Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGF4_LEIMA

TriTrypDb:

LmjF.12.1340 , LMJLV39_120015700 , LMJSD75_120016600

Length:

438

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	146	148	PF00675	0.669
CLV_NRD_NRD_1	178	180	PF00675	0.625
CLV_NRD_NRD_1	215	217	PF00675	0.655
CLV_NRD_NRD_1	254	256	PF00675	0.462
CLV_NRD_NRD_1	413	415	PF00675	0.749
CLV_PCSK_FUR_1	144	148	PF00082	0.588
CLV_PCSK_KEX2_1	146	148	PF00082	0.656
CLV_PCSK_KEX2_1	178	180	PF00082	0.658
CLV_PCSK_KEX2_1	215	217	PF00082	0.659
CLV_PCSK_KEX2_1	256	258	PF00082	0.526
CLV_PCSK_KEX2_1	413	415	PF00082	0.750
CLV_PCSK_KEX2_1	88	90	PF00082	0.378
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.593
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.378
CLV_PCSK_PC7_1	211	217	PF00082	0.540
CLV_PCSK_SKI1_1	118	122	PF00082	0.742
CLV_PCSK_SKI1_1	385	389	PF00082	0.583
DEG_SCF_FBW7_1	316	322	PF00400	0.590
DOC_CDC14_PxL_1	372	380	PF14671	0.554
DOC_CKS1_1	1	6	PF01111	0.531
DOC_CKS1_1	119	124	PF01111	0.662
DOC_CKS1_1	140	145	PF01111	0.639
DOC_CKS1_1	278	283	PF01111	0.559
DOC_CKS1_1	305	310	PF01111	0.719
DOC_CKS1_1	316	321	PF01111	0.458
DOC_CYCLIN_yClb3_PxF_3	412	420	PF00134	0.472
DOC_CYCLIN_yCln2_LP_2	378	384	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	99	105	PF00134	0.542
DOC_MAPK_gen_1	130	138	PF00069	0.612
DOC_PP1_RVXF_1	422	429	PF00149	0.562
DOC_PP1_RVXF_1	431	437	PF00149	0.471
DOC_PP2B_LxvP_1	138	141	PF13499	0.745
DOC_PP2B_LxvP_1	302	305	PF13499	0.507
DOC_PP2B_LxvP_1	378	381	PF13499	0.444
DOC_PP4_FxxP_1	428	431	PF00568	0.554
DOC_USP7_MATH_1	112	116	PF00917	0.617
DOC_USP7_MATH_1	126	130	PF00917	0.740
DOC_USP7_MATH_1	169	173	PF00917	0.612
DOC_USP7_MATH_1	219	223	PF00917	0.686
DOC_USP7_MATH_1	262	266	PF00917	0.580
DOC_USP7_MATH_1	294	298	PF00917	0.467
DOC_USP7_MATH_1	327	331	PF00917	0.554
DOC_USP7_MATH_1	429	433	PF00917	0.681
DOC_USP7_UBL2_3	157	161	PF12436	0.612
DOC_WW_Pin1_4	118	123	PF00397	0.685
DOC_WW_Pin1_4	136	141	PF00397	0.683
DOC_WW_Pin1_4	167	172	PF00397	0.710
DOC_WW_Pin1_4	18	23	PF00397	0.655
DOC_WW_Pin1_4	201	206	PF00397	0.671
DOC_WW_Pin1_4	223	228	PF00397	0.645
DOC_WW_Pin1_4	274	279	PF00397	0.566
DOC_WW_Pin1_4	304	309	PF00397	0.653
DOC_WW_Pin1_4	312	317	PF00397	0.573
DOC_WW_Pin1_4	394	399	PF00397	0.520
DOC_WW_Pin1_4	427	432	PF00397	0.608
DOC_WW_Pin1_4	98	103	PF00397	0.470
LIG_14-3-3_CanoR_1	132	137	PF00244	0.788
LIG_14-3-3_CanoR_1	163	171	PF00244	0.730
LIG_14-3-3_CanoR_1	178	183	PF00244	0.670
LIG_14-3-3_CanoR_1	223	227	PF00244	0.652
LIG_14-3-3_CanoR_1	320	324	PF00244	0.564
LIG_14-3-3_CanoR_1	343	348	PF00244	0.462
LIG_14-3-3_CanoR_1	362	372	PF00244	0.511
LIG_14-3-3_CanoR_1	379	385	PF00244	0.570
LIG_14-3-3_CanoR_1	401	405	PF00244	0.639
LIG_14-3-3_CanoR_1	424	429	PF00244	0.757
LIG_14-3-3_CterR_2	435	438	PF00244	0.554
LIG_BIR_II_1	1	5	PF00653	0.604
LIG_BIR_III_1	1	5	PF00653	0.535
LIG_BIR_III_3	1	5	PF00653	0.535
LIG_FHA_1	132	138	PF00498	0.703
LIG_FHA_1	284	290	PF00498	0.517
LIG_FHA_1	316	322	PF00498	0.497
LIG_FHA_1	386	392	PF00498	0.505
LIG_FHA_2	305	311	PF00498	0.573
LIG_LIR_Apic_2	288	294	PF02991	0.574
LIG_LIR_Apic_2	427	431	PF02991	0.737
LIG_LIR_Gen_1	241	251	PF02991	0.533
LIG_LIR_Gen_1	296	305	PF02991	0.596
LIG_LIR_Gen_1	52	61	PF02991	0.469
LIG_LIR_Gen_1	70	80	PF02991	0.388
LIG_LIR_Nem_3	241	246	PF02991	0.454
LIG_LIR_Nem_3	296	302	PF02991	0.605
LIG_LIR_Nem_3	52	57	PF02991	0.429
LIG_LIR_Nem_3	69	75	PF02991	0.384
LIG_MYND_3	103	107	PF01753	0.581
LIG_NRBOX	31	37	PF00104	0.483
LIG_SH2_CRK	291	295	PF00017	0.610
LIG_SH2_CRK	73	77	PF00017	0.413
LIG_SH2_NCK_1	291	295	PF00017	0.585
LIG_SH2_NCK_1	352	356	PF00017	0.491
LIG_SH2_SRC	337	340	PF00017	0.459
LIG_SH2_SRC	352	355	PF00017	0.566
LIG_SH2_SRC	73	76	PF00017	0.464
LIG_SH2_STAP1	73	77	PF00017	0.472
LIG_SH2_STAT5	279	282	PF00017	0.633
LIG_SH2_STAT5	298	301	PF00017	0.630
LIG_SH2_STAT5	337	340	PF00017	0.448
LIG_SH2_STAT5	347	350	PF00017	0.418
LIG_SH2_STAT5	51	54	PF00017	0.465
LIG_SH2_STAT5	97	100	PF00017	0.514
LIG_SH3_2	119	124	PF14604	0.662
LIG_SH3_3	116	122	PF00018	0.635
LIG_SH3_3	137	143	PF00018	0.585
LIG_SH3_3	275	281	PF00018	0.549
LIG_SH3_3	302	308	PF00018	0.564
LIG_SH3_3	313	319	PF00018	0.519
LIG_SH3_3	370	376	PF00018	0.513
LIG_SH3_3	409	415	PF00018	0.497
LIG_SH3_3	423	429	PF00018	0.531
LIG_SUMO_SIM_par_1	133	139	PF11976	0.654
LIG_SUMO_SIM_par_1	28	37	PF11976	0.506
LIG_WW_3	121	125	PF00397	0.665
MOD_CDC14_SPxK_1	204	207	PF00782	0.815
MOD_CDC14_SPxK_1	430	433	PF00782	0.609
MOD_CDK_SPK_2	139	144	PF00069	0.629
MOD_CDK_SPK_2	18	23	PF00069	0.560
MOD_CDK_SPK_2	277	282	PF00069	0.552
MOD_CDK_SPK_2	315	320	PF00069	0.596
MOD_CDK_SPxK_1	118	124	PF00069	0.662
MOD_CDK_SPxK_1	201	207	PF00069	0.633
MOD_CDK_SPxK_1	427	433	PF00069	0.642
MOD_CDK_SPxxK_3	139	146	PF00069	0.643
MOD_CDK_SPxxK_3	394	401	PF00069	0.526
MOD_CK1_1	11	17	PF00069	0.573
MOD_CK1_1	139	145	PF00069	0.665
MOD_CK1_1	150	156	PF00069	0.595
MOD_CK1_1	18	24	PF00069	0.629
MOD_CK1_1	222	228	PF00069	0.669
MOD_CK1_1	232	238	PF00069	0.695
MOD_CK1_1	241	247	PF00069	0.591
MOD_CK1_1	315	321	PF00069	0.665
MOD_CK1_1	397	403	PF00069	0.588
MOD_CK1_1	427	433	PF00069	0.663
MOD_CK2_1	13	19	PF00069	0.620
MOD_GlcNHglycan	114	117	PF01048	0.549
MOD_GlcNHglycan	234	237	PF01048	0.637
MOD_GlcNHglycan	365	368	PF01048	0.579
MOD_GSK3_1	107	114	PF00069	0.650
MOD_GSK3_1	11	18	PF00069	0.586
MOD_GSK3_1	126	133	PF00069	0.777
MOD_GSK3_1	147	154	PF00069	0.593
MOD_GSK3_1	163	170	PF00069	0.588
MOD_GSK3_1	214	221	PF00069	0.664
MOD_GSK3_1	223	230	PF00069	0.662
MOD_GSK3_1	231	238	PF00069	0.535
MOD_GSK3_1	300	307	PF00069	0.688
MOD_GSK3_1	315	322	PF00069	0.577
MOD_GSK3_1	343	350	PF00069	0.500
MOD_GSK3_1	353	360	PF00069	0.492
MOD_GSK3_1	49	56	PF00069	0.502
MOD_LATS_1	213	219	PF00433	0.544
MOD_N-GLC_1	49	54	PF02516	0.377
MOD_NEK2_1	106	111	PF00069	0.668
MOD_NEK2_1	231	236	PF00069	0.757
MOD_NEK2_1	357	362	PF00069	0.497
MOD_NEK2_1	49	54	PF00069	0.440
MOD_NEK2_1	57	62	PF00069	0.409
MOD_PIKK_1	169	175	PF00454	0.588
MOD_PIKK_1	229	235	PF00454	0.800
MOD_PK_1	147	153	PF00069	0.588
MOD_PK_1	406	412	PF00069	0.573
MOD_PKA_1	178	184	PF00069	0.548
MOD_PKA_1	199	205	PF00069	0.676
MOD_PKA_1	215	221	PF00069	0.660
MOD_PKA_2	131	137	PF00069	0.708
MOD_PKA_2	162	168	PF00069	0.613
MOD_PKA_2	178	184	PF00069	0.640
MOD_PKA_2	206	212	PF00069	0.801
MOD_PKA_2	214	220	PF00069	0.700
MOD_PKA_2	222	228	PF00069	0.621
MOD_PKA_2	319	325	PF00069	0.562
MOD_PKA_2	361	367	PF00069	0.618
MOD_PKA_2	400	406	PF00069	0.706
MOD_PKB_1	130	138	PF00069	0.612
MOD_Plk_1	106	112	PF00069	0.568
MOD_Plk_1	268	274	PF00069	0.627
MOD_Plk_1	406	412	PF00069	0.573
MOD_Plk_4	132	138	PF00069	0.668
MOD_Plk_4	238	244	PF00069	0.613
MOD_Plk_4	294	300	PF00069	0.547
MOD_ProDKin_1	118	124	PF00069	0.688
MOD_ProDKin_1	136	142	PF00069	0.681
MOD_ProDKin_1	167	173	PF00069	0.710
MOD_ProDKin_1	18	24	PF00069	0.651
MOD_ProDKin_1	201	207	PF00069	0.674
MOD_ProDKin_1	223	229	PF00069	0.645
MOD_ProDKin_1	274	280	PF00069	0.564
MOD_ProDKin_1	304	310	PF00069	0.655
MOD_ProDKin_1	312	318	PF00069	0.568
MOD_ProDKin_1	394	400	PF00069	0.523
MOD_ProDKin_1	427	433	PF00069	0.612
MOD_ProDKin_1	98	104	PF00069	0.479
MOD_SUMO_rev_2	192	201	PF00179	0.599
MOD_SUMO_rev_2	83	90	PF00179	0.385
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.485
TRG_ENDOCYTIC_2	51	54	PF00928	0.359
TRG_ENDOCYTIC_2	73	76	PF00928	0.370
TRG_ER_diArg_1	145	147	PF00400	0.653
TRG_ER_diArg_1	255	258	PF00400	0.538
TRG_ER_diArg_1	412	414	PF00400	0.742
TRG_ER_diArg_1	417	420	PF00400	0.703
TRG_ER_diArg_1	433	436	PF00400	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F0	Leptomonas seymouri	50%	91%
A0A3R7KKI7	Trypanosoma rangeli	31%	97%
A0A3S7WS94	Leishmania donovani	85%	100%
C9ZI49	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	94%
E9AGJ7	Leishmania infantum	85%	100%
E9AIN1	Leishmania braziliensis	63%	100%
E9AP34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%