Sister chromatid cohesion protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGG9_LEIMA

TriTrypDb:

LmjF.12.1200 , LMJLV39_120014100 , LMJSD75_120014800

Length:

528

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	375	379	PF00656	0.628
CLV_C14_Caspase3-7	38	42	PF00656	0.600
CLV_C14_Caspase3-7	48	52	PF00656	0.606
CLV_C14_Caspase3-7	513	517	PF00656	0.656
CLV_NRD_NRD_1	127	129	PF00675	0.638
CLV_NRD_NRD_1	210	212	PF00675	0.734
CLV_NRD_NRD_1	401	403	PF00675	0.603
CLV_NRD_NRD_1	422	424	PF00675	0.592
CLV_NRD_NRD_1	428	430	PF00675	0.597
CLV_NRD_NRD_1	449	451	PF00675	0.614
CLV_NRD_NRD_1	494	496	PF00675	0.658
CLV_NRD_NRD_1	96	98	PF00675	0.604
CLV_PCSK_KEX2_1	250	252	PF00082	0.503
CLV_PCSK_KEX2_1	422	424	PF00082	0.592
CLV_PCSK_KEX2_1	428	430	PF00082	0.597
CLV_PCSK_KEX2_1	449	451	PF00082	0.611
CLV_PCSK_KEX2_1	494	496	PF00082	0.658
CLV_PCSK_KEX2_1	96	98	PF00082	0.543
CLV_PCSK_PC1ET2_1	250	252	PF00082	0.454
CLV_PCSK_SKI1_1	191	195	PF00082	0.511
CLV_PCSK_SKI1_1	262	266	PF00082	0.517
CLV_PCSK_SKI1_1	272	276	PF00082	0.475
CLV_PCSK_SKI1_1	417	421	PF00082	0.612
CLV_PCSK_SKI1_1	454	458	PF00082	0.613
CLV_PCSK_SKI1_1	97	101	PF00082	0.479
DEG_APCC_DBOX_1	95	103	PF00400	0.584
DEG_COP1_1	430	439	PF00400	0.545
DOC_CKS1_1	194	199	PF01111	0.579
DOC_CYCLIN_RxL_1	187	196	PF00134	0.489
DOC_CYCLIN_RxL_1	76	87	PF00134	0.668
DOC_CYCLIN_RxL_1	93	104	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	194	200	PF00134	0.582
DOC_MAPK_gen_1	112	121	PF00069	0.496
DOC_MAPK_gen_1	179	188	PF00069	0.463
DOC_MAPK_gen_1	494	501	PF00069	0.655
DOC_MAPK_gen_1	93	102	PF00069	0.593
DOC_PP2B_LxvP_1	198	201	PF13499	0.714
DOC_PP2B_LxvP_1	410	413	PF13499	0.637
DOC_USP7_MATH_1	172	176	PF00917	0.601
DOC_USP7_MATH_1	210	214	PF00917	0.593
DOC_USP7_MATH_1	481	485	PF00917	0.698
DOC_USP7_UBL2_3	212	216	PF12436	0.661
DOC_USP7_UBL2_3	443	447	PF12436	0.665
DOC_WW_Pin1_4	17	22	PF00397	0.717
DOC_WW_Pin1_4	193	198	PF00397	0.569
DOC_WW_Pin1_4	30	35	PF00397	0.556
DOC_WW_Pin1_4	318	323	PF00397	0.572
DOC_WW_Pin1_4	391	396	PF00397	0.649
DOC_WW_Pin1_4	504	509	PF00397	0.697
LIG_14-3-3_CanoR_1	428	437	PF00244	0.619
LIG_14-3-3_CanoR_1	494	501	PF00244	0.633
LIG_14-3-3_CanoR_1	6	15	PF00244	0.643
LIG_14-3-3_CanoR_1	66	74	PF00244	0.494
LIG_BIR_II_1	1	5	PF00653	0.638
LIG_BIR_III_2	459	463	PF00653	0.535
LIG_BRCT_BRCA1_1	146	150	PF00533	0.513
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.485
LIG_FHA_1	152	158	PF00498	0.595
LIG_FHA_1	301	307	PF00498	0.606
LIG_FHA_1	351	357	PF00498	0.572
LIG_FHA_1	358	364	PF00498	0.529
LIG_FHA_1	456	462	PF00498	0.590
LIG_FHA_1	62	68	PF00498	0.588
LIG_FHA_1	76	82	PF00498	0.454
LIG_FHA_2	14	20	PF00498	0.599
LIG_FHA_2	234	240	PF00498	0.511
LIG_FHA_2	312	318	PF00498	0.544
LIG_FHA_2	373	379	PF00498	0.675
LIG_LIR_Apic_2	317	322	PF02991	0.544
LIG_LIR_Gen_1	233	242	PF02991	0.509
LIG_LIR_Gen_1	324	334	PF02991	0.481
LIG_LIR_Nem_3	233	237	PF02991	0.617
LIG_LIR_Nem_3	257	263	PF02991	0.502
LIG_LIR_Nem_3	324	329	PF02991	0.459
LIG_LIR_Nem_3	78	83	PF02991	0.541
LIG_Pex14_1	252	256	PF04695	0.489
LIG_REV1ctd_RIR_1	335	344	PF16727	0.634
LIG_SH2_PTP2	331	334	PF00017	0.400
LIG_SH2_SRC	294	297	PF00017	0.647
LIG_SH2_STAP1	415	419	PF00017	0.597
LIG_SH2_STAT5	255	258	PF00017	0.525
LIG_SH2_STAT5	260	263	PF00017	0.475
LIG_SH2_STAT5	294	297	PF00017	0.647
LIG_SH2_STAT5	331	334	PF00017	0.602
LIG_SH2_STAT5	348	351	PF00017	0.399
LIG_SH2_STAT5	358	361	PF00017	0.476
LIG_SH3_3	18	24	PF00018	0.614
LIG_SH3_3	194	200	PF00018	0.598
LIG_SUMO_SIM_anti_2	116	122	PF11976	0.494
LIG_SUMO_SIM_par_1	241	246	PF11976	0.471
LIG_SUMO_SIM_par_1	369	378	PF11976	0.612
LIG_SUMO_SIM_par_1	98	104	PF11976	0.492
LIG_TRAF2_1	171	174	PF00917	0.574
LIG_TRAF2_1	221	224	PF00917	0.710
LIG_TRAF2_1	396	399	PF00917	0.697
LIG_WRC_WIRS_1	439	444	PF05994	0.548
LIG_WW_2	21	24	PF00397	0.551
MOD_CDC14_SPxK_1	507	510	PF00782	0.597
MOD_CDK_SPxK_1	193	199	PF00069	0.686
MOD_CDK_SPxK_1	504	510	PF00069	0.697
MOD_CK1_1	124	130	PF00069	0.550
MOD_CK1_1	299	305	PF00069	0.570
MOD_CK1_1	321	327	PF00069	0.478
MOD_CK1_1	383	389	PF00069	0.846
MOD_CK1_1	427	433	PF00069	0.636
MOD_CK1_1	502	508	PF00069	0.605
MOD_CK1_1	52	58	PF00069	0.594
MOD_CK1_1	521	527	PF00069	0.571
MOD_CK1_1	84	90	PF00069	0.511
MOD_CK2_1	13	19	PF00069	0.558
MOD_CK2_1	161	167	PF00069	0.538
MOD_CK2_1	168	174	PF00069	0.489
MOD_CK2_1	374	380	PF00069	0.668
MOD_CK2_1	383	389	PF00069	0.686
MOD_CMANNOS	249	252	PF00535	0.483
MOD_GlcNHglycan	170	173	PF01048	0.686
MOD_GlcNHglycan	174	177	PF01048	0.647
MOD_GlcNHglycan	212	215	PF01048	0.682
MOD_GlcNHglycan	298	301	PF01048	0.632
MOD_GlcNHglycan	323	326	PF01048	0.514
MOD_GlcNHglycan	380	385	PF01048	0.767
MOD_GlcNHglycan	45	48	PF01048	0.615
MOD_GlcNHglycan	495	498	PF01048	0.679
MOD_GlcNHglycan	88	91	PF01048	0.535
MOD_GSK3_1	13	20	PF00069	0.684
MOD_GSK3_1	144	151	PF00069	0.507
MOD_GSK3_1	168	175	PF00069	0.588
MOD_GSK3_1	206	213	PF00069	0.652
MOD_GSK3_1	296	303	PF00069	0.706
MOD_GSK3_1	338	345	PF00069	0.532
MOD_GSK3_1	35	42	PF00069	0.631
MOD_GSK3_1	424	431	PF00069	0.615
MOD_GSK3_1	45	52	PF00069	0.578
MOD_GSK3_1	481	488	PF00069	0.633
MOD_GSK3_1	82	89	PF00069	0.539
MOD_N-GLC_2	137	139	PF02516	0.498
MOD_NEK2_1	121	126	PF00069	0.546
MOD_NEK2_1	144	149	PF00069	0.645
MOD_NEK2_1	168	173	PF00069	0.570
MOD_NEK2_1	311	316	PF00069	0.580
MOD_NEK2_1	424	429	PF00069	0.557
MOD_NEK2_1	81	86	PF00069	0.534
MOD_PIKK_1	121	127	PF00454	0.597
MOD_PIKK_1	300	306	PF00454	0.634
MOD_PIKK_1	417	423	PF00454	0.660
MOD_PIKK_1	429	435	PF00454	0.550
MOD_PIKK_1	67	73	PF00454	0.510
MOD_PKA_1	428	434	PF00069	0.616
MOD_PKA_2	210	216	PF00069	0.658
MOD_PKA_2	350	356	PF00069	0.525
MOD_PKA_2	424	430	PF00069	0.639
MOD_PKA_2	43	49	PF00069	0.640
MOD_PKA_2	465	471	PF00069	0.695
MOD_PKA_2	481	487	PF00069	0.578
MOD_PKA_2	493	499	PF00069	0.580
MOD_Plk_1	342	348	PF00069	0.527
MOD_Plk_1	485	491	PF00069	0.602
MOD_Plk_1	502	508	PF00069	0.622
MOD_Plk_1	518	524	PF00069	0.504
MOD_Plk_2-3	233	239	PF00069	0.510
MOD_Plk_2-3	35	41	PF00069	0.566
MOD_Plk_4	161	167	PF00069	0.583
MOD_Plk_4	435	441	PF00069	0.673
MOD_Plk_4	45	51	PF00069	0.625
MOD_ProDKin_1	17	23	PF00069	0.717
MOD_ProDKin_1	193	199	PF00069	0.577
MOD_ProDKin_1	30	36	PF00069	0.553
MOD_ProDKin_1	318	324	PF00069	0.562
MOD_ProDKin_1	391	397	PF00069	0.653
MOD_ProDKin_1	504	510	PF00069	0.697
MOD_SUMO_for_1	225	228	PF00179	0.609
MOD_SUMO_rev_2	171	181	PF00179	0.503
MOD_SUMO_rev_2	218	227	PF00179	0.660
TRG_DiLeu_BaEn_2	229	235	PF01217	0.526
TRG_DiLeu_BaEn_4	270	276	PF01217	0.537
TRG_DiLeu_BaEn_4	485	491	PF01217	0.647
TRG_ENDOCYTIC_2	326	329	PF00928	0.472
TRG_ENDOCYTIC_2	331	334	PF00928	0.462
TRG_ER_diArg_1	422	424	PF00400	0.603
TRG_ER_diArg_1	448	450	PF00400	0.607
TRG_ER_diArg_1	493	495	PF00400	0.664
TRG_ER_diArg_1	95	97	PF00400	0.597

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY24	Leptomonas seymouri	45%	92%
A0A3Q8I9I2	Leishmania donovani	82%	94%
A4H700	Leishmania braziliensis	50%	100%
E9AGI4	Leishmania infantum	84%	100%
E9AP20	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%