SNARE associated Golgi protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SNARE associated Golgi protein, putative

Species:

Leishmania major

UniProt:

Q4QGG6_LEIMA

TriTrypDb:

LmjF.12.1230 , LMJLV39_120014500 , LMJSD75_120015200

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	11
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QGG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGG6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.444
CLV_MEL_PAP_1	254	260	PF00089	0.412
CLV_NRD_NRD_1	27	29	PF00675	0.296
CLV_NRD_NRD_1	302	304	PF00675	0.443
CLV_PCSK_KEX2_1	27	29	PF00082	0.296
CLV_PCSK_KEX2_1	271	273	PF00082	0.680
CLV_PCSK_PC1ET2_1	271	273	PF00082	0.680
CLV_PCSK_SKI1_1	192	196	PF00082	0.240
CLV_PCSK_SKI1_1	20	24	PF00082	0.313
CLV_PCSK_SKI1_1	272	276	PF00082	0.506
CLV_PCSK_SKI1_1	55	59	PF00082	0.517
DEG_APCC_DBOX_1	54	62	PF00400	0.321
DEG_SCF_FBW7_1	273	279	PF00400	0.325
DOC_CKS1_1	273	278	PF01111	0.381
DOC_MAPK_gen_1	27	38	PF00069	0.363
DOC_MAPK_gen_1	52	62	PF00069	0.327
DOC_MAPK_MEF2A_6	11	18	PF00069	0.508
DOC_MAPK_MEF2A_6	205	214	PF00069	0.455
DOC_MAPK_MEF2A_6	31	40	PF00069	0.229
DOC_MAPK_MEF2A_6	55	64	PF00069	0.328
DOC_PP2B_LxvP_1	153	156	PF13499	0.290
DOC_PP2B_LxvP_1	233	236	PF13499	0.325
DOC_PP4_FxxP_1	133	136	PF00568	0.328
DOC_USP7_MATH_1	183	187	PF00917	0.557
DOC_USP7_UBL2_3	106	110	PF12436	0.498
DOC_USP7_UBL2_3	192	196	PF12436	0.400
DOC_WW_Pin1_4	215	220	PF00397	0.433
DOC_WW_Pin1_4	227	232	PF00397	0.322
DOC_WW_Pin1_4	272	277	PF00397	0.269
DOC_WW_Pin1_4	326	331	PF00397	0.537
DOC_WW_Pin1_4	5	10	PF00397	0.562
LIG_14-3-3_CanoR_1	11	17	PF00244	0.513
LIG_14-3-3_CanoR_1	198	204	PF00244	0.522
LIG_Actin_WH2_2	80	98	PF00022	0.419
LIG_BIR_II_1	1	5	PF00653	0.575
LIG_BRCT_BRCA1_1	1	5	PF00533	0.558
LIG_eIF4E_1	116	122	PF01652	0.472
LIG_eIF4E_1	203	209	PF01652	0.363
LIG_FHA_1	11	17	PF00498	0.508
LIG_FHA_1	130	136	PF00498	0.282
LIG_FHA_1	176	182	PF00498	0.506
LIG_FHA_1	216	222	PF00498	0.436
LIG_FHA_1	277	283	PF00498	0.302
LIG_FHA_1	37	43	PF00498	0.352
LIG_FHA_1	75	81	PF00498	0.281
LIG_FHA_2	273	279	PF00498	0.328
LIG_LIR_Apic_2	132	136	PF02991	0.351
LIG_LIR_Gen_1	124	135	PF02991	0.249
LIG_LIR_Gen_1	207	217	PF02991	0.414
LIG_LIR_Gen_1	252	261	PF02991	0.212
LIG_LIR_Gen_1	275	284	PF02991	0.249
LIG_LIR_Gen_1	75	84	PF02991	0.306
LIG_LIR_Nem_3	124	130	PF02991	0.249
LIG_LIR_Nem_3	207	212	PF02991	0.414
LIG_LIR_Nem_3	252	256	PF02991	0.223
LIG_LIR_Nem_3	275	280	PF02991	0.252
LIG_LIR_Nem_3	75	81	PF02991	0.349
LIG_SH2_CRK	157	161	PF00017	0.218
LIG_SH2_STAT5	127	130	PF00017	0.276
LIG_SH2_STAT5	157	160	PF00017	0.301
LIG_SH2_STAT5	211	214	PF00017	0.412
LIG_SH2_STAT5	253	256	PF00017	0.212
LIG_SH2_STAT5	73	76	PF00017	0.255
LIG_SH3_1	216	222	PF00018	0.412
LIG_SH3_3	216	222	PF00018	0.412
LIG_SH3_3	3	9	PF00018	0.549
LIG_SH3_3	47	53	PF00018	0.355
LIG_SH3_3	57	63	PF00018	0.267
LIG_SUMO_SIM_par_1	278	285	PF11976	0.387
LIG_TYR_ITIM	155	160	PF00017	0.218
LIG_Vh1_VBS_1	18	36	PF01044	0.364
LIG_WRC_WIRS_1	130	135	PF05994	0.328
LIG_WRC_WIRS_1	237	242	PF05994	0.351
MOD_CDC14_SPxK_1	8	11	PF00782	0.397
MOD_CDK_SPxK_1	5	11	PF00069	0.405
MOD_CK1_1	10	16	PF00069	0.548
MOD_CK1_1	199	205	PF00069	0.283
MOD_CK1_1	317	323	PF00069	0.582
MOD_CK1_1	79	85	PF00069	0.497
MOD_CK1_1	94	100	PF00069	0.449
MOD_CK2_1	176	182	PF00069	0.388
MOD_GlcNHglycan	1	4	PF01048	0.578
MOD_GlcNHglycan	263	266	PF01048	0.477
MOD_GlcNHglycan	307	310	PF01048	0.594
MOD_GlcNHglycan	316	319	PF01048	0.570
MOD_GlcNHglycan	322	325	PF01048	0.560
MOD_GlcNHglycan	96	99	PF01048	0.446
MOD_GSK3_1	122	129	PF00069	0.441
MOD_GSK3_1	156	163	PF00069	0.254
MOD_GSK3_1	192	199	PF00069	0.381
MOD_GSK3_1	257	264	PF00069	0.294
MOD_GSK3_1	272	279	PF00069	0.219
MOD_GSK3_1	322	329	PF00069	0.697
MOD_GSK3_1	5	12	PF00069	0.586
MOD_GSK3_1	72	79	PF00069	0.381
MOD_GSK3_1	90	97	PF00069	0.503
MOD_NEK2_1	121	126	PF00069	0.300
MOD_NEK2_1	160	165	PF00069	0.246
MOD_NEK2_1	170	175	PF00069	0.266
MOD_NEK2_1	261	266	PF00069	0.503
MOD_NEK2_1	282	287	PF00069	0.327
MOD_NEK2_1	72	77	PF00069	0.246
MOD_NEK2_2	76	81	PF00069	0.362
MOD_PIKK_1	196	202	PF00454	0.362
MOD_PKA_2	10	16	PF00069	0.393
MOD_PKA_2	314	320	PF00069	0.677
MOD_Plk_1	90	96	PF00069	0.450
MOD_Plk_4	122	128	PF00069	0.325
MOD_Plk_4	135	141	PF00069	0.283
MOD_Plk_4	148	154	PF00069	0.237
MOD_Plk_4	156	162	PF00069	0.273
MOD_Plk_4	176	182	PF00069	0.127
MOD_Plk_4	241	247	PF00069	0.277
MOD_Plk_4	249	255	PF00069	0.273
MOD_Plk_4	276	282	PF00069	0.286
MOD_ProDKin_1	215	221	PF00069	0.278
MOD_ProDKin_1	227	233	PF00069	0.322
MOD_ProDKin_1	272	278	PF00069	0.328
MOD_ProDKin_1	326	332	PF00069	0.426
MOD_ProDKin_1	5	11	PF00069	0.458
MOD_SUMO_rev_2	264	273	PF00179	0.606
TRG_AP2beta_CARGO_1	207	216	PF09066	0.249
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.404
TRG_ENDOCYTIC_2	116	119	PF00928	0.468
TRG_ENDOCYTIC_2	127	130	PF00928	0.249
TRG_ENDOCYTIC_2	157	160	PF00928	0.268
TRG_ENDOCYTIC_2	211	214	PF00928	0.249
TRG_ENDOCYTIC_2	253	256	PF00928	0.249
TRG_ER_diArg_1	27	29	PF00400	0.366
TRG_NLS_MonoExtN_4	294	300	PF00514	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM9	Leptomonas seymouri	78%	100%
A0A1X0NMH8	Trypanosomatidae	60%	100%
A0A3Q8I9D7	Leishmania donovani	85%	100%
A0A422NV37	Trypanosoma rangeli	57%	100%
A4H703	Leishmania braziliensis	79%	100%
A4II98	Xenopus tropicalis	29%	100%
C9ZI22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGI5	Leishmania infantum	94%	100%
E9AP23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
O62126	Caenorhabditis elegans	31%	100%
Q08D99	Bos taurus	32%	100%
Q5BJD5	Homo sapiens	30%	100%
Q5RBZ8	Pongo abelii	30%	100%
Q5U4K5	Xenopus laevis	29%	100%
Q5ZIL6	Gallus gallus	30%	100%
Q9D8U2	Mus musculus	30%	100%
V5BJQ3	Trypanosoma cruzi	58%	100%