Putative serine peptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase domain-containing protein

Species:

Leishmania major

UniProt:

Q4QGF5_LEIMA

TriTrypDb:

LmjF.12.1330 , LMJLV39_120015600 , LMJSD75_120016500

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QGF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0019538	protein metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044238	primary metabolic process	2	3
GO:0071704	organic substance metabolic process	2	3
GO:1901564	organonitrogen compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0016787	hydrolase activity	2	4
GO:0008233	peptidase activity	3	3
GO:0008236	serine-type peptidase activity	4	3
GO:0017171	serine hydrolase activity	3	3
GO:0140096	catalytic activity, acting on a protein	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	304	308	PF00656	0.452
CLV_C14_Caspase3-7	406	410	PF00656	0.572
CLV_C14_Caspase3-7	6	10	PF00656	0.593
CLV_NRD_NRD_1	126	128	PF00675	0.495
CLV_NRD_NRD_1	354	356	PF00675	0.443
CLV_NRD_NRD_1	513	515	PF00675	0.625
CLV_PCSK_FUR_1	511	515	PF00082	0.593
CLV_PCSK_KEX2_1	126	128	PF00082	0.495
CLV_PCSK_KEX2_1	365	367	PF00082	0.500
CLV_PCSK_KEX2_1	443	445	PF00082	0.486
CLV_PCSK_KEX2_1	513	515	PF00082	0.625
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.521
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.504
CLV_PCSK_SKI1_1	135	139	PF00082	0.353
CLV_PCSK_SKI1_1	21	25	PF00082	0.572
CLV_PCSK_SKI1_1	266	270	PF00082	0.585
CLV_PCSK_SKI1_1	281	285	PF00082	0.288
CLV_PCSK_SKI1_1	369	373	PF00082	0.509
DEG_APCC_DBOX_1	159	167	PF00400	0.419
DEG_SCF_FBW7_2	104	111	PF00400	0.527
DEG_SPOP_SBC_1	536	540	PF00917	0.541
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	272	275	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.638
DOC_MAPK_gen_1	365	373	PF00069	0.314
DOC_MAPK_JIP1_4	160	166	PF00069	0.416
DOC_MAPK_MEF2A_6	88	96	PF00069	0.423
DOC_PP1_RVXF_1	11	18	PF00149	0.532
DOC_PP1_RVXF_1	474	481	PF00149	0.400
DOC_PP2B_LxvP_1	272	275	PF13499	0.561
DOC_PP2B_LxvP_1	412	415	PF13499	0.602
DOC_PP4_FxxP_1	129	132	PF00568	0.446
DOC_PP4_FxxP_1	154	157	PF00568	0.546
DOC_PP4_FxxP_1	17	20	PF00568	0.441
DOC_USP7_MATH_1	3	7	PF00917	0.561
DOC_USP7_MATH_1	308	312	PF00917	0.527
DOC_USP7_MATH_1	419	423	PF00917	0.606
DOC_USP7_MATH_1	520	524	PF00917	0.699
DOC_USP7_MATH_1	536	540	PF00917	0.424
DOC_USP7_MATH_1	90	94	PF00917	0.345
DOC_USP7_UBL2_3	365	369	PF12436	0.334
DOC_WW_Pin1_4	104	109	PF00397	0.571
DOC_WW_Pin1_4	143	148	PF00397	0.423
DOC_WW_Pin1_4	379	384	PF00397	0.364
DOC_WW_Pin1_4	432	437	PF00397	0.450
DOC_WW_Pin1_4	512	517	PF00397	0.633
LIG_14-3-3_CanoR_1	266	275	PF00244	0.585
LIG_14-3-3_CanoR_1	392	399	PF00244	0.563
LIG_14-3-3_CanoR_1	444	450	PF00244	0.516
LIG_14-3-3_CanoR_1	514	520	PF00244	0.699
LIG_14-3-3_CanoR_1	535	545	PF00244	0.609
LIG_14-3-3_CanoR_1	560	565	PF00244	0.522
LIG_Actin_WH2_2	497	515	PF00022	0.561
LIG_Actin_WH2_2	592	607	PF00022	0.503
LIG_Actin_WH2_2	71	86	PF00022	0.497
LIG_BRCT_BRCA1_1	13	17	PF00533	0.494
LIG_deltaCOP1_diTrp_1	532	537	PF00928	0.464
LIG_FHA_1	196	202	PF00498	0.376
LIG_FHA_1	217	223	PF00498	0.564
LIG_FHA_1	267	273	PF00498	0.613
LIG_FHA_1	3	9	PF00498	0.392
LIG_FHA_1	331	337	PF00498	0.392
LIG_FHA_1	366	372	PF00498	0.411
LIG_FHA_1	394	400	PF00498	0.515
LIG_FHA_1	421	427	PF00498	0.461
LIG_FHA_1	433	439	PF00498	0.366
LIG_FHA_1	61	67	PF00498	0.428
LIG_FHA_1	611	617	PF00498	0.673
LIG_FHA_2	302	308	PF00498	0.449
LIG_FHA_2	404	410	PF00498	0.580
LIG_FHA_2	446	452	PF00498	0.438
LIG_FHA_2	480	486	PF00498	0.470
LIG_HCF-1_HBM_1	223	226	PF13415	0.523
LIG_LIR_Apic_2	14	20	PF02991	0.445
LIG_LIR_Apic_2	532	536	PF02991	0.467
LIG_LIR_Apic_2	600	606	PF02991	0.529
LIG_LIR_Gen_1	120	129	PF02991	0.425
LIG_LIR_Gen_1	311	318	PF02991	0.472
LIG_LIR_Gen_1	326	336	PF02991	0.405
LIG_LIR_Gen_1	525	534	PF02991	0.539
LIG_LIR_Gen_1	594	604	PF02991	0.509
LIG_LIR_Nem_3	120	125	PF02991	0.378
LIG_LIR_Nem_3	311	316	PF02991	0.472
LIG_LIR_Nem_3	326	332	PF02991	0.410
LIG_LIR_Nem_3	346	350	PF02991	0.171
LIG_LIR_Nem_3	52	56	PF02991	0.379
LIG_LIR_Nem_3	525	530	PF02991	0.546
LIG_LIR_Nem_3	551	557	PF02991	0.421
LIG_LIR_Nem_3	587	593	PF02991	0.420
LIG_LIR_Nem_3	98	102	PF02991	0.346
LIG_MAD2	266	274	PF02301	0.605
LIG_MYND_1	274	278	PF01753	0.507
LIG_NRBOX	327	333	PF00104	0.381
LIG_NRBOX	488	494	PF00104	0.455
LIG_PALB2_WD40_1	308	316	PF16756	0.319
LIG_PCNA_PIPBox_1	116	125	PF02747	0.493
LIG_PCNA_yPIPBox_3	116	127	PF02747	0.474
LIG_PDZ_Class_1	615	620	PF00595	0.690
LIG_Pex14_2	150	154	PF04695	0.515
LIG_PTB_Apo_2	45	52	PF02174	0.512
LIG_PTB_Apo_2	503	510	PF02174	0.419
LIG_PTB_Phospho_1	503	509	PF10480	0.413
LIG_SH2_CRK	290	294	PF00017	0.482
LIG_SH2_CRK	350	354	PF00017	0.508
LIG_SH2_CRK	53	57	PF00017	0.390
LIG_SH2_NCK_1	68	72	PF00017	0.442
LIG_SH2_PTP2	329	332	PF00017	0.390
LIG_SH2_SRC	68	71	PF00017	0.433
LIG_SH2_STAP1	290	294	PF00017	0.409
LIG_SH2_STAT3	226	229	PF00017	0.516
LIG_SH2_STAT3	242	245	PF00017	0.435
LIG_SH2_STAT5	122	125	PF00017	0.362
LIG_SH2_STAT5	128	131	PF00017	0.392
LIG_SH2_STAT5	226	229	PF00017	0.418
LIG_SH2_STAT5	242	245	PF00017	0.480
LIG_SH2_STAT5	329	332	PF00017	0.390
LIG_SH2_STAT5	350	353	PF00017	0.388
LIG_SH2_STAT5	55	58	PF00017	0.428
LIG_SH2_STAT5	557	560	PF00017	0.403
LIG_SH2_STAT5	593	596	PF00017	0.523
LIG_SH2_STAT5	603	606	PF00017	0.447
LIG_SH2_STAT5	85	88	PF00017	0.394
LIG_SH3_3	202	208	PF00018	0.376
LIG_SH3_3	272	278	PF00018	0.476
LIG_SH3_3	32	38	PF00018	0.454
LIG_SH3_5	553	557	PF00018	0.533
LIG_SUMO_SIM_anti_2	198	204	PF11976	0.386
LIG_SUMO_SIM_par_1	197	204	PF11976	0.518
LIG_SUMO_SIM_par_1	422	431	PF11976	0.536
LIG_TRAF2_1	526	529	PF00917	0.547
LIG_TRAF2_1	575	578	PF00917	0.567
LIG_TRAF2_1	582	585	PF00917	0.515
LIG_UBA3_1	272	281	PF00899	0.604
LIG_UBA3_1	438	443	PF00899	0.482
MOD_CK1_1	255	261	PF00069	0.531
MOD_CK1_1	515	521	PF00069	0.674
MOD_CK1_1	523	529	PF00069	0.610
MOD_CK2_1	392	398	PF00069	0.571
MOD_CK2_1	425	431	PF00069	0.388
MOD_CK2_1	523	529	PF00069	0.581
MOD_CK2_1	572	578	PF00069	0.533
MOD_GlcNHglycan	119	122	PF01048	0.357
MOD_GlcNHglycan	255	258	PF01048	0.452
MOD_GlcNHglycan	467	470	PF01048	0.489
MOD_GlcNHglycan	522	525	PF01048	0.669
MOD_GlcNHglycan	598	602	PF01048	0.538
MOD_GlcNHglycan	98	102	PF01048	0.445
MOD_GSK3_1	139	146	PF00069	0.409
MOD_GSK3_1	21	28	PF00069	0.489
MOD_GSK3_1	212	219	PF00069	0.537
MOD_GSK3_1	498	505	PF00069	0.441
MOD_GSK3_1	512	519	PF00069	0.527
MOD_GSK3_1	536	543	PF00069	0.611
MOD_GSK3_1	84	91	PF00069	0.395
MOD_N-GLC_1	215	220	PF02516	0.472
MOD_N-GLC_1	252	257	PF02516	0.450
MOD_N-GLC_1	393	398	PF02516	0.597
MOD_N-GLC_1	502	507	PF02516	0.582
MOD_N-GLC_1	570	575	PF02516	0.531
MOD_N-GLC_2	357	359	PF02516	0.564
MOD_NEK2_1	11	16	PF00069	0.446
MOD_NEK2_1	332	337	PF00069	0.346
MOD_NEK2_1	558	563	PF00069	0.535
MOD_NEK2_1	570	575	PF00069	0.519
MOD_NEK2_1	97	102	PF00069	0.379
MOD_NEK2_2	314	319	PF00069	0.516
MOD_NEK2_2	403	408	PF00069	0.557
MOD_OFUCOSY	401	407	PF10250	0.555
MOD_PIKK_1	178	184	PF00454	0.588
MOD_PK_1	560	566	PF00069	0.470
MOD_PKA_1	365	371	PF00069	0.328
MOD_PKA_2	231	237	PF00069	0.532
MOD_PKA_2	365	371	PF00069	0.446
MOD_PKA_2	540	546	PF00069	0.643
MOD_PKA_2	604	610	PF00069	0.537
MOD_PKB_1	264	272	PF00069	0.599
MOD_Plk_1	110	116	PF00069	0.407
MOD_Plk_1	215	221	PF00069	0.548
MOD_Plk_1	222	228	PF00069	0.498
MOD_Plk_1	474	480	PF00069	0.462
MOD_Plk_1	570	576	PF00069	0.457
MOD_Plk_1	88	94	PF00069	0.441
MOD_Plk_2-3	572	578	PF00069	0.567
MOD_Plk_4	11	17	PF00069	0.421
MOD_Plk_4	238	244	PF00069	0.524
MOD_Plk_4	255	261	PF00069	0.505
MOD_Plk_4	308	314	PF00069	0.490
MOD_Plk_4	425	431	PF00069	0.396
MOD_Plk_4	591	597	PF00069	0.539
MOD_Plk_4	90	96	PF00069	0.371
MOD_ProDKin_1	104	110	PF00069	0.571
MOD_ProDKin_1	143	149	PF00069	0.423
MOD_ProDKin_1	379	385	PF00069	0.362
MOD_ProDKin_1	432	438	PF00069	0.446
MOD_ProDKin_1	512	518	PF00069	0.643
TRG_DiLeu_BaEn_3	456	462	PF01217	0.377
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.500
TRG_ENDOCYTIC_2	122	125	PF00928	0.367
TRG_ENDOCYTIC_2	128	131	PF00928	0.387
TRG_ENDOCYTIC_2	193	196	PF00928	0.390
TRG_ENDOCYTIC_2	290	293	PF00928	0.382
TRG_ENDOCYTIC_2	329	332	PF00928	0.390
TRG_ENDOCYTIC_2	350	353	PF00928	0.481
TRG_ENDOCYTIC_2	509	512	PF00928	0.533
TRG_ENDOCYTIC_2	53	56	PF00928	0.391
TRG_ENDOCYTIC_2	593	596	PF00928	0.490
TRG_ENDOCYTIC_2	80	83	PF00928	0.479
TRG_ER_diArg_1	125	127	PF00400	0.484
TRG_ER_diArg_1	511	514	PF00400	0.581
TRG_ER_diArg_1	559	562	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4W3	Leptomonas seymouri	65%	100%
A0A0S4IVT2	Bodo saltans	23%	78%
A0A1X0NMT5	Trypanosomatidae	39%	100%
A0A3S7WSC7	Leishmania donovani	95%	100%
A0A422NV23	Trypanosoma rangeli	40%	100%
C9ZI47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	83%
E9AGJ6	Leishmania infantum	94%	100%
E9AIN2	Leishmania braziliensis	82%	100%
E9AP33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BP52	Trypanosoma cruzi	40%	100%