Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGB3_LEIMA

TriTrypDb:

LmjF.13.0410 , LMJLV39_130008000 , LMJSD75_130008100

Length:

1096

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGB3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1061	1065	PF00656	0.609
CLV_C14_Caspase3-7	134	138	PF00656	0.524
CLV_NRD_NRD_1	380	382	PF00675	0.496
CLV_NRD_NRD_1	400	402	PF00675	0.342
CLV_NRD_NRD_1	769	771	PF00675	0.503
CLV_NRD_NRD_1	801	803	PF00675	0.609
CLV_NRD_NRD_1	862	864	PF00675	0.658
CLV_NRD_NRD_1	874	876	PF00675	0.696
CLV_NRD_NRD_1	881	883	PF00675	0.718
CLV_NRD_NRD_1	90	92	PF00675	0.335
CLV_NRD_NRD_1	985	987	PF00675	0.508
CLV_PCSK_FUR_1	879	883	PF00082	0.626
CLV_PCSK_KEX2_1	400	402	PF00082	0.630
CLV_PCSK_KEX2_1	769	771	PF00082	0.510
CLV_PCSK_KEX2_1	801	803	PF00082	0.684
CLV_PCSK_KEX2_1	864	866	PF00082	0.662
CLV_PCSK_KEX2_1	873	875	PF00082	0.695
CLV_PCSK_KEX2_1	881	883	PF00082	0.738
CLV_PCSK_KEX2_1	90	92	PF00082	0.335
CLV_PCSK_KEX2_1	985	987	PF00082	0.516
CLV_PCSK_PC1ET2_1	864	866	PF00082	0.691
CLV_PCSK_SKI1_1	1048	1052	PF00082	0.513
CLV_PCSK_SKI1_1	215	219	PF00082	0.474
CLV_PCSK_SKI1_1	600	604	PF00082	0.468
CLV_PCSK_SKI1_1	770	774	PF00082	0.497
CLV_PCSK_SKI1_1	777	781	PF00082	0.495
CLV_PCSK_SKI1_1	844	848	PF00082	0.452
DEG_APCC_DBOX_1	1032	1040	PF00400	0.475
DEG_APCC_DBOX_1	151	159	PF00400	0.412
DEG_APCC_DBOX_1	671	679	PF00400	0.513
DEG_APCC_DBOX_1	769	777	PF00400	0.497
DEG_APCC_DBOX_1	945	953	PF00400	0.470
DEG_APCC_DBOX_1	984	992	PF00400	0.483
DEG_Nend_UBRbox_3	1	3	PF02207	0.647
DEG_SCF_FBW7_1	252	259	PF00400	0.478
DEG_SCF_FBW7_1	908	915	PF00400	0.690
DEG_SCF_FBW7_2	1081	1088	PF00400	0.583
DOC_CKS1_1	1082	1087	PF01111	0.592
DOC_CKS1_1	913	918	PF01111	0.761
DOC_CYCLIN_RxL_1	567	577	PF00134	0.426
DOC_CYCLIN_RxL_1	807	819	PF00134	0.500
DOC_CYCLIN_yCln2_LP_2	963	969	PF00134	0.541
DOC_MAPK_DCC_7	1018	1028	PF00069	0.452
DOC_MAPK_gen_1	225	233	PF00069	0.354
DOC_MAPK_gen_1	346	354	PF00069	0.571
DOC_MAPK_gen_1	769	775	PF00069	0.498
DOC_MAPK_gen_1	809	818	PF00069	0.566
DOC_MAPK_gen_1	985	993	PF00069	0.573
DOC_MAPK_MEF2A_6	173	180	PF00069	0.334
DOC_MAPK_MEF2A_6	215	224	PF00069	0.559
DOC_MAPK_MEF2A_6	237	245	PF00069	0.493
DOC_MAPK_MEF2A_6	600	608	PF00069	0.411
DOC_MAPK_MEF2A_6	809	817	PF00069	0.429
DOC_PP1_RVXF_1	480	487	PF00149	0.373
DOC_PP2B_LxvP_1	153	156	PF13499	0.415
DOC_PP2B_LxvP_1	352	355	PF13499	0.678
DOC_USP7_MATH_1	1083	1087	PF00917	0.645
DOC_USP7_MATH_1	213	217	PF00917	0.508
DOC_USP7_MATH_1	235	239	PF00917	0.465
DOC_USP7_MATH_1	256	260	PF00917	0.526
DOC_USP7_MATH_1	287	291	PF00917	0.666
DOC_USP7_MATH_1	514	518	PF00917	0.730
DOC_USP7_MATH_1	613	617	PF00917	0.589
DOC_USP7_MATH_1	65	69	PF00917	0.704
DOC_USP7_MATH_1	666	670	PF00917	0.568
DOC_USP7_UBL2_3	173	177	PF12436	0.546
DOC_WW_Pin1_4	1081	1086	PF00397	0.639
DOC_WW_Pin1_4	252	257	PF00397	0.461
DOC_WW_Pin1_4	362	367	PF00397	0.736
DOC_WW_Pin1_4	38	43	PF00397	0.602
DOC_WW_Pin1_4	428	433	PF00397	0.562
DOC_WW_Pin1_4	498	503	PF00397	0.743
DOC_WW_Pin1_4	908	913	PF00397	0.730
DOC_WW_Pin1_4	924	929	PF00397	0.660
DOC_WW_Pin1_4	991	996	PF00397	0.478
LIG_14-3-3_CanoR_1	228	234	PF00244	0.540
LIG_14-3-3_CanoR_1	600	605	PF00244	0.537
LIG_14-3-3_CanoR_1	645	651	PF00244	0.524
LIG_14-3-3_CanoR_1	708	714	PF00244	0.664
LIG_14-3-3_CanoR_1	722	730	PF00244	0.552
LIG_14-3-3_CanoR_1	756	766	PF00244	0.512
LIG_14-3-3_CanoR_1	770	776	PF00244	0.426
LIG_14-3-3_CanoR_1	801	810	PF00244	0.536
LIG_14-3-3_CanoR_1	954	960	PF00244	0.501
LIG_Actin_WH2_2	313	330	PF00022	0.402
LIG_AP2alpha_1	34	38	PF02296	0.517
LIG_APCC_Cbox_2	347	353	PF00515	0.650
LIG_BRCT_BRCA1_1	716	720	PF00533	0.600
LIG_Clathr_ClatBox_1	111	115	PF01394	0.513
LIG_Clathr_ClatBox_1	815	819	PF01394	0.475
LIG_deltaCOP1_diTrp_1	920	923	PF00928	0.731
LIG_eIF4E_1	478	484	PF01652	0.365
LIG_EVH1_1	913	917	PF00568	0.802
LIG_FAT_LD_1	23	31	PF03623	0.448
LIG_FHA_1	146	152	PF00498	0.474
LIG_FHA_1	209	215	PF00498	0.528
LIG_FHA_1	286	292	PF00498	0.680
LIG_FHA_1	451	457	PF00498	0.543
LIG_FHA_1	502	508	PF00498	0.781
LIG_FHA_1	601	607	PF00498	0.497
LIG_FHA_1	702	708	PF00498	0.637
LIG_FHA_1	741	747	PF00498	0.411
LIG_FHA_1	748	754	PF00498	0.451
LIG_FHA_1	810	816	PF00498	0.333
LIG_FHA_1	845	851	PF00498	0.438
LIG_FHA_2	1039	1045	PF00498	0.537
LIG_FHA_2	144	150	PF00498	0.471
LIG_FHA_2	387	393	PF00498	0.546
LIG_FHA_2	445	451	PF00498	0.542
LIG_FHA_2	827	833	PF00498	0.506
LIG_FHA_2	855	861	PF00498	0.579
LIG_GBD_Chelix_1	263	271	PF00786	0.518
LIG_GBD_Chelix_1	564	572	PF00786	0.371
LIG_HP1_1	1025	1029	PF01393	0.488
LIG_IRF3_LxIS_1	186	193	PF10401	0.472
LIG_LIR_Apic_2	517	523	PF02991	0.586
LIG_LIR_Gen_1	313	323	PF02991	0.558
LIG_LIR_Gen_1	458	464	PF02991	0.533
LIG_LIR_Gen_1	532	543	PF02991	0.435
LIG_LIR_Gen_1	554	563	PF02991	0.583
LIG_LIR_Gen_1	605	615	PF02991	0.524
LIG_LIR_Gen_1	819	830	PF02991	0.530
LIG_LIR_Gen_1	857	866	PF02991	0.691
LIG_LIR_Gen_1	958	968	PF02991	0.439
LIG_LIR_LC3C_4	481	485	PF02991	0.432
LIG_LIR_LC3C_4	812	817	PF02991	0.321
LIG_LIR_Nem_3	313	318	PF02991	0.568
LIG_LIR_Nem_3	347	352	PF02991	0.576
LIG_LIR_Nem_3	458	463	PF02991	0.437
LIG_LIR_Nem_3	466	470	PF02991	0.403
LIG_LIR_Nem_3	554	558	PF02991	0.531
LIG_LIR_Nem_3	605	610	PF02991	0.488
LIG_LIR_Nem_3	819	825	PF02991	0.501
LIG_LIR_Nem_3	857	861	PF02991	0.679
LIG_LIR_Nem_3	920	926	PF02991	0.731
LIG_LIR_Nem_3	951	956	PF02991	0.385
LIG_LIR_Nem_3	958	963	PF02991	0.375
LIG_NRBOX	639	645	PF00104	0.517
LIG_NRBOX	958	964	PF00104	0.425
LIG_OCRL_FandH_1	641	653	PF00620	0.514
LIG_PALB2_WD40_1	123	131	PF16756	0.524
LIG_Pex14_2	34	38	PF04695	0.417
LIG_Pex14_2	531	535	PF04695	0.425
LIG_REV1ctd_RIR_1	97	106	PF16727	0.492
LIG_SH2_CRK	555	559	PF00017	0.522
LIG_SH2_CRK	788	792	PF00017	0.614
LIG_SH2_CRK	822	826	PF00017	0.517
LIG_SH2_GRB2like	785	788	PF00017	0.566
LIG_SH2_NCK_1	265	269	PF00017	0.518
LIG_SH2_SRC	265	268	PF00017	0.512
LIG_SH2_STAP1	460	464	PF00017	0.554
LIG_SH2_STAT5	165	168	PF00017	0.413
LIG_SH2_STAT5	326	329	PF00017	0.520
LIG_SH2_STAT5	397	400	PF00017	0.582
LIG_SH2_STAT5	478	481	PF00017	0.361
LIG_SH2_STAT5	607	610	PF00017	0.404
LIG_SH2_STAT5	785	788	PF00017	0.566
LIG_SH2_STAT5	926	929	PF00017	0.530
LIG_SH2_STAT5	956	959	PF00017	0.377
LIG_SH3_3	504	510	PF00018	0.755
LIG_SH3_3	6	12	PF00018	0.558
LIG_SH3_3	911	917	PF00018	0.717
LIG_SUMO_SIM_anti_2	674	679	PF11976	0.556
LIG_SUMO_SIM_par_1	141	146	PF11976	0.448
LIG_SUMO_SIM_par_1	316	322	PF11976	0.546
LIG_SUMO_SIM_par_1	814	819	PF11976	0.473
LIG_TRAF2_1	1085	1088	PF00917	0.674
LIG_TRAF2_1	729	732	PF00917	0.592
LIG_TRAF2_1	73	76	PF00917	0.486
LIG_TRFH_1	1079	1083	PF08558	0.574
LIG_TRFH_1	38	42	PF08558	0.673
LIG_TYR_ITIM	263	268	PF00017	0.428
LIG_UBA3_1	10	16	PF00899	0.547
LIG_UBA3_1	111	118	PF00899	0.482
MOD_CDK_SPxxK_3	362	369	PF00069	0.557
MOD_CDK_SPxxK_3	428	435	PF00069	0.568
MOD_CK1_1	193	199	PF00069	0.451
MOD_CK1_1	247	253	PF00069	0.482
MOD_CK1_1	297	303	PF00069	0.663
MOD_CK1_1	41	47	PF00069	0.686
MOD_CK1_1	501	507	PF00069	0.767
MOD_CK1_1	587	593	PF00069	0.503
MOD_CK1_1	696	702	PF00069	0.663
MOD_CK1_1	805	811	PF00069	0.562
MOD_CK2_1	1038	1044	PF00069	0.545
MOD_CK2_1	143	149	PF00069	0.471
MOD_CK2_1	25	31	PF00069	0.480
MOD_CK2_1	358	364	PF00069	0.733
MOD_CK2_1	444	450	PF00069	0.577
MOD_CK2_1	455	461	PF00069	0.482
MOD_CK2_1	587	593	PF00069	0.629
MOD_CK2_1	726	732	PF00069	0.610
MOD_CK2_1	889	895	PF00069	0.651
MOD_Cter_Amidation	767	770	PF01082	0.534
MOD_Cter_Amidation	879	882	PF01082	0.648
MOD_GlcNHglycan	15	19	PF01048	0.558
MOD_GlcNHglycan	211	214	PF01048	0.554
MOD_GlcNHglycan	225	228	PF01048	0.522
MOD_GlcNHglycan	246	249	PF01048	0.534
MOD_GlcNHglycan	370	373	PF01048	0.409
MOD_GlcNHglycan	574	577	PF01048	0.498
MOD_GlcNHglycan	59	62	PF01048	0.758
MOD_GlcNHglycan	6	9	PF01048	0.564
MOD_GlcNHglycan	615	618	PF01048	0.579
MOD_GlcNHglycan	630	633	PF01048	0.434
MOD_GlcNHglycan	646	649	PF01048	0.319
MOD_GlcNHglycan	67	70	PF01048	0.723
MOD_GlcNHglycan	695	698	PF01048	0.724
MOD_GlcNHglycan	716	719	PF01048	0.574
MOD_GlcNHglycan	723	726	PF01048	0.617
MOD_GlcNHglycan	804	807	PF01048	0.592
MOD_GSK3_1	1034	1041	PF00069	0.571
MOD_GSK3_1	209	216	PF00069	0.558
MOD_GSK3_1	235	242	PF00069	0.437
MOD_GSK3_1	243	250	PF00069	0.405
MOD_GSK3_1	252	259	PF00069	0.327
MOD_GSK3_1	287	294	PF00069	0.719
MOD_GSK3_1	298	305	PF00069	0.657
MOD_GSK3_1	306	313	PF00069	0.264
MOD_GSK3_1	355	362	PF00069	0.728
MOD_GSK3_1	498	505	PF00069	0.763
MOD_GSK3_1	583	590	PF00069	0.620
MOD_GSK3_1	59	66	PF00069	0.610
MOD_GSK3_1	714	721	PF00069	0.629
MOD_GSK3_1	752	759	PF00069	0.582
MOD_GSK3_1	801	808	PF00069	0.599
MOD_GSK3_1	834	841	PF00069	0.468
MOD_GSK3_1	844	851	PF00069	0.396
MOD_GSK3_1	908	915	PF00069	0.768
MOD_GSK3_1	944	951	PF00069	0.546
MOD_LATS_1	807	813	PF00433	0.367
MOD_N-GLC_1	1062	1067	PF02516	0.531
MOD_N-GLC_1	757	762	PF02516	0.609
MOD_N-GLC_2	787	789	PF02516	0.593
MOD_NEK2_1	1068	1073	PF00069	0.545
MOD_NEK2_1	116	121	PF00069	0.455
MOD_NEK2_1	143	148	PF00069	0.484
MOD_NEK2_1	190	195	PF00069	0.388
MOD_NEK2_1	223	228	PF00069	0.527
MOD_NEK2_1	239	244	PF00069	0.283
MOD_NEK2_1	292	297	PF00069	0.760
MOD_NEK2_1	310	315	PF00069	0.469
MOD_NEK2_1	335	340	PF00069	0.420
MOD_NEK2_1	602	607	PF00069	0.508
MOD_NEK2_1	63	68	PF00069	0.763
MOD_NEK2_1	644	649	PF00069	0.442
MOD_NEK2_1	671	676	PF00069	0.476
MOD_NEK2_1	711	716	PF00069	0.621
MOD_NEK2_1	739	744	PF00069	0.404
MOD_NEK2_1	849	854	PF00069	0.557
MOD_NEK2_1	997	1002	PF00069	0.550
MOD_NEK2_2	172	177	PF00069	0.362
MOD_PIKK_1	1048	1054	PF00454	0.539
MOD_PIKK_1	1083	1089	PF00454	0.711
MOD_PIKK_1	874	880	PF00454	0.659
MOD_PKA_1	801	807	PF00069	0.619
MOD_PKA_1	873	879	PF00069	0.655
MOD_PKA_2	368	374	PF00069	0.579
MOD_PKA_2	450	456	PF00069	0.559
MOD_PKA_2	644	650	PF00069	0.511
MOD_PKA_2	671	677	PF00069	0.456
MOD_PKA_2	709	715	PF00069	0.628
MOD_PKA_2	721	727	PF00069	0.656
MOD_PKA_2	747	753	PF00069	0.427
MOD_PKA_2	800	806	PF00069	0.543
MOD_PKA_2	873	879	PF00069	0.655
MOD_Plk_1	1062	1068	PF00069	0.375
MOD_Plk_1	444	450	PF00069	0.674
MOD_Plk_2-3	25	31	PF00069	0.480
MOD_Plk_2-3	444	450	PF00069	0.428
MOD_Plk_4	1068	1074	PF00069	0.523
MOD_Plk_4	235	241	PF00069	0.355
MOD_Plk_4	25	31	PF00069	0.480
MOD_Plk_4	256	262	PF00069	0.438
MOD_Plk_4	287	293	PF00069	0.726
MOD_Plk_4	306	312	PF00069	0.380
MOD_Plk_4	375	381	PF00069	0.502
MOD_Plk_4	564	570	PF00069	0.373
MOD_Plk_4	59	65	PF00069	0.761
MOD_Plk_4	602	608	PF00069	0.474
MOD_Plk_4	636	642	PF00069	0.464
MOD_Plk_4	666	672	PF00069	0.434
MOD_Plk_4	702	708	PF00069	0.601
MOD_Plk_4	771	777	PF00069	0.450
MOD_Plk_4	948	954	PF00069	0.471
MOD_Plk_4	955	961	PF00069	0.397
MOD_ProDKin_1	1081	1087	PF00069	0.651
MOD_ProDKin_1	252	258	PF00069	0.454
MOD_ProDKin_1	362	368	PF00069	0.729
MOD_ProDKin_1	38	44	PF00069	0.610
MOD_ProDKin_1	428	434	PF00069	0.564
MOD_ProDKin_1	498	504	PF00069	0.747
MOD_ProDKin_1	908	914	PF00069	0.729
MOD_ProDKin_1	924	930	PF00069	0.658
MOD_ProDKin_1	991	997	PF00069	0.470
MOD_SUMO_rev_2	70	80	PF00179	0.476
TRG_DiLeu_BaEn_1	1005	1010	PF01217	0.525
TRG_DiLeu_BaEn_1	636	641	PF01217	0.567
TRG_DiLeu_BaEn_1	75	80	PF01217	0.438
TRG_DiLeu_BaEn_3	24	30	PF01217	0.513
TRG_DiLeu_BaEn_4	1044	1050	PF01217	0.554
TRG_DiLeu_BaEn_4	75	81	PF01217	0.456
TRG_DiLeu_LyEn_5	1005	1010	PF01217	0.525
TRG_ENDOCYTIC_2	265	268	PF00928	0.427
TRG_ENDOCYTIC_2	460	463	PF00928	0.484
TRG_ENDOCYTIC_2	555	558	PF00928	0.530
TRG_ENDOCYTIC_2	607	610	PF00928	0.401
TRG_ENDOCYTIC_2	822	825	PF00928	0.501
TRG_ENDOCYTIC_2	956	959	PF00928	0.397
TRG_ER_diArg_1	100	103	PF00400	0.585
TRG_ER_diArg_1	400	403	PF00400	0.575
TRG_ER_diArg_1	707	710	PF00400	0.597
TRG_ER_diArg_1	863	866	PF00400	0.664
TRG_ER_diArg_1	873	875	PF00400	0.683
TRG_ER_diArg_1	879	882	PF00400	0.704
TRG_NES_CRM1_1	132	144	PF08389	0.442
TRG_NES_CRM1_1	24	36	PF08389	0.331
TRG_NES_CRM1_1	596	611	PF08389	0.516
TRG_NLS_MonoExtC_3	862	868	PF00514	0.591
TRG_Pf-PMV_PEXEL_1	1008	1013	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	129	134	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	986	990	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEI3	Leptomonas seymouri	58%	96%
A0A1X0NN90	Trypanosomatidae	36%	100%
A0A3S7WSD9	Leishmania donovani	95%	100%
A4H730	Leishmania braziliensis	83%	100%
A4HVG4	Leishmania infantum	95%	100%
D0A6U5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AP65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5ATV9	Trypanosoma cruzi	35%	100%