RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGG3_LEIMA

TriTrypDb:

LmjF.12.1260 , LMJLV39_120014800 , LMJSD75_120015700

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGG3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.756
CLV_C14_Caspase3-7	319	323	PF00656	0.491
CLV_NRD_NRD_1	152	154	PF00675	0.595
CLV_NRD_NRD_1	156	158	PF00675	0.578
CLV_NRD_NRD_1	160	162	PF00675	0.587
CLV_NRD_NRD_1	336	338	PF00675	0.510
CLV_NRD_NRD_1	411	413	PF00675	0.770
CLV_NRD_NRD_1	415	417	PF00675	0.731
CLV_PCSK_KEX2_1	151	153	PF00082	0.607
CLV_PCSK_KEX2_1	156	158	PF00082	0.576
CLV_PCSK_KEX2_1	160	162	PF00082	0.584
CLV_PCSK_KEX2_1	261	263	PF00082	0.535
CLV_PCSK_KEX2_1	336	338	PF00082	0.510
CLV_PCSK_KEX2_1	388	390	PF00082	0.478
CLV_PCSK_KEX2_1	411	413	PF00082	0.773
CLV_PCSK_KEX2_1	415	417	PF00082	0.715
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.535
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.435
CLV_PCSK_PC7_1	152	158	PF00082	0.624
CLV_PCSK_PC7_1	411	417	PF00082	0.532
CLV_PCSK_SKI1_1	128	132	PF00082	0.632
CLV_PCSK_SKI1_1	20	24	PF00082	0.540
CLV_PCSK_SKI1_1	349	353	PF00082	0.326
CLV_PCSK_SKI1_1	389	393	PF00082	0.503
CLV_PCSK_SKI1_1	411	415	PF00082	0.602
DEG_Nend_Nbox_1	1	3	PF02207	0.682
DEG_SPOP_SBC_1	139	143	PF00917	0.560
DEG_SPOP_SBC_1	144	148	PF00917	0.600
DOC_ANK_TNKS_1	271	278	PF00023	0.378
DOC_CYCLIN_yCln2_LP_2	391	397	PF00134	0.462
DOC_MAPK_gen_1	326	335	PF00069	0.359
DOC_MAPK_gen_1	388	395	PF00069	0.501
DOC_MAPK_JIP1_4	389	395	PF00069	0.471
DOC_MAPK_MEF2A_6	20	29	PF00069	0.452
DOC_MAPK_MEF2A_6	388	395	PF00069	0.517
DOC_PP2B_LxvP_1	391	394	PF13499	0.464
DOC_PP2B_PxIxI_1	305	311	PF00149	0.357
DOC_USP7_MATH_1	144	148	PF00917	0.607
DOC_USP7_MATH_1	16	20	PF00917	0.461
DOC_USP7_MATH_1	183	187	PF00917	0.578
DOC_USP7_MATH_1	249	253	PF00917	0.446
DOC_USP7_MATH_1	36	40	PF00917	0.426
DOC_USP7_MATH_1	404	408	PF00917	0.588
DOC_USP7_MATH_1	430	434	PF00917	0.647
DOC_WW_Pin1_4	240	245	PF00397	0.401
DOC_WW_Pin1_4	393	398	PF00397	0.455
LIG_14-3-3_CanoR_1	182	188	PF00244	0.543
LIG_14-3-3_CanoR_1	82	88	PF00244	0.550
LIG_DCNL_PONY_1	1	4	PF03556	0.681
LIG_FHA_1	133	139	PF00498	0.692
LIG_FHA_1	173	179	PF00498	0.576
LIG_FHA_1	292	298	PF00498	0.418
LIG_FHA_1	357	363	PF00498	0.459
LIG_FHA_1	78	84	PF00498	0.596
LIG_FHA_2	114	120	PF00498	0.617
LIG_FHA_2	317	323	PF00498	0.572
LIG_LIR_Gen_1	191	200	PF02991	0.405
LIG_LIR_Gen_1	204	215	PF02991	0.409
LIG_LIR_Gen_1	216	225	PF02991	0.450
LIG_LIR_Gen_1	39	48	PF02991	0.642
LIG_LIR_Gen_1	62	70	PF02991	0.498
LIG_LIR_LC3C_4	396	400	PF02991	0.403
LIG_LIR_Nem_3	204	210	PF02991	0.448
LIG_LIR_Nem_3	211	217	PF02991	0.374
LIG_LIR_Nem_3	39	44	PF02991	0.645
LIG_Pex14_1	374	378	PF04695	0.340
LIG_SH2_CRK	279	283	PF00017	0.317
LIG_SH2_SRC	366	369	PF00017	0.333
LIG_SH2_STAP1	236	240	PF00017	0.423
LIG_SH2_STAP1	279	283	PF00017	0.365
LIG_SH2_STAT3	368	371	PF00017	0.352
LIG_SH2_STAT3	378	381	PF00017	0.507
LIG_SH2_STAT5	225	228	PF00017	0.329
LIG_SH2_STAT5	334	337	PF00017	0.343
LIG_SH2_STAT5	366	369	PF00017	0.377
LIG_SH3_1	10	16	PF00018	0.626
LIG_SH3_3	10	16	PF00018	0.626
LIG_SH3_3	229	235	PF00018	0.425
LIG_SH3_3	391	397	PF00018	0.491
LIG_SH3_3	94	100	PF00018	0.749
LIG_SUMO_SIM_par_1	27	34	PF11976	0.557
LIG_SUMO_SIM_par_1	396	403	PF11976	0.473
LIG_TRAF2_1	70	73	PF00917	0.497
LIG_WRC_WIRS_1	60	65	PF05994	0.506
MOD_CDK_SPK_2	240	245	PF00069	0.454
MOD_CK1_1	143	149	PF00069	0.690
MOD_CK1_1	166	172	PF00069	0.560
MOD_CK1_1	201	207	PF00069	0.481
MOD_CK1_1	252	258	PF00069	0.392
MOD_CK1_1	39	45	PF00069	0.617
MOD_CK1_1	403	409	PF00069	0.648
MOD_CK1_1	52	58	PF00069	0.477
MOD_CK2_1	113	119	PF00069	0.595
MOD_CK2_1	354	360	PF00069	0.419
MOD_Cter_Amidation	259	262	PF01082	0.455
MOD_Cter_Amidation	386	389	PF01082	0.414
MOD_GlcNHglycan	108	111	PF01048	0.630
MOD_GlcNHglycan	142	145	PF01048	0.581
MOD_GlcNHglycan	161	164	PF01048	0.600
MOD_GlcNHglycan	178	181	PF01048	0.622
MOD_GlcNHglycan	401	405	PF01048	0.477
MOD_GlcNHglycan	53	57	PF01048	0.588
MOD_GSK3_1	100	107	PF00069	0.779
MOD_GSK3_1	111	118	PF00069	0.641
MOD_GSK3_1	120	127	PF00069	0.559
MOD_GSK3_1	128	135	PF00069	0.464
MOD_GSK3_1	139	146	PF00069	0.644
MOD_GSK3_1	159	166	PF00069	0.483
MOD_GSK3_1	168	175	PF00069	0.539
MOD_GSK3_1	248	255	PF00069	0.397
MOD_GSK3_1	39	46	PF00069	0.564
MOD_GSK3_1	400	407	PF00069	0.540
MOD_GSK3_1	421	428	PF00069	0.647
MOD_GSK3_1	83	90	PF00069	0.552
MOD_LATS_1	113	119	PF00433	0.675
MOD_NEK2_1	126	131	PF00069	0.659
MOD_NEK2_1	178	183	PF00069	0.602
MOD_NEK2_1	198	203	PF00069	0.502
MOD_NEK2_1	248	253	PF00069	0.404
MOD_NEK2_1	27	32	PF00069	0.533
MOD_NEK2_1	301	306	PF00069	0.310
MOD_NEK2_1	83	88	PF00069	0.527
MOD_NEK2_2	329	334	PF00069	0.420
MOD_PIKK_1	188	194	PF00454	0.403
MOD_PIKK_1	36	42	PF00454	0.604
MOD_PIKK_1	83	89	PF00454	0.531
MOD_PKA_1	411	417	PF00069	0.797
MOD_PKA_2	159	165	PF00069	0.689
MOD_PKA_2	252	258	PF00069	0.393
MOD_PKA_2	266	272	PF00069	0.381
MOD_PKA_2	411	417	PF00069	0.716
MOD_PKA_2	421	427	PF00069	0.604
MOD_Plk_1	16	22	PF00069	0.571
MOD_Plk_2-3	354	360	PF00069	0.441
MOD_Plk_4	27	33	PF00069	0.535
MOD_Plk_4	293	299	PF00069	0.401
MOD_Plk_4	329	335	PF00069	0.358
MOD_Plk_4	43	49	PF00069	0.479
MOD_ProDKin_1	240	246	PF00069	0.397
MOD_ProDKin_1	393	399	PF00069	0.457
TRG_DiLeu_BaEn_1	338	343	PF01217	0.374
TRG_DiLeu_BaEn_2	16	22	PF01217	0.542
TRG_ENDOCYTIC_2	217	220	PF00928	0.385
TRG_ENDOCYTIC_2	279	282	PF00928	0.305
TRG_ER_diArg_1	151	153	PF00400	0.600
TRG_ER_diArg_1	271	274	PF00400	0.435
TRG_ER_diArg_1	335	337	PF00400	0.478
TRG_ER_diArg_1	411	413	PF00400	0.749
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W8	Leptomonas seymouri	55%	96%
A0A3R7L7Q9	Trypanosoma rangeli	35%	97%
A0A3S7WS83	Leishmania donovani	94%	99%
A4H706	Leishmania braziliensis	75%	100%
E9AGI8	Leishmania infantum	94%	99%
E9AP26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5DFZ8	Trypanosoma cruzi	34%	98%