Putative MOZ/SAS family acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MOZ/SAS family acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QGD7_LEIMA

TriTrypDb:

LmjF.13.0170 , LMJLV39_130006700 , LMJSD75_130006800

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	11
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2
GO:0010558	negative regulation of macromolecule biosynthetic process	6	2
GO:0010604	positive regulation of macromolecule metabolic process	5	2
GO:0010605	negative regulation of macromolecule metabolic process	5	2
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	11
GO:0019222	regulation of metabolic process	3	11
GO:0031323	regulation of cellular metabolic process	4	11
GO:0031324	negative regulation of cellular metabolic process	5	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031326	regulation of cellular biosynthetic process	5	11
GO:0031327	negative regulation of cellular biosynthetic process	6	2
GO:0031328	positive regulation of cellular biosynthetic process	6	2
GO:0045892	negative regulation of DNA-templated transcription	7	2
GO:0045893	positive regulation of DNA-templated transcription	7	2
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	2
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	2
GO:0045944	positive regulation of transcription by RNA polymerase II	8	2
GO:0048518	positive regulation of biological process	3	2
GO:0048519	negative regulation of biological process	3	2
GO:0048522	positive regulation of cellular process	4	2
GO:0048523	negative regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0051171	regulation of nitrogen compound metabolic process	4	11
GO:0051172	negative regulation of nitrogen compound metabolic process	5	2
GO:0051173	positive regulation of nitrogen compound metabolic process	5	2
GO:0051252	regulation of RNA metabolic process	5	11
GO:0051253	negative regulation of RNA metabolic process	6	2
GO:0051254	positive regulation of RNA metabolic process	6	2
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0080090	regulation of primary metabolic process	4	11
GO:1902679	negative regulation of RNA biosynthetic process	7	2
GO:1902680	positive regulation of RNA biosynthetic process	7	2
GO:1903506	regulation of nucleic acid-templated transcription	7	11
GO:1903507	negative regulation of nucleic acid-templated transcription	8	2
GO:1903508	positive regulation of nucleic acid-templated transcription	8	2
GO:2001141	regulation of RNA biosynthetic process	6	11

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003824	catalytic activity	1	11
GO:0004402	histone acetyltransferase activity	4	11
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0034212	peptide N-acetyltransferase activity	7	11
GO:0042393	histone binding	3	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.805
CLV_NRD_NRD_1	441	443	PF00675	0.316
CLV_NRD_NRD_1	456	458	PF00675	0.606
CLV_NRD_NRD_1	49	51	PF00675	0.419
CLV_NRD_NRD_1	528	530	PF00675	0.775
CLV_NRD_NRD_1	69	71	PF00675	0.518
CLV_PCSK_FUR_1	67	71	PF00082	0.623
CLV_PCSK_KEX2_1	441	443	PF00082	0.314
CLV_PCSK_KEX2_1	456	458	PF00082	0.613
CLV_PCSK_KEX2_1	49	51	PF00082	0.419
CLV_PCSK_KEX2_1	527	529	PF00082	0.792
CLV_PCSK_KEX2_1	603	605	PF00082	0.664
CLV_PCSK_KEX2_1	69	71	PF00082	0.518
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.670
CLV_PCSK_SKI1_1	270	274	PF00082	0.348
CLV_PCSK_SKI1_1	392	396	PF00082	0.320
CLV_PCSK_SKI1_1	441	445	PF00082	0.326
DEG_APCC_DBOX_1	314	322	PF00400	0.424
DEG_APCC_DBOX_1	441	449	PF00400	0.550
DEG_APCC_DBOX_1	466	474	PF00400	0.545
DEG_Nend_UBRbox_2	1	3	PF02207	0.516
DOC_CKS1_1	253	258	PF01111	0.494
DOC_CKS1_1	616	621	PF01111	0.640
DOC_CYCLIN_RxL_1	278	290	PF00134	0.482
DOC_MAPK_gen_1	593	601	PF00069	0.607
DOC_MAPK_MEF2A_6	460	468	PF00069	0.673
DOC_MAPK_MEF2A_6	474	481	PF00069	0.406
DOC_PP1_RVXF_1	56	62	PF00149	0.314
DOC_PP2B_LxvP_1	215	218	PF13499	0.526
DOC_PP4_FxxP_1	205	208	PF00568	0.373
DOC_PP4_FxxP_1	497	500	PF00568	0.644
DOC_USP7_MATH_1	137	141	PF00917	0.701
DOC_USP7_MATH_1	150	154	PF00917	0.656
DOC_USP7_MATH_1	162	166	PF00917	0.636
DOC_USP7_MATH_1	19	23	PF00917	0.621
DOC_USP7_MATH_1	314	318	PF00917	0.413
DOC_USP7_MATH_1	324	328	PF00917	0.580
DOC_USP7_MATH_1	557	561	PF00917	0.753
DOC_USP7_MATH_1	73	77	PF00917	0.573
DOC_USP7_MATH_1	99	103	PF00917	0.496
DOC_WW_Pin1_4	120	125	PF00397	0.463
DOC_WW_Pin1_4	141	146	PF00397	0.761
DOC_WW_Pin1_4	231	236	PF00397	0.362
DOC_WW_Pin1_4	252	257	PF00397	0.507
DOC_WW_Pin1_4	426	431	PF00397	0.472
DOC_WW_Pin1_4	515	520	PF00397	0.764
DOC_WW_Pin1_4	591	596	PF00397	0.513
DOC_WW_Pin1_4	615	620	PF00397	0.638
LIG_14-3-3_CanoR_1	284	289	PF00244	0.477
LIG_14-3-3_CanoR_1	315	319	PF00244	0.407
LIG_14-3-3_CanoR_1	392	397	PF00244	0.552
LIG_14-3-3_CanoR_1	457	466	PF00244	0.647
LIG_14-3-3_CanoR_1	467	471	PF00244	0.560
LIG_14-3-3_CanoR_1	534	541	PF00244	0.745
LIG_APCC_ABBA_1	40	45	PF00400	0.505
LIG_APCC_ABBA_1	489	494	PF00400	0.493
LIG_BRCT_BRCA1_1	233	237	PF00533	0.450
LIG_BRCT_BRCA1_1	424	428	PF00533	0.472
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.414
LIG_eIF4E_1	439	445	PF01652	0.548
LIG_FHA_1	32	38	PF00498	0.543
LIG_FHA_1	393	399	PF00498	0.558
LIG_FHA_1	486	492	PF00498	0.545
LIG_FHA_1	572	578	PF00498	0.676
LIG_FHA_2	149	155	PF00498	0.748
LIG_FHA_2	327	333	PF00498	0.701
LIG_FHA_2	467	473	PF00498	0.557
LIG_FHA_2	55	61	PF00498	0.531
LIG_GSK3_LRP6_1	519	525	PF00069	0.694
LIG_LIR_Apic_2	494	500	PF02991	0.637
LIG_LIR_Gen_1	114	125	PF02991	0.418
LIG_LIR_Gen_1	206	217	PF02991	0.375
LIG_LIR_Gen_1	240	250	PF02991	0.523
LIG_LIR_Gen_1	304	314	PF02991	0.458
LIG_LIR_Nem_3	114	120	PF02991	0.414
LIG_LIR_Nem_3	193	199	PF02991	0.358
LIG_LIR_Nem_3	206	212	PF02991	0.379
LIG_LIR_Nem_3	240	246	PF02991	0.505
LIG_LIR_Nem_3	249	253	PF02991	0.531
LIG_LIR_Nem_3	266	272	PF02991	0.549
LIG_LIR_Nem_3	304	309	PF02991	0.458
LIG_LIR_Nem_3	45	51	PF02991	0.548
LIG_LIR_Nem_3	493	498	PF02991	0.577
LIG_MLH1_MIPbox_1	233	237	PF16413	0.442
LIG_PCNA_PIPBox_1	433	442	PF02747	0.455
LIG_PCNA_yPIPBox_3	333	344	PF02747	0.564
LIG_PCNA_yPIPBox_3	426	440	PF02747	0.455
LIG_Pex14_1	116	120	PF04695	0.495
LIG_Pex14_1	48	52	PF04695	0.505
LIG_Pex14_2	201	205	PF04695	0.390
LIG_Pex14_2	601	605	PF04695	0.570
LIG_PTB_Apo_2	103	110	PF02174	0.526
LIG_PTB_Phospho_1	103	109	PF10480	0.529
LIG_REV1ctd_RIR_1	234	243	PF16727	0.480
LIG_SH2_CRK	209	213	PF00017	0.506
LIG_SH2_CRK	250	254	PF00017	0.523
LIG_SH2_CRK	616	620	PF00017	0.700
LIG_SH2_NCK_1	16	20	PF00017	0.486
LIG_SH2_NCK_1	616	620	PF00017	0.636
LIG_SH2_PTP2	243	246	PF00017	0.496
LIG_SH2_PTP2	308	311	PF00017	0.548
LIG_SH2_SRC	306	309	PF00017	0.551
LIG_SH2_SRC	498	501	PF00017	0.650
LIG_SH2_STAP1	117	121	PF00017	0.402
LIG_SH2_STAP1	306	310	PF00017	0.458
LIG_SH2_STAT3	199	202	PF00017	0.516
LIG_SH2_STAT5	16	19	PF00017	0.484
LIG_SH2_STAT5	196	199	PF00017	0.365
LIG_SH2_STAT5	214	217	PF00017	0.411
LIG_SH2_STAT5	227	230	PF00017	0.347
LIG_SH2_STAT5	243	246	PF00017	0.256
LIG_SH2_STAT5	250	253	PF00017	0.386
LIG_SH2_STAT5	308	311	PF00017	0.512
LIG_SH2_STAT5	367	370	PF00017	0.459
LIG_SH2_STAT5	53	56	PF00017	0.364
LIG_SH2_STAT5	573	576	PF00017	0.682
LIG_SH2_STAT6	268	272	PF00017	0.548
LIG_SH3_3	142	148	PF00018	0.709
LIG_SH3_3	149	155	PF00018	0.675
LIG_SH3_3	308	314	PF00018	0.472
LIG_SH3_3	316	322	PF00018	0.432
LIG_SH3_3	380	386	PF00018	0.514
LIG_SH3_3	424	430	PF00018	0.472
LIG_SH3_3	517	523	PF00018	0.722
LIG_SUMO_SIM_par_1	338	343	PF11976	0.546
LIG_SUMO_SIM_par_1	487	494	PF11976	0.566
LIG_SUMO_SIM_par_1	574	580	PF11976	0.632
LIG_TRAF2_1	177	180	PF00917	0.577
LIG_TRAF2_2	171	176	PF00917	0.473
LIG_TRFH_1	120	124	PF08558	0.505
LIG_TYR_ITIM	212	217	PF00017	0.483
LIG_WRC_WIRS_1	393	398	PF05994	0.548
MOD_CDK_SPK_2	591	596	PF00069	0.513
MOD_CDK_SPxxK_3	252	259	PF00069	0.514
MOD_CK1_1	102	108	PF00069	0.542
MOD_CK1_1	140	146	PF00069	0.768
MOD_CK1_1	165	171	PF00069	0.719
MOD_CK1_1	287	293	PF00069	0.406
MOD_CK1_1	327	333	PF00069	0.697
MOD_CK1_1	518	524	PF00069	0.756
MOD_CK1_1	536	542	PF00069	0.551
MOD_CK1_1	544	550	PF00069	0.633
MOD_CK1_1	553	559	PF00069	0.542
MOD_CK1_1	566	572	PF00069	0.596
MOD_CK2_1	141	147	PF00069	0.718
MOD_CK2_1	148	154	PF00069	0.767
MOD_CK2_1	326	332	PF00069	0.691
MOD_CK2_1	444	450	PF00069	0.493
MOD_CK2_1	466	472	PF00069	0.557
MOD_CK2_1	54	60	PF00069	0.501
MOD_CK2_1	89	95	PF00069	0.589
MOD_DYRK1A_RPxSP_1	426	430	PF00069	0.472
MOD_GlcNHglycan	125	128	PF01048	0.617
MOD_GlcNHglycan	139	142	PF01048	0.716
MOD_GlcNHglycan	162	165	PF01048	0.737
MOD_GlcNHglycan	205	208	PF01048	0.402
MOD_GlcNHglycan	209	212	PF01048	0.565
MOD_GlcNHglycan	329	332	PF01048	0.706
MOD_GlcNHglycan	419	422	PF01048	0.396
MOD_GlcNHglycan	512	518	PF01048	0.710
MOD_GlcNHglycan	524	527	PF01048	0.762
MOD_GlcNHglycan	547	550	PF01048	0.700
MOD_GlcNHglycan	555	558	PF01048	0.678
MOD_GlcNHglycan	559	562	PF01048	0.631
MOD_GlcNHglycan	568	571	PF01048	0.604
MOD_GlcNHglycan	77	80	PF01048	0.663
MOD_GlcNHglycan	86	89	PF01048	0.595
MOD_GSK3_1	137	144	PF00069	0.752
MOD_GSK3_1	203	210	PF00069	0.353
MOD_GSK3_1	231	238	PF00069	0.353
MOD_GSK3_1	293	300	PF00069	0.486
MOD_GSK3_1	377	384	PF00069	0.468
MOD_GSK3_1	388	395	PF00069	0.460
MOD_GSK3_1	422	429	PF00069	0.472
MOD_GSK3_1	431	438	PF00069	0.423
MOD_GSK3_1	515	522	PF00069	0.686
MOD_GSK3_1	533	540	PF00069	0.536
MOD_GSK3_1	541	548	PF00069	0.675
MOD_GSK3_1	553	560	PF00069	0.533
MOD_GSK3_1	80	87	PF00069	0.729
MOD_LATS_1	532	538	PF00433	0.561
MOD_N-GLC_1	132	137	PF02516	0.678
MOD_N-GLC_1	20	25	PF02516	0.628
MOD_NEK2_1	293	298	PF00069	0.465
MOD_NEK2_1	31	36	PF00069	0.560
MOD_NEK2_1	388	393	PF00069	0.596
MOD_NEK2_1	435	440	PF00069	0.478
MOD_NEK2_1	444	449	PF00069	0.483
MOD_NEK2_1	466	471	PF00069	0.495
MOD_NEK2_1	541	546	PF00069	0.773
MOD_NEK2_1	552	557	PF00069	0.811
MOD_NEK2_2	86	91	PF00069	0.661
MOD_PIKK_1	541	547	PF00454	0.670
MOD_PKA_1	456	462	PF00069	0.646
MOD_PKA_2	186	192	PF00069	0.468
MOD_PKA_2	314	320	PF00069	0.419
MOD_PKA_2	456	462	PF00069	0.619
MOD_PKA_2	466	472	PF00069	0.558
MOD_PKA_2	508	514	PF00069	0.633
MOD_PKA_2	533	539	PF00069	0.690
MOD_PKA_2	571	577	PF00069	0.676
MOD_PKB_1	390	398	PF00069	0.520
MOD_Plk_1	12	18	PF00069	0.490
MOD_Plk_1	375	381	PF00069	0.548
MOD_Plk_4	222	228	PF00069	0.461
MOD_Plk_4	284	290	PF00069	0.481
MOD_Plk_4	392	398	PF00069	0.554
MOD_Plk_4	431	437	PF00069	0.483
MOD_Plk_4	485	491	PF00069	0.554
MOD_Plk_4	573	579	PF00069	0.548
MOD_Plk_4	99	105	PF00069	0.542
MOD_ProDKin_1	120	126	PF00069	0.473
MOD_ProDKin_1	141	147	PF00069	0.765
MOD_ProDKin_1	231	237	PF00069	0.362
MOD_ProDKin_1	252	258	PF00069	0.510
MOD_ProDKin_1	426	432	PF00069	0.472
MOD_ProDKin_1	515	521	PF00069	0.767
MOD_ProDKin_1	591	597	PF00069	0.514
MOD_ProDKin_1	615	621	PF00069	0.641
MOD_SUMO_rev_2	290	299	PF00179	0.446
TRG_DiLeu_BaEn_1	472	477	PF01217	0.536
TRG_DiLeu_BaLyEn_6	256	261	PF01217	0.548
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.405
TRG_ENDOCYTIC_2	117	120	PF00928	0.430
TRG_ENDOCYTIC_2	209	212	PF00928	0.409
TRG_ENDOCYTIC_2	214	217	PF00928	0.408
TRG_ENDOCYTIC_2	243	246	PF00928	0.459
TRG_ENDOCYTIC_2	250	253	PF00928	0.425
TRG_ENDOCYTIC_2	269	272	PF00928	0.549
TRG_ENDOCYTIC_2	306	309	PF00928	0.459
TRG_ER_diArg_1	390	393	PF00400	0.574
TRG_ER_diArg_1	408	411	PF00400	0.403
TRG_ER_diArg_1	440	442	PF00400	0.472
TRG_ER_diArg_1	48	50	PF00400	0.504
TRG_ER_diArg_1	527	529	PF00400	0.698
TRG_ER_diArg_1	6	9	PF00400	0.488
TRG_ER_diArg_1	67	70	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.314
TRG_Pf-PMV_PEXEL_1	446	450	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	474	478	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4F2	Leptomonas seymouri	58%	100%
A0A0S4JFL5	Bodo saltans	29%	100%
A0A1X0NNC2	Trypanosomatidae	43%	100%
A0A3R7KIN4	Trypanosoma rangeli	42%	100%
A0A3S7WSE3	Leishmania donovani	95%	100%
A4H724	Leishmania braziliensis	80%	100%
A4HVF3	Leishmania infantum	95%	100%
E9AP51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B9B5	Trypanosoma cruzi	43%	100%