Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGF0_LEIMA

TriTrypDb:

LmjF.13.0040 , LMJLV39_130005400 , LMJSD75_130005500

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	196	200	PF00656	0.603
CLV_C14_Caspase3-7	219	223	PF00656	0.401
CLV_NRD_NRD_1	159	161	PF00675	0.505
CLV_NRD_NRD_1	82	84	PF00675	0.564
CLV_PCSK_KEX2_1	135	137	PF00082	0.672
CLV_PCSK_KEX2_1	159	161	PF00082	0.505
CLV_PCSK_KEX2_1	82	84	PF00082	0.475
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.672
CLV_PCSK_SKI1_1	105	109	PF00082	0.461
CLV_PCSK_SKI1_1	229	233	PF00082	0.488
CLV_PCSK_SKI1_1	273	277	PF00082	0.469
CLV_Separin_Metazoa	56	60	PF03568	0.398
DEG_APCC_DBOX_1	102	110	PF00400	0.454
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_PP4_FxxP_1	207	210	PF00568	0.563
DOC_USP7_MATH_1	137	141	PF00917	0.653
DOC_USP7_MATH_1	21	25	PF00917	0.596
DOC_WW_Pin1_4	142	147	PF00397	0.628
DOC_WW_Pin1_4	34	39	PF00397	0.620
DOC_WW_Pin1_4	43	48	PF00397	0.615
LIG_14-3-3_CanoR_1	105	110	PF00244	0.492
LIG_14-3-3_CanoR_1	113	121	PF00244	0.466
LIG_14-3-3_CanoR_1	124	132	PF00244	0.717
LIG_14-3-3_CanoR_1	136	142	PF00244	0.650
LIG_14-3-3_CanoR_1	202	210	PF00244	0.585
LIG_14-3-3_CanoR_1	217	221	PF00244	0.439
LIG_14-3-3_CanoR_1	273	280	PF00244	0.482
LIG_14-3-3_CanoR_1	50	54	PF00244	0.597
LIG_FHA_1	150	156	PF00498	0.490
LIG_FHA_1	164	170	PF00498	0.453
LIG_FHA_1	76	82	PF00498	0.509
LIG_FHA_2	194	200	PF00498	0.558
LIG_FHA_2	217	223	PF00498	0.413
LIG_FHA_2	254	260	PF00498	0.566
LIG_FHA_2	35	41	PF00498	0.697
LIG_LIR_Apic_2	204	210	PF02991	0.582
LIG_LIR_Gen_1	256	266	PF02991	0.522
LIG_LIR_Nem_3	256	261	PF02991	0.533
LIG_Pex14_2	14	18	PF04695	0.509
LIG_PTAP_UEV_1	279	284	PF05743	0.497
LIG_SH2_GRB2like	151	154	PF00017	0.490
LIG_SH2_STAP1	151	155	PF00017	0.510
LIG_SH2_STAT5	151	154	PF00017	0.490
LIG_SH3_3	277	283	PF00018	0.522
MOD_CDK_SPxxK_3	43	50	PF00069	0.533
MOD_CK1_1	4	10	PF00069	0.692
MOD_CK1_1	52	58	PF00069	0.569
MOD_CK2_1	220	226	PF00069	0.555
MOD_GlcNHglycan	127	130	PF01048	0.623
MOD_GlcNHglycan	187	190	PF01048	0.555
MOD_GlcNHglycan	234	237	PF01048	0.543
MOD_GlcNHglycan	72	75	PF01048	0.486
MOD_GSK3_1	216	223	PF00069	0.459
MOD_NEK2_1	1	6	PF00069	0.684
MOD_NEK2_1	169	174	PF00069	0.535
MOD_NEK2_1	288	293	PF00069	0.604
MOD_PIKK_1	169	175	PF00454	0.511
MOD_PIKK_1	61	67	PF00454	0.434
MOD_PIKK_1	7	13	PF00454	0.644
MOD_PKA_2	112	118	PF00069	0.441
MOD_PKA_2	125	131	PF00069	0.537
MOD_PKA_2	201	207	PF00069	0.619
MOD_PKA_2	216	222	PF00069	0.438
MOD_PKA_2	49	55	PF00069	0.572
MOD_PKA_2	75	81	PF00069	0.564
MOD_PKB_1	103	111	PF00069	0.400
MOD_Plk_1	169	175	PF00069	0.538
MOD_Plk_4	137	143	PF00069	0.510
MOD_Plk_4	216	222	PF00069	0.438
MOD_Plk_4	253	259	PF00069	0.532
MOD_Plk_4	283	289	PF00069	0.555
MOD_Plk_4	49	55	PF00069	0.552
MOD_ProDKin_1	142	148	PF00069	0.628
MOD_ProDKin_1	34	40	PF00069	0.622
MOD_ProDKin_1	43	49	PF00069	0.606
MOD_SUMO_rev_2	86	92	PF00179	0.535
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.522
TRG_ER_diArg_1	102	105	PF00400	0.460
TRG_ER_diArg_1	81	83	PF00400	0.569
TRG_ER_diArg_1	98	101	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V4	Leptomonas seymouri	58%	92%
A0A3Q8IBM3	Leishmania donovani	91%	100%
A4H712	Leishmania braziliensis	69%	82%
A4HVE0	Leishmania infantum	92%	100%
E9AP38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%