DUF4200 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4200), putative

Species:

Leishmania major

UniProt:

Q4QGD0_LEIMA

TriTrypDb:

LmjF.13.0240 , LMJLV39_130007400 , LMJSD75_130007500

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005930	axoneme	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	4
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

Q4QGD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.621
CLV_C14_Caspase3-7	3	7	PF00656	0.653
CLV_NRD_NRD_1	15	17	PF00675	0.247
CLV_NRD_NRD_1	157	159	PF00675	0.435
CLV_NRD_NRD_1	179	181	PF00675	0.471
CLV_NRD_NRD_1	34	36	PF00675	0.191
CLV_NRD_NRD_1	84	86	PF00675	0.294
CLV_PCSK_FUR_1	177	181	PF00082	0.521
CLV_PCSK_KEX2_1	105	107	PF00082	0.303
CLV_PCSK_KEX2_1	143	145	PF00082	0.503
CLV_PCSK_KEX2_1	15	17	PF00082	0.252
CLV_PCSK_KEX2_1	179	181	PF00082	0.445
CLV_PCSK_KEX2_1	28	30	PF00082	0.252
CLV_PCSK_KEX2_1	34	36	PF00082	0.252
CLV_PCSK_KEX2_1	70	72	PF00082	0.252
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.345
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.579
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.252
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.261
CLV_PCSK_PC7_1	139	145	PF00082	0.547
CLV_PCSK_SKI1_1	144	148	PF00082	0.540
CLV_PCSK_SKI1_1	203	207	PF00082	0.441
CLV_PCSK_SKI1_1	214	218	PF00082	0.465
CLV_PCSK_SKI1_1	73	77	PF00082	0.261
DOC_MAPK_gen_1	13	21	PF00069	0.379
DOC_MAPK_gen_1	168	175	PF00069	0.444
DOC_MAPK_gen_1	177	187	PF00069	0.417
DOC_MAPK_gen_1	70	80	PF00069	0.523
DOC_MAPK_RevD_3	90	106	PF00069	0.502
DOC_PP1_RVXF_1	237	244	PF00149	0.385
DOC_USP7_MATH_1	4	8	PF00917	0.610
LIG_14-3-3_CanoR_1	144	149	PF00244	0.416
LIG_14-3-3_CanoR_1	158	166	PF00244	0.421
LIG_14-3-3_CanoR_1	168	174	PF00244	0.440
LIG_14-3-3_CanoR_1	224	231	PF00244	0.463
LIG_14-3-3_CanoR_1	239	244	PF00244	0.468
LIG_Actin_WH2_2	1	17	PF00022	0.530
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_FHA_1	150	156	PF00498	0.418
LIG_FHA_1	180	186	PF00498	0.550
LIG_FHA_1	221	227	PF00498	0.504
LIG_FHA_1	231	237	PF00498	0.452
LIG_FHA_1	94	100	PF00498	0.456
LIG_FHA_2	109	115	PF00498	0.484
LIG_FHA_2	119	125	PF00498	0.402
LIG_FHA_2	145	151	PF00498	0.414
LIG_FHA_2	158	164	PF00498	0.421
LIG_LIR_Apic_2	133	138	PF02991	0.451
LIG_LIR_Gen_1	111	119	PF02991	0.533
LIG_LIR_Gen_1	197	205	PF02991	0.454
LIG_LIR_Gen_1	272	279	PF02991	0.441
LIG_LIR_Nem_3	111	116	PF02991	0.462
LIG_LIR_Nem_3	117	122	PF02991	0.443
LIG_LIR_Nem_3	197	201	PF02991	0.474
LIG_LIR_Nem_3	272	277	PF02991	0.423
LIG_LRP6_Inhibitor_1	64	70	PF00058	0.264
LIG_PCNA_PIPBox_1	54	63	PF02747	0.452
LIG_PCNA_yPIPBox_3	203	216	PF02747	0.500
LIG_PCNA_yPIPBox_3	50	61	PF02747	0.452
LIG_Pex14_1	243	247	PF04695	0.461
LIG_SH2_CRK	61	65	PF00017	0.452
LIG_SH2_NCK_1	113	117	PF00017	0.502
LIG_SH2_SRC	113	116	PF00017	0.547
LIG_SH2_SRC	135	138	PF00017	0.506
LIG_SH2_STAP1	237	241	PF00017	0.400
LIG_SH2_STAT3	91	94	PF00017	0.538
LIG_SH2_STAT5	91	94	PF00017	0.538
LIG_TRAF2_1	79	82	PF00917	0.493
LIG_TYR_ITSM	109	116	PF00017	0.474
LIG_WRC_WIRS_1	119	124	PF05994	0.502
MOD_CK1_1	197	203	PF00069	0.582
MOD_CK1_1	220	226	PF00069	0.480
MOD_CK1_1	227	233	PF00069	0.465
MOD_CK2_1	108	114	PF00069	0.530
MOD_CK2_1	118	124	PF00069	0.556
MOD_CK2_1	157	163	PF00069	0.443
MOD_GlcNHglycan	2	5	PF01048	0.625
MOD_GlcNHglycan	246	250	PF01048	0.514
MOD_GSK3_1	218	225	PF00069	0.449
MOD_N-GLC_1	150	155	PF02516	0.525
MOD_NEK2_1	166	171	PF00069	0.552
MOD_NEK2_1	53	58	PF00069	0.493
MOD_PIKK_1	108	114	PF00454	0.363
MOD_PIKK_1	157	163	PF00454	0.438
MOD_PIKK_1	93	99	PF00454	0.530
MOD_PKA_1	179	185	PF00069	0.556
MOD_PKA_2	157	163	PF00069	0.433
MOD_PKA_2	169	175	PF00069	0.431
MOD_PKA_2	179	185	PF00069	0.556
MOD_PKB_1	177	185	PF00069	0.557
MOD_Plk_1	149	155	PF00069	0.533
MOD_Plk_4	118	124	PF00069	0.553
MOD_Plk_4	150	156	PF00069	0.490
MOD_Plk_4	239	245	PF00069	0.494
MOD_Plk_4	273	279	PF00069	0.465
MOD_Plk_4	53	59	PF00069	0.479
MOD_SUMO_for_1	27	30	PF00179	0.450
MOD_SUMO_rev_2	103	111	PF00179	0.557
MOD_SUMO_rev_2	66	72	PF00179	0.477
TRG_ENDOCYTIC_2	113	116	PF00928	0.538
TRG_ENDOCYTIC_2	119	122	PF00928	0.538
TRG_ENDOCYTIC_2	60	63	PF00928	0.452
TRG_ER_diArg_1	14	16	PF00400	0.305
TRG_ER_diArg_1	167	170	PF00400	0.555
TRG_ER_diArg_1	177	180	PF00400	0.562
TRG_ER_diArg_1	34	36	PF00400	0.321
TRG_NES_CRM1_1	254	269	PF08389	0.504
TRG_NES_CRM1_1	94	108	PF08389	0.418
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ4	Leptomonas seymouri	85%	100%
A0A0S4JBA5	Bodo saltans	52%	100%
A0A1X0NNL1	Trypanosomatidae	60%	100%
A0A3S5H6N0	Leishmania donovani	98%	100%
A0A422NNY8	Trypanosoma rangeli	62%	100%
A4HHR6	Leishmania braziliensis	89%	88%
A4HVF9	Leishmania infantum	98%	100%
A6QQM8	Bos taurus	23%	97%
A7S8T5	Nematostella vectensis	29%	98%
A9UQN0	Monosiga brevicollis	28%	100%
B0BMJ2	Xenopus tropicalis	29%	98%
D0A6V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AP58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
M1V4Y8	Chlamydomonas reinhardtii	32%	100%
Q5SV66	Mus musculus	25%	97%
Q6NTM6	Xenopus laevis	28%	98%
Q96M95	Homo sapiens	24%	97%
V5ATV5	Trypanosoma cruzi	59%	100%