Glyco_hydro_43

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Glyco_hydro_43

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGF8_LEIMA

TriTrypDb:

LmjF.12.1305 , LMJLV39_120015300 , LMJSD75_120016200

Length:

121

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0032299	ribonuclease H2 complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0110165	cellular anatomical entity	1	2
GO:0140535	intracellular protein-containing complex	2	8
GO:1902494	catalytic complex	2	8

Expansion

Sequence features

Q4QGF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006401	RNA catabolic process	5	8
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009057	macromolecule catabolic process	4	8
GO:0009987	cellular process	1	8
GO:0016070	RNA metabolic process	5	8
GO:0019439	aromatic compound catabolic process	4	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034655	nucleobase-containing compound catabolic process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044265	obsolete cellular macromolecule catabolic process	4	8
GO:0044270	cellular nitrogen compound catabolic process	4	8
GO:0046483	heterocycle metabolic process	3	8
GO:0046700	heterocycle catabolic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901361	organic cyclic compound catabolic process	4	8
GO:1901575	organic substance catabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	17	21	PF00082	0.277
DEG_Nend_UBRbox_3	1	3	PF02207	0.382
DOC_CKS1_1	47	52	PF01111	0.297
DOC_CYCLIN_RxL_1	14	23	PF00134	0.371
DOC_PP1_RVXF_1	78	85	PF00149	0.332
DOC_PP4_FxxP_1	47	50	PF00568	0.252
DOC_USP7_MATH_1	92	96	PF00917	0.232
DOC_WW_Pin1_4	42	47	PF00397	0.317
DOC_WW_Pin1_4	88	93	PF00397	0.215
LIG_14-3-3_CanoR_1	15	20	PF00244	0.292
LIG_LIR_Apic_2	45	50	PF02991	0.254
LIG_PDZ_Class_1	116	121	PF00595	0.483
LIG_SH2_CRK	11	15	PF00017	0.218
LIG_SH2_STAT5	81	84	PF00017	0.309
LIG_SH3_3	21	27	PF00018	0.273
LIG_TYR_ITIM	9	14	PF00017	0.215
MOD_CK1_1	40	46	PF00069	0.451
MOD_CK1_1	52	58	PF00069	0.302
MOD_DYRK1A_RPxSP_1	88	92	PF00069	0.215
MOD_GlcNHglycan	28	31	PF01048	0.225
MOD_GSK3_1	32	39	PF00069	0.485
MOD_GSK3_1	42	49	PF00069	0.344
MOD_GSK3_1	88	95	PF00069	0.375
MOD_NEK2_2	10	15	PF00069	0.322
MOD_Plk_4	92	98	PF00069	0.426
MOD_ProDKin_1	42	48	PF00069	0.317
MOD_ProDKin_1	88	94	PF00069	0.215
TRG_ENDOCYTIC_2	11	14	PF00928	0.476
TRG_ER_diArg_1	14	17	PF00400	0.273
TRG_NES_CRM1_1	59	71	PF08389	0.285
TRG_Pf-PMV_PEXEL_1	17	22	PF00026	0.332

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL20	Leptomonas seymouri	40%	85%
A0A1X0NN29	Trypanosomatidae	31%	80%
A0A3S7WSA4	Leishmania donovani	79%	100%
C9ZI43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	77%
E9AGJ3	Leishmania infantum	79%	100%
E9AIN5	Leishmania braziliensis	57%	100%