Putative class 3 lipase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Triglyceride lipase, putative

Species:

Leishmania major

UniProt:

Q4QGD3_LEIMA

TriTrypDb:

LmjF.13.0210 , LMJLV39_130007100 , LMJSD75_130007200

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGD3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0008152	metabolic process	1	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004806	triglyceride lipase activity	5	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	2
GO:0052689	carboxylic ester hydrolase activity	4	2
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.603
CLV_NRD_NRD_1	248	250	PF00675	0.537
CLV_NRD_NRD_1	51	53	PF00675	0.409
CLV_NRD_NRD_1	546	548	PF00675	0.666
CLV_NRD_NRD_1	553	555	PF00675	0.615
CLV_NRD_NRD_1	599	601	PF00675	0.577
CLV_PCSK_KEX2_1	51	53	PF00082	0.409
CLV_PCSK_KEX2_1	546	548	PF00082	0.666
CLV_PCSK_KEX2_1	553	555	PF00082	0.615
CLV_PCSK_KEX2_1	599	601	PF00082	0.577
CLV_PCSK_PC7_1	47	53	PF00082	0.394
CLV_PCSK_SKI1_1	114	118	PF00082	0.558
CLV_PCSK_SKI1_1	127	131	PF00082	0.410
CLV_PCSK_SKI1_1	137	141	PF00082	0.428
CLV_PCSK_SKI1_1	47	51	PF00082	0.455
CLV_PCSK_SKI1_1	603	607	PF00082	0.457
DEG_APCC_DBOX_1	136	144	PF00400	0.428
DEG_SPOP_SBC_1	414	418	PF00917	0.672
DOC_CKS1_1	434	439	PF01111	0.561
DOC_CKS1_1	576	581	PF01111	0.689
DOC_CYCLIN_RxL_1	111	121	PF00134	0.592
DOC_CYCLIN_RxL_1	134	141	PF00134	0.532
DOC_MAPK_gen_1	200	208	PF00069	0.654
DOC_PP1_RVXF_1	185	191	PF00149	0.459
DOC_PP2B_LxvP_1	152	155	PF13499	0.581
DOC_PP2B_LxvP_1	182	185	PF13499	0.440
DOC_PP2B_LxvP_1	311	314	PF13499	0.411
DOC_PP2B_LxvP_1	329	332	PF13499	0.411
DOC_USP7_MATH_1	165	169	PF00917	0.294
DOC_USP7_MATH_1	17	21	PF00917	0.421
DOC_USP7_MATH_1	314	318	PF00917	0.423
DOC_USP7_MATH_1	389	393	PF00917	0.684
DOC_USP7_MATH_1	415	419	PF00917	0.783
DOC_USP7_MATH_1	519	523	PF00917	0.700
DOC_USP7_MATH_1	545	549	PF00917	0.633
DOC_USP7_MATH_1	570	574	PF00917	0.569
DOC_USP7_MATH_1	595	599	PF00917	0.705
DOC_WW_Pin1_4	318	323	PF00397	0.439
DOC_WW_Pin1_4	399	404	PF00397	0.670
DOC_WW_Pin1_4	405	410	PF00397	0.683
DOC_WW_Pin1_4	423	428	PF00397	0.542
DOC_WW_Pin1_4	433	438	PF00397	0.617
DOC_WW_Pin1_4	442	447	PF00397	0.513
DOC_WW_Pin1_4	515	520	PF00397	0.712
DOC_WW_Pin1_4	575	580	PF00397	0.737
LIG_14-3-3_CanoR_1	127	134	PF00244	0.487
LIG_14-3-3_CanoR_1	137	143	PF00244	0.428
LIG_14-3-3_CanoR_1	171	175	PF00244	0.500
LIG_14-3-3_CanoR_1	210	216	PF00244	0.595
LIG_14-3-3_CanoR_1	307	312	PF00244	0.423
LIG_14-3-3_CanoR_1	364	373	PF00244	0.535
LIG_14-3-3_CanoR_1	433	437	PF00244	0.768
LIG_14-3-3_CanoR_1	508	514	PF00244	0.584
LIG_14-3-3_CanoR_1	553	559	PF00244	0.700
LIG_14-3-3_CanoR_1	6	11	PF00244	0.536
LIG_14-3-3_CanoR_1	603	611	PF00244	0.448
LIG_Actin_WH2_2	157	173	PF00022	0.555
LIG_BRCT_BRCA1_1	463	467	PF00533	0.779
LIG_eIF4E_1	299	305	PF01652	0.368
LIG_FHA_1	104	110	PF00498	0.471
LIG_FHA_1	128	134	PF00498	0.481
LIG_FHA_1	156	162	PF00498	0.549
LIG_FHA_1	199	205	PF00498	0.561
LIG_FHA_1	210	216	PF00498	0.495
LIG_FHA_1	239	245	PF00498	0.668
LIG_FHA_1	282	288	PF00498	0.411
LIG_FHA_1	319	325	PF00498	0.398
LIG_FHA_1	366	372	PF00498	0.640
LIG_FHA_1	424	430	PF00498	0.767
LIG_FHA_1	461	467	PF00498	0.616
LIG_FHA_1	48	54	PF00498	0.479
LIG_FHA_1	67	73	PF00498	0.507
LIG_FHA_2	105	111	PF00498	0.502
LIG_FHA_2	16	22	PF00498	0.593
LIG_FHA_2	178	184	PF00498	0.439
LIG_FHA_2	216	222	PF00498	0.671
LIG_FHA_2	225	231	PF00498	0.601
LIG_FHA_2	271	277	PF00498	0.423
LIG_FHA_2	471	477	PF00498	0.705
LIG_FHA_2	576	582	PF00498	0.776
LIG_FHA_2	586	592	PF00498	0.782
LIG_LIR_Gen_1	163	174	PF02991	0.389
LIG_LIR_Gen_1	177	185	PF02991	0.515
LIG_LIR_Gen_1	201	211	PF02991	0.541
LIG_LIR_Gen_1	213	223	PF02991	0.551
LIG_LIR_Gen_1	280	287	PF02991	0.458
LIG_LIR_Gen_1	296	305	PF02991	0.248
LIG_LIR_Gen_1	345	356	PF02991	0.406
LIG_LIR_Nem_3	110	116	PF02991	0.588
LIG_LIR_Nem_3	163	169	PF02991	0.391
LIG_LIR_Nem_3	177	182	PF02991	0.516
LIG_LIR_Nem_3	205	211	PF02991	0.534
LIG_LIR_Nem_3	213	219	PF02991	0.513
LIG_LIR_Nem_3	280	286	PF02991	0.458
LIG_LIR_Nem_3	296	302	PF02991	0.248
LIG_LIR_Nem_3	345	351	PF02991	0.385
LIG_LIR_Nem_3	453	458	PF02991	0.572
LIG_LIR_Nem_3	552	558	PF02991	0.519
LIG_LIR_Nem_3	606	611	PF02991	0.436
LIG_LIR_Nem_3	628	634	PF02991	0.488
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.527
LIG_Pex14_1	348	352	PF04695	0.411
LIG_Pex14_2	113	117	PF04695	0.474
LIG_PTB_Apo_2	351	358	PF02174	0.346
LIG_PTB_Phospho_1	351	357	PF10480	0.346
LIG_SH2_CRK	166	170	PF00017	0.308
LIG_SH2_CRK	283	287	PF00017	0.411
LIG_SH2_CRK	611	615	PF00017	0.437
LIG_SH2_CRK	619	623	PF00017	0.511
LIG_SH2_NCK_1	337	341	PF00017	0.511
LIG_SH2_STAP1	120	124	PF00017	0.581
LIG_SH2_STAP1	166	170	PF00017	0.441
LIG_SH2_STAP1	283	287	PF00017	0.411
LIG_SH2_STAT5	151	154	PF00017	0.492
LIG_SH2_STAT5	179	182	PF00017	0.431
LIG_SH2_STAT5	283	286	PF00017	0.411
LIG_SH2_STAT5	29	32	PF00017	0.644
LIG_SH2_STAT5	299	302	PF00017	0.411
LIG_SH2_STAT5	621	624	PF00017	0.478
LIG_SH3_3	264	270	PF00018	0.411
LIG_SH3_3	573	579	PF00018	0.740
LIG_SH3_3	589	595	PF00018	0.655
LIG_SH3_3	61	67	PF00018	0.480
LIG_SH3_3	69	75	PF00018	0.505
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.322
LIG_SUMO_SIM_par_1	157	163	PF11976	0.555
LIG_SxIP_EBH_1	157	171	PF03271	0.454
LIG_TRAF2_1	317	320	PF00917	0.423
LIG_TRAF2_1	480	483	PF00917	0.745
LIG_TYR_ITIM	147	152	PF00017	0.470
LIG_TYR_ITIM	164	169	PF00017	0.458
MOD_CDK_SPK_2	318	323	PF00069	0.423
MOD_CDK_SPxxK_3	433	440	PF00069	0.542
MOD_CK1_1	385	391	PF00069	0.535
MOD_CK1_1	399	405	PF00069	0.643
MOD_CK1_1	418	424	PF00069	0.726
MOD_CK1_1	425	431	PF00069	0.646
MOD_CK1_1	447	453	PF00069	0.718
MOD_CK1_1	461	467	PF00069	0.707
MOD_CK1_1	486	492	PF00069	0.790
MOD_CK1_1	642	648	PF00069	0.381
MOD_CK2_1	104	110	PF00069	0.553
MOD_CK2_1	177	183	PF00069	0.449
MOD_CK2_1	215	221	PF00069	0.654
MOD_CK2_1	224	230	PF00069	0.594
MOD_CK2_1	270	276	PF00069	0.511
MOD_CK2_1	314	320	PF00069	0.423
MOD_CK2_1	470	476	PF00069	0.688
MOD_CK2_1	558	564	PF00069	0.759
MOD_CK2_1	575	581	PF00069	0.649
MOD_DYRK1A_RPxSP_1	442	446	PF00069	0.671
MOD_GlcNHglycan	144	147	PF01048	0.534
MOD_GlcNHglycan	279	282	PF01048	0.511
MOD_GlcNHglycan	404	407	PF01048	0.805
MOD_GlcNHglycan	417	420	PF01048	0.589
MOD_GlcNHglycan	429	432	PF01048	0.643
MOD_GlcNHglycan	446	449	PF01048	0.587
MOD_GlcNHglycan	463	466	PF01048	0.748
MOD_GlcNHglycan	487	492	PF01048	0.719
MOD_GlcNHglycan	547	550	PF01048	0.600
MOD_GSK3_1	138	145	PF00069	0.520
MOD_GSK3_1	155	162	PF00069	0.296
MOD_GSK3_1	211	218	PF00069	0.605
MOD_GSK3_1	277	284	PF00069	0.511
MOD_GSK3_1	314	321	PF00069	0.423
MOD_GSK3_1	342	349	PF00069	0.312
MOD_GSK3_1	381	388	PF00069	0.693
MOD_GSK3_1	398	405	PF00069	0.805
MOD_GSK3_1	410	417	PF00069	0.662
MOD_GSK3_1	418	425	PF00069	0.570
MOD_GSK3_1	442	449	PF00069	0.705
MOD_GSK3_1	461	468	PF00069	0.754
MOD_GSK3_1	470	477	PF00069	0.640
MOD_GSK3_1	483	490	PF00069	0.684
MOD_GSK3_1	503	510	PF00069	0.759
MOD_GSK3_1	515	522	PF00069	0.699
MOD_GSK3_1	545	552	PF00069	0.655
MOD_GSK3_1	554	561	PF00069	0.681
MOD_GSK3_1	62	69	PF00069	0.551
MOD_GSK3_1	620	627	PF00069	0.488
MOD_N-GLC_1	155	160	PF02516	0.440
MOD_N-GLC_1	470	475	PF02516	0.554
MOD_N-GLC_1	515	520	PF02516	0.796
MOD_NEK2_1	104	109	PF00069	0.532
MOD_NEK2_1	142	147	PF00069	0.506
MOD_NEK2_1	170	175	PF00069	0.461
MOD_NEK2_1	325	330	PF00069	0.386
MOD_NEK2_1	382	387	PF00069	0.609
MOD_NEK2_2	503	508	PF00069	0.621
MOD_OFUCOSY	41	46	PF10250	0.584
MOD_PIKK_1	104	110	PF00454	0.553
MOD_PIKK_1	314	320	PF00454	0.423
MOD_PIKK_1	396	402	PF00454	0.700
MOD_PIKK_1	62	68	PF00454	0.478
MOD_PKA_2	170	176	PF00069	0.499
MOD_PKA_2	177	183	PF00069	0.413
MOD_PKA_2	209	215	PF00069	0.596
MOD_PKA_2	314	320	PF00069	0.362
MOD_PKA_2	363	369	PF00069	0.411
MOD_PKA_2	432	438	PF00069	0.697
MOD_PKA_2	5	11	PF00069	0.530
MOD_PKA_2	507	513	PF00069	0.644
MOD_PKA_2	545	551	PF00069	0.729
MOD_Plk_1	155	161	PF00069	0.443
MOD_Plk_1	238	244	PF00069	0.587
MOD_Plk_1	487	493	PF00069	0.693
MOD_Plk_1	503	509	PF00069	0.645
MOD_Plk_1	639	645	PF00069	0.605
MOD_Plk_1	84	90	PF00069	0.322
MOD_Plk_2-3	177	183	PF00069	0.449
MOD_Plk_2-3	483	489	PF00069	0.556
MOD_Plk_2-3	84	90	PF00069	0.322
MOD_Plk_4	138	144	PF00069	0.524
MOD_Plk_4	165	171	PF00069	0.473
MOD_Plk_4	177	183	PF00069	0.439
MOD_Plk_4	211	217	PF00069	0.597
MOD_Plk_4	238	244	PF00069	0.587
MOD_Plk_4	270	276	PF00069	0.465
MOD_Plk_4	281	287	PF00069	0.343
MOD_Plk_4	307	313	PF00069	0.423
MOD_Plk_4	382	388	PF00069	0.555
MOD_Plk_4	389	395	PF00069	0.707
MOD_Plk_4	59	65	PF00069	0.557
MOD_Plk_4	6	12	PF00069	0.657
MOD_Plk_4	639	645	PF00069	0.678
MOD_Plk_4	78	84	PF00069	0.297
MOD_ProDKin_1	318	324	PF00069	0.439
MOD_ProDKin_1	399	405	PF00069	0.673
MOD_ProDKin_1	423	429	PF00069	0.724
MOD_ProDKin_1	433	439	PF00069	0.617
MOD_ProDKin_1	442	448	PF00069	0.511
MOD_ProDKin_1	515	521	PF00069	0.708
MOD_ProDKin_1	575	581	PF00069	0.736
MOD_SUMO_rev_2	534	542	PF00179	0.639
TRG_DiLeu_BaEn_1	239	244	PF01217	0.451
TRG_DiLeu_BaEn_1	320	325	PF01217	0.423
TRG_DiLeu_BaEn_4	494	500	PF01217	0.669
TRG_DiLeu_BaLyEn_6	329	334	PF01217	0.472
TRG_DiLeu_LyEn_5	320	325	PF01217	0.423
TRG_ENDOCYTIC_2	120	123	PF00928	0.571
TRG_ENDOCYTIC_2	149	152	PF00928	0.489
TRG_ENDOCYTIC_2	166	169	PF00928	0.445
TRG_ENDOCYTIC_2	179	182	PF00928	0.490
TRG_ENDOCYTIC_2	283	286	PF00928	0.411
TRG_ENDOCYTIC_2	299	302	PF00928	0.411
TRG_ENDOCYTIC_2	611	614	PF00928	0.429
TRG_ENDOCYTIC_2	619	622	PF00928	0.518
TRG_ER_diArg_1	199	202	PF00400	0.667
TRG_ER_diArg_1	51	53	PF00400	0.409
TRG_ER_diArg_1	553	555	PF00400	0.555
TRG_ER_diArg_1	599	601	PF00400	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7D8	Leptomonas seymouri	52%	79%
A0A3Q8I9H1	Leishmania donovani	91%	100%
A4HHR9	Leishmania braziliensis	77%	83%
A4HVF6	Leishmania infantum	91%	100%
E9AP55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%