Putative MOZ/SAS family acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MOZ/SAS family acetyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QGD7_LEIMA

TriTrypDb:

LmjF.13.0170 , LMJLV39_130006700 , LMJSD75_130006800

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD7

Function

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Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	11
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0009889	regulation of biosynthetic process	4	11
GO:0009890	negative regulation of biosynthetic process	5	2
GO:0009891	positive regulation of biosynthetic process	5	2
GO:0009892	negative regulation of metabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	2
GO:0010468	regulation of gene expression	5	11
GO:0010556	regulation of macromolecule biosynthetic process	5	11
GO:0010557	positive regulation of macromolecule biosynthetic process	6	2

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Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003824	catalytic activity	1	11
GO:0004402	histone acetyltransferase activity	4	11
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0008080	N-acetyltransferase activity	6	11
GO:0016407	acetyltransferase activity	5	11
GO:0016410	N-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.805
CLV_NRD_NRD_1	441	443	PF00675	0.316
CLV_NRD_NRD_1	456	458	PF00675	0.606
CLV_NRD_NRD_1	49	51	PF00675	0.419
CLV_NRD_NRD_1	528	530	PF00675	0.775
CLV_NRD_NRD_1	69	71	PF00675	0.518
CLV_PCSK_FUR_1	67	71	PF00082	0.623
CLV_PCSK_KEX2_1	441	443	PF00082	0.314
CLV_PCSK_KEX2_1	456	458	PF00082	0.613
CLV_PCSK_KEX2_1	49	51	PF00082	0.419

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4F2	Leptomonas seymouri	58%	100%
A0A0S4JFL5	Bodo saltans	29%	100%
A0A1X0NNC2	Trypanosomatidae	43%	100%
A0A3R7KIN4	Trypanosoma rangeli	42%	100%
A0A3S7WSE3	Leishmania donovani	95%	100%
A4H724	Leishmania braziliensis	80%	100%
A4HVF3	Leishmania infantum	95%	100%
E9AP51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B9B5	Trypanosoma cruzi	43%	100%

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