Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP48

Species:

Leishmania major

UniProt:

Q4QGC9_LEIMA

TriTrypDb:

LmjF.13.0250 , LMJLV39_130007500 , LMJSD75_130007600

Length:

533

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QGC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGC9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0046907	intracellular transport	3	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.749
CLV_C14_Caspase3-7	269	273	PF00656	0.513
CLV_NRD_NRD_1	120	122	PF00675	0.687
CLV_NRD_NRD_1	126	128	PF00675	0.668
CLV_NRD_NRD_1	171	173	PF00675	0.599
CLV_NRD_NRD_1	177	179	PF00675	0.559
CLV_NRD_NRD_1	466	468	PF00675	0.404
CLV_PCSK_KEX2_1	119	121	PF00082	0.682
CLV_PCSK_KEX2_1	126	128	PF00082	0.678
CLV_PCSK_KEX2_1	171	173	PF00082	0.596
CLV_PCSK_KEX2_1	177	179	PF00082	0.562
CLV_PCSK_KEX2_1	465	467	PF00082	0.412
CLV_PCSK_SKI1_1	160	164	PF00082	0.564
CLV_PCSK_SKI1_1	171	175	PF00082	0.493
CLV_PCSK_SKI1_1	246	250	PF00082	0.390
CLV_PCSK_SKI1_1	289	293	PF00082	0.472
CLV_PCSK_SKI1_1	323	327	PF00082	0.507
CLV_PCSK_SKI1_1	6	10	PF00082	0.508
CLV_Separin_Metazoa	3	7	PF03568	0.518
DEG_APCC_DBOX_1	126	134	PF00400	0.673
DEG_Nend_Nbox_1	1	3	PF02207	0.456
DEG_SPOP_SBC_1	208	212	PF00917	0.348
DOC_CKS1_1	399	404	PF01111	0.518
DOC_CYCLIN_RxL_1	169	179	PF00134	0.574
DOC_CYCLIN_RxL_1	3	12	PF00134	0.456
DOC_MAPK_HePTP_8	430	442	PF00069	0.514
DOC_MAPK_MEF2A_6	433	442	PF00069	0.508
DOC_PP1_RVXF_1	233	239	PF00149	0.443
DOC_PP1_RVXF_1	321	327	PF00149	0.527
DOC_PP2B_PxIxI_1	435	441	PF00149	0.497
DOC_PP4_FxxP_1	154	157	PF00568	0.538
DOC_USP7_MATH_1	176	180	PF00917	0.614
DOC_USP7_MATH_1	208	212	PF00917	0.496
DOC_USP7_MATH_1	264	268	PF00917	0.643
DOC_USP7_MATH_1	284	288	PF00917	0.659
DOC_USP7_MATH_1	294	298	PF00917	0.545
DOC_USP7_MATH_1	315	319	PF00917	0.375
DOC_USP7_MATH_1	387	391	PF00917	0.621
DOC_USP7_MATH_1	393	397	PF00917	0.549
DOC_USP7_MATH_1	503	507	PF00917	0.482
DOC_USP7_MATH_1	78	82	PF00917	0.722
DOC_WW_Pin1_4	378	383	PF00397	0.637
DOC_WW_Pin1_4	398	403	PF00397	0.216
LIG_14-3-3_CanoR_1	107	113	PF00244	0.710
LIG_14-3-3_CanoR_1	126	130	PF00244	0.644
LIG_14-3-3_CanoR_1	296	302	PF00244	0.460
LIG_14-3-3_CanoR_1	77	85	PF00244	0.766
LIG_BRCT_BRCA1_1	416	420	PF00533	0.497
LIG_deltaCOP1_diTrp_1	272	281	PF00928	0.508
LIG_EH_1	434	438	PF12763	0.454
LIG_FHA_1	210	216	PF00498	0.458
LIG_FHA_1	320	326	PF00498	0.507
LIG_FHA_1	339	345	PF00498	0.405
LIG_FHA_1	421	427	PF00498	0.473
LIG_FHA_1	472	478	PF00498	0.380
LIG_FHA_1	510	516	PF00498	0.511
LIG_FHA_2	112	118	PF00498	0.700
LIG_FHA_2	364	370	PF00498	0.517
LIG_FHA_2	457	463	PF00498	0.470
LIG_GBD_Chelix_1	442	450	PF00786	0.505
LIG_LIR_Apic_2	151	157	PF02991	0.574
LIG_LIR_Gen_1	106	115	PF02991	0.629
LIG_LIR_Gen_1	37	47	PF02991	0.518
LIG_LIR_Nem_3	106	112	PF02991	0.748
LIG_LIR_Nem_3	191	195	PF02991	0.456
LIG_LIR_Nem_3	37	42	PF02991	0.546
LIG_LIR_Nem_3	448	454	PF02991	0.515
LIG_LIR_Nem_3	514	519	PF02991	0.408
LIG_LYPXL_S_1	46	50	PF13949	0.568
LIG_LYPXL_yS_3	47	50	PF13949	0.567
LIG_MLH1_MIPbox_1	416	420	PF16413	0.497
LIG_MYND_1	138	142	PF01753	0.621
LIG_NBox_RRM_1	163	173	PF00076	0.527
LIG_SH2_CRK	39	43	PF00017	0.525
LIG_SH2_CRK	451	455	PF00017	0.520
LIG_SH2_STAT5	419	422	PF00017	0.469
LIG_SH3_3	330	336	PF00018	0.569
LIG_SH3_3	339	345	PF00018	0.578
LIG_SH3_3	396	402	PF00018	0.488
LIG_SUMO_SIM_anti_2	371	377	PF11976	0.436
LIG_SUMO_SIM_par_1	340	346	PF11976	0.599
LIG_TRAF2_1	202	205	PF00917	0.527
LIG_WRC_WIRS_1	504	509	PF05994	0.522
MOD_CK1_1	111	117	PF00069	0.693
MOD_CK1_1	297	303	PF00069	0.533
MOD_CK1_1	381	387	PF00069	0.597
MOD_CK1_1	444	450	PF00069	0.526
MOD_CK1_1	70	76	PF00069	0.718
MOD_CK1_1	81	87	PF00069	0.745
MOD_CK2_1	363	369	PF00069	0.499
MOD_CK2_1	456	462	PF00069	0.470
MOD_CMANNOS	238	241	PF00535	0.486
MOD_Cter_Amidation	124	127	PF01082	0.630
MOD_GlcNHglycan	135	138	PF01048	0.628
MOD_GlcNHglycan	265	269	PF01048	0.607
MOD_GlcNHglycan	285	289	PF01048	0.546
MOD_GlcNHglycan	296	299	PF01048	0.449
MOD_GlcNHglycan	35	39	PF01048	0.494
MOD_GlcNHglycan	383	386	PF01048	0.693
MOD_GlcNHglycan	389	392	PF01048	0.671
MOD_GlcNHglycan	72	75	PF01048	0.758
MOD_GlcNHglycan	80	83	PF01048	0.767
MOD_GlcNHglycan	85	88	PF01048	0.753
MOD_GSK3_1	103	110	PF00069	0.710
MOD_GSK3_1	158	165	PF00069	0.570
MOD_GSK3_1	315	322	PF00069	0.527
MOD_GSK3_1	34	41	PF00069	0.515
MOD_GSK3_1	383	390	PF00069	0.584
MOD_GSK3_1	441	448	PF00069	0.542
MOD_GSK3_1	66	73	PF00069	0.653
MOD_GSK3_1	76	83	PF00069	0.708
MOD_N-GLC_1	66	71	PF02516	0.759
MOD_NEK2_1	133	138	PF00069	0.636
MOD_NEK2_1	148	153	PF00069	0.416
MOD_NEK2_1	234	239	PF00069	0.335
MOD_NEK2_1	263	268	PF00069	0.487
MOD_NEK2_1	299	304	PF00069	0.461
MOD_NEK2_1	363	368	PF00069	0.494
MOD_NEK2_1	420	425	PF00069	0.506
MOD_NEK2_1	445	450	PF00069	0.375
MOD_NEK2_1	461	466	PF00069	0.385
MOD_NEK2_1	93	98	PF00069	0.767
MOD_NEK2_2	158	163	PF00069	0.605
MOD_PKA_1	119	125	PF00069	0.713
MOD_PKA_2	119	125	PF00069	0.711
MOD_PKA_2	176	182	PF00069	0.540
MOD_PKA_2	185	191	PF00069	0.386
MOD_PKA_2	409	415	PF00069	0.510
MOD_PKA_2	76	82	PF00069	0.777
MOD_Plk_1	34	40	PF00069	0.522
MOD_Plk_1	368	374	PF00069	0.370
MOD_Plk_4	234	240	PF00069	0.530
MOD_Plk_4	338	344	PF00069	0.529
MOD_Plk_4	414	420	PF00069	0.500
MOD_Plk_4	441	447	PF00069	0.537
MOD_Plk_4	511	517	PF00069	0.379
MOD_ProDKin_1	378	384	PF00069	0.645
MOD_ProDKin_1	398	404	PF00069	0.214
TRG_DiLeu_BaEn_1	473	478	PF01217	0.401
TRG_DiLeu_BaLyEn_6	169	174	PF01217	0.523
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.488
TRG_ENDOCYTIC_2	196	199	PF00928	0.496
TRG_ENDOCYTIC_2	39	42	PF00928	0.504
TRG_ENDOCYTIC_2	451	454	PF00928	0.518
TRG_ENDOCYTIC_2	47	50	PF00928	0.486
TRG_ER_diArg_1	119	121	PF00400	0.699
TRG_ER_diArg_1	171	173	PF00400	0.598
TRG_ER_diArg_1	177	180	PF00400	0.566
TRG_ER_diArg_1	376	379	PF00400	0.534
TRG_ER_diArg_1	465	467	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.410
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6I3	Leptomonas seymouri	56%	100%
A0A0S4JJV4	Bodo saltans	26%	100%
A0A1X0NPX8	Trypanosomatidae	41%	100%
A0A3Q8ICS9	Leishmania donovani	95%	100%
A0A3R7KGG9	Trypanosoma rangeli	36%	100%
A4HHS4	Leishmania braziliensis	84%	100%
A4HVH0	Leishmania infantum	95%	100%
D0A6U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AP59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5D9X2	Trypanosoma cruzi	36%	100%