SURF1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

SURF1-like protein

Gene product:

SURF1 family, putative

Species:

Leishmania major

UniProt:

Q4QGE3_LEIMA

TriTrypDb:

LmjF.13.0110 , LMJLV39_130006100 , LMJSD75_130006200

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005743	mitochondrial inner membrane	5	12
GO:0016020	membrane	2	12
GO:0019866	organelle inner membrane	4	12
GO:0031090	organelle membrane	3	12
GO:0031966	mitochondrial membrane	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QGE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.272
CLV_NRD_NRD_1	149	151	PF00675	0.450
CLV_NRD_NRD_1	192	194	PF00675	0.449
CLV_NRD_NRD_1	235	237	PF00675	0.466
CLV_NRD_NRD_1	27	29	PF00675	0.462
CLV_NRD_NRD_1	274	276	PF00675	0.359
CLV_NRD_NRD_1	282	284	PF00675	0.335
CLV_NRD_NRD_1	296	298	PF00675	0.327
CLV_NRD_NRD_1	342	344	PF00675	0.420
CLV_NRD_NRD_1	62	64	PF00675	0.528
CLV_PCSK_FUR_1	313	317	PF00082	0.388
CLV_PCSK_KEX2_1	191	193	PF00082	0.463
CLV_PCSK_KEX2_1	234	236	PF00082	0.467
CLV_PCSK_KEX2_1	27	29	PF00082	0.437
CLV_PCSK_KEX2_1	274	276	PF00082	0.364
CLV_PCSK_KEX2_1	296	298	PF00082	0.381
CLV_PCSK_KEX2_1	315	317	PF00082	0.335
CLV_PCSK_KEX2_1	62	64	PF00082	0.504
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.473
CLV_PCSK_PC7_1	230	236	PF00082	0.457
CLV_PCSK_SKI1_1	129	133	PF00082	0.437
CLV_PCSK_SKI1_1	146	150	PF00082	0.437
CLV_PCSK_SKI1_1	277	281	PF00082	0.309
CLV_PCSK_SKI1_1	62	66	PF00082	0.529
DOC_CKS1_1	101	106	PF01111	0.237
DOC_MAPK_MEF2A_6	2	10	PF00069	0.462
DOC_USP7_UBL2_3	284	288	PF12436	0.540
DOC_USP7_UBL2_3	39	43	PF12436	0.222
DOC_WW_Pin1_4	100	105	PF00397	0.254
DOC_WW_Pin1_4	138	143	PF00397	0.329
DOC_WW_Pin1_4	161	166	PF00397	0.318
DOC_WW_Pin1_4	244	249	PF00397	0.329
DOC_WW_Pin1_4	41	46	PF00397	0.291
LIG_Actin_WH2_2	301	317	PF00022	0.626
LIG_deltaCOP1_diTrp_1	174	183	PF00928	0.248
LIG_FHA_1	245	251	PF00498	0.248
LIG_FHA_2	101	107	PF00498	0.259
LIG_FHA_2	333	339	PF00498	0.660
LIG_FHA_2	53	59	PF00498	0.280
LIG_LIR_Gen_1	110	121	PF02991	0.237
LIG_LIR_Gen_1	174	185	PF02991	0.237
LIG_LIR_Gen_1	240	250	PF02991	0.237
LIG_LIR_Gen_1	252	261	PF02991	0.237
LIG_LIR_LC3C_4	176	180	PF02991	0.257
LIG_LIR_Nem_3	110	116	PF02991	0.237
LIG_LIR_Nem_3	174	180	PF02991	0.245
LIG_LIR_Nem_3	240	246	PF02991	0.237
LIG_LIR_Nem_3	252	257	PF02991	0.237
LIG_LIR_Nem_3	265	270	PF02991	0.417
LIG_LIR_Nem_3	4	8	PF02991	0.422
LIG_LIR_Nem_3	58	64	PF02991	0.251
LIG_MAD2	225	233	PF02301	0.280
LIG_SH2_CRK	267	271	PF00017	0.350
LIG_SH2_CRK	5	9	PF00017	0.452
LIG_SH2_CRK	61	65	PF00017	0.291
LIG_SH2_GRB2like	285	288	PF00017	0.520
LIG_SH2_PTP2	243	246	PF00017	0.237
LIG_SH2_STAT3	346	349	PF00017	0.587
LIG_SH2_STAT5	135	138	PF00017	0.237
LIG_SH2_STAT5	212	215	PF00017	0.238
LIG_SH2_STAT5	243	246	PF00017	0.237
LIG_SH2_STAT5	254	257	PF00017	0.274
LIG_SH2_STAT5	285	288	PF00017	0.667
LIG_SH3_3	176	182	PF00018	0.288
LIG_SH3_3	98	104	PF00018	0.237
LIG_TRAF2_1	307	310	PF00917	0.556
LIG_TYR_ITIM	241	246	PF00017	0.237
LIG_UBA3_1	279	284	PF00899	0.616
LIG_WRC_WIRS_1	15	20	PF05994	0.274
MOD_CK1_1	14	20	PF00069	0.417
MOD_CK1_1	337	343	PF00069	0.653
MOD_CK1_1	44	50	PF00069	0.366
MOD_CK1_1	82	88	PF00069	0.339
MOD_CK2_1	100	106	PF00069	0.281
MOD_CK2_1	332	338	PF00069	0.660
MOD_CK2_1	52	58	PF00069	0.282
MOD_GlcNHglycan	201	204	PF01048	0.521
MOD_GlcNHglycan	217	222	PF01048	0.391
MOD_GlcNHglycan	52	55	PF01048	0.388
MOD_GSK3_1	10	17	PF00069	0.274
MOD_GSK3_1	330	337	PF00069	0.680
MOD_N-GLC_2	57	59	PF02516	0.539
MOD_NEK2_1	10	15	PF00069	0.278
MOD_NEK2_1	155	160	PF00069	0.258
MOD_NEK2_1	185	190	PF00069	0.346
MOD_NEK2_1	257	262	PF00069	0.329
MOD_PIKK_1	345	351	PF00454	0.653
MOD_PKA_1	315	321	PF00069	0.581
MOD_PKA_2	315	321	PF00069	0.581
MOD_Plk_1	173	179	PF00069	0.237
MOD_Plk_1	239	245	PF00069	0.237
MOD_Plk_2-3	52	58	PF00069	0.291
MOD_Plk_4	11	17	PF00069	0.411
MOD_Plk_4	155	161	PF00069	0.238
MOD_Plk_4	173	179	PF00069	0.259
MOD_Plk_4	185	191	PF00069	0.278
MOD_Plk_4	239	245	PF00069	0.242
MOD_Plk_4	249	255	PF00069	0.228
MOD_Plk_4	262	268	PF00069	0.286
MOD_ProDKin_1	100	106	PF00069	0.254
MOD_ProDKin_1	138	144	PF00069	0.329
MOD_ProDKin_1	161	167	PF00069	0.318
MOD_ProDKin_1	244	250	PF00069	0.329
MOD_ProDKin_1	41	47	PF00069	0.291
TRG_DiLeu_BaEn_1	73	78	PF01217	0.237
TRG_DiLeu_BaEn_4	309	315	PF01217	0.627
TRG_ENDOCYTIC_2	212	215	PF00928	0.248
TRG_ENDOCYTIC_2	243	246	PF00928	0.237
TRG_ENDOCYTIC_2	254	257	PF00928	0.274
TRG_ENDOCYTIC_2	267	270	PF00928	0.274
TRG_ENDOCYTIC_2	5	8	PF00928	0.428
TRG_ENDOCYTIC_2	61	64	PF00928	0.339
TRG_ER_diArg_1	190	193	PF00400	0.253
TRG_ER_diArg_1	227	230	PF00400	0.280
TRG_ER_diArg_1	233	236	PF00400	0.258
TRG_ER_diArg_1	26	28	PF00400	0.238
TRG_ER_diArg_1	273	275	PF00400	0.564
TRG_ER_diArg_1	61	63	PF00400	0.304
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA6	Leptomonas seymouri	82%	100%
A0A0S4IJQ4	Bodo saltans	61%	74%
A0A1X0NNA6	Trypanosomatidae	67%	100%
A0A3R7MI38	Trypanosoma rangeli	66%	100%
A0A3S5H6M9	Leishmania donovani	95%	100%
A4H718	Leishmania braziliensis	88%	100%
A4HVE7	Leishmania infantum	95%	100%
D0A6W3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	66%	100%
E9AP45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BIC3	Trypanosoma cruzi	65%	100%