Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QGE4_LEIMA

TriTrypDb:

LmjF.13.0100 , LMJLV39_130006000 , LMJSD75_130006100

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	496	500	PF00656	0.667
CLV_NRD_NRD_1	149	151	PF00675	0.413
CLV_NRD_NRD_1	410	412	PF00675	0.410
CLV_NRD_NRD_1	58	60	PF00675	0.400
CLV_PCSK_FUR_1	147	151	PF00082	0.415
CLV_PCSK_KEX2_1	149	151	PF00082	0.413
CLV_PCSK_KEX2_1	290	292	PF00082	0.414
CLV_PCSK_KEX2_1	57	59	PF00082	0.399
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.414
CLV_PCSK_SKI1_1	192	196	PF00082	0.231
CLV_PCSK_SKI1_1	317	321	PF00082	0.371
CLV_PCSK_SKI1_1	335	339	PF00082	0.384
DEG_APCC_DBOX_1	316	324	PF00400	0.567
DEG_APCC_DBOX_1	82	90	PF00400	0.596
DEG_MDM2_SWIB_1	226	234	PF02201	0.624
DEG_SPOP_SBC_1	258	262	PF00917	0.603
DEG_SPOP_SBC_1	483	487	PF00917	0.651
DOC_CDC14_PxL_1	182	190	PF14671	0.222
DOC_CKS1_1	103	108	PF01111	0.648
DOC_CKS1_1	520	525	PF01111	0.666
DOC_CYCLIN_RxL_1	129	140	PF00134	0.622
DOC_MAPK_DCC_7	83	91	PF00069	0.596
DOC_MAPK_gen_1	149	159	PF00069	0.599
DOC_MAPK_gen_1	39	47	PF00069	0.607
DOC_MAPK_gen_1	71	80	PF00069	0.601
DOC_MAPK_MEF2A_6	152	161	PF00069	0.595
DOC_MAPK_MEF2A_6	83	92	PF00069	0.597
DOC_PP1_SILK_1	192	197	PF00149	0.231
DOC_PP2B_LxvP_1	110	113	PF13499	0.631
DOC_PP2B_LxvP_1	450	453	PF13499	0.645
DOC_PP2B_PxIxI_1	431	437	PF00149	0.632
DOC_PP4_FxxP_1	181	184	PF00568	0.403
DOC_PP4_FxxP_1	25	28	PF00568	0.603
DOC_PP4_FxxP_1	272	275	PF00568	0.621
DOC_PP4_FxxP_1	92	95	PF00568	0.599
DOC_USP7_MATH_1	235	239	PF00917	0.632
DOC_USP7_MATH_1	259	263	PF00917	0.613
DOC_USP7_MATH_1	275	279	PF00917	0.609
DOC_USP7_MATH_1	29	33	PF00917	0.640
DOC_USP7_MATH_1	399	403	PF00917	0.607
DOC_USP7_UBL2_3	290	294	PF12436	0.611
DOC_WW_Pin1_4	102	107	PF00397	0.648
DOC_WW_Pin1_4	180	185	PF00397	0.419
DOC_WW_Pin1_4	207	212	PF00397	0.675
DOC_WW_Pin1_4	24	29	PF00397	0.632
DOC_WW_Pin1_4	271	276	PF00397	0.651
DOC_WW_Pin1_4	31	36	PF00397	0.631
DOC_WW_Pin1_4	393	398	PF00397	0.779
DOC_WW_Pin1_4	419	424	PF00397	0.654
DOC_WW_Pin1_4	470	475	PF00397	0.674
DOC_WW_Pin1_4	502	507	PF00397	0.716
DOC_WW_Pin1_4	51	56	PF00397	0.578
DOC_WW_Pin1_4	510	515	PF00397	0.674
DOC_WW_Pin1_4	519	524	PF00397	0.667
LIG_14-3-3_CanoR_1	204	209	PF00244	0.632
LIG_14-3-3_CanoR_1	317	323	PF00244	0.566
LIG_14-3-3_CanoR_1	354	360	PF00244	0.603
LIG_14-3-3_CanoR_1	424	434	PF00244	0.672
LIG_14-3-3_CanoR_1	438	446	PF00244	0.640
LIG_14-3-3_CanoR_1	7	13	PF00244	0.616
LIG_14-3-3_CterR_2	528	533	PF00244	0.657
LIG_Actin_WH2_2	183	198	PF00022	0.222
LIG_Actin_WH2_2	238	255	PF00022	0.609
LIG_Actin_WH2_2	340	356	PF00022	0.586
LIG_BIR_III_2	499	503	PF00653	0.670
LIG_BRCT_BRCA1_1	73	77	PF00533	0.647
LIG_FHA_1	140	146	PF00498	0.618
LIG_FHA_1	167	173	PF00498	0.231
LIG_FHA_1	297	303	PF00498	0.614
LIG_FHA_1	408	414	PF00498	0.598
LIG_FHA_1	47	53	PF00498	0.606
LIG_FHA_2	494	500	PF00498	0.667
LIG_GBD_Chelix_1	413	421	PF00786	0.418
LIG_LIR_Apic_2	101	106	PF02991	0.601
LIG_LIR_Apic_2	269	275	PF02991	0.621
LIG_LIR_Gen_1	116	124	PF02991	0.659
LIG_LIR_Gen_1	220	227	PF02991	0.639
LIG_LIR_Gen_1	247	255	PF02991	0.611
LIG_LIR_Gen_1	280	289	PF02991	0.609
LIG_LIR_Gen_1	365	376	PF02991	0.580
LIG_LIR_Gen_1	74	84	PF02991	0.645
LIG_LIR_LC3C_4	169	174	PF02991	0.231
LIG_LIR_Nem_3	116	121	PF02991	0.657
LIG_LIR_Nem_3	220	226	PF02991	0.641
LIG_LIR_Nem_3	229	233	PF02991	0.593
LIG_LIR_Nem_3	243	249	PF02991	0.559
LIG_LIR_Nem_3	280	285	PF02991	0.766
LIG_LIR_Nem_3	365	371	PF02991	0.585
LIG_LIR_Nem_3	74	80	PF02991	0.646
LIG_MYND_1	84	88	PF01753	0.593
LIG_Pex14_2	226	230	PF04695	0.626
LIG_Pex14_2	282	286	PF04695	0.607
LIG_Pex14_2	336	340	PF04695	0.597
LIG_Pex14_2	36	40	PF04695	0.603
LIG_REV1ctd_RIR_1	334	342	PF16727	0.597
LIG_REV1ctd_RIR_1	89	94	PF16727	0.602
LIG_SH2_CRK	249	253	PF00017	0.614
LIG_SH2_NCK_1	368	372	PF00017	0.583
LIG_SH2_SRC	368	371	PF00017	0.659
LIG_SH2_STAP1	368	372	PF00017	0.679
LIG_SH3_3	170	176	PF00018	0.231
LIG_SH3_3	468	474	PF00018	0.638
LIG_SH3_3	508	514	PF00018	0.659
LIG_SH3_CIN85_PxpxPR_1	498	503	PF14604	0.667
LIG_SUMO_SIM_anti_2	169	175	PF11976	0.231
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.638
LIG_SUMO_SIM_par_1	159	164	PF11976	0.231
LIG_SUMO_SIM_par_1	185	191	PF11976	0.231
LIG_SUMO_SIM_par_1	432	437	PF11976	0.633
LIG_SUMO_SIM_par_1	467	473	PF11976	0.681
LIG_TRAF2_1	123	126	PF00917	0.661
LIG_WW_2	514	517	PF00397	0.662
MOD_CDC14_SPxK_1	473	476	PF00782	0.674
MOD_CDC14_SPxK_1	477	480	PF00782	0.676
MOD_CDC14_SPxK_1	54	57	PF00782	0.595
MOD_CDK_SPK_2	419	424	PF00069	0.654
MOD_CDK_SPxK_1	470	476	PF00069	0.674
MOD_CDK_SPxK_1	51	57	PF00069	0.601
MOD_CDK_SPxxK_3	51	58	PF00069	0.600
MOD_CDK_SPxxK_3	519	526	PF00069	0.660
MOD_CK1_1	207	213	PF00069	0.673
MOD_CK1_1	221	227	PF00069	0.592
MOD_CK1_1	238	244	PF00069	0.551
MOD_CK1_1	260	266	PF00069	0.658
MOD_CK1_1	419	425	PF00069	0.689
MOD_CK1_1	439	445	PF00069	0.618
MOD_CK1_1	484	490	PF00069	0.653
MOD_CK1_1	504	510	PF00069	0.669
MOD_CK1_1	66	72	PF00069	0.602
MOD_CK1_1	98	104	PF00069	0.623
MOD_CK2_1	119	125	PF00069	0.662
MOD_CK2_1	259	265	PF00069	0.652
MOD_CK2_1	363	369	PF00069	0.589
MOD_GlcNHglycan	121	124	PF01048	0.465
MOD_GlcNHglycan	163	166	PF01048	0.231
MOD_GlcNHglycan	237	241	PF01048	0.414
MOD_GlcNHglycan	265	269	PF01048	0.453
MOD_GlcNHglycan	31	34	PF01048	0.439
MOD_GlcNHglycan	357	360	PF01048	0.363
MOD_GlcNHglycan	418	421	PF01048	0.430
MOD_GlcNHglycan	439	442	PF01048	0.484
MOD_GlcNHglycan	65	68	PF01048	0.432
MOD_GlcNHglycan	73	76	PF01048	0.437
MOD_GlcNHglycan	97	100	PF01048	0.428
MOD_GSK3_1	135	142	PF00069	0.647
MOD_GSK3_1	196	203	PF00069	0.483
MOD_GSK3_1	207	214	PF00069	0.651
MOD_GSK3_1	217	224	PF00069	0.625
MOD_GSK3_1	24	31	PF00069	0.581
MOD_GSK3_1	257	264	PF00069	0.646
MOD_GSK3_1	271	278	PF00069	0.596
MOD_GSK3_1	301	308	PF00069	0.628
MOD_GSK3_1	309	316	PF00069	0.599
MOD_GSK3_1	432	439	PF00069	0.663
MOD_GSK3_1	470	477	PF00069	0.682
MOD_GSK3_1	502	509	PF00069	0.715
MOD_GSK3_1	7	14	PF00069	0.653
MOD_GSK3_1	78	85	PF00069	0.624
MOD_GSK3_1	98	105	PF00069	0.597
MOD_N-GLC_1	116	121	PF02516	0.457
MOD_NEK2_1	188	193	PF00069	0.231
MOD_NEK2_1	195	200	PF00069	0.220
MOD_NEK2_1	245	250	PF00069	0.560
MOD_NEK2_1	301	306	PF00069	0.624
MOD_NEK2_1	318	323	PF00069	0.551
MOD_NEK2_1	353	358	PF00069	0.598
MOD_NEK2_1	407	412	PF00069	0.607
MOD_NEK2_1	63	68	PF00069	0.617
MOD_NEK2_1	78	83	PF00069	0.630
MOD_PIKK_1	311	317	PF00454	0.622
MOD_PIKK_1	493	499	PF00454	0.666
MOD_PIKK_1	504	510	PF00454	0.648
MOD_PK_1	196	202	PF00069	0.231
MOD_PKA_2	195	201	PF00069	0.231
MOD_PKA_2	305	311	PF00069	0.631
MOD_PKA_2	353	359	PF00069	0.600
MOD_PKA_2	437	443	PF00069	0.656
MOD_PKA_2	82	88	PF00069	0.595
MOD_PKB_1	204	212	PF00069	0.631
MOD_Plk_1	116	122	PF00069	0.659
MOD_Plk_1	296	302	PF00069	0.613
MOD_Plk_2-3	363	369	PF00069	0.544
MOD_Plk_4	196	202	PF00069	0.260
MOD_Plk_4	318	324	PF00069	0.609
MOD_Plk_4	363	369	PF00069	0.589
MOD_Plk_4	382	388	PF00069	0.536
MOD_Plk_4	98	104	PF00069	0.627
MOD_ProDKin_1	102	108	PF00069	0.649
MOD_ProDKin_1	180	186	PF00069	0.419
MOD_ProDKin_1	207	213	PF00069	0.673
MOD_ProDKin_1	24	30	PF00069	0.632
MOD_ProDKin_1	271	277	PF00069	0.645
MOD_ProDKin_1	31	37	PF00069	0.633
MOD_ProDKin_1	393	399	PF00069	0.777
MOD_ProDKin_1	419	425	PF00069	0.657
MOD_ProDKin_1	470	476	PF00069	0.674
MOD_ProDKin_1	502	508	PF00069	0.717
MOD_ProDKin_1	51	57	PF00069	0.578
MOD_ProDKin_1	510	516	PF00069	0.676
MOD_ProDKin_1	519	525	PF00069	0.666
MOD_SUMO_rev_2	332	337	PF00179	0.556
TRG_DiLeu_BaEn_1	229	234	PF01217	0.623
TRG_DiLeu_BaEn_1	403	408	PF01217	0.621
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.594
TRG_DiLeu_BaLyEn_6	183	188	PF01217	0.222
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.654
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.599
TRG_ENDOCYTIC_2	249	252	PF00928	0.615
TRG_ENDOCYTIC_2	368	371	PF00928	0.582
TRG_ER_diArg_1	146	149	PF00400	0.616
TRG_ER_diArg_1	526	529	PF00400	0.655
TRG_ER_diArg_1	56	59	PF00400	0.599
TRG_NES_CRM1_1	365	378	PF08389	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
E9AP44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	86%