LeishMANIAdb
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SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
SET domain-containing protein
Gene product:
SET domain containing protein, putative
Species:
Leishmania major
UniProt:
Q4QGF9_LEIMA
TriTrypDb:
LmjF.12.1300 , LMJLV39_120015200 , LMJSD75_120016100 *
Length:
622

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QGF9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF9

Function

Biological processes
Term Name Level Count
GO:0006479 protein methylation 4 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0008152 metabolic process 1 2
GO:0008213 protein alkylation 5 2
GO:0009987 cellular process 1 2
GO:0016570 histone modification 5 2
GO:0016571 histone methylation 5 2
GO:0018022 peptidyl-lysine methylation 5 2
GO:0018193 peptidyl-amino acid modification 5 2
GO:0018205 peptidyl-lysine modification 6 2
GO:0019538 protein metabolic process 3 2
GO:0032259 methylation 2 2
GO:0034968 histone lysine methylation 6 2
GO:0036211 protein modification process 4 2
GO:0043170 macromolecule metabolic process 3 2
GO:0043412 macromolecule modification 4 2
GO:0043414 macromolecule methylation 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0071704 organic substance metabolic process 2 2
GO:1901564 organonitrogen compound metabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0005488 binding 1 6
GO:0008168 methyltransferase activity 4 2
GO:0008170 N-methyltransferase activity 5 2
GO:0008276 protein methyltransferase activity 3 2
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 5 2
GO:0016278 lysine N-methyltransferase activity 6 2
GO:0016279 protein-lysine N-methyltransferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016741 transferase activity, transferring one-carbon groups 3 2
GO:0018024 obsolete histone lysine N-methyltransferase activity 5 2
GO:0042054 histone methyltransferase activity 4 2
GO:0043167 ion binding 2 6
GO:0043169 cation binding 3 6
GO:0046872 metal ion binding 4 6
GO:0140096 catalytic activity, acting on a protein 2 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 226 230 PF00656 0.757
CLV_C14_Caspase3-7 513 517 PF00656 0.412
CLV_MEL_PAP_1 154 160 PF00089 0.494
CLV_NRD_NRD_1 302 304 PF00675 0.607
CLV_NRD_NRD_1 449 451 PF00675 0.350
CLV_NRD_NRD_1 486 488 PF00675 0.553
CLV_PCSK_FUR_1 447 451 PF00082 0.425
CLV_PCSK_KEX2_1 328 330 PF00082 0.526
CLV_PCSK_KEX2_1 449 451 PF00082 0.350
CLV_PCSK_KEX2_1 486 488 PF00082 0.429
CLV_PCSK_KEX2_1 580 582 PF00082 0.375
CLV_PCSK_PC1ET2_1 328 330 PF00082 0.526
CLV_PCSK_PC1ET2_1 580 582 PF00082 0.375
CLV_PCSK_SKI1_1 102 106 PF00082 0.386
CLV_PCSK_SKI1_1 334 338 PF00082 0.427
CLV_PCSK_SKI1_1 365 369 PF00082 0.353
CLV_PCSK_SKI1_1 487 491 PF00082 0.528
CLV_PCSK_SKI1_1 580 584 PF00082 0.363
CLV_PCSK_SKI1_1 611 615 PF00082 0.482
DEG_APCC_DBOX_1 541 549 PF00400 0.317
DOC_CDC14_PxL_1 132 140 PF14671 0.501
DOC_CDC14_PxL_1 186 194 PF14671 0.456
DOC_CDC14_PxL_1 436 444 PF14671 0.482
DOC_CKS1_1 198 203 PF01111 0.480
DOC_CYCLIN_RxL_1 328 339 PF00134 0.434
DOC_CYCLIN_yClb1_LxF_4 542 548 PF00134 0.333
DOC_CYCLIN_yCln2_LP_2 198 204 PF00134 0.430
DOC_MAPK_DCC_7 187 195 PF00069 0.453
DOC_MAPK_gen_1 173 183 PF00069 0.541
DOC_MAPK_JIP1_4 221 227 PF00069 0.399
DOC_MAPK_MEF2A_6 187 195 PF00069 0.453
DOC_PP2B_LxvP_1 305 308 PF13499 0.537
DOC_USP7_MATH_1 3 7 PF00917 0.659
DOC_USP7_MATH_1 384 388 PF00917 0.500
DOC_USP7_MATH_1 397 401 PF00917 0.561
DOC_USP7_MATH_1 52 56 PF00917 0.353
DOC_USP7_MATH_1 596 600 PF00917 0.476
DOC_WW_Pin1_4 164 169 PF00397 0.590
DOC_WW_Pin1_4 197 202 PF00397 0.456
DOC_WW_Pin1_4 268 273 PF00397 0.428
DOC_WW_Pin1_4 407 412 PF00397 0.526
LIG_14-3-3_CanoR_1 157 161 PF00244 0.533
LIG_14-3-3_CanoR_1 292 300 PF00244 0.523
LIG_14-3-3_CanoR_1 334 339 PF00244 0.567
LIG_14-3-3_CanoR_1 365 370 PF00244 0.386
LIG_14-3-3_CanoR_1 452 460 PF00244 0.451
LIG_14-3-3_CanoR_1 476 481 PF00244 0.527
LIG_14-3-3_CanoR_1 542 548 PF00244 0.333
LIG_AP2alpha_2 472 474 PF02296 0.466
LIG_APCC_ABBA_1 41 46 PF00400 0.521
LIG_BIR_II_1 1 5 PF00653 0.518
LIG_BIR_III_4 617 621 PF00653 0.514
LIG_BRCT_BRCA1_1 113 117 PF00533 0.469
LIG_BRCT_BRCA1_1 455 459 PF00533 0.407
LIG_BRCT_BRCA1_1 5 9 PF00533 0.658
LIG_eIF4E_1 100 106 PF01652 0.433
LIG_FHA_1 149 155 PF00498 0.494
LIG_FHA_1 337 343 PF00498 0.519
LIG_FHA_1 36 42 PF00498 0.498
LIG_FHA_1 423 429 PF00498 0.448
LIG_LIR_Gen_1 313 323 PF02991 0.411
LIG_LIR_Gen_1 368 376 PF02991 0.520
LIG_LIR_Nem_3 309 314 PF02991 0.412
LIG_LIR_Nem_3 368 373 PF02991 0.520
LIG_LIR_Nem_3 454 460 PF02991 0.456
LIG_LIR_Nem_3 490 496 PF02991 0.464
LIG_LIR_Nem_3 546 552 PF02991 0.329
LIG_MLH1_MIPbox_1 455 459 PF16413 0.277
LIG_MYND_1 136 140 PF01753 0.483
LIG_MYND_3 135 139 PF01753 0.514
LIG_NRBOX 519 525 PF00104 0.375
LIG_NRBOX 562 568 PF00104 0.402
LIG_SH2_CRK 269 273 PF00017 0.393
LIG_SH2_CRK 316 320 PF00017 0.444
LIG_SH2_CRK 370 374 PF00017 0.480
LIG_SH2_CRK 549 553 PF00017 0.392
LIG_SH2_NCK_1 133 137 PF00017 0.507
LIG_SH2_NCK_1 370 374 PF00017 0.480
LIG_SH2_STAP1 37 41 PF00017 0.492
LIG_SH2_STAT3 36 39 PF00017 0.483
LIG_SH2_STAT3 438 441 PF00017 0.349
LIG_SH2_STAT5 269 272 PF00017 0.306
LIG_SH2_STAT5 37 40 PF00017 0.465
LIG_SH2_STAT5 370 373 PF00017 0.522
LIG_SH2_STAT5 438 441 PF00017 0.340
LIG_SH2_STAT5 458 461 PF00017 0.193
LIG_SH2_STAT5 536 539 PF00017 0.315
LIG_SH3_3 348 354 PF00018 0.497
LIG_SUMO_SIM_anti_2 194 200 PF11976 0.465
LIG_SUMO_SIM_anti_2 610 617 PF11976 0.479
LIG_SUMO_SIM_par_1 191 197 PF11976 0.403
LIG_SUMO_SIM_par_1 333 339 PF11976 0.544
LIG_TRAF2_1 231 234 PF00917 0.788
LIG_TYR_ITIM 314 319 PF00017 0.442
LIG_TYR_ITSM 366 373 PF00017 0.522
LIG_UBA3_1 296 304 PF00899 0.554
LIG_UBA3_1 355 361 PF00899 0.452
LIG_WRC_WIRS_1 401 406 PF05994 0.549
MOD_CK1_1 109 115 PF00069 0.588
MOD_CK1_1 197 203 PF00069 0.384
MOD_CK1_1 259 265 PF00069 0.406
MOD_CK1_1 400 406 PF00069 0.478
MOD_CK1_1 599 605 PF00069 0.430
MOD_CK2_1 156 162 PF00069 0.454
MOD_CK2_1 52 58 PF00069 0.512
MOD_GlcNHglycan 1 4 PF01048 0.696
MOD_GlcNHglycan 120 123 PF01048 0.470
MOD_GlcNHglycan 385 389 PF01048 0.274
MOD_GlcNHglycan 600 604 PF01048 0.472
MOD_GlcNHglycan 61 64 PF01048 0.400
MOD_GSK3_1 112 119 PF00069 0.557
MOD_GSK3_1 156 163 PF00069 0.455
MOD_GSK3_1 496 503 PF00069 0.455
MOD_LATS_1 332 338 PF00433 0.433
MOD_N-GLC_1 405 410 PF02516 0.252
MOD_N-GLC_1 596 601 PF02516 0.400
MOD_N-GLC_2 23 25 PF02516 0.525
MOD_NEK2_1 336 341 PF00069 0.488
MOD_NEK2_1 405 410 PF00069 0.457
MOD_NEK2_1 453 458 PF00069 0.346
MOD_NEK2_1 59 64 PF00069 0.456
MOD_NEK2_2 414 419 PF00069 0.578
MOD_PIKK_1 35 41 PF00454 0.403
MOD_PIKK_1 510 516 PF00454 0.489
MOD_PKA_2 156 162 PF00069 0.536
MOD_PKA_2 288 294 PF00069 0.510
MOD_PKA_2 451 457 PF00069 0.504
MOD_Plk_1 432 438 PF00069 0.448
MOD_Plk_2-3 11 17 PF00069 0.348
MOD_Plk_2-3 156 162 PF00069 0.573
MOD_Plk_4 194 200 PF00069 0.489
MOD_Plk_4 365 371 PF00069 0.518
MOD_Plk_4 400 406 PF00069 0.448
MOD_Plk_4 453 459 PF00069 0.271
MOD_Plk_4 543 549 PF00069 0.334
MOD_ProDKin_1 164 170 PF00069 0.592
MOD_ProDKin_1 197 203 PF00069 0.451
MOD_ProDKin_1 268 274 PF00069 0.428
MOD_ProDKin_1 407 413 PF00069 0.526
MOD_SUMO_for_1 360 363 PF00179 0.477
MOD_SUMO_for_1 582 585 PF00179 0.381
TRG_DiLeu_BaEn_1 194 199 PF01217 0.460
TRG_DiLeu_BaEn_1 519 524 PF01217 0.474
TRG_DiLeu_BaEn_2 454 460 PF01217 0.456
TRG_DiLeu_BaLyEn_6 149 154 PF01217 0.432
TRG_ENDOCYTIC_2 316 319 PF00928 0.423
TRG_ENDOCYTIC_2 370 373 PF00928 0.522
TRG_ENDOCYTIC_2 457 460 PF00928 0.529
TRG_ENDOCYTIC_2 549 552 PF00928 0.335
TRG_ER_diArg_1 447 450 PF00400 0.356
TRG_ER_diArg_1 504 507 PF00400 0.475
TRG_NES_CRM1_1 148 162 PF08389 0.432
TRG_NES_CRM1_1 557 570 PF08389 0.453
TRG_NLS_MonoExtC_3 579 585 PF00514 0.379
TRG_NLS_MonoExtN_4 578 584 PF00514 0.374
TRG_Pf-PMV_PEXEL_1 130 134 PF00026 0.449
TRG_Pf-PMV_PEXEL_1 152 156 PF00026 0.402
TRG_Pf-PMV_PEXEL_1 476 481 PF00026 0.430
TRG_Pf-PMV_PEXEL_1 522 526 PF00026 0.456

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDV1 Leptomonas seymouri 61% 100%
A0A0S4IJK9 Bodo saltans 39% 100%
A0A1X0NMI4 Trypanosomatidae 42% 100%
A0A3S7WS98 Leishmania donovani 93% 100%
A0A422NUZ8 Trypanosoma rangeli 46% 100%
C9ZI42 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 99%
E9AGJ2 Leishmania infantum 93% 100%
E9AIN6 Leishmania braziliensis 82% 100%
E9AP30 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5DFZ1 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS