LeishMANIAdb
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Ribonuclease

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ribonuclease
Gene product:
ribonuclease HII, putative
Species:
Leishmania major
UniProt:
Q4QGE9_LEIMA
TriTrypDb:
LmjF.13.0050 * , LMJLV39_130005500 * , LMJSD75_130005600 *
Length:
268

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 7
GO:0032299 ribonuclease H2 complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0110165 cellular anatomical entity 1 7
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2

Expansion

Sequence features

Q4QGE9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE9

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 2
GO:0006259 DNA metabolic process 4 2
GO:0006281 DNA repair 5 2
GO:0006298 mismatch repair 6 2
GO:0006401 RNA catabolic process 5 2
GO:0006725 cellular aromatic compound metabolic process 3 2
GO:0006807 nitrogen compound metabolic process 2 2
GO:0006950 response to stress 2 2
GO:0006974 DNA damage response 4 2
GO:0008152 metabolic process 1 2
GO:0009056 catabolic process 2 2
GO:0009057 macromolecule catabolic process 4 2
GO:0009987 cellular process 1 2
GO:0016070 RNA metabolic process 5 2
GO:0019439 aromatic compound catabolic process 4 2
GO:0033554 cellular response to stress 3 2
GO:0034641 cellular nitrogen compound metabolic process 3 2
GO:0034655 nucleobase-containing compound catabolic process 4 2
GO:0043137 DNA replication, removal of RNA primer 6 2
GO:0043170 macromolecule metabolic process 3 2
GO:0044237 cellular metabolic process 2 2
GO:0044238 primary metabolic process 2 2
GO:0044248 cellular catabolic process 3 2
GO:0044260 obsolete cellular macromolecule metabolic process 3 2
GO:0044265 obsolete cellular macromolecule catabolic process 4 2
GO:0044270 cellular nitrogen compound catabolic process 4 2
GO:0046483 heterocycle metabolic process 3 2
GO:0046700 heterocycle catabolic process 4 2
GO:0050896 response to stimulus 1 2
GO:0051716 cellular response to stimulus 2 2
GO:0071704 organic substance metabolic process 2 2
GO:0090304 nucleic acid metabolic process 4 2
GO:1901360 organic cyclic compound metabolic process 3 2
GO:1901361 organic cyclic compound catabolic process 4 2
GO:1901575 organic substance catabolic process 3 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003723 RNA binding 4 7
GO:0003824 catalytic activity 1 7
GO:0004518 nuclease activity 4 7
GO:0004519 endonuclease activity 5 7
GO:0004521 RNA endonuclease activity 5 7
GO:0004523 RNA-DNA hybrid ribonuclease activity 7 7
GO:0004540 RNA nuclease activity 4 7
GO:0005488 binding 1 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters 6 7
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 6 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7
GO:0097159 organic cyclic compound binding 2 7
GO:0140098 catalytic activity, acting on RNA 3 7
GO:0140640 catalytic activity, acting on a nucleic acid 2 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 44 48 PF00656 0.564
CLV_C14_Caspase3-7 57 61 PF00656 0.594
CLV_NRD_NRD_1 152 154 PF00675 0.310
CLV_NRD_NRD_1 157 159 PF00675 0.326
CLV_NRD_NRD_1 70 72 PF00675 0.309
CLV_PCSK_KEX2_1 159 161 PF00082 0.321
CLV_PCSK_KEX2_1 70 72 PF00082 0.306
CLV_PCSK_PC1ET2_1 159 161 PF00082 0.321
CLV_PCSK_SKI1_1 27 31 PF00082 0.394
CLV_PCSK_SKI1_1 90 94 PF00082 0.394
DEG_APCC_DBOX_1 70 78 PF00400 0.594
DOC_MAPK_gen_1 194 204 PF00069 0.521
DOC_USP7_MATH_1 187 191 PF00917 0.521
DOC_WW_Pin1_4 118 123 PF00397 0.521
DOC_WW_Pin1_4 14 19 PF00397 0.521
DOC_WW_Pin1_4 256 261 PF00397 0.678
LIG_14-3-3_CanoR_1 13 21 PF00244 0.495
LIG_14-3-3_CanoR_1 133 139 PF00244 0.511
LIG_14-3-3_CanoR_1 258 264 PF00244 0.676
LIG_BIR_II_1 1 5 PF00653 0.411
LIG_BIR_III_1 1 5 PF00653 0.411
LIG_BIR_III_3 1 5 PF00653 0.411
LIG_FHA_1 122 128 PF00498 0.569
LIG_FHA_1 172 178 PF00498 0.594
LIG_FHA_2 55 61 PF00498 0.560
LIG_Integrin_RGD_1 253 255 PF01839 0.543
LIG_LIR_Gen_1 110 117 PF02991 0.594
LIG_LIR_Gen_1 235 245 PF02991 0.594
LIG_LIR_Nem_3 110 114 PF02991 0.566
LIG_LIR_Nem_3 164 168 PF02991 0.527
LIG_LIR_Nem_3 235 240 PF02991 0.504
LIG_LIR_Nem_3 241 245 PF02991 0.482
LIG_LYPXL_yS_3 165 168 PF13949 0.594
LIG_SH2_CRK 111 115 PF00017 0.566
LIG_SH2_CRK 242 246 PF00017 0.521
LIG_SH2_NCK_1 111 115 PF00017 0.511
LIG_SH2_SRC 242 245 PF00017 0.521
LIG_SH2_STAP1 200 204 PF00017 0.473
LIG_SH2_STAT5 220 223 PF00017 0.521
LIG_SH3_3 160 166 PF00018 0.566
LIG_SH3_3 201 207 PF00018 0.427
LIG_SUMO_SIM_anti_2 83 89 PF11976 0.521
LIG_SUMO_SIM_par_1 80 85 PF11976 0.594
LIG_TRAF2_1 140 143 PF00917 0.594
LIG_TYR_ITIM 163 168 PF00017 0.521
LIG_TYR_ITIM 240 245 PF00017 0.521
MOD_CDK_SPxK_1 14 20 PF00069 0.594
MOD_CK1_1 172 178 PF00069 0.427
MOD_CK2_1 137 143 PF00069 0.594
MOD_GlcNHglycan 100 103 PF01048 0.395
MOD_GlcNHglycan 114 117 PF01048 0.365
MOD_GlcNHglycan 139 142 PF01048 0.339
MOD_GlcNHglycan 14 17 PF01048 0.308
MOD_GSK3_1 112 119 PF00069 0.552
MOD_N-GLC_1 93 98 PF02516 0.321
MOD_NEK2_1 171 176 PF00069 0.548
MOD_NEK2_1 53 58 PF00069 0.531
MOD_PKA_2 12 18 PF00069 0.521
MOD_Plk_1 179 185 PF00069 0.584
MOD_Plk_1 82 88 PF00069 0.554
MOD_Plk_1 93 99 PF00069 0.461
MOD_Plk_4 172 178 PF00069 0.576
MOD_Plk_4 179 185 PF00069 0.520
MOD_Plk_4 187 193 PF00069 0.430
MOD_Plk_4 200 206 PF00069 0.449
MOD_Plk_4 7 13 PF00069 0.521
MOD_Plk_4 82 88 PF00069 0.523
MOD_ProDKin_1 118 124 PF00069 0.521
MOD_ProDKin_1 14 20 PF00069 0.521
MOD_ProDKin_1 256 262 PF00069 0.705
TRG_ENDOCYTIC_2 111 114 PF00928 0.594
TRG_ENDOCYTIC_2 165 168 PF00928 0.521
TRG_ENDOCYTIC_2 21 24 PF00928 0.539
TRG_ENDOCYTIC_2 242 245 PF00928 0.499
TRG_ER_diArg_1 144 147 PF00400 0.520
TRG_ER_diArg_1 158 161 PF00400 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHU4 Leptomonas seymouri 65% 94%
A0A0S4J8A1 Bodo saltans 26% 100%
A0A3S7WSB6 Leishmania donovani 96% 100%
A0JXT5 Arthrobacter sp. (strain FB24) 31% 100%
A0KZ09 Shewanella sp. (strain ANA-3) 31% 100%
A0L4Z0 Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) 29% 100%
A0M5H5 Gramella forsetii (strain KT0803) 26% 100%
A0Q7F9 Francisella tularensis subsp. novicida (strain U112) 30% 100%
A1B3V0 Paracoccus denitrificans (strain Pd 1222) 30% 100%
A1T759 Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1) 31% 100%
A1WHV6 Verminephrobacter eiseniae (strain EF01-2) 32% 100%
A2SH85 Methylibium petroleiphilum (strain ATCC BAA-1232 / LMG 22953 / PM1) 31% 100%
A3D2L9 Shewanella baltica (strain OS155 / ATCC BAA-1091) 30% 100%
A3DDG7 Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372) 26% 100%
A3QG89 Shewanella loihica (strain ATCC BAA-1088 / PV-4) 32% 100%
A4H713 Leishmania braziliensis 80% 100%
A4HVE1 Leishmania infantum 96% 100%
A4IX19 Francisella tularensis subsp. tularensis (strain WY96-3418) 31% 100%
A4TE84 Mycolicibacterium gilvum (strain PYR-GCK) 29% 100%
A4VJT5 Pseudomonas stutzeri (strain A1501) 30% 100%
A4XLE8 Caldicellulosiruptor saccharolyticus (strain ATCC 43494 / DSM 8903 / Tp8T 6331) 26% 100%
A5FIL7 Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) 26% 100%
A5VF46 Rhizorhabdus wittichii (strain DSM 6014 / CCUG 31198 / JCM 15750 / NBRC 105917 / EY 4224 / RW1) 30% 100%
A5WDY2 Psychrobacter sp. (strain PRwf-1) 37% 89%
A6GYW0 Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86) 31% 100%
A6LHT2 Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152) 30% 100%
A6V1E6 Pseudomonas aeruginosa (strain PA7) 32% 100%
A6VUT6 Marinomonas sp. (strain MWYL1) 29% 100%
A6WLC0 Shewanella baltica (strain OS185) 31% 100%
A7HQZ3 Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966) 29% 100%
A7NCM0 Francisella tularensis subsp. holarctica (strain FTNF002-00 / FTA) 30% 100%
A9BML8 Delftia acidovorans (strain DSM 14801 / SPH-1) 31% 100%
A9KGD3 Coxiella burnetii (strain Dugway 5J108-111) 27% 100%
A9KUL9 Shewanella baltica (strain OS195) 31% 100%
A9N8L5 Coxiella burnetii (strain RSA 331 / Henzerling II) 27% 100%
A9VT75 Bacillus mycoides (strain KBAB4) 25% 100%
B0CAM1 Acaryochloris marina (strain MBIC 11017) 30% 100%
B0KSB3 Pseudomonas putida (strain GB-1) 29% 100%
B0TYD6 Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036) 30% 100%
B1GZ18 Endomicrobium trichonymphae 29% 100%
B1IQF8 Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks) 32% 100%
B1JBP6 Pseudomonas putida (strain W619) 29% 100%
B1LGY5 Escherichia coli (strain SMS-3-5 / SECEC) 32% 100%
B2SGW7 Francisella tularensis subsp. mediasiatica (strain FSC147) 30% 100%
B2U326 Shigella boydii serotype 18 (strain CDC 3083-94 / BS512) 32% 100%
B3CM59 Wolbachia pipientis subsp. Culex pipiens (strain wPip) 26% 100%
B4F256 Proteus mirabilis (strain HI4320) 29% 100%
B4SAK8 Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1) 28% 100%
B5EBC6 Citrifermentans bemidjiense (strain ATCC BAA-1014 / DSM 16622 / JCM 12645 / Bem) 30% 100%
B5Y1I8 Klebsiella pneumoniae (strain 342) 32% 100%
B5Z0G2 Escherichia coli O157:H7 (strain EC4115 / EHEC) 32% 100%
B6IZE4 Coxiella burnetii (strain CbuG_Q212) 27% 100%
B6J7Z2 Coxiella burnetii (strain CbuK_Q154) 27% 100%
B7GGD5 Anoxybacillus flavithermus (strain DSM 21510 / WK1) 28% 100%
B7LW62 Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73) 32% 100%
B7MP43 Escherichia coli O81 (strain ED1a) 32% 100%
B7N850 Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) 32% 100%
B7NIE5 Escherichia coli O7:K1 (strain IAI39 / ExPEC) 32% 100%
B7UJ84 Escherichia coli O127:H6 (strain E2348/69 / EPEC) 32% 100%
B7V7U6 Pseudomonas aeruginosa (strain LESB58) 31% 100%
B8E7Q2 Shewanella baltica (strain OS223) 31% 100%
B8GQ66 Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) 28% 100%
B8I7T9 Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) 28% 100%
B9M597 Geotalea daltonii (strain DSM 22248 / JCM 15807 / FRC-32) 30% 100%
B9MQX2 Caldicellulosiruptor bescii (strain ATCC BAA-1888 / DSM 6725 / Z-1320) 27% 100%
C1DST2 Azotobacter vinelandii (strain DJ / ATCC BAA-1303) 32% 100%
E9AP39 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q02RB4 Pseudomonas aeruginosa (strain UCBPP-PA14) 31% 100%
Q049Z9 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365 / Lb-18) 31% 100%
Q0A7J3 Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1) 33% 100%
Q0AWX1 Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen) 30% 100%
Q0BLL3 Francisella tularensis subsp. holarctica (strain OSU18) 30% 100%
Q0BQZ6 Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) 30% 100%
Q0BYK9 Hyphomonas neptunium (strain ATCC 15444) 31% 100%
Q0KA30 Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) 30% 100%
Q0TLF0 Escherichia coli O6:K15:H31 (strain 536 / UPEC) 32% 100%
Q12A45 Polaromonas sp. (strain JS666 / ATCC BAA-500) 29% 100%
Q12NX3 Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013) 31% 100%
Q13XD0 Paraburkholderia xenovorans (strain LB400) 30% 100%
Q14GW0 Francisella tularensis subsp. tularensis (strain FSC 198) 31% 100%
Q18BC9 Clostridioides difficile (strain 630) 26% 100%
Q1G9U8 Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC 11842 / DSM 20081 / BCRC 10696 / JCM 1002 / NBRC 13953 / NCIMB 11778 / NCTC 12712 / WDCM 00102 / Lb 14) 31% 100%
Q1QAL9 Psychrobacter cryohalolentis (strain ATCC BAA-1226 / DSM 17306 / VKM B-2378 / K5) 35% 94%
Q21WX6 Albidiferax ferrireducens (strain ATCC BAA-621 / DSM 15236 / T118) 29% 100%
Q2A337 Francisella tularensis subsp. holarctica (strain LVS) 30% 100%
Q2GFP8 Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) 27% 100%
Q325V7 Shigella boydii serotype 4 (strain Sb227) 32% 100%
Q3MDN0 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 26% 100%
Q3YST1 Ehrlichia canis (strain Jake) 26% 100%
Q470F1 Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) 29% 100%
Q4FPF7 Pelagibacter ubique (strain HTCC1062) 25% 100%
Q4FT93 Psychrobacter arcticus (strain DSM 17307 / VKM B-2377 / 273-4) 34% 93%
Q4KHG2 Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) 29% 100%
Q50412 Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) 29% 100%
Q5LIL2 Bacteroides fragilis (strain ATCC 25285 / DSM 2151 / CCUG 4856 / JCM 11019 / NCTC 9343 / Onslow) 33% 100%
Q5NFF8 Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) 31% 100%
Q5NZG1 Aromatoleum aromaticum (strain EbN1) 33% 100%
Q5QZK7 Idiomarina loihiensis (strain ATCC BAA-735 / DSM 15497 / L2-TR) 28% 100%
Q64ZN7 Bacteroides fragilis (strain YCH46) 33% 100%
Q6MLA0 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) 29% 100%
Q82U06 Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298) 33% 100%
Q83BZ8 Coxiella burnetii (strain RSA 493 / Nine Mile phase I) 27% 100%
Q8A293 Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 / VPI-5482 / E50) 31% 100%
Q8FL06 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 32% 100%
Q8PML9 Xanthomonas axonopodis pv. citri (strain 306) 34% 100%
Q8RDX3 Fusobacterium nucleatum subsp. nucleatum (strain ATCC 25586 / DSM 15643 / BCRC 10681 / CIP 101130 / JCM 8532 / KCTC 2640 / LMG 13131 / VPI 4355) 28% 100%
Q8X8X6 Escherichia coli O157:H7 32% 100%
Q8YP68 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 26% 100%
Q986D0 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 32% 100%
Q9HXY9 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 31% 100%
Q9Z962 Chlamydia pneumoniae 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS