Metallo-peptidase, Clan MA(E), family 32

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-peptidase, Clan MA(E) Family M32

Species:

Leishmania major

UniProt:

Q4QGE5_LEIMA

TriTrypDb:

LmjF.13.0090 , LMJLV39_130005900 , LMJSD75_130006000

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 1
Forrest at al. (metacyclic)	no	yes: 3
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 9

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	25
GO:0006807	nitrogen compound metabolic process	2	25
GO:0008152	metabolic process	1	25
GO:0019538	protein metabolic process	3	25
GO:0043170	macromolecule metabolic process	3	25
GO:0044238	primary metabolic process	2	25
GO:0071704	organic substance metabolic process	2	25
GO:1901564	organonitrogen compound metabolic process	3	25
GO:0006518	peptide metabolic process	4	1
GO:0043603	amide metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	25
GO:0004180	carboxypeptidase activity	5	25
GO:0004181	metallocarboxypeptidase activity	6	25
GO:0008233	peptidase activity	3	25
GO:0008235	metalloexopeptidase activity	5	25
GO:0008237	metallopeptidase activity	4	25
GO:0008238	exopeptidase activity	4	25
GO:0016787	hydrolase activity	2	25
GO:0140096	catalytic activity, acting on a protein	2	25
GO:0016853	isomerase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	138	140	PF00675	0.329
CLV_NRD_NRD_1	496	498	PF00675	0.428
CLV_NRD_NRD_1	86	88	PF00675	0.396
CLV_PCSK_KEX2_1	138	140	PF00082	0.306
CLV_PCSK_KEX2_1	496	498	PF00082	0.400
CLV_PCSK_KEX2_1	86	88	PF00082	0.412
CLV_PCSK_SKI1_1	100	104	PF00082	0.329
CLV_PCSK_SKI1_1	171	175	PF00082	0.552
CLV_PCSK_SKI1_1	258	262	PF00082	0.453
CLV_PCSK_SKI1_1	290	294	PF00082	0.306
CLV_PCSK_SKI1_1	61	65	PF00082	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.602
DOC_CKS1_1	315	320	PF01111	0.436
DOC_CYCLIN_RxL_1	168	178	PF00134	0.311
DOC_CYCLIN_RxL_1	255	263	PF00134	0.447
DOC_MAPK_gen_1	13	23	PF00069	0.378
DOC_MAPK_gen_1	387	394	PF00069	0.406
DOC_PP4_FxxP_1	315	318	PF00568	0.348
DOC_USP7_UBL2_3	459	463	PF12436	0.379
DOC_USP7_UBL2_3	9	13	PF12436	0.348
DOC_WW_Pin1_4	107	112	PF00397	0.310
DOC_WW_Pin1_4	314	319	PF00397	0.435
DOC_WW_Pin1_4	54	59	PF00397	0.399
LIG_14-3-3_CanoR_1	16	23	PF00244	0.338
LIG_14-3-3_CanoR_1	246	253	PF00244	0.539
LIG_14-3-3_CanoR_1	87	96	PF00244	0.445
LIG_Actin_WH2_2	70	88	PF00022	0.401
LIG_BRCT_BRCA1_1	308	312	PF00533	0.365
LIG_CtBP_PxDLS_1	278	282	PF00389	0.457
LIG_deltaCOP1_diTrp_1	219	225	PF00928	0.461
LIG_deltaCOP1_diTrp_1	407	415	PF00928	0.406
LIG_eIF4E_1	356	362	PF01652	0.330
LIG_eIF4E_1	471	477	PF01652	0.518
LIG_FHA_1	107	113	PF00498	0.340
LIG_FHA_1	16	22	PF00498	0.263
LIG_FHA_1	236	242	PF00498	0.298
LIG_FHA_1	315	321	PF00498	0.470
LIG_FHA_1	418	424	PF00498	0.377
LIG_FHA_1	471	477	PF00498	0.396
LIG_FHA_1	50	56	PF00498	0.488
LIG_FHA_1	58	64	PF00498	0.464
LIG_FHA_2	247	253	PF00498	0.411
LIG_FHA_2	261	267	PF00498	0.460
LIG_FHA_2	291	297	PF00498	0.306
LIG_FHA_2	3	9	PF00498	0.359
LIG_LIR_Apic_2	314	318	PF02991	0.406
LIG_LIR_Gen_1	122	130	PF02991	0.533
LIG_LIR_Gen_1	299	306	PF02991	0.398
LIG_LIR_Gen_1	309	320	PF02991	0.320
LIG_LIR_Nem_3	122	126	PF02991	0.409
LIG_LIR_Nem_3	154	160	PF02991	0.488
LIG_LIR_Nem_3	299	304	PF02991	0.429
LIG_LIR_Nem_3	309	315	PF02991	0.421
LIG_NRBOX	16	22	PF00104	0.349
LIG_PCNA_PIPBox_1	210	219	PF02747	0.417
LIG_PCNA_yPIPBox_3	382	392	PF02747	0.400
LIG_Pex14_1	221	225	PF04695	0.309
LIG_SH2_STAP1	153	157	PF00017	0.390
LIG_SH2_STAP1	89	93	PF00017	0.330
LIG_SH2_STAT3	251	254	PF00017	0.452
LIG_SH2_STAT3	498	501	PF00017	0.403
LIG_SH2_STAT3	89	92	PF00017	0.330
LIG_SH2_STAT5	323	326	PF00017	0.331
LIG_SH2_STAT5	391	394	PF00017	0.358
LIG_SH2_STAT5	4	7	PF00017	0.358
LIG_SH2_STAT5	417	420	PF00017	0.401
LIG_SH2_STAT5	493	496	PF00017	0.524
LIG_SH2_STAT5	498	501	PF00017	0.404
LIG_SH3_3	195	201	PF00018	0.309
LIG_SH3_3	351	357	PF00018	0.404
LIG_SUMO_SIM_par_1	172	178	PF11976	0.502
LIG_UBA3_1	431	436	PF00899	0.518
LIG_WRC_WIRS_1	123	128	PF05994	0.436
MOD_CDK_SPxxK_3	314	321	PF00069	0.324
MOD_CDK_SPxxK_3	54	61	PF00069	0.306
MOD_CK1_1	107	113	PF00069	0.480
MOD_CK1_1	145	151	PF00069	0.358
MOD_CK1_1	162	168	PF00069	0.338
MOD_CK1_1	245	251	PF00069	0.330
MOD_CK1_1	422	428	PF00069	0.317
MOD_CK1_1	57	63	PF00069	0.348
MOD_CK2_1	2	8	PF00069	0.518
MOD_CK2_1	260	266	PF00069	0.533
MOD_CK2_1	267	273	PF00069	0.572
MOD_CK2_1	290	296	PF00069	0.309
MOD_GlcNHglycan	106	109	PF01048	0.495
MOD_GlcNHglycan	144	147	PF01048	0.459
MOD_GlcNHglycan	161	164	PF01048	0.306
MOD_GlcNHglycan	226	229	PF01048	0.391
MOD_GlcNHglycan	309	312	PF01048	0.379
MOD_GSK3_1	15	22	PF00069	0.460
MOD_GSK3_1	242	249	PF00069	0.529
MOD_GSK3_1	260	267	PF00069	0.506
MOD_GSK3_1	27	34	PF00069	0.504
MOD_GSK3_1	290	297	PF00069	0.480
MOD_GSK3_1	49	56	PF00069	0.448
MOD_LATS_1	269	275	PF00433	0.330
MOD_N-GLC_1	338	343	PF02516	0.474
MOD_NEK2_1	106	111	PF00069	0.494
MOD_NEK2_1	260	265	PF00069	0.424
MOD_NEK2_1	338	343	PF00069	0.515
MOD_NEK2_1	431	436	PF00069	0.328
MOD_PIKK_1	2	8	PF00454	0.389
MOD_PIKK_1	294	300	PF00454	0.464
MOD_PIKK_1	463	469	PF00454	0.515
MOD_PIKK_1	88	94	PF00454	0.578
MOD_PKA_2	15	21	PF00069	0.257
MOD_PKA_2	245	251	PF00069	0.397
MOD_Plk_1	242	248	PF00069	0.342
MOD_Plk_1	338	344	PF00069	0.465
MOD_Plk_1	440	446	PF00069	0.330
MOD_Plk_1	72	78	PF00069	0.485
MOD_Plk_4	122	128	PF00069	0.525
MOD_Plk_4	175	181	PF00069	0.408
MOD_Plk_4	27	33	PF00069	0.408
MOD_Plk_4	422	428	PF00069	0.427
MOD_ProDKin_1	107	113	PF00069	0.310
MOD_ProDKin_1	314	320	PF00069	0.435
MOD_ProDKin_1	54	60	PF00069	0.399
MOD_SUMO_for_1	435	438	PF00179	0.330
MOD_SUMO_for_1	70	73	PF00179	0.561
MOD_SUMO_rev_2	170	178	PF00179	0.449
MOD_SUMO_rev_2	22	31	PF00179	0.317
TRG_DiLeu_BaEn_1	333	338	PF01217	0.330
TRG_DiLeu_BaEn_1	46	51	PF01217	0.495
TRG_DiLeu_BaLyEn_6	108	113	PF01217	0.330
TRG_DiLeu_BaLyEn_6	315	320	PF01217	0.447
TRG_ENDOCYTIC_2	153	156	PF00928	0.398
TRG_ENDOCYTIC_2	391	394	PF00928	0.400
TRG_ENDOCYTIC_2	4	7	PF00928	0.448
TRG_ER_diArg_1	347	350	PF00400	0.501
TRG_ER_diArg_1	496	498	PF00400	0.400
TRG_ER_diArg_1	85	87	PF00400	0.407
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.330
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.564

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IZ28	Bodo saltans	45%	100%
A0A1X0NY67	Trypanosomatidae	53%	99%
A0A1X0P441	Trypanosomatidae	55%	100%
A0A1X0P598	Trypanosomatidae	57%	100%
A0A3Q8IBW2	Leishmania donovani	53%	100%
A0A3Q8IJY8	Leishmania donovani	47%	100%
A0A3Q8IU74	Leishmania donovani	55%	100%
A0A3S7WSA3	Leishmania donovani	96%	100%
A0A422P042	Trypanosoma rangeli	54%	100%
A0A422P4R1	Trypanosoma rangeli	54%	100%
A4H716	Leishmania braziliensis	80%	100%
A4HLW4	Leishmania braziliensis	56%	100%
A4HVE5	Leishmania infantum	95%	100%
A4HVW0	Leishmania infantum	53%	100%
A4I993	Leishmania infantum	55%	100%
A4IC85	Leishmania infantum	47%	100%
D0A656	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
E9AP43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B493	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
P42663	Thermus aquaticus	36%	98%
P50848	Bacillus subtilis (strain 168)	34%	100%
Q4Q0D4	Leishmania major	51%	100%
Q4Q3T3	Leishmania major	55%	100%
Q4QFW7	Leishmania major	53%	100%
Q5SLM3	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	35%	99%
Q8U3L0	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	34%	100%
V5DQA0	Trypanosoma cruzi	55%	100%