Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGD9_LEIMA

TriTrypDb:

LmjF.13.0150 , LMJLV39_130006500 , LMJSD75_130006600

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	3
GO:0043226	organelle	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QGD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	321	325	PF00656	0.469
CLV_NRD_NRD_1	136	138	PF00675	0.609
CLV_NRD_NRD_1	146	148	PF00675	0.551
CLV_NRD_NRD_1	154	156	PF00675	0.595
CLV_NRD_NRD_1	167	169	PF00675	0.603
CLV_NRD_NRD_1	452	454	PF00675	0.514
CLV_PCSK_FUR_1	144	148	PF00082	0.613
CLV_PCSK_KEX2_1	146	148	PF00082	0.605
CLV_PCSK_KEX2_1	154	156	PF00082	0.692
CLV_PCSK_KEX2_1	167	169	PF00082	0.649
CLV_PCSK_KEX2_1	435	437	PF00082	0.531
CLV_PCSK_KEX2_1	452	454	PF00082	0.578
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.493
CLV_PCSK_SKI1_1	12	16	PF00082	0.470
CLV_PCSK_SKI1_1	154	158	PF00082	0.658
CLV_PCSK_SKI1_1	429	433	PF00082	0.428
CLV_PCSK_SKI1_1	79	83	PF00082	0.667
DEG_SCF_TRCP1_1	209	215	PF00400	0.585
DEG_SPOP_SBC_1	103	107	PF00917	0.785
DOC_CKS1_1	81	86	PF01111	0.761
DOC_CKS1_1	97	102	PF01111	0.524
DOC_MAPK_gen_1	135	143	PF00069	0.583
DOC_MAPK_MEF2A_6	135	143	PF00069	0.637
DOC_PP4_FxxP_1	303	306	PF00568	0.491
DOC_USP7_MATH_1	101	105	PF00917	0.783
DOC_USP7_MATH_1	366	370	PF00917	0.593
DOC_WW_Pin1_4	241	246	PF00397	0.440
DOC_WW_Pin1_4	289	294	PF00397	0.473
DOC_WW_Pin1_4	377	382	PF00397	0.486
DOC_WW_Pin1_4	80	85	PF00397	0.740
DOC_WW_Pin1_4	96	101	PF00397	0.623
LIG_14-3-3_CanoR_1	162	169	PF00244	0.502
LIG_14-3-3_CanoR_1	339	343	PF00244	0.610
LIG_14-3-3_CanoR_1	436	440	PF00244	0.432
LIG_14-3-3_CanoR_1	67	73	PF00244	0.729
LIG_APCC_ABBA_1	275	280	PF00400	0.384
LIG_BRCT_BRCA1_1	106	110	PF00533	0.764
LIG_deltaCOP1_diTrp_1	232	239	PF00928	0.556
LIG_EH1_1	355	363	PF00400	0.635
LIG_eIF4E_1	451	457	PF01652	0.567
LIG_FHA_1	405	411	PF00498	0.643
LIG_FHA_1	97	103	PF00498	0.766
LIG_FHA_2	172	178	PF00498	0.619
LIG_FHA_2	194	200	PF00498	0.570
LIG_FHA_2	241	247	PF00498	0.467
LIG_FHA_2	319	325	PF00498	0.614
LIG_Integrin_RGD_1	54	56	PF01839	0.607
LIG_LIR_Apic_2	301	306	PF02991	0.521
LIG_LIR_Gen_1	196	204	PF02991	0.580
LIG_LIR_Gen_1	236	245	PF02991	0.412
LIG_LIR_Nem_3	13	18	PF02991	0.498
LIG_LIR_Nem_3	150	156	PF02991	0.616
LIG_LIR_Nem_3	196	200	PF02991	0.558
LIG_LIR_Nem_3	236	240	PF02991	0.395
LIG_LIR_Nem_3	460	466	PF02991	0.389
LIG_LIR_Nem_3	56	62	PF02991	0.601
LIG_MYND_1	377	381	PF01753	0.528
LIG_Pex14_2	11	15	PF04695	0.539
LIG_Pex14_2	229	233	PF04695	0.595
LIG_SH2_CRK	153	157	PF00017	0.610
LIG_SH2_CRK	26	30	PF00017	0.480
LIG_SH2_STAP1	278	282	PF00017	0.501
LIG_SH2_STAP1	421	425	PF00017	0.371
LIG_SH2_STAT5	172	175	PF00017	0.612
LIG_SH2_STAT5	195	198	PF00017	0.665
LIG_SH2_STAT5	268	271	PF00017	0.494
LIG_SH2_STAT5	390	393	PF00017	0.391
LIG_SH3_2	114	119	PF14604	0.633
LIG_SH3_3	11	17	PF00018	0.545
LIG_SH3_3	111	117	PF00018	0.428
LIG_SH3_3	375	381	PF00018	0.416
LIG_SH3_3	91	97	PF00018	0.796
LIG_TRAF2_1	174	177	PF00917	0.592
MOD_CDK_SPxxK_3	241	248	PF00069	0.486
MOD_CK1_1	104	110	PF00069	0.787
MOD_CK1_1	193	199	PF00069	0.588
MOD_CK1_1	207	213	PF00069	0.558
MOD_CK1_1	289	295	PF00069	0.525
MOD_CK1_1	320	326	PF00069	0.580
MOD_CK1_1	438	444	PF00069	0.435
MOD_CK2_1	171	177	PF00069	0.622
MOD_CK2_1	240	246	PF00069	0.506
MOD_CK2_1	278	284	PF00069	0.460
MOD_Cter_Amidation	144	147	PF01082	0.462
MOD_Cter_Amidation	433	436	PF01082	0.504
MOD_GlcNHglycan	163	166	PF01048	0.603
MOD_GlcNHglycan	209	212	PF01048	0.531
MOD_GlcNHglycan	252	255	PF01048	0.580
MOD_GlcNHglycan	280	283	PF01048	0.499
MOD_GlcNHglycan	309	312	PF01048	0.547
MOD_GSK3_1	200	207	PF00069	0.597
MOD_GSK3_1	276	283	PF00069	0.529
MOD_GSK3_1	320	327	PF00069	0.578
MOD_GSK3_1	417	424	PF00069	0.444
MOD_GSK3_1	42	49	PF00069	0.456
MOD_N-GLC_1	181	186	PF02516	0.715
MOD_N-GLC_1	289	294	PF02516	0.473
MOD_N-GLC_1	318	323	PF02516	0.533
MOD_N-GLC_1	404	409	PF02516	0.661
MOD_NEK2_1	102	107	PF00069	0.783
MOD_NEK2_1	200	205	PF00069	0.691
MOD_NEK2_1	212	217	PF00069	0.511
MOD_NEK2_1	240	245	PF00069	0.514
MOD_NEK2_1	392	397	PF00069	0.482
MOD_NEK2_1	46	51	PF00069	0.471
MOD_NEK2_1	68	73	PF00069	0.708
MOD_PIKK_1	392	398	PF00454	0.523
MOD_PKA_1	154	160	PF00069	0.695
MOD_PKA_1	435	441	PF00069	0.504
MOD_PKA_2	154	160	PF00069	0.615
MOD_PKA_2	161	167	PF00069	0.654
MOD_PKA_2	207	213	PF00069	0.558
MOD_PKA_2	338	344	PF00069	0.583
MOD_PKA_2	435	441	PF00069	0.444
MOD_Plk_1	283	289	PF00069	0.589
MOD_Plk_1	366	372	PF00069	0.588
MOD_Plk_4	225	231	PF00069	0.627
MOD_Plk_4	324	330	PF00069	0.546
MOD_Plk_4	357	363	PF00069	0.571
MOD_Plk_4	421	427	PF00069	0.371
MOD_Plk_4	46	52	PF00069	0.541
MOD_ProDKin_1	241	247	PF00069	0.433
MOD_ProDKin_1	289	295	PF00069	0.468
MOD_ProDKin_1	377	383	PF00069	0.477
MOD_ProDKin_1	80	86	PF00069	0.738
MOD_ProDKin_1	96	102	PF00069	0.624
MOD_SUMO_rev_2	244	250	PF00179	0.510
MOD_SUMO_rev_2	341	347	PF00179	0.592
TRG_ENDOCYTIC_2	153	156	PF00928	0.643
TRG_ENDOCYTIC_2	197	200	PF00928	0.570
TRG_ENDOCYTIC_2	26	29	PF00928	0.421
TRG_ENDOCYTIC_2	390	393	PF00928	0.512
TRG_ER_diArg_1	143	146	PF00400	0.625
TRG_ER_diArg_1	153	155	PF00400	0.669
TRG_ER_diArg_1	167	169	PF00400	0.634
TRG_ER_diArg_1	451	453	PF00400	0.518
TRG_ER_diArg_1	51	54	PF00400	0.567
TRG_Pf-PMV_PEXEL_1	363	367	PF00026	0.552
TRG_Pf-PMV_PEXEL_1	468	473	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I6	Leptomonas seymouri	54%	100%
A0A0S4JBB6	Bodo saltans	26%	96%
A0A1X0NPY5	Trypanosomatidae	37%	100%
A0A3R7KWR6	Trypanosoma rangeli	39%	100%
A0A3S7WSC4	Leishmania donovani	96%	100%
A4H722	Leishmania braziliensis	83%	100%
A4HVF1	Leishmania infantum	97%	100%
D0A6V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AP49	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BDY2	Trypanosoma cruzi	39%	100%