Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGE8_LEIMA

TriTrypDb:

LmjF.13.0060 , LMJLV39_130005600 , LMJSD75_130005700

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.564
CLV_NRD_NRD_1	20	22	PF00675	0.676
CLV_NRD_NRD_1	264	266	PF00675	0.489
CLV_NRD_NRD_1	291	293	PF00675	0.749
CLV_NRD_NRD_1	325	327	PF00675	0.710
CLV_NRD_NRD_1	74	76	PF00675	0.526
CLV_PCSK_FUR_1	289	293	PF00082	0.512
CLV_PCSK_FUR_1	90	94	PF00082	0.630
CLV_PCSK_KEX2_1	101	103	PF00082	0.437
CLV_PCSK_KEX2_1	178	180	PF00082	0.536
CLV_PCSK_KEX2_1	20	22	PF00082	0.630
CLV_PCSK_KEX2_1	211	213	PF00082	0.659
CLV_PCSK_KEX2_1	263	265	PF00082	0.530
CLV_PCSK_KEX2_1	291	293	PF00082	0.512
CLV_PCSK_KEX2_1	325	327	PF00082	0.710
CLV_PCSK_KEX2_1	73	75	PF00082	0.570
CLV_PCSK_KEX2_1	92	94	PF00082	0.419
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.414
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.691
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.547
CLV_PCSK_SKI1_1	20	24	PF00082	0.666
CLV_PCSK_SKI1_1	224	228	PF00082	0.641
CLV_PCSK_SKI1_1	292	296	PF00082	0.617
CLV_Separin_Metazoa	322	326	PF03568	0.625
DEG_APCC_DBOX_1	290	298	PF00400	0.508
DOC_CKS1_1	24	29	PF01111	0.645
DOC_CYCLIN_RxL_1	17	26	PF00134	0.674
DOC_CYCLIN_yClb5_NLxxxL_5	376	385	PF00134	0.653
DOC_MAPK_gen_1	219	229	PF00069	0.646
DOC_MAPK_gen_1	73	81	PF00069	0.572
DOC_MAPK_MEF2A_6	350	359	PF00069	0.489
DOC_MAPK_MEF2A_6	74	83	PF00069	0.626
DOC_PP2B_LxvP_1	22	25	PF13499	0.672
DOC_PP4_MxPP_1	11	14	PF00568	0.493
DOC_USP7_MATH_1	25	29	PF00917	0.620
DOC_USP7_MATH_1	312	316	PF00917	0.725
DOC_USP7_MATH_1	6	10	PF00917	0.613
DOC_WW_Pin1_4	12	17	PF00397	0.672
DOC_WW_Pin1_4	23	28	PF00397	0.652
LIG_14-3-3_CanoR_1	108	112	PF00244	0.692
LIG_14-3-3_CanoR_1	118	123	PF00244	0.542
LIG_14-3-3_CanoR_1	242	252	PF00244	0.595
LIG_14-3-3_CanoR_1	303	309	PF00244	0.507
LIG_14-3-3_CanoR_1	51	59	PF00244	0.646
LIG_Actin_WH2_2	309	327	PF00022	0.623
LIG_BIR_II_1	1	5	PF00653	0.490
LIG_BRCT_BRCA1_1	245	249	PF00533	0.634
LIG_FHA_1	199	205	PF00498	0.673
LIG_FHA_1	24	30	PF00498	0.639
LIG_FHA_1	308	314	PF00498	0.636
LIG_FHA_1	352	358	PF00498	0.484
LIG_FHA_2	143	149	PF00498	0.684
LIG_FHA_2	213	219	PF00498	0.581
LIG_FHA_2	245	251	PF00498	0.597
LIG_FHA_2	377	383	PF00498	0.717
LIG_Integrin_RGD_1	212	214	PF01839	0.698
LIG_LIR_Apic_2	307	312	PF02991	0.496
LIG_LIR_Gen_1	143	152	PF02991	0.751
LIG_LIR_Gen_1	167	176	PF02991	0.628
LIG_LIR_Gen_1	246	256	PF02991	0.458
LIG_LIR_Nem_3	143	149	PF02991	0.743
LIG_LIR_Nem_3	167	171	PF02991	0.570
LIG_LIR_Nem_3	246	252	PF02991	0.475
LIG_PAM2_1	252	264	PF00658	0.533
LIG_PCNA_yPIPBox_3	73	87	PF02747	0.545
LIG_SH2_CRK	168	172	PF00017	0.580
LIG_SH2_CRK	309	313	PF00017	0.492
LIG_SH2_SRC	172	175	PF00017	0.463
LIG_SH2_STAT5	309	312	PF00017	0.495
LIG_SH2_STAT5	55	58	PF00017	0.658
LIG_SH3_3	10	16	PF00018	0.709
LIG_SH3_3	21	27	PF00018	0.484
LIG_SUMO_SIM_anti_2	358	365	PF11976	0.650
LIG_TRAF2_1	319	322	PF00917	0.616
MOD_CK1_1	164	170	PF00069	0.621
MOD_CK1_1	315	321	PF00069	0.703
MOD_CK1_1	32	38	PF00069	0.613
MOD_CK1_1	386	392	PF00069	0.645
MOD_CK2_1	152	158	PF00069	0.691
MOD_CK2_1	190	196	PF00069	0.676
MOD_CK2_1	212	218	PF00069	0.544
MOD_CK2_1	244	250	PF00069	0.683
MOD_CK2_1	315	321	PF00069	0.577
MOD_DYRK1A_RPxSP_1	12	16	PF00069	0.730
MOD_GlcNHglycan	115	118	PF01048	0.662
MOD_GlcNHglycan	133	136	PF01048	0.518
MOD_GlcNHglycan	155	158	PF01048	0.766
MOD_GlcNHglycan	204	207	PF01048	0.642
MOD_GlcNHglycan	254	257	PF01048	0.526
MOD_GlcNHglycan	31	34	PF01048	0.560
MOD_GlcNHglycan	318	321	PF01048	0.542
MOD_GlcNHglycan	330	334	PF01048	0.616
MOD_GlcNHglycan	337	340	PF01048	0.752
MOD_GlcNHglycan	44	47	PF01048	0.468
MOD_GSK3_1	107	114	PF00069	0.631
MOD_GSK3_1	118	125	PF00069	0.566
MOD_GSK3_1	138	145	PF00069	0.568
MOD_GSK3_1	147	154	PF00069	0.696
MOD_GSK3_1	157	164	PF00069	0.518
MOD_GSK3_1	198	205	PF00069	0.684
MOD_GSK3_1	25	32	PF00069	0.673
MOD_GSK3_1	312	319	PF00069	0.614
MOD_GSK3_1	383	390	PF00069	0.745
MOD_N-GLC_1	243	248	PF02516	0.657
MOD_NEK2_1	122	127	PF00069	0.616
MOD_NEK2_1	152	157	PF00069	0.617
MOD_NEK2_1	207	212	PF00069	0.530
MOD_NEK2_1	329	334	PF00069	0.688
MOD_NEK2_1	383	388	PF00069	0.671
MOD_NEK2_2	107	112	PF00069	0.652
MOD_PIKK_1	295	301	PF00454	0.654
MOD_PIKK_1	383	389	PF00454	0.711
MOD_PKA_1	263	269	PF00069	0.563
MOD_PKA_2	107	113	PF00069	0.687
MOD_PKA_2	152	158	PF00069	0.679
MOD_PKA_2	263	269	PF00069	0.638
MOD_PKA_2	302	308	PF00069	0.677
MOD_PKA_2	42	48	PF00069	0.569
MOD_PKA_2	50	56	PF00069	0.540
MOD_Plk_1	282	288	PF00069	0.620
MOD_Plk_2-3	142	148	PF00069	0.678
MOD_Plk_4	312	318	PF00069	0.693
MOD_Plk_4	6	12	PF00069	0.667
MOD_ProDKin_1	12	18	PF00069	0.675
MOD_ProDKin_1	23	29	PF00069	0.651
MOD_SUMO_rev_2	346	352	PF00179	0.737
TRG_DiLeu_BaEn_1	371	376	PF01217	0.594
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.554
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.691
TRG_DiLeu_LyEn_5	371	376	PF01217	0.594
TRG_ENDOCYTIC_2	168	171	PF00928	0.503
TRG_ER_diArg_1	20	22	PF00400	0.676
TRG_ER_diArg_1	263	265	PF00400	0.547
TRG_ER_diArg_1	288	291	PF00400	0.512
TRG_ER_diArg_1	324	326	PF00400	0.700
TRG_ER_diArg_1	73	75	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1S5	Leptomonas seymouri	44%	86%
A0A1X0NNN8	Trypanosomatidae	24%	72%
A0A3R7MBM6	Trypanosoma rangeli	24%	76%
A0A3S5H6M8	Leishmania donovani	90%	71%
A4H714	Leishmania braziliensis	72%	85%
A4HVE2	Leishmania infantum	89%	71%
E9AP40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%