RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-RING finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QGD1_LEIMA

TriTrypDb:

LmjF.13.0230 , LMJLV39_130007300 , LMJSD75_130007400

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0000795	synaptonemal complex	3	6
GO:0099086	synaptonemal structure	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QGD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006259	DNA metabolic process	4	6
GO:0006310	DNA recombination	5	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006996	organelle organization	4	2
GO:0007129	homologous chromosome pairing at meiosis	4	2
GO:0007131	reciprocal meiotic recombination	3	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	2
GO:0016925	protein sumoylation	7	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018205	peptidyl-lysine modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0022402	cell cycle process	2	6
GO:0022414	reproductive process	1	6
GO:0032446	protein modification by small protein conjugation	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0035825	homologous recombination	6	6
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044260	obsolete cellular macromolecule metabolic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0051276	chromosome organization	5	2
GO:0070192	chromosome organization involved in meiotic cell cycle	3	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	6
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090304	nucleic acid metabolic process	4	6
GO:0140527	reciprocal homologous recombination	7	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1903046	meiotic cell cycle process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005488	binding	1	4
GO:0016740	transferase activity	2	6
GO:0019787	ubiquitin-like protein transferase activity	3	6
GO:0019789	SUMO transferase activity	4	6
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.414
CLV_NRD_NRD_1	149	151	PF00675	0.448
CLV_NRD_NRD_1	306	308	PF00675	0.575
CLV_NRD_NRD_1	385	387	PF00675	0.571
CLV_PCSK_KEX2_1	293	295	PF00082	0.581
CLV_PCSK_KEX2_1	305	307	PF00082	0.557
CLV_PCSK_KEX2_1	385	387	PF00082	0.571
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.581
CLV_PCSK_SKI1_1	327	331	PF00082	0.562
CLV_PCSK_SKI1_1	91	95	PF00082	0.395
DEG_APCC_DBOX_1	90	98	PF00400	0.399
DEG_SPOP_SBC_1	399	403	PF00917	0.512
DOC_CKS1_1	372	377	PF01111	0.548
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.549
DOC_PP4_FxxP_1	410	413	PF00568	0.575
DOC_USP7_MATH_1	105	109	PF00917	0.400
DOC_USP7_MATH_1	117	121	PF00917	0.357
DOC_USP7_MATH_1	221	225	PF00917	0.559
DOC_USP7_MATH_1	228	232	PF00917	0.556
DOC_USP7_MATH_1	233	237	PF00917	0.544
DOC_USP7_MATH_1	241	245	PF00917	0.578
DOC_USP7_MATH_1	266	270	PF00917	0.592
DOC_USP7_MATH_1	318	322	PF00917	0.560
DOC_USP7_MATH_1	345	349	PF00917	0.580
DOC_USP7_MATH_1	353	357	PF00917	0.560
DOC_USP7_MATH_1	364	368	PF00917	0.478
DOC_USP7_MATH_1	393	397	PF00917	0.564
DOC_USP7_MATH_1	399	403	PF00917	0.526
DOC_WW_Pin1_4	193	198	PF00397	0.552
DOC_WW_Pin1_4	224	229	PF00397	0.568
DOC_WW_Pin1_4	237	242	PF00397	0.561
DOC_WW_Pin1_4	328	333	PF00397	0.577
DOC_WW_Pin1_4	336	341	PF00397	0.568
DOC_WW_Pin1_4	360	365	PF00397	0.552
DOC_WW_Pin1_4	371	376	PF00397	0.515
DOC_WW_Pin1_4	409	414	PF00397	0.573
LIG_14-3-3_CanoR_1	150	159	PF00244	0.519
LIG_14-3-3_CanoR_1	175	183	PF00244	0.533
LIG_14-3-3_CanoR_1	222	228	PF00244	0.551
LIG_14-3-3_CanoR_1	234	243	PF00244	0.541
LIG_14-3-3_CanoR_1	294	303	PF00244	0.559
LIG_14-3-3_CanoR_1	312	316	PF00244	0.511
LIG_14-3-3_CanoR_1	333	339	PF00244	0.570
LIG_14-3-3_CanoR_1	400	406	PF00244	0.544
LIG_14-3-3_CanoR_1	408	413	PF00244	0.568
LIG_BIR_II_1	1	5	PF00653	0.386
LIG_BRCT_BRCA1_1	348	352	PF00533	0.583
LIG_BRCT_BRCA1_1	366	370	PF00533	0.480
LIG_Clathr_ClatBox_1	50	54	PF01394	0.383
LIG_FHA_1	188	194	PF00498	0.550
LIG_FHA_1	371	377	PF00498	0.549
LIG_FHA_1	70	76	PF00498	0.381
LIG_LIR_Apic_2	231	235	PF02991	0.575
LIG_LIR_Nem_3	2	6	PF02991	0.377
LIG_SH2_CRK	48	52	PF00017	0.619
LIG_SH2_CRK	83	87	PF00017	0.633
LIG_SH2_STAT5	26	29	PF00017	0.304
LIG_SH3_1	209	215	PF00018	0.567
LIG_SH3_2	301	306	PF14604	0.560
LIG_SH3_3	156	162	PF00018	0.799
LIG_SH3_3	209	215	PF00018	0.567
LIG_SH3_3	298	304	PF00018	0.558
LIG_SUMO_SIM_par_1	49	54	PF11976	0.332
LIG_TRAF2_1	124	127	PF00917	0.369
MOD_CDK_SPK_2	224	229	PF00069	0.562
MOD_CDK_SPK_2	328	333	PF00069	0.568
MOD_CDK_SPK_2	409	414	PF00069	0.573
MOD_CDK_SPxxK_3	336	343	PF00069	0.558
MOD_CK1_1	224	230	PF00069	0.572
MOD_CK1_1	236	242	PF00069	0.561
MOD_CK1_1	244	250	PF00069	0.588
MOD_CK1_1	269	275	PF00069	0.578
MOD_CK1_1	286	292	PF00069	0.519
MOD_CK1_1	299	305	PF00069	0.538
MOD_GlcNHglycan	179	182	PF01048	0.508
MOD_GlcNHglycan	270	274	PF01048	0.705
MOD_GlcNHglycan	285	288	PF01048	0.708
MOD_GlcNHglycan	355	358	PF01048	0.588
MOD_GSK3_1	137	144	PF00069	0.520
MOD_GSK3_1	145	152	PF00069	0.373
MOD_GSK3_1	177	184	PF00069	0.511
MOD_GSK3_1	224	231	PF00069	0.580
MOD_GSK3_1	233	240	PF00069	0.565
MOD_GSK3_1	26	33	PF00069	0.307
MOD_GSK3_1	268	275	PF00069	0.572
MOD_GSK3_1	360	367	PF00069	0.537
MOD_NEK2_1	283	288	PF00069	0.556
MOD_NEK2_1	370	375	PF00069	0.547
MOD_PIKK_1	105	111	PF00454	0.406
MOD_PIKK_1	117	123	PF00454	0.331
MOD_PIKK_1	145	151	PF00454	0.436
MOD_PIKK_1	154	160	PF00454	0.523
MOD_PIKK_1	75	81	PF00454	0.398
MOD_PKA_1	150	156	PF00069	0.481
MOD_PKA_2	105	111	PF00069	0.396
MOD_PKA_2	149	155	PF00069	0.466
MOD_PKA_2	174	180	PF00069	0.548
MOD_PKA_2	221	227	PF00069	0.571
MOD_PKA_2	228	234	PF00069	0.573
MOD_PKA_2	311	317	PF00069	0.556
MOD_PKA_2	399	405	PF00069	0.559
MOD_PKB_1	294	302	PF00069	0.584
MOD_Plk_4	286	292	PF00069	0.566
MOD_Plk_4	386	392	PF00069	0.572
MOD_Plk_4	393	399	PF00069	0.543
MOD_Plk_4	64	70	PF00069	0.441
MOD_ProDKin_1	193	199	PF00069	0.551
MOD_ProDKin_1	224	230	PF00069	0.570
MOD_ProDKin_1	237	243	PF00069	0.558
MOD_ProDKin_1	328	334	PF00069	0.579
MOD_ProDKin_1	336	342	PF00069	0.571
MOD_ProDKin_1	360	366	PF00069	0.552
MOD_ProDKin_1	371	377	PF00069	0.516
MOD_ProDKin_1	409	415	PF00069	0.568
TRG_DiLeu_BaEn_4	127	133	PF01217	0.371
TRG_ENDOCYTIC_2	48	51	PF00928	0.616
TRG_ENDOCYTIC_2	83	86	PF00928	0.635
TRG_ER_diArg_1	304	307	PF00400	0.575
TRG_ER_diArg_1	385	387	PF00400	0.571
TRG_NLS_MonoExtC_3	292	298	PF00514	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WSB0	Leishmania donovani	93%	100%
A4HHR7	Leishmania braziliensis	64%	83%
A4HVF8	Leishmania infantum	94%	100%
E9AP57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%