RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGG5_LEIMA

TriTrypDb:

LmjF.12.1240 , LMJLV39_120014600 , LMJSD75_120015300

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGG5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	142	146	PF00656	0.558
CLV_C14_Caspase3-7	195	199	PF00656	0.526
CLV_C14_Caspase3-7	42	46	PF00656	0.571
CLV_MEL_PAP_1	391	397	PF00089	0.459
CLV_NRD_NRD_1	127	129	PF00675	0.591
CLV_NRD_NRD_1	393	395	PF00675	0.640
CLV_NRD_NRD_1	439	441	PF00675	0.601
CLV_NRD_NRD_1	459	461	PF00675	0.533
CLV_NRD_NRD_1	490	492	PF00675	0.513
CLV_NRD_NRD_1	496	498	PF00675	0.567
CLV_NRD_NRD_1	5	7	PF00675	0.657
CLV_NRD_NRD_1	640	642	PF00675	0.535
CLV_NRD_NRD_1	67	69	PF00675	0.623
CLV_NRD_NRD_1	689	691	PF00675	0.414
CLV_NRD_NRD_1	700	702	PF00675	0.369
CLV_PCSK_KEX2_1	127	129	PF00082	0.591
CLV_PCSK_KEX2_1	393	395	PF00082	0.640
CLV_PCSK_KEX2_1	441	443	PF00082	0.622
CLV_PCSK_KEX2_1	459	461	PF00082	0.533
CLV_PCSK_KEX2_1	490	492	PF00082	0.522
CLV_PCSK_KEX2_1	496	498	PF00082	0.575
CLV_PCSK_KEX2_1	5	7	PF00082	0.657
CLV_PCSK_KEX2_1	509	511	PF00082	0.452
CLV_PCSK_KEX2_1	689	691	PF00082	0.414
CLV_PCSK_KEX2_1	700	702	PF00082	0.369
CLV_PCSK_KEX2_1	857	859	PF00082	0.541
CLV_PCSK_PC1ET2_1	441	443	PF00082	0.622
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.491
CLV_PCSK_PC1ET2_1	857	859	PF00082	0.533
CLV_PCSK_SKI1_1	201	205	PF00082	0.599
CLV_PCSK_SKI1_1	323	327	PF00082	0.502
CLV_PCSK_SKI1_1	345	349	PF00082	0.581
CLV_PCSK_SKI1_1	367	371	PF00082	0.532
CLV_PCSK_SKI1_1	539	543	PF00082	0.680
CLV_PCSK_SKI1_1	578	582	PF00082	0.582
CLV_PCSK_SKI1_1	625	629	PF00082	0.633
CLV_PCSK_SKI1_1	808	812	PF00082	0.451
CLV_Separin_Metazoa	281	285	PF03568	0.532
CLV_Separin_Metazoa	328	332	PF03568	0.494
DEG_APCC_DBOX_1	322	330	PF00400	0.474
DEG_APCC_DBOX_1	439	447	PF00400	0.596
DEG_APCC_DBOX_1	83	91	PF00400	0.518
DOC_MAPK_gen_1	317	326	PF00069	0.423
DOC_MAPK_gen_1	537	544	PF00069	0.518
DOC_MAPK_gen_1	550	559	PF00069	0.503
DOC_MAPK_gen_1	81	90	PF00069	0.520
DOC_MAPK_gen_1	856	864	PF00069	0.534
DOC_MAPK_MEF2A_6	317	326	PF00069	0.423
DOC_MAPK_MEF2A_6	553	561	PF00069	0.546
DOC_MAPK_MEF2A_6	84	92	PF00069	0.522
DOC_MAPK_MEF2A_6	856	864	PF00069	0.532
DOC_MAPK_NFAT4_5	319	327	PF00069	0.415
DOC_PIKK_1	438	446	PF02985	0.518
DOC_PP1_RVXF_1	403	410	PF00149	0.558
DOC_PP1_RVXF_1	671	678	PF00149	0.431
DOC_USP7_MATH_1	178	182	PF00917	0.523
DOC_USP7_MATH_1	261	265	PF00917	0.579
DOC_USP7_MATH_1	272	276	PF00917	0.619
DOC_USP7_MATH_1	379	383	PF00917	0.603
DOC_USP7_MATH_1	743	747	PF00917	0.570
DOC_USP7_MATH_1	795	799	PF00917	0.663
DOC_USP7_MATH_1	835	839	PF00917	0.462
DOC_USP7_UBL2_3	65	69	PF12436	0.644
DOC_USP7_UBL2_3	852	856	PF12436	0.529
DOC_WW_Pin1_4	22	27	PF00397	0.576
DOC_WW_Pin1_4	71	76	PF00397	0.624
DOC_WW_Pin1_4	79	84	PF00397	0.454
DOC_WW_Pin1_4	819	824	PF00397	0.580
LIG_14-3-3_CanoR_1	191	200	PF00244	0.531
LIG_14-3-3_CanoR_1	266	272	PF00244	0.517
LIG_14-3-3_CanoR_1	381	385	PF00244	0.551
LIG_14-3-3_CanoR_1	5	11	PF00244	0.653
LIG_14-3-3_CanoR_1	537	542	PF00244	0.558
LIG_14-3-3_CanoR_1	68	78	PF00244	0.510
LIG_14-3-3_CanoR_1	700	707	PF00244	0.509
LIG_14-3-3_CanoR_1	727	737	PF00244	0.453
LIG_14-3-3_CanoR_1	780	785	PF00244	0.547
LIG_14-3-3_CanoR_1	818	823	PF00244	0.587
LIG_Actin_WH2_2	275	290	PF00022	0.554
LIG_Actin_WH2_2	322	337	PF00022	0.469
LIG_APCC_ABBA_1	542	547	PF00400	0.438
LIG_APCC_ABBA_1	557	562	PF00400	0.408
LIG_BIR_III_2	45	49	PF00653	0.573
LIG_eIF4E_1	770	776	PF01652	0.461
LIG_FHA_1	100	106	PF00498	0.636
LIG_FHA_1	146	152	PF00498	0.561
LIG_FHA_1	165	171	PF00498	0.474
LIG_FHA_1	252	258	PF00498	0.462
LIG_FHA_1	274	280	PF00498	0.634
LIG_FHA_1	385	391	PF00498	0.591
LIG_FHA_1	430	436	PF00498	0.586
LIG_FHA_1	451	457	PF00498	0.426
LIG_FHA_1	588	594	PF00498	0.664
LIG_FHA_1	605	611	PF00498	0.444
LIG_FHA_1	812	818	PF00498	0.515
LIG_FHA_2	133	139	PF00498	0.572
LIG_FHA_2	276	282	PF00498	0.618
LIG_FHA_2	538	544	PF00498	0.540
LIG_FHA_2	717	723	PF00498	0.554
LIG_FHA_2	837	843	PF00498	0.510
LIG_LIR_Gen_1	167	176	PF02991	0.523
LIG_LIR_Gen_1	634	644	PF02991	0.596
LIG_LIR_Nem_3	198	203	PF02991	0.626
LIG_LIR_Nem_3	634	639	PF02991	0.589
LIG_LIR_Nem_3	722	726	PF02991	0.559
LIG_NRBOX	325	331	PF00104	0.485
LIG_NRBOX	859	865	PF00104	0.477
LIG_Rb_LxCxE_1	822	842	PF01857	0.523
LIG_RPA_C_Fungi	492	504	PF08784	0.510
LIG_SH2_CRK	757	761	PF00017	0.474
LIG_SH2_SRC	545	548	PF00017	0.517
LIG_SH2_STAP1	572	576	PF00017	0.538
LIG_SH2_STAT3	572	575	PF00017	0.542
LIG_SH2_STAT5	297	300	PF00017	0.595
LIG_SH2_STAT5	757	760	PF00017	0.463
LIG_SH2_STAT5	76	79	PF00017	0.546
LIG_SH2_STAT5	770	773	PF00017	0.327
LIG_SH3_3	23	29	PF00018	0.675
LIG_SH3_3	838	844	PF00018	0.485
LIG_SUMO_SIM_anti_2	58	67	PF11976	0.594
LIG_SUMO_SIM_anti_2	859	864	PF11976	0.528
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.515
LIG_TRAF2_1	278	281	PF00917	0.453
LIG_TRAF2_1	304	307	PF00917	0.541
LIG_TRAF2_1	336	339	PF00917	0.588
LIG_TRAF2_1	362	365	PF00917	0.467
LIG_TRAF2_1	708	711	PF00917	0.439
LIG_UBA3_1	505	509	PF00899	0.428
LIG_UBA3_1	610	618	PF00899	0.446
LIG_UBA3_1	845	852	PF00899	0.470
LIG_WW_2	28	31	PF00397	0.653
MOD_CDK_SPK_2	79	84	PF00069	0.542
MOD_CK1_1	217	223	PF00069	0.574
MOD_CK1_1	275	281	PF00069	0.636
MOD_CK1_1	525	531	PF00069	0.513
MOD_CK1_1	631	637	PF00069	0.434
MOD_CK1_1	67	73	PF00069	0.535
MOD_CK1_1	783	789	PF00069	0.590
MOD_CK1_1	790	796	PF00069	0.577
MOD_CK2_1	132	138	PF00069	0.574
MOD_CK2_1	224	230	PF00069	0.644
MOD_CK2_1	275	281	PF00069	0.617
MOD_CK2_1	379	385	PF00069	0.606
MOD_CK2_1	413	419	PF00069	0.651
MOD_CK2_1	537	543	PF00069	0.525
MOD_CK2_1	739	745	PF00069	0.513
MOD_CK2_1	795	801	PF00069	0.660
MOD_CK2_1	836	842	PF00069	0.517
MOD_GlcNHglycan	11	15	PF01048	0.631
MOD_GlcNHglycan	115	118	PF01048	0.582
MOD_GlcNHglycan	216	219	PF01048	0.542
MOD_GlcNHglycan	41	44	PF01048	0.668
MOD_GlcNHglycan	524	527	PF01048	0.613
MOD_GlcNHglycan	58	61	PF01048	0.539
MOD_GlcNHglycan	730	733	PF01048	0.433
MOD_GlcNHglycan	741	744	PF01048	0.546
MOD_GlcNHglycan	745	748	PF01048	0.515
MOD_GlcNHglycan	792	795	PF01048	0.659
MOD_GlcNHglycan	833	836	PF01048	0.465
MOD_GSK3_1	380	387	PF00069	0.589
MOD_GSK3_1	389	396	PF00069	0.479
MOD_GSK3_1	409	416	PF00069	0.573
MOD_GSK3_1	425	432	PF00069	0.529
MOD_GSK3_1	446	453	PF00069	0.527
MOD_GSK3_1	6	13	PF00069	0.645
MOD_GSK3_1	63	70	PF00069	0.577
MOD_GSK3_1	739	746	PF00069	0.567
MOD_GSK3_1	782	789	PF00069	0.480
MOD_GSK3_1	831	838	PF00069	0.549
MOD_LATS_1	585	591	PF00433	0.652
MOD_LATS_1	778	784	PF00433	0.470
MOD_N-GLC_1	179	184	PF02516	0.440
MOD_N-GLC_1	587	592	PF02516	0.626
MOD_N-GLC_1	780	785	PF02516	0.480
MOD_NEK2_1	10	15	PF00069	0.647
MOD_NEK2_1	132	137	PF00069	0.615
MOD_NEK2_1	192	197	PF00069	0.563
MOD_NEK2_1	214	219	PF00069	0.616
MOD_NEK2_1	267	272	PF00069	0.570
MOD_NEK2_1	446	451	PF00069	0.587
MOD_NEK2_1	563	568	PF00069	0.420
MOD_NEK2_1	581	586	PF00069	0.564
MOD_NEK2_1	64	69	PF00069	0.592
MOD_NEK2_1	716	721	PF00069	0.566
MOD_NEK2_1	811	816	PF00069	0.520
MOD_NEK2_2	261	266	PF00069	0.500
MOD_NEK2_2	297	302	PF00069	0.429
MOD_PIKK_1	209	215	PF00454	0.591
MOD_PIKK_1	229	235	PF00454	0.364
MOD_PIKK_1	425	431	PF00454	0.615
MOD_PIKK_1	446	452	PF00454	0.589
MOD_PIKK_1	587	593	PF00454	0.655
MOD_PIKK_1	716	722	PF00454	0.554
MOD_PIKK_1	96	102	PF00454	0.567
MOD_PK_1	101	107	PF00069	0.580
MOD_PKA_1	393	399	PF00069	0.552
MOD_PKA_1	5	11	PF00069	0.653
MOD_PKA_1	700	706	PF00069	0.402
MOD_PKA_1	856	862	PF00069	0.537
MOD_PKA_2	113	119	PF00069	0.583
MOD_PKA_2	287	293	PF00069	0.538
MOD_PKA_2	334	340	PF00069	0.576
MOD_PKA_2	380	386	PF00069	0.550
MOD_PKA_2	393	399	PF00069	0.632
MOD_PKA_2	495	501	PF00069	0.569
MOD_PKA_2	5	11	PF00069	0.653
MOD_PKA_2	67	73	PF00069	0.558
MOD_PKA_2	700	706	PF00069	0.514
MOD_PKB_1	780	788	PF00069	0.422
MOD_Plk_1	10	16	PF00069	0.628
MOD_Plk_1	413	419	PF00069	0.651
MOD_Plk_1	780	786	PF00069	0.538
MOD_Plk_1	811	817	PF00069	0.542
MOD_Plk_4	150	156	PF00069	0.615
MOD_Plk_4	165	171	PF00069	0.414
MOD_Plk_4	836	842	PF00069	0.447
MOD_ProDKin_1	22	28	PF00069	0.574
MOD_ProDKin_1	71	77	PF00069	0.617
MOD_ProDKin_1	79	85	PF00069	0.454
MOD_ProDKin_1	819	825	PF00069	0.569
MOD_SUMO_rev_2	434	443	PF00179	0.587
TRG_DiLeu_BaEn_1	364	369	PF01217	0.472
TRG_DiLeu_BaEn_4	364	370	PF01217	0.471
TRG_DiLeu_BaEn_4	438	444	PF01217	0.440
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.600
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.529
TRG_DiLeu_LyEn_5	364	369	PF01217	0.445
TRG_ER_diArg_1	126	128	PF00400	0.586
TRG_ER_diArg_1	321	324	PF00400	0.630
TRG_ER_diArg_1	330	333	PF00400	0.548
TRG_ER_diArg_1	393	395	PF00400	0.645
TRG_ER_diArg_1	440	443	PF00400	0.602
TRG_ER_diArg_1	458	460	PF00400	0.535
TRG_ER_diArg_1	490	492	PF00400	0.504
TRG_ER_diArg_1	688	690	PF00400	0.438
TRG_ER_diArg_1	699	701	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB7	Leishmania donovani	87%	100%
A4H704	Leishmania braziliensis	66%	100%
E9AGI6	Leishmania infantum	87%	100%
E9AP24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%