CNH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative

Species:

Leishmania major

UniProt:

Q4QGF6_LEIMA

TriTrypDb:

LmjF.12.1320 , LMJLV39_120015500 , LMJSD75_120016400

Length:

971

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF6

Function

Biological processes
Term	Name	Level	Count
GO:0006906	vesicle fusion	6	2
GO:0006914	autophagy	3	2
GO:0006996	organelle organization	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0034058	endosomal vesicle fusion	7	2
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0048284	organelle fusion	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0061919	process utilizing autophagic mechanism	2	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0006810	transport	3	9
GO:0016192	vesicle-mediated transport	4	9
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.381
CLV_C14_Caspase3-7	607	611	PF00656	0.590
CLV_C14_Caspase3-7	68	72	PF00656	0.468
CLV_C14_Caspase3-7	848	852	PF00656	0.425
CLV_NRD_NRD_1	144	146	PF00675	0.395
CLV_NRD_NRD_1	186	188	PF00675	0.432
CLV_NRD_NRD_1	387	389	PF00675	0.345
CLV_NRD_NRD_1	526	528	PF00675	0.381
CLV_NRD_NRD_1	630	632	PF00675	0.446
CLV_NRD_NRD_1	73	75	PF00675	0.515
CLV_NRD_NRD_1	782	784	PF00675	0.494
CLV_NRD_NRD_1	86	88	PF00675	0.445
CLV_NRD_NRD_1	925	927	PF00675	0.417
CLV_PCSK_FUR_1	524	528	PF00082	0.381
CLV_PCSK_KEX2_1	146	148	PF00082	0.528
CLV_PCSK_KEX2_1	387	389	PF00082	0.431
CLV_PCSK_KEX2_1	526	528	PF00082	0.445
CLV_PCSK_KEX2_1	629	631	PF00082	0.429
CLV_PCSK_KEX2_1	73	75	PF00082	0.515
CLV_PCSK_KEX2_1	782	784	PF00082	0.468
CLV_PCSK_KEX2_1	86	88	PF00082	0.445
CLV_PCSK_KEX2_1	925	927	PF00082	0.406
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.528
CLV_PCSK_SKI1_1	115	119	PF00082	0.476
CLV_PCSK_SKI1_1	146	150	PF00082	0.430
CLV_PCSK_SKI1_1	234	238	PF00082	0.502
CLV_PCSK_SKI1_1	306	310	PF00082	0.495
CLV_PCSK_SKI1_1	571	575	PF00082	0.466
CLV_PCSK_SKI1_1	658	662	PF00082	0.495
CLV_PCSK_SKI1_1	688	692	PF00082	0.492
CLV_PCSK_SKI1_1	730	734	PF00082	0.610
CLV_PCSK_SKI1_1	746	750	PF00082	0.460
CLV_PCSK_SKI1_1	78	82	PF00082	0.405
CLV_PCSK_SKI1_1	86	90	PF00082	0.330
CLV_Separin_Metazoa	506	510	PF03568	0.381
DEG_APCC_DBOX_1	85	93	PF00400	0.478
DEG_Nend_UBRbox_3	1	3	PF02207	0.690
DEG_SCF_FBW7_2	250	257	PF00400	0.581
DOC_CKS1_1	204	209	PF01111	0.567
DOC_CKS1_1	251	256	PF01111	0.586
DOC_CYCLIN_RxL_1	33	44	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.543
DOC_MAPK_gen_1	132	142	PF00069	0.398
DOC_MAPK_gen_1	524	534	PF00069	0.458
DOC_MAPK_gen_1	715	725	PF00069	0.516
DOC_MAPK_gen_1	86	92	PF00069	0.468
DOC_MAPK_gen_1	925	935	PF00069	0.406
DOC_MAPK_MEF2A_6	526	534	PF00069	0.454
DOC_PP1_RVXF_1	144	151	PF00149	0.441
DOC_PP1_RVXF_1	171	178	PF00149	0.371
DOC_PP1_RVXF_1	246	252	PF00149	0.565
DOC_PP1_RVXF_1	34	41	PF00149	0.436
DOC_PP1_RVXF_1	656	662	PF00149	0.482
DOC_PP2B_LxvP_1	214	217	PF13499	0.464
DOC_PP2B_LxvP_1	443	446	PF13499	0.557
DOC_PP4_FxxP_1	428	431	PF00568	0.530
DOC_PP4_FxxP_1	725	728	PF00568	0.610
DOC_USP7_MATH_1	244	248	PF00917	0.561
DOC_USP7_MATH_1	321	325	PF00917	0.507
DOC_USP7_MATH_1	350	354	PF00917	0.459
DOC_USP7_MATH_1	479	483	PF00917	0.604
DOC_USP7_MATH_1	608	612	PF00917	0.572
DOC_USP7_MATH_1	813	817	PF00917	0.604
DOC_USP7_MATH_1	866	870	PF00917	0.458
DOC_WW_Pin1_4	203	208	PF00397	0.527
DOC_WW_Pin1_4	250	255	PF00397	0.489
DOC_WW_Pin1_4	332	337	PF00397	0.501
DOC_WW_Pin1_4	432	437	PF00397	0.596
DOC_WW_Pin1_4	641	646	PF00397	0.347
DOC_WW_Pin1_4	683	688	PF00397	0.592
DOC_WW_Pin1_4	724	729	PF00397	0.571
DOC_WW_Pin1_4	749	754	PF00397	0.562
DOC_WW_Pin1_4	831	836	PF00397	0.557
LIG_14-3-3_CanoR_1	135	141	PF00244	0.396
LIG_14-3-3_CanoR_1	145	151	PF00244	0.399
LIG_14-3-3_CanoR_1	17	22	PF00244	0.497
LIG_14-3-3_CanoR_1	351	361	PF00244	0.504
LIG_14-3-3_CanoR_1	576	584	PF00244	0.569
LIG_14-3-3_CanoR_1	600	606	PF00244	0.587
LIG_14-3-3_CanoR_1	658	667	PF00244	0.464
LIG_14-3-3_CanoR_1	78	83	PF00244	0.467
LIG_14-3-3_CanoR_1	896	905	PF00244	0.396
LIG_14-3-3_CanoR_1	906	914	PF00244	0.465
LIG_Actin_WH2_2	110	126	PF00022	0.470
LIG_APCC_ABBA_1	697	702	PF00400	0.447
LIG_CtBP_PxDLS_1	255	259	PF00389	0.303
LIG_eIF4E_1	260	266	PF01652	0.289
LIG_FHA_1	163	169	PF00498	0.500
LIG_FHA_1	198	204	PF00498	0.514
LIG_FHA_1	251	257	PF00498	0.455
LIG_FHA_1	299	305	PF00498	0.475
LIG_FHA_1	475	481	PF00498	0.535
LIG_FHA_1	531	537	PF00498	0.460
LIG_FHA_1	558	564	PF00498	0.671
LIG_FHA_1	668	674	PF00498	0.453
LIG_FHA_1	684	690	PF00498	0.559
LIG_FHA_1	819	825	PF00498	0.504
LIG_FHA_1	836	842	PF00498	0.560
LIG_FHA_2	147	153	PF00498	0.440
LIG_FHA_2	154	160	PF00498	0.501
LIG_FHA_2	283	289	PF00498	0.530
LIG_FHA_2	590	596	PF00498	0.521
LIG_FHA_2	676	682	PF00498	0.514
LIG_FHA_2	729	735	PF00498	0.575
LIG_FHA_2	945	951	PF00498	0.339
LIG_FHA_2	954	960	PF00498	0.408
LIG_HCF-1_HBM_1	261	264	PF13415	0.484
LIG_LIR_Apic_2	257	263	PF02991	0.386
LIG_LIR_Apic_2	722	728	PF02991	0.575
LIG_LIR_Gen_1	296	307	PF02991	0.447
LIG_LIR_Gen_1	494	503	PF02991	0.373
LIG_LIR_Gen_1	694	705	PF02991	0.389
LIG_LIR_Gen_1	817	828	PF02991	0.406
LIG_LIR_Gen_1	963	971	PF02991	0.629
LIG_LIR_Nem_3	14	19	PF02991	0.454
LIG_LIR_Nem_3	296	302	PF02991	0.429
LIG_LIR_Nem_3	33	38	PF02991	0.488
LIG_LIR_Nem_3	482	487	PF02991	0.466
LIG_LIR_Nem_3	694	700	PF02991	0.363
LIG_LIR_Nem_3	714	720	PF02991	0.376
LIG_LIR_Nem_3	817	823	PF02991	0.418
LIG_LIR_Nem_3	963	968	PF02991	0.569
LIG_NRBOX	157	163	PF00104	0.567
LIG_NRBOX	232	238	PF00104	0.544
LIG_NRBOX	503	509	PF00104	0.427
LIG_NRBOX	531	537	PF00104	0.458
LIG_NRBOX	719	725	PF00104	0.413
LIG_NRBOX	823	829	PF00104	0.414
LIG_PCNA_yPIPBox_3	590	600	PF02747	0.529
LIG_PDZ_Class_3	966	971	PF00595	0.577
LIG_Pex14_2	636	640	PF04695	0.456
LIG_PTAP_UEV_1	269	274	PF05743	0.607
LIG_REV1ctd_RIR_1	625	631	PF16727	0.469
LIG_RPA_C_Fungi	130	142	PF08784	0.411
LIG_RPA_C_Fungi	778	790	PF08784	0.524
LIG_SH2_CRK	16	20	PF00017	0.489
LIG_SH2_CRK	35	39	PF00017	0.492
LIG_SH2_CRK	820	824	PF00017	0.455
LIG_SH2_CRK	889	893	PF00017	0.387
LIG_SH2_NCK_1	260	264	PF00017	0.483
LIG_SH2_NCK_1	542	546	PF00017	0.381
LIG_SH2_SRC	260	263	PF00017	0.373
LIG_SH2_SRC	542	545	PF00017	0.458
LIG_SH2_SRC	812	815	PF00017	0.615
LIG_SH2_STAP1	318	322	PF00017	0.563
LIG_SH2_STAP1	542	546	PF00017	0.425
LIG_SH2_STAP1	669	673	PF00017	0.398
LIG_SH2_STAP1	713	717	PF00017	0.483
LIG_SH2_STAP1	807	811	PF00017	0.415
LIG_SH2_STAP1	820	824	PF00017	0.388
LIG_SH2_STAP1	889	893	PF00017	0.367
LIG_SH2_STAT3	587	590	PF00017	0.480
LIG_SH2_STAT3	695	698	PF00017	0.502
LIG_SH2_STAT5	190	193	PF00017	0.378
LIG_SH2_STAT5	264	267	PF00017	0.386
LIG_SH2_STAT5	347	350	PF00017	0.372
LIG_SH2_STAT5	404	407	PF00017	0.540
LIG_SH2_STAT5	460	463	PF00017	0.426
LIG_SH2_STAT5	587	590	PF00017	0.457
LIG_SH2_STAT5	669	672	PF00017	0.459
LIG_SH2_STAT5	679	682	PF00017	0.492
LIG_SH2_STAT5	695	698	PF00017	0.469
LIG_SH2_STAT5	763	766	PF00017	0.453
LIG_SH2_STAT5	820	823	PF00017	0.456
LIG_SH3_3	214	220	PF00018	0.464
LIG_SH3_3	267	273	PF00018	0.520
LIG_SH3_3	276	282	PF00018	0.340
LIG_SH3_3	433	439	PF00018	0.604
LIG_SH3_3	473	479	PF00018	0.518
LIG_SH3_3	704	710	PF00018	0.570
LIG_SH3_3	829	835	PF00018	0.394
LIG_SH3_3	854	860	PF00018	0.333
LIG_Sin3_3	212	219	PF02671	0.391
LIG_SUMO_SIM_anti_2	518	523	PF11976	0.333
LIG_SUMO_SIM_anti_2	838	846	PF11976	0.348
LIG_SUMO_SIM_anti_2	94	99	PF11976	0.395
LIG_SUMO_SIM_par_1	335	341	PF11976	0.401
LIG_SUMO_SIM_par_1	532	537	PF11976	0.458
LIG_SUMO_SIM_par_1	689	694	PF11976	0.439
LIG_SUMO_SIM_par_1	88	94	PF11976	0.359
LIG_Vh1_VBS_1	605	623	PF01044	0.489
LIG_WRC_WIRS_1	492	497	PF05994	0.377
MOD_CDC14_SPxK_1	727	730	PF00782	0.666
MOD_CDK_SPK_2	203	208	PF00069	0.557
MOD_CDK_SPK_2	683	688	PF00069	0.592
MOD_CDK_SPxK_1	724	730	PF00069	0.613
MOD_CK1_1	107	113	PF00069	0.473
MOD_CK1_1	163	169	PF00069	0.504
MOD_CK1_1	196	202	PF00069	0.508
MOD_CK1_1	31	37	PF00069	0.388
MOD_CK1_1	413	419	PF00069	0.542
MOD_CK1_1	599	605	PF00069	0.604
MOD_CK1_1	878	884	PF00069	0.261
MOD_CK1_1	900	906	PF00069	0.342
MOD_CK2_1	146	152	PF00069	0.419
MOD_CK2_1	282	288	PF00069	0.478
MOD_CK2_1	409	415	PF00069	0.525
MOD_CK2_1	551	557	PF00069	0.306
MOD_CK2_1	589	595	PF00069	0.500
MOD_CK2_1	635	641	PF00069	0.463
MOD_CK2_1	675	681	PF00069	0.501
MOD_CK2_1	730	736	PF00069	0.534
MOD_CK2_1	944	950	PF00069	0.471
MOD_Cter_Amidation	185	188	PF01082	0.490
MOD_Cter_Amidation	84	87	PF01082	0.518
MOD_GlcNHglycan	106	110	PF01048	0.575
MOD_GlcNHglycan	162	165	PF01048	0.446
MOD_GlcNHglycan	208	211	PF01048	0.523
MOD_GlcNHglycan	270	273	PF01048	0.547
MOD_GlcNHglycan	391	394	PF01048	0.399
MOD_GlcNHglycan	566	569	PF01048	0.616
MOD_GlcNHglycan	579	582	PF01048	0.487
MOD_GlcNHglycan	58	61	PF01048	0.536
MOD_GlcNHglycan	601	604	PF01048	0.643
MOD_GlcNHglycan	606	609	PF01048	0.553
MOD_GlcNHglycan	758	761	PF01048	0.528
MOD_GlcNHglycan	770	773	PF01048	0.521
MOD_GlcNHglycan	889	892	PF01048	0.361
MOD_GSK3_1	193	200	PF00069	0.534
MOD_GSK3_1	264	271	PF00069	0.456
MOD_GSK3_1	30	37	PF00069	0.502
MOD_GSK3_1	409	416	PF00069	0.553
MOD_GSK3_1	52	59	PF00069	0.426
MOD_GSK3_1	595	602	PF00069	0.535
MOD_GSK3_1	604	611	PF00069	0.564
MOD_GSK3_1	616	623	PF00069	0.376
MOD_GSK3_1	677	684	PF00069	0.538
MOD_GSK3_1	724	731	PF00069	0.583
MOD_GSK3_1	814	821	PF00069	0.574
MOD_GSK3_1	831	838	PF00069	0.384
MOD_LATS_1	781	787	PF00433	0.561
MOD_N-GLC_1	56	61	PF02516	0.376
MOD_N-GLC_1	681	686	PF02516	0.343
MOD_N-GLC_1	878	883	PF02516	0.412
MOD_N-GLC_2	512	514	PF02516	0.310
MOD_N-GLC_2	845	847	PF02516	0.387
MOD_NEK2_1	160	165	PF00069	0.523
MOD_NEK2_1	178	183	PF00069	0.332
MOD_NEK2_1	349	354	PF00069	0.508
MOD_NEK2_1	491	496	PF00069	0.463
MOD_NEK2_1	748	753	PF00069	0.394
MOD_NEK2_1	795	800	PF00069	0.361
MOD_NEK2_1	872	877	PF00069	0.253
MOD_NEK2_2	589	594	PF00069	0.415
MOD_NEK2_2	807	812	PF00069	0.424
MOD_PIKK_1	308	314	PF00454	0.329
MOD_PIKK_1	460	466	PF00454	0.522
MOD_PIKK_1	479	485	PF00454	0.510
MOD_PIKK_1	544	550	PF00454	0.458
MOD_PIKK_1	562	568	PF00454	0.466
MOD_PIKK_1	795	801	PF00454	0.533
MOD_PIKK_1	897	903	PF00454	0.264
MOD_PK_1	28	34	PF00069	0.405
MOD_PKA_1	146	152	PF00069	0.396
MOD_PKA_1	783	789	PF00069	0.494
MOD_PKA_2	146	152	PF00069	0.507
MOD_PKA_2	350	356	PF00069	0.514
MOD_PKA_2	599	605	PF00069	0.543
MOD_PKA_2	905	911	PF00069	0.464
MOD_PKB_1	926	934	PF00069	0.458
MOD_Plk_1	115	121	PF00069	0.456
MOD_Plk_1	288	294	PF00069	0.585
MOD_Plk_1	409	415	PF00069	0.558
MOD_Plk_1	609	615	PF00069	0.505
MOD_Plk_1	802	808	PF00069	0.560
MOD_Plk_1	878	884	PF00069	0.412
MOD_Plk_2-3	410	416	PF00069	0.550
MOD_Plk_4	107	113	PF00069	0.536
MOD_Plk_4	146	152	PF00069	0.467
MOD_Plk_4	173	179	PF00069	0.433
MOD_Plk_4	530	536	PF00069	0.425
MOD_Plk_4	61	67	PF00069	0.519
MOD_Plk_4	623	629	PF00069	0.364
MOD_Plk_4	635	641	PF00069	0.493
MOD_Plk_4	78	84	PF00069	0.476
MOD_Plk_4	867	873	PF00069	0.455
MOD_Plk_4	928	934	PF00069	0.387
MOD_ProDKin_1	203	209	PF00069	0.533
MOD_ProDKin_1	250	256	PF00069	0.489
MOD_ProDKin_1	332	338	PF00069	0.491
MOD_ProDKin_1	432	438	PF00069	0.592
MOD_ProDKin_1	641	647	PF00069	0.342
MOD_ProDKin_1	683	689	PF00069	0.586
MOD_ProDKin_1	724	730	PF00069	0.583
MOD_ProDKin_1	749	755	PF00069	0.557
MOD_ProDKin_1	831	837	PF00069	0.551
TRG_AP2beta_CARGO_1	694	704	PF09066	0.527
TRG_DiLeu_BaEn_1	261	266	PF01217	0.475
TRG_DiLeu_BaEn_4	736	742	PF01217	0.550
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.474
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.500
TRG_ENDOCYTIC_2	16	19	PF00928	0.452
TRG_ENDOCYTIC_2	299	302	PF00928	0.518
TRG_ENDOCYTIC_2	35	38	PF00928	0.502
TRG_ENDOCYTIC_2	820	823	PF00928	0.530
TRG_ENDOCYTIC_2	889	892	PF00928	0.387
TRG_ENDOCYTIC_2	965	968	PF00928	0.578
TRG_ER_diArg_1	145	148	PF00400	0.501
TRG_ER_diArg_1	386	388	PF00400	0.353
TRG_ER_diArg_1	628	631	PF00400	0.424
TRG_ER_diArg_1	738	741	PF00400	0.454
TRG_ER_diArg_1	86	88	PF00400	0.496
TRG_ER_diArg_1	925	928	PF00400	0.463
TRG_Pf-PMV_PEXEL_1	234	239	PF00026	0.416
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	718	722	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	896	901	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	925	930	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT4	Leptomonas seymouri	52%	99%
A0A1X0NP42	Trypanosomatidae	30%	97%
A0A3R7M5A4	Trypanosoma rangeli	32%	99%
A0A3S7WSC2	Leishmania donovani	91%	100%
C9ZI46	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	94%
E9AGJ5	Leishmania infantum	91%	100%
E9AIN3	Leishmania braziliensis	78%	100%
E9AP32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q96JC1	Homo sapiens	22%	100%
V5BF34	Trypanosoma cruzi	33%	98%