Lipase_3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Lipase (class 3), putative

Species:

Leishmania major

UniProt:

Q4QGD4_LEIMA

TriTrypDb:

LmjF.13.0200 , LMJLV39_130007000 , LMJSD75_130007100

Length:

754

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD4

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	8
GO:0008152	metabolic process	1	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	587	591	PF00656	0.654
CLV_NRD_NRD_1	171	173	PF00675	0.679
CLV_NRD_NRD_1	202	204	PF00675	0.540
CLV_NRD_NRD_1	310	312	PF00675	0.423
CLV_NRD_NRD_1	559	561	PF00675	0.566
CLV_NRD_NRD_1	616	618	PF00675	0.723
CLV_PCSK_KEX2_1	202	204	PF00082	0.540
CLV_PCSK_KEX2_1	297	299	PF00082	0.530
CLV_PCSK_KEX2_1	31	33	PF00082	0.698
CLV_PCSK_KEX2_1	622	624	PF00082	0.705
CLV_PCSK_KEX2_1	681	683	PF00082	0.657
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.497
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.698
CLV_PCSK_PC1ET2_1	622	624	PF00082	0.705
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.598
CLV_PCSK_SKI1_1	245	249	PF00082	0.656
CLV_PCSK_SKI1_1	297	301	PF00082	0.488
CLV_PCSK_SKI1_1	311	315	PF00082	0.335
CLV_PCSK_SKI1_1	451	455	PF00082	0.409
CLV_PCSK_SKI1_1	49	53	PF00082	0.571
CLV_PCSK_SKI1_1	691	695	PF00082	0.452
CLV_PCSK_SKI1_1	730	734	PF00082	0.485
DEG_APCC_DBOX_1	187	195	PF00400	0.499
DEG_APCC_DBOX_1	310	318	PF00400	0.374
DEG_APCC_DBOX_1	486	494	PF00400	0.441
DEG_APCC_DBOX_1	725	733	PF00400	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.545
DEG_SPOP_SBC_1	18	22	PF00917	0.669
DOC_CYCLIN_RxL_1	109	118	PF00134	0.586
DOC_CYCLIN_RxL_1	294	302	PF00134	0.539
DOC_CYCLIN_yClb5_NLxxxL_5	726	733	PF00134	0.378
DOC_MAPK_DCC_7	689	699	PF00069	0.355
DOC_MAPK_gen_1	221	229	PF00069	0.468
DOC_MAPK_gen_1	311	317	PF00069	0.414
DOC_MAPK_gen_1	451	461	PF00069	0.441
DOC_MAPK_gen_1	487	495	PF00069	0.330
DOC_MAPK_gen_1	560	568	PF00069	0.500
DOC_MAPK_MEF2A_6	221	229	PF00069	0.491
DOC_MAPK_MEF2A_6	444	452	PF00069	0.435
DOC_MAPK_MEF2A_6	487	495	PF00069	0.388
DOC_MAPK_MEF2A_6	726	733	PF00069	0.569
DOC_PP1_RVXF_1	110	117	PF00149	0.590
DOC_PP1_RVXF_1	363	370	PF00149	0.456
DOC_PP1_RVXF_1	75	81	PF00149	0.459
DOC_PP2B_LxvP_1	327	330	PF13499	0.488
DOC_PP2B_PxIxI_1	629	635	PF00149	0.676
DOC_PP4_FxxP_1	358	361	PF00568	0.428
DOC_PP4_FxxP_1	495	498	PF00568	0.383
DOC_USP7_MATH_1	128	132	PF00917	0.646
DOC_USP7_MATH_1	19	23	PF00917	0.625
DOC_USP7_MATH_1	207	211	PF00917	0.510
DOC_USP7_MATH_1	256	260	PF00917	0.641
DOC_USP7_MATH_1	368	372	PF00917	0.527
DOC_USP7_MATH_1	469	473	PF00917	0.360
DOC_USP7_MATH_1	501	505	PF00917	0.409
DOC_USP7_MATH_1	555	559	PF00917	0.592
DOC_USP7_MATH_1	85	89	PF00917	0.451
DOC_USP7_UBL2_3	244	248	PF12436	0.627
DOC_USP7_UBL2_3	618	622	PF12436	0.782
DOC_WW_Pin1_4	208	213	PF00397	0.504
DOC_WW_Pin1_4	221	226	PF00397	0.441
DOC_WW_Pin1_4	623	628	PF00397	0.735
DOC_WW_Pin1_4	66	71	PF00397	0.562
LIG_14-3-3_CanoR_1	100	110	PF00244	0.532
LIG_14-3-3_CanoR_1	121	125	PF00244	0.675
LIG_14-3-3_CanoR_1	235	240	PF00244	0.531
LIG_14-3-3_CanoR_1	298	304	PF00244	0.504
LIG_14-3-3_CanoR_1	444	449	PF00244	0.441
LIG_14-3-3_CanoR_1	603	608	PF00244	0.644
LIG_Actin_WH2_2	350	367	PF00022	0.328
LIG_Actin_WH2_2	438	453	PF00022	0.441
LIG_Actin_WH2_2	715	732	PF00022	0.355
LIG_BIR_III_4	168	172	PF00653	0.649
LIG_BRCT_BRCA1_1	209	213	PF00533	0.455
LIG_EH1_1	442	450	PF00400	0.282
LIG_eIF4E_1	8	14	PF01652	0.667
LIG_FHA_1	105	111	PF00498	0.485
LIG_FHA_1	224	230	PF00498	0.463
LIG_FHA_1	383	389	PF00498	0.523
LIG_FHA_1	423	429	PF00498	0.498
LIG_FHA_1	474	480	PF00498	0.380
LIG_FHA_2	178	184	PF00498	0.490
LIG_FHA_2	81	87	PF00498	0.513
LIG_GBD_Chelix_1	470	478	PF00786	0.301
LIG_LIR_Apic_2	356	361	PF02991	0.426
LIG_LIR_Apic_2	494	498	PF02991	0.323
LIG_LIR_Apic_2	747	753	PF02991	0.494
LIG_LIR_Gen_1	210	220	PF02991	0.498
LIG_LIR_Gen_1	269	275	PF02991	0.556
LIG_LIR_Gen_1	352	361	PF02991	0.491
LIG_LIR_Gen_1	517	522	PF02991	0.292
LIG_LIR_Gen_1	88	97	PF02991	0.413
LIG_LIR_Nem_3	186	192	PF02991	0.513
LIG_LIR_Nem_3	210	216	PF02991	0.494
LIG_LIR_Nem_3	269	274	PF02991	0.514
LIG_LIR_Nem_3	337	342	PF02991	0.399
LIG_LIR_Nem_3	352	358	PF02991	0.447
LIG_LIR_Nem_3	517	521	PF02991	0.292
LIG_LIR_Nem_3	601	607	PF02991	0.642
LIG_LIR_Nem_3	677	683	PF02991	0.679
LIG_PCNA_yPIPBox_3	502	516	PF02747	0.346
LIG_SH2_CRK	342	346	PF00017	0.380
LIG_SH2_CRK	750	754	PF00017	0.537
LIG_SH2_GRB2like	518	521	PF00017	0.346
LIG_SH2_NCK_1	125	129	PF00017	0.684
LIG_SH2_NCK_1	750	754	PF00017	0.537
LIG_SH2_SRC	533	536	PF00017	0.486
LIG_SH2_SRC	748	751	PF00017	0.500
LIG_SH2_STAP1	271	275	PF00017	0.546
LIG_SH2_STAP1	342	346	PF00017	0.380
LIG_SH2_STAP1	605	609	PF00017	0.541
LIG_SH2_STAT5	192	195	PF00017	0.583
LIG_SH2_STAT5	215	218	PF00017	0.505
LIG_SH2_STAT5	435	438	PF00017	0.448
LIG_SH2_STAT5	533	536	PF00017	0.486
LIG_SH2_STAT5	710	713	PF00017	0.402
LIG_SH2_STAT5	748	751	PF00017	0.496
LIG_SH3_3	178	184	PF00018	0.713
LIG_SH3_3	342	348	PF00018	0.521
LIG_SH3_3	621	627	PF00018	0.757
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.388
LIG_SUMO_SIM_par_1	224	230	PF11976	0.383
LIG_TRAF2_1	572	575	PF00917	0.539
MOD_CK1_1	131	137	PF00069	0.677
MOD_CK1_1	139	145	PF00069	0.617
MOD_CK1_1	147	153	PF00069	0.543
MOD_CK1_1	155	161	PF00069	0.656
MOD_CK1_1	254	260	PF00069	0.639
MOD_CK1_1	371	377	PF00069	0.541
MOD_CK1_1	472	478	PF00069	0.360
MOD_CK1_1	536	542	PF00069	0.468
MOD_CK1_1	545	551	PF00069	0.516
MOD_CK1_1	69	75	PF00069	0.483
MOD_CK1_1	724	730	PF00069	0.513
MOD_CK2_1	177	183	PF00069	0.500
MOD_CK2_1	227	233	PF00069	0.389
MOD_CK2_1	276	282	PF00069	0.581
MOD_CK2_1	32	38	PF00069	0.662
MOD_CK2_1	569	575	PF00069	0.598
MOD_CK2_1	681	687	PF00069	0.514
MOD_CK2_1	80	86	PF00069	0.443
MOD_Cter_Amidation	170	173	PF01082	0.680
MOD_DYRK1A_RPxSP_1	623	627	PF00069	0.693
MOD_GlcNHglycan	126	129	PF01048	0.668
MOD_GlcNHglycan	21	24	PF01048	0.678
MOD_GlcNHglycan	256	259	PF01048	0.669
MOD_GlcNHglycan	278	281	PF01048	0.563
MOD_GlcNHglycan	358	361	PF01048	0.479
MOD_GlcNHglycan	370	373	PF01048	0.461
MOD_GlcNHglycan	539	542	PF01048	0.506
MOD_GlcNHglycan	593	596	PF01048	0.704
MOD_GlcNHglycan	600	603	PF01048	0.738
MOD_GlcNHglycan	714	719	PF01048	0.345
MOD_GlcNHglycan	738	741	PF01048	0.440
MOD_GlcNHglycan	750	753	PF01048	0.502
MOD_GSK3_1	120	127	PF00069	0.597
MOD_GSK3_1	19	26	PF00069	0.692
MOD_GSK3_1	221	228	PF00069	0.549
MOD_GSK3_1	235	242	PF00069	0.513
MOD_GSK3_1	330	337	PF00069	0.442
MOD_GSK3_1	349	356	PF00069	0.359
MOD_GSK3_1	367	374	PF00069	0.483
MOD_GSK3_1	382	389	PF00069	0.518
MOD_GSK3_1	418	425	PF00069	0.468
MOD_GSK3_1	469	476	PF00069	0.447
MOD_GSK3_1	503	510	PF00069	0.340
MOD_GSK3_1	533	540	PF00069	0.581
MOD_GSK3_1	710	717	PF00069	0.406
MOD_N-GLC_1	240	245	PF02516	0.657
MOD_N-GLC_1	481	486	PF02516	0.250
MOD_N-GLC_1	501	506	PF02516	0.328
MOD_N-GLC_1	522	527	PF02516	0.346
MOD_N-GLC_1	591	596	PF02516	0.600
MOD_N-GLC_1	634	639	PF02516	0.675
MOD_NEK2_1	120	125	PF00069	0.621
MOD_NEK2_1	239	244	PF00069	0.674
MOD_NEK2_1	274	279	PF00069	0.578
MOD_NEK2_1	299	304	PF00069	0.503
MOD_NEK2_1	480	485	PF00069	0.288
MOD_NEK2_1	491	496	PF00069	0.375
MOD_NEK2_1	514	519	PF00069	0.326
MOD_NEK2_1	537	542	PF00069	0.492
MOD_NEK2_2	555	560	PF00069	0.499
MOD_OFUCOSY	55	60	PF10250	0.575
MOD_OFUCOSY	79	84	PF10250	0.444
MOD_PIKK_1	115	121	PF00454	0.623
MOD_PIKK_1	481	487	PF00454	0.250
MOD_PK_1	375	381	PF00069	0.401
MOD_PK_1	603	609	PF00069	0.663
MOD_PK_1	665	671	PF00069	0.558
MOD_PKA_1	618	624	PF00069	0.774
MOD_PKA_1	681	687	PF00069	0.641
MOD_PKA_2	120	126	PF00069	0.680
MOD_PKA_2	576	582	PF00069	0.780
MOD_PKA_2	681	687	PF00069	0.547
MOD_PKA_2	80	86	PF00069	0.456
MOD_PKA_2	99	105	PF00069	0.338
MOD_Plk_1	481	487	PF00069	0.250
MOD_Plk_1	501	507	PF00069	0.328
MOD_Plk_1	591	597	PF00069	0.595
MOD_Plk_4	120	126	PF00069	0.616
MOD_Plk_4	177	183	PF00069	0.500
MOD_Plk_4	235	241	PF00069	0.533
MOD_Plk_4	444	450	PF00069	0.451
MOD_Plk_4	469	475	PF00069	0.367
MOD_Plk_4	533	539	PF00069	0.503
MOD_Plk_4	545	551	PF00069	0.513
MOD_ProDKin_1	208	214	PF00069	0.499
MOD_ProDKin_1	221	227	PF00069	0.437
MOD_ProDKin_1	623	629	PF00069	0.734
MOD_ProDKin_1	66	72	PF00069	0.559
TRG_DiLeu_BaLyEn_6	486	491	PF01217	0.476
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.383
TRG_ENDOCYTIC_2	271	274	PF00928	0.552
TRG_ENDOCYTIC_2	342	345	PF00928	0.438
TRG_ENDOCYTIC_2	518	521	PF00928	0.377
TRG_ENDOCYTIC_2	604	607	PF00928	0.663
TRG_ENDOCYTIC_2	700	703	PF00928	0.380
TRG_ENDOCYTIC_2	90	93	PF00928	0.486
TRG_ER_diArg_1	201	203	PF00400	0.550
TRG_NES_CRM1_1	325	338	PF08389	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5R6	Leptomonas seymouri	45%	96%
A0A0N1I7D8	Leptomonas seymouri	27%	89%
A0A3S7WSB8	Leishmania donovani	86%	100%
A4HHS0	Leishmania braziliensis	52%	97%
A4HVG0	Leishmania infantum	86%	93%
E9AP54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%