BaLyEn_6	621	626	PF01217	0.613
TRG_ENDOCYTIC_2	875	878	PF00928	0.557
TRG_ER_diArg_1	163	165	PF00400	0.679
TRG_ER_diArg_1	181	183	PF00400	0.609
TRG_ER_diArg_1	76	78	PF00400	0.755
TRG_ER_diArg_1	821	823	PF00400	0.748
TRG_ER_diArg_1	856	859	PF00400	0.670
TRG_NLS_MonoExtN_4	856	861	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	588	593	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	624	629	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IHU8	Leishmania donovani	86%	100%
A4H6Z8	Leishmania braziliensis	68%	100%
C9ZI14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AGI2	Leishmania infantum	86%	100%
E9AP18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%