DUF4976 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGG0_LEIMA

TriTrypDb:

LmjF.12.1290 , LMJLV39_120015100 , LMJSD75_120016000

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	201	203	PF00675	0.598
CLV_PCSK_FUR_1	199	203	PF00082	0.593
CLV_PCSK_KEX2_1	199	201	PF00082	0.586
CLV_PCSK_KEX2_1	204	206	PF00082	0.614
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.640
CLV_PCSK_PC7_1	200	206	PF00082	0.608
CLV_PCSK_SKI1_1	174	178	PF00082	0.616
CLV_PCSK_SKI1_1	60	64	PF00082	0.685
DEG_Nend_UBRbox_2	1	3	PF02207	0.778
DOC_PP1_RVXF_1	92	98	PF00149	0.575
DOC_PP2B_LxvP_1	80	83	PF13499	0.565
DOC_PP4_FxxP_1	143	146	PF00568	0.734
LIG_14-3-3_CanoR_1	94	98	PF00244	0.676
LIG_Actin_WH2_2	92	108	PF00022	0.559
LIG_AP2alpha_2	51	53	PF02296	0.630
LIG_EVH1_2	127	131	PF00568	0.649
LIG_FHA_1	127	133	PF00498	0.664
LIG_FHA_1	142	148	PF00498	0.517
LIG_FHA_1	176	182	PF00498	0.609
LIG_FHA_1	64	70	PF00498	0.527
LIG_Integrin_RGD_1	160	162	PF01839	0.690
LIG_LIR_Apic_2	123	127	PF02991	0.605
LIG_LIR_Gen_1	96	105	PF02991	0.674
LIG_LIR_Nem_3	96	100	PF02991	0.671
LIG_SH2_CRK	119	123	PF00017	0.570
LIG_SH2_SRC	119	122	PF00017	0.497
LIG_SH2_STAP1	31	35	PF00017	0.718
LIG_SH2_STAT5	121	124	PF00017	0.562
LIG_SH3_3	129	135	PF00018	0.611
LIG_SH3_5	117	121	PF00018	0.633
LIG_TRAF2_1	107	110	PF00917	0.676
MOD_CK1_1	170	176	PF00069	0.567
MOD_GlcNHglycan	21	24	PF01048	0.753
MOD_GlcNHglycan	31	34	PF01048	0.643
MOD_GlcNHglycan	53	56	PF01048	0.535
MOD_GlcNHglycan	80	83	PF01048	0.685
MOD_GSK3_1	25	32	PF00069	0.545
MOD_NEK2_1	189	194	PF00069	0.571
MOD_NEK2_1	63	68	PF00069	0.586
MOD_PKA_1	200	206	PF00069	0.701
MOD_PKA_2	189	195	PF00069	0.564
MOD_PKA_2	200	206	PF00069	0.701
MOD_PKA_2	93	99	PF00069	0.675
MOD_SUMO_for_1	6	9	PF00179	0.644
MOD_SUMO_rev_2	43	52	PF00179	0.664
TRG_ENDOCYTIC_2	119	122	PF00928	0.583
TRG_ER_diArg_1	152	155	PF00400	0.613
TRG_ER_diArg_1	198	201	PF00400	0.581
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD1	Leptomonas seymouri	49%	95%
A0A3Q8ICR8	Leishmania donovani	86%	100%
E9AGJ1	Leishmania infantum	86%	100%
E9AIN7	Leishmania braziliensis	75%	100%
E9AP29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%