TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4QGD6_LEIMA

TriTrypDb:

LmjF.13.0180 , LMJLV39_130006800 , LMJSD75_130006900

Length:

422

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.504
CLV_C14_Caspase3-7	82	86	PF00656	0.699
CLV_NRD_NRD_1	184	186	PF00675	0.605
CLV_NRD_NRD_1	298	300	PF00675	0.478
CLV_NRD_NRD_1	359	361	PF00675	0.307
CLV_PCSK_KEX2_1	184	186	PF00082	0.605
CLV_PCSK_KEX2_1	297	299	PF00082	0.505
CLV_PCSK_KEX2_1	358	360	PF00082	0.308
CLV_PCSK_SKI1_1	175	179	PF00082	0.455
CLV_PCSK_SKI1_1	256	260	PF00082	0.354
CLV_PCSK_SKI1_1	325	329	PF00082	0.373
CLV_PCSK_SKI1_1	376	380	PF00082	0.350
CLV_PCSK_SKI1_1	390	394	PF00082	0.245
DEG_APCC_DBOX_1	255	263	PF00400	0.342
DEG_APCC_DBOX_1	289	297	PF00400	0.399
DEG_Nend_UBRbox_4	1	3	PF02207	0.560
DEG_SCF_FBW7_1	405	411	PF00400	0.532
DEG_SPOP_SBC_1	219	223	PF00917	0.623
DEG_SPOP_SBC_1	409	413	PF00917	0.539
DOC_ANK_TNKS_1	394	401	PF00023	0.215
DOC_CKS1_1	405	410	PF01111	0.578
DOC_CYCLIN_RxL_1	250	261	PF00134	0.454
DOC_CYCLIN_RxL_1	385	397	PF00134	0.498
DOC_MAPK_MEF2A_6	21	28	PF00069	0.422
DOC_MAPK_MEF2A_6	285	293	PF00069	0.425
DOC_MAPK_NFAT4_5	21	29	PF00069	0.411
DOC_PP2B_LxvP_1	252	255	PF13499	0.485
DOC_USP7_MATH_1	10	14	PF00917	0.508
DOC_USP7_MATH_1	159	163	PF00917	0.519
DOC_USP7_MATH_1	219	223	PF00917	0.593
DOC_USP7_MATH_1	224	228	PF00917	0.543
DOC_USP7_MATH_1	410	414	PF00917	0.588
DOC_USP7_MATH_1	83	87	PF00917	0.538
DOC_WW_Pin1_4	183	188	PF00397	0.563
DOC_WW_Pin1_4	226	231	PF00397	0.639
DOC_WW_Pin1_4	401	406	PF00397	0.571
DOC_WW_Pin1_4	59	64	PF00397	0.592
LIG_14-3-3_CanoR_1	11	16	PF00244	0.611
LIG_14-3-3_CanoR_1	127	136	PF00244	0.361
LIG_14-3-3_CanoR_1	139	147	PF00244	0.525
LIG_14-3-3_CanoR_1	21	27	PF00244	0.390
LIG_14-3-3_CanoR_1	212	218	PF00244	0.734
LIG_14-3-3_CanoR_1	247	253	PF00244	0.468
LIG_BIR_III_2	402	406	PF00653	0.488
LIG_CaM_IQ_9	277	292	PF13499	0.365
LIG_CaM_NSCaTE_8	136	143	PF13499	0.435
LIG_FHA_1	106	112	PF00498	0.368
LIG_FHA_1	12	18	PF00498	0.544
LIG_FHA_1	21	27	PF00498	0.377
LIG_FHA_1	212	218	PF00498	0.713
LIG_FHA_1	263	269	PF00498	0.497
LIG_FHA_1	319	325	PF00498	0.512
LIG_FHA_1	363	369	PF00498	0.408
LIG_FHA_1	370	376	PF00498	0.303
LIG_FHA_2	150	156	PF00498	0.547
LIG_LIR_Apic_2	197	202	PF02991	0.551
LIG_LIR_Gen_1	113	123	PF02991	0.454
LIG_LIR_Gen_1	214	220	PF02991	0.713
LIG_LIR_Nem_3	113	119	PF02991	0.445
LIG_LIR_Nem_3	214	218	PF02991	0.748
LIG_LYPXL_SIV_4	172	180	PF13949	0.452
LIG_RPA_C_Fungi	44	56	PF08784	0.430
LIG_SH2_CRK	116	120	PF00017	0.461
LIG_SH2_CRK	215	219	PF00017	0.479
LIG_SH2_NCK_1	122	126	PF00017	0.457
LIG_SH2_NCK_1	215	219	PF00017	0.479
LIG_SH2_NCK_1	271	275	PF00017	0.443
LIG_SH2_NCK_1	33	37	PF00017	0.460
LIG_SH2_SRC	122	125	PF00017	0.453
LIG_SH2_SRC	33	36	PF00017	0.462
LIG_SH2_STAT3	415	418	PF00017	0.522
LIG_SH2_STAT5	276	279	PF00017	0.400
LIG_SH2_STAT5	361	364	PF00017	0.284
LIG_SH3_1	184	190	PF00018	0.508
LIG_SH3_1	361	367	PF00018	0.284
LIG_SH3_3	184	190	PF00018	0.508
LIG_SH3_3	197	203	PF00018	0.642
LIG_SH3_3	361	367	PF00018	0.284
LIG_SH3_3	402	408	PF00018	0.646
LIG_SUMO_SIM_anti_2	108	114	PF11976	0.338
LIG_SUMO_SIM_par_1	107	114	PF11976	0.338
LIG_SUMO_SIM_par_1	53	60	PF11976	0.491
LIG_SxIP_EBH_1	212	224	PF03271	0.619
LIG_TRAF2_1	416	419	PF00917	0.613
LIG_TRAF2_1	51	54	PF00917	0.443
LIG_TRFH_1	215	219	PF08558	0.479
LIG_TYR_ITIM	213	218	PF00017	0.478
LIG_WW_3	253	257	PF00397	0.455
MOD_CK1_1	142	148	PF00069	0.530
MOD_CK1_1	149	155	PF00069	0.499
MOD_CK1_1	226	232	PF00069	0.549
MOD_CK1_1	27	33	PF00069	0.563
MOD_CK1_1	404	410	PF00069	0.590
MOD_CK1_1	62	68	PF00069	0.609
MOD_CK2_1	149	155	PF00069	0.602
MOD_GlcNHglycan	152	155	PF01048	0.590
MOD_GlcNHglycan	226	229	PF01048	0.602
MOD_GlcNHglycan	396	399	PF01048	0.420
MOD_GlcNHglycan	412	415	PF01048	0.460
MOD_GSK3_1	138	145	PF00069	0.510
MOD_GSK3_1	146	153	PF00069	0.477
MOD_GSK3_1	185	192	PF00069	0.508
MOD_GSK3_1	20	27	PF00069	0.417
MOD_GSK3_1	219	226	PF00069	0.651
MOD_GSK3_1	229	236	PF00069	0.546
MOD_GSK3_1	350	357	PF00069	0.400
MOD_GSK3_1	404	411	PF00069	0.724
MOD_GSK3_1	55	62	PF00069	0.430
MOD_LATS_1	144	150	PF00433	0.512
MOD_NEK2_1	105	110	PF00069	0.374
MOD_NEK2_1	111	116	PF00069	0.302
MOD_NEK2_1	140	145	PF00069	0.523
MOD_NEK2_1	213	218	PF00069	0.566
MOD_NEK2_1	220	225	PF00069	0.526
MOD_NEK2_1	233	238	PF00069	0.487
MOD_NEK2_1	24	29	PF00069	0.425
MOD_NEK2_1	248	253	PF00069	0.399
MOD_NEK2_1	350	355	PF00069	0.440
MOD_NEK2_1	383	388	PF00069	0.414
MOD_NEK2_1	57	62	PF00069	0.505
MOD_PIKK_1	383	389	PF00454	0.215
MOD_PIKK_1	91	97	PF00454	0.527
MOD_PK_1	146	152	PF00069	0.514
MOD_PKA_1	297	303	PF00069	0.554
MOD_PKA_2	10	16	PF00069	0.615
MOD_PKA_2	138	144	PF00069	0.580
MOD_PKA_2	145	151	PF00069	0.583
MOD_PKA_2	20	26	PF00069	0.405
MOD_PKA_2	211	217	PF00069	0.741
MOD_PKA_2	297	303	PF00069	0.546
MOD_PKA_2	394	400	PF00069	0.404
MOD_PKB_1	137	145	PF00069	0.458
MOD_Plk_1	34	40	PF00069	0.556
MOD_Plk_2-3	341	347	PF00069	0.360
MOD_Plk_4	105	111	PF00069	0.376
MOD_Plk_4	213	219	PF00069	0.722
MOD_Plk_4	229	235	PF00069	0.380
MOD_ProDKin_1	183	189	PF00069	0.577
MOD_ProDKin_1	226	232	PF00069	0.631
MOD_ProDKin_1	401	407	PF00069	0.574
MOD_ProDKin_1	59	65	PF00069	0.601
MOD_SUMO_rev_2	319	327	PF00179	0.502
TRG_DiLeu_BaEn_1	124	129	PF01217	0.380
TRG_DiLeu_BaEn_1	346	351	PF01217	0.344
TRG_DiLeu_BaLyEn_6	335	340	PF01217	0.400
TRG_DiLeu_LyEn_5	124	129	PF01217	0.443
TRG_ENDOCYTIC_2	116	119	PF00928	0.455
TRG_ENDOCYTIC_2	215	218	PF00928	0.481
TRG_ENDOCYTIC_2	337	340	PF00928	0.320
TRG_ER_diArg_1	101	104	PF00400	0.461
TRG_ER_diArg_1	183	185	PF00400	0.498
TRG_ER_diArg_1	296	299	PF00400	0.548
TRG_ER_diArg_1	358	360	PF00400	0.286
TRG_NES_CRM1_1	231	246	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	256	261	PF00026	0.405
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN7	Leptomonas seymouri	47%	100%
A0A0S4JF77	Bodo saltans	31%	85%
A0A1X0NNA0	Trypanosomatidae	30%	100%
A0A3S7WSE7	Leishmania donovani	93%	100%
A0A422NP89	Trypanosoma rangeli	32%	100%
A4H725	Leishmania braziliensis	78%	97%
A4HVF4	Leishmania infantum	93%	100%
E9AP52	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	91%