Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinesin-13 2

Species:

Leishmania major

UniProt:

Q4QGE1_LEIMA

TriTrypDb:

LmjF.13.0130 , LMJLV39_130006300 , LMJSD75_130006400

Length:

729

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005874	microtubule	6	11
GO:0005929	cilium	4	2
GO:0005930	axoneme	2	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0097542	ciliary tip	2	2
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QGE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGE1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0006996	organelle organization	4	2
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0007019	microtubule depolymerization	5	2
GO:0009987	cellular process	1	11
GO:0010938	cytoplasmic microtubule depolymerization	5	2
GO:0016043	cellular component organization	3	2
GO:0022411	cellular component disassembly	4	2
GO:0022607	cellular component assembly	4	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0031109	microtubule polymerization or depolymerization	4	2
GO:0031122	cytoplasmic microtubule organization	4	2
GO:0032984	protein-containing complex disassembly	5	2
GO:0043933	protein-containing complex organization	4	2
GO:0044782	cilium organization	5	2
GO:0051261	protein depolymerization	6	2
GO:0060271	cilium assembly	6	2
GO:0060404	axonemal microtubule depolymerization	6	2
GO:0061523	cilium disassembly	6	2
GO:0070925	organelle assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0097435	supramolecular fiber organization	4	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2
GO:1903008	organelle disassembly	5	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0008270	zinc ion binding	6	11
GO:0015631	tubulin binding	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.322
CLV_NRD_NRD_1	300	302	PF00675	0.325
CLV_NRD_NRD_1	39	41	PF00675	0.377
CLV_NRD_NRD_1	435	437	PF00675	0.270
CLV_NRD_NRD_1	504	506	PF00675	0.472
CLV_NRD_NRD_1	507	509	PF00675	0.494
CLV_NRD_NRD_1	611	613	PF00675	0.679
CLV_NRD_NRD_1	708	710	PF00675	0.543
CLV_PCSK_FUR_1	505	509	PF00082	0.568
CLV_PCSK_KEX2_1	278	280	PF00082	0.322
CLV_PCSK_KEX2_1	302	304	PF00082	0.322
CLV_PCSK_KEX2_1	386	388	PF00082	0.629
CLV_PCSK_KEX2_1	41	43	PF00082	0.405
CLV_PCSK_KEX2_1	435	437	PF00082	0.283
CLV_PCSK_KEX2_1	506	508	PF00082	0.563
CLV_PCSK_KEX2_1	611	613	PF00082	0.679
CLV_PCSK_KEX2_1	708	710	PF00082	0.543
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.347
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.602
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.405
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.581
CLV_PCSK_PC7_1	382	388	PF00082	0.593
CLV_PCSK_SKI1_1	286	290	PF00082	0.304
CLV_PCSK_SKI1_1	353	357	PF00082	0.498
CLV_PCSK_SKI1_1	480	484	PF00082	0.527
CLV_PCSK_SKI1_1	561	565	PF00082	0.627
DEG_APCC_DBOX_1	140	148	PF00400	0.369
DEG_Nend_UBRbox_1	1	4	PF02207	0.681
DEG_SCF_FBW7_1	524	530	PF00400	0.663
DEG_SCF_FBW7_2	75	82	PF00400	0.322
DEG_SPOP_SBC_1	245	249	PF00917	0.259
DEG_SPOP_SBC_1	547	551	PF00917	0.771
DOC_CKS1_1	524	529	PF01111	0.668
DOC_CYCLIN_RxL_1	283	293	PF00134	0.304
DOC_CYCLIN_RxL_1	477	487	PF00134	0.550
DOC_CYCLIN_yCln2_LP_2	355	361	PF00134	0.636
DOC_MAPK_gen_1	230	240	PF00069	0.322
DOC_MAPK_gen_1	301	307	PF00069	0.305
DOC_MAPK_MEF2A_6	233	242	PF00069	0.304
DOC_PP1_RVXF_1	253	259	PF00149	0.437
DOC_PP2B_PxIxI_1	32	38	PF00149	0.470
DOC_USP7_MATH_1	245	249	PF00917	0.280
DOC_USP7_MATH_1	3	7	PF00917	0.797
DOC_USP7_MATH_1	31	35	PF00917	0.539
DOC_USP7_MATH_1	536	540	PF00917	0.626
DOC_USP7_MATH_1	547	551	PF00917	0.704
DOC_USP7_MATH_1	555	559	PF00917	0.731
DOC_USP7_MATH_1	568	572	PF00917	0.822
DOC_USP7_MATH_1	573	577	PF00917	0.733
DOC_USP7_MATH_1	607	611	PF00917	0.804
DOC_USP7_MATH_1	624	628	PF00917	0.688
DOC_USP7_MATH_1	652	656	PF00917	0.730
DOC_WW_Pin1_4	19	24	PF00397	0.605
DOC_WW_Pin1_4	29	34	PF00397	0.641
DOC_WW_Pin1_4	330	335	PF00397	0.304
DOC_WW_Pin1_4	411	416	PF00397	0.487
DOC_WW_Pin1_4	523	528	PF00397	0.560
DOC_WW_Pin1_4	75	80	PF00397	0.322
LIG_14-3-3_CanoR_1	13	21	PF00244	0.739
LIG_14-3-3_CanoR_1	230	240	PF00244	0.374
LIG_14-3-3_CanoR_1	255	259	PF00244	0.304
LIG_14-3-3_CanoR_1	296	301	PF00244	0.347
LIG_14-3-3_CanoR_1	323	332	PF00244	0.347
LIG_14-3-3_CanoR_1	528	535	PF00244	0.718
LIG_14-3-3_CanoR_1	572	581	PF00244	0.804
LIG_14-3-3_CanoR_1	611	617	PF00244	0.741
LIG_14-3-3_CanoR_1	721	725	PF00244	0.550
LIG_Actin_WH2_2	205	222	PF00022	0.322
LIG_Actin_WH2_2	669	685	PF00022	0.642
LIG_FHA_1	148	154	PF00498	0.404
LIG_FHA_1	16	22	PF00498	0.721
LIG_FHA_1	197	203	PF00498	0.370
LIG_FHA_1	311	317	PF00498	0.304
LIG_FHA_1	324	330	PF00498	0.304
LIG_FHA_1	597	603	PF00498	0.777
LIG_FHA_1	713	719	PF00498	0.616
LIG_FHA_1	76	82	PF00498	0.355
LIG_FHA_2	152	158	PF00498	0.487
LIG_FHA_2	255	261	PF00498	0.332
LIG_FHA_2	275	281	PF00498	0.249
LIG_FHA_2	536	542	PF00498	0.664
LIG_FHA_2	65	71	PF00498	0.439
LIG_FHA_2	693	699	PF00498	0.514
LIG_FHA_2	95	101	PF00498	0.404
LIG_GBD_Chelix_1	678	686	PF00786	0.606
LIG_LIR_Apic_2	665	670	PF02991	0.620
LIG_LIR_Gen_1	188	198	PF02991	0.423
LIG_LIR_Gen_1	257	262	PF02991	0.347
LIG_LIR_Gen_1	85	95	PF02991	0.327
LIG_LIR_Nem_3	164	169	PF02991	0.346
LIG_LIR_Nem_3	188	193	PF02991	0.366
LIG_LIR_Nem_3	257	261	PF02991	0.356
LIG_LIR_Nem_3	85	91	PF02991	0.327
LIG_NRBOX	172	178	PF00104	0.304
LIG_PCNA_yPIPBox_3	699	711	PF02747	0.574
LIG_RPA_C_Fungi	606	618	PF08784	0.539
LIG_SH2_CRK	174	178	PF00017	0.437
LIG_SH2_CRK	190	194	PF00017	0.382
LIG_SH2_CRK	667	671	PF00017	0.562
LIG_SH2_GRB2like	190	193	PF00017	0.437
LIG_SH2_NCK_1	88	92	PF00017	0.437
LIG_SH2_SRC	190	193	PF00017	0.437
LIG_SH2_SRC	88	91	PF00017	0.437
LIG_SH2_STAP1	145	149	PF00017	0.451
LIG_SH2_STAP1	348	352	PF00017	0.304
LIG_SH2_STAP1	696	700	PF00017	0.500
LIG_SH2_STAP1	88	92	PF00017	0.437
LIG_SH2_STAT5	420	423	PF00017	0.475
LIG_SH2_STAT5	473	476	PF00017	0.304
LIG_SH3_1	40	46	PF00018	0.469
LIG_SH3_2	43	48	PF14604	0.510
LIG_SH3_3	20	26	PF00018	0.636
LIG_SH3_3	355	361	PF00018	0.634
LIG_SH3_3	387	393	PF00018	0.374
LIG_SH3_3	40	46	PF00018	0.317
LIG_SH3_3	492	498	PF00018	0.570
LIG_SH3_3	65	71	PF00018	0.395
LIG_SH3_3	657	663	PF00018	0.564
LIG_SUMO_SIM_par_1	287	293	PF11976	0.304
LIG_TRAF2_1	460	463	PF00917	0.369
LIG_TRAF2_1	97	100	PF00917	0.369
LIG_TRAF2_2	452	457	PF00917	0.369
LIG_UBA3_1	288	292	PF00899	0.304
MOD_CDC14_SPxK_1	414	417	PF00782	0.481
MOD_CDK_SPK_2	523	528	PF00069	0.672
MOD_CDK_SPxK_1	411	417	PF00069	0.487
MOD_CK1_1	12	18	PF00069	0.737
MOD_CK1_1	129	135	PF00069	0.304
MOD_CK1_1	159	165	PF00069	0.369
MOD_CK1_1	231	237	PF00069	0.335
MOD_CK1_1	248	254	PF00069	0.345
MOD_CK1_1	310	316	PF00069	0.310
MOD_CK1_1	5	11	PF00069	0.769
MOD_CK1_1	539	545	PF00069	0.620
MOD_CK1_1	548	554	PF00069	0.642
MOD_CK1_1	571	577	PF00069	0.725
MOD_CK1_1	610	616	PF00069	0.718
MOD_CK1_1	619	625	PF00069	0.663
MOD_CK1_1	720	726	PF00069	0.661
MOD_CK1_1	84	90	PF00069	0.395
MOD_CK2_1	151	157	PF00069	0.480
MOD_CK2_1	161	167	PF00069	0.224
MOD_CK2_1	244	250	PF00069	0.360
MOD_CK2_1	274	280	PF00069	0.417
MOD_CK2_1	3	9	PF00069	0.578
MOD_CK2_1	535	541	PF00069	0.620
MOD_CK2_1	64	70	PF00069	0.473
MOD_CK2_1	94	100	PF00069	0.509
MOD_GlcNHglycan	128	131	PF01048	0.323
MOD_GlcNHglycan	4	8	PF01048	0.834
MOD_GlcNHglycan	561	564	PF01048	0.735
MOD_GlcNHglycan	613	616	PF01048	0.688
MOD_GlcNHglycan	618	621	PF01048	0.696
MOD_GlcNHglycan	647	652	PF01048	0.646
MOD_GSK3_1	131	138	PF00069	0.369
MOD_GSK3_1	143	150	PF00069	0.219
MOD_GSK3_1	15	22	PF00069	0.628
MOD_GSK3_1	153	160	PF00069	0.235
MOD_GSK3_1	244	251	PF00069	0.504
MOD_GSK3_1	261	268	PF00069	0.368
MOD_GSK3_1	270	277	PF00069	0.400
MOD_GSK3_1	3	10	PF00069	0.803
MOD_GSK3_1	427	434	PF00069	0.517
MOD_GSK3_1	523	530	PF00069	0.591
MOD_GSK3_1	535	542	PF00069	0.553
MOD_GSK3_1	545	552	PF00069	0.625
MOD_GSK3_1	555	562	PF00069	0.691
MOD_GSK3_1	564	571	PF00069	0.780
MOD_GSK3_1	602	609	PF00069	0.794
MOD_GSK3_1	652	659	PF00069	0.546
MOD_GSK3_1	712	719	PF00069	0.576
MOD_N-GLC_1	284	289	PF02516	0.304
MOD_N-GLC_1	518	523	PF02516	0.566
MOD_N-GLC_1	602	607	PF02516	0.681
MOD_N-GLC_1	624	629	PF02516	0.606
MOD_NEK2_1	124	129	PF00069	0.319
MOD_NEK2_1	161	166	PF00069	0.385
MOD_NEK2_1	244	249	PF00069	0.412
MOD_NEK2_1	307	312	PF00069	0.316
MOD_NEK2_1	316	321	PF00069	0.315
MOD_NEK2_1	540	545	PF00069	0.615
MOD_NEK2_1	546	551	PF00069	0.590
MOD_NEK2_1	602	607	PF00069	0.729
MOD_NEK2_1	682	687	PF00069	0.516
MOD_NEK2_1	692	697	PF00069	0.611
MOD_NEK2_2	64	69	PF00069	0.531
MOD_PIKK_1	248	254	PF00454	0.438
MOD_PIKK_1	310	316	PF00454	0.304
MOD_PIKK_1	540	546	PF00454	0.739
MOD_PIKK_1	624	630	PF00454	0.608
MOD_PIKK_1	7	13	PF00454	0.661
MOD_PK_1	427	433	PF00069	0.429
MOD_PKA_1	611	617	PF00069	0.535
MOD_PKA_2	12	18	PF00069	0.846
MOD_PKA_2	229	235	PF00069	0.334
MOD_PKA_2	254	260	PF00069	0.304
MOD_PKA_2	265	271	PF00069	0.304
MOD_PKA_2	307	313	PF00069	0.304
MOD_PKA_2	316	322	PF00069	0.304
MOD_PKA_2	527	533	PF00069	0.684
MOD_PKA_2	571	577	PF00069	0.756
MOD_PKA_2	610	616	PF00069	0.628
MOD_PKA_2	720	726	PF00069	0.677
MOD_Plk_1	156	162	PF00069	0.444
MOD_Plk_1	284	290	PF00069	0.326
MOD_Plk_1	339	345	PF00069	0.304
MOD_Plk_2-3	151	157	PF00069	0.369
MOD_Plk_4	131	137	PF00069	0.321
MOD_Plk_4	161	167	PF00069	0.349
MOD_Plk_4	284	290	PF00069	0.304
MOD_Plk_4	31	37	PF00069	0.621
MOD_Plk_4	316	322	PF00069	0.368
MOD_Plk_4	64	70	PF00069	0.446
MOD_Plk_4	656	662	PF00069	0.608
MOD_ProDKin_1	19	25	PF00069	0.606
MOD_ProDKin_1	29	35	PF00069	0.621
MOD_ProDKin_1	330	336	PF00069	0.304
MOD_ProDKin_1	411	417	PF00069	0.487
MOD_ProDKin_1	523	529	PF00069	0.561
MOD_ProDKin_1	75	81	PF00069	0.322
MOD_SUMO_rev_2	179	186	PF00179	0.382
MOD_SUMO_rev_2	234	242	PF00179	0.347
MOD_SUMO_rev_2	268	277	PF00179	0.387
MOD_SUMO_rev_2	350	358	PF00179	0.369
MOD_SUMO_rev_2	405	414	PF00179	0.433
MOD_SUMO_rev_2	463	469	PF00179	0.369
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.304
TRG_ENDOCYTIC_2	174	177	PF00928	0.465
TRG_ENDOCYTIC_2	190	193	PF00928	0.387
TRG_ENDOCYTIC_2	88	91	PF00928	0.437
TRG_ER_diArg_1	300	303	PF00400	0.347
TRG_ER_diArg_1	39	42	PF00400	0.381
TRG_ER_diArg_1	504	507	PF00400	0.535
TRG_ER_diArg_1	707	709	PF00400	0.542
TRG_NES_CRM1_1	252	265	PF08389	0.369
TRG_NLS_MonoCore_2	40	45	PF00514	0.454
TRG_NLS_MonoCore_2	504	509	PF00514	0.563
TRG_NLS_MonoExtC_3	39	44	PF00514	0.418
TRG_NLS_MonoExtC_3	504	510	PF00514	0.488
TRG_NLS_MonoExtN_4	40	45	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P647	Leptomonas seymouri	69%	99%
A0A0S4IJP8	Bodo saltans	49%	97%
A0A1X0NNY0	Trypanosomatidae	63%	100%
A0A3S7WS99	Leishmania donovani	95%	100%
A0A422NBP2	Trypanosoma rangeli	63%	100%
A4H720	Leishmania braziliensis	85%	100%
A4HVE9	Leishmania infantum	95%	100%
D0A6W1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AP47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P46865	Leishmania chagasi	27%	76%