Putative flagellar radial spoke protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellar radial spoke protein 4/6

Species:

Leishmania major

UniProt:

Q4QGB1_LEIMA

TriTrypDb:

LmjF.13.0430 , LMJLV39_130008200 , LMJSD75_130008300

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0001534	radial spoke	2	12
GO:0005929	cilium	4	12
GO:0005930	axoneme	2	2
GO:0031514	motile cilium	5	12
GO:0032991	protein-containing complex	1	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0097730	non-motile cilium	5	2
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4QGB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGB1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	2
GO:0001578	microtubule bundle formation	4	2
GO:0003341	cilium movement	4	12
GO:0006996	organelle organization	4	12
GO:0007010	cytoskeleton organization	5	2
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0035082	axoneme assembly	5	2
GO:0060294	cilium movement involved in cell motility	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0030030	cell projection organization	4	10
GO:0030031	cell projection assembly	5	10
GO:0044782	cilium organization	5	10
GO:0060271	cilium assembly	6	10
GO:0070925	organelle assembly	5	10
GO:0120031	plasma membrane bounded cell projection assembly	6	10
GO:0120036	plasma membrane bounded cell projection organization	5	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.246
CLV_NRD_NRD_1	213	215	PF00675	0.271
CLV_NRD_NRD_1	327	329	PF00675	0.308
CLV_NRD_NRD_1	568	570	PF00675	0.498
CLV_NRD_NRD_1	91	93	PF00675	0.278
CLV_PCSK_FUR_1	191	195	PF00082	0.327
CLV_PCSK_KEX2_1	193	195	PF00082	0.259
CLV_PCSK_KEX2_1	263	265	PF00082	0.212
CLV_PCSK_KEX2_1	520	522	PF00082	0.271
CLV_PCSK_KEX2_1	568	570	PF00082	0.498
CLV_PCSK_KEX2_1	91	93	PF00082	0.319
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.215
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.263
CLV_PCSK_SKI1_1	160	164	PF00082	0.215
CLV_PCSK_SKI1_1	263	267	PF00082	0.235
CLV_PCSK_SKI1_1	328	332	PF00082	0.205
CLV_PCSK_SKI1_1	97	101	PF00082	0.271
DEG_APCC_DBOX_1	286	294	PF00400	0.397
DEG_SCF_SKP2-CKS1_1	459	466	PF00560	0.508
DOC_MAPK_gen_1	211	221	PF00069	0.437
DOC_MAPK_gen_1	331	340	PF00069	0.529
DOC_MAPK_gen_1	520	527	PF00069	0.471
DOC_PP2B_LxvP_1	102	105	PF13499	0.419
DOC_PP2B_LxvP_1	128	131	PF13499	0.508
DOC_PP2B_LxvP_1	338	341	PF13499	0.508
DOC_PP2B_LxvP_1	416	419	PF13499	0.463
DOC_PP4_FxxP_1	100	103	PF00568	0.446
DOC_PP4_FxxP_1	538	541	PF00568	0.492
DOC_USP7_MATH_1	239	243	PF00917	0.450
DOC_USP7_MATH_1	545	549	PF00917	0.450
DOC_USP7_UBL2_3	211	215	PF12436	0.491
DOC_USP7_UBL2_3	375	379	PF12436	0.415
DOC_WW_Pin1_4	237	242	PF00397	0.460
DOC_WW_Pin1_4	249	254	PF00397	0.361
DOC_WW_Pin1_4	339	344	PF00397	0.482
DOC_WW_Pin1_4	460	465	PF00397	0.508
DOC_WW_Pin1_4	536	541	PF00397	0.404
LIG_14-3-3_CanoR_1	232	236	PF00244	0.428
LIG_14-3-3_CanoR_1	292	301	PF00244	0.492
LIG_14-3-3_CanoR_1	521	527	PF00244	0.546
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_BIR_III_4	398	402	PF00653	0.450
LIG_BRCT_BRCA1_1	184	188	PF00533	0.434
LIG_FHA_1	120	126	PF00498	0.428
LIG_FHA_1	199	205	PF00498	0.419
LIG_FHA_1	232	238	PF00498	0.477
LIG_FHA_1	265	271	PF00498	0.428
LIG_FHA_1	485	491	PF00498	0.428
LIG_FHA_1	558	564	PF00498	0.422
LIG_FHA_2	107	113	PF00498	0.414
LIG_FHA_2	181	187	PF00498	0.446
LIG_FHA_2	312	318	PF00498	0.520
LIG_FHA_2	552	558	PF00498	0.455
LIG_Integrin_isoDGR_2	370	372	PF01839	0.215
LIG_KLC1_Yacidic_2	200	205	PF13176	0.508
LIG_LIR_Apic_2	535	541	PF02991	0.519
LIG_LIR_Gen_1	115	125	PF02991	0.404
LIG_LIR_Gen_1	132	138	PF02991	0.404
LIG_LIR_Gen_1	242	253	PF02991	0.471
LIG_LIR_Gen_1	31	40	PF02991	0.404
LIG_LIR_Nem_3	115	120	PF02991	0.404
LIG_LIR_Nem_3	132	136	PF02991	0.404
LIG_LIR_Nem_3	185	190	PF02991	0.423
LIG_LIR_Nem_3	224	230	PF02991	0.448
LIG_LIR_Nem_3	242	248	PF02991	0.422
LIG_LIR_Nem_3	31	36	PF02991	0.404
LIG_LIR_Nem_3	332	338	PF02991	0.415
LIG_LIR_Nem_3	415	420	PF02991	0.438
LIG_LIR_Nem_3	423	429	PF02991	0.445
LIG_MLH1_MIPbox_1	184	188	PF16413	0.434
LIG_NRBOX	38	44	PF00104	0.547
LIG_Pex14_1	522	526	PF04695	0.415
LIG_Pex14_2	177	181	PF04695	0.446
LIG_REV1ctd_RIR_1	174	183	PF16727	0.446
LIG_SH2_CRK	117	121	PF00017	0.415
LIG_SH2_CRK	33	37	PF00017	0.419
LIG_SH2_CRK	335	339	PF00017	0.415
LIG_SH2_NCK_1	117	121	PF00017	0.415
LIG_SH2_PTP2	227	230	PF00017	0.450
LIG_SH2_SRC	195	198	PF00017	0.465
LIG_SH2_SRC	424	427	PF00017	0.446
LIG_SH2_STAP1	233	237	PF00017	0.508
LIG_SH2_STAT3	21	24	PF00017	0.486
LIG_SH2_STAT5	117	120	PF00017	0.415
LIG_SH2_STAT5	187	190	PF00017	0.410
LIG_SH2_STAT5	195	198	PF00017	0.396
LIG_SH2_STAT5	203	206	PF00017	0.384
LIG_SH2_STAT5	21	24	PF00017	0.404
LIG_SH2_STAT5	227	230	PF00017	0.522
LIG_SH2_STAT5	233	236	PF00017	0.490
LIG_SH2_STAT5	285	288	PF00017	0.410
LIG_SH2_STAT5	366	369	PF00017	0.415
LIG_SH2_STAT5	424	427	PF00017	0.397
LIG_SH2_STAT5	526	529	PF00017	0.404
LIG_SH3_2	464	469	PF14604	0.508
LIG_SH3_3	337	343	PF00018	0.536
LIG_SH3_3	374	380	PF00018	0.471
LIG_SH3_3	426	432	PF00018	0.464
LIG_SH3_3	454	460	PF00018	0.431
LIG_SH3_3	461	467	PF00018	0.407
LIG_SH3_3	538	544	PF00018	0.455
LIG_SH3_3	553	559	PF00018	0.433
LIG_SH3_4	211	218	PF00018	0.471
LIG_SH3_5	341	345	PF00018	0.419
LIG_SUMO_SIM_par_1	336	342	PF11976	0.450
LIG_TRAF2_1	151	154	PF00917	0.415
LIG_TRAF2_1	304	307	PF00917	0.415
LIG_TRAF2_1	310	313	PF00917	0.415
LIG_TRAF2_1	408	411	PF00917	0.456
LIG_TRAF2_1	449	452	PF00917	0.462
LIG_TRAF2_1	86	89	PF00917	0.508
LIG_WRC_WIRS_1	61	66	PF05994	0.508
LIG_WW_3	211	215	PF00397	0.495
MOD_CDK_SPxK_1	460	466	PF00069	0.508
MOD_CDK_SPxxK_3	237	244	PF00069	0.450
MOD_CK1_1	132	138	PF00069	0.471
MOD_CK1_1	295	301	PF00069	0.523
MOD_CK2_1	106	112	PF00069	0.437
MOD_CK2_1	148	154	PF00069	0.377
MOD_CK2_1	4	10	PF00069	0.552
MOD_CK2_1	551	557	PF00069	0.439
MOD_CK2_1	575	581	PF00069	0.623
MOD_Cter_Amidation	518	521	PF01082	0.215
MOD_GlcNHglycan	269	273	PF01048	0.261
MOD_GlcNHglycan	30	33	PF01048	0.282
MOD_GlcNHglycan	6	9	PF01048	0.509
MOD_GlcNHglycan	76	79	PF01048	0.287
MOD_GSK3_1	115	122	PF00069	0.405
MOD_GSK3_1	231	238	PF00069	0.408
MOD_GSK3_1	264	271	PF00069	0.471
MOD_GSK3_1	291	298	PF00069	0.434
MOD_GSK3_1	60	67	PF00069	0.477
MOD_N-GLC_1	492	497	PF02516	0.215
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	158	163	PF00069	0.404
MOD_NEK2_1	235	240	PF00069	0.420
MOD_NEK2_1	270	275	PF00069	0.419
MOD_NEK2_1	64	69	PF00069	0.472
MOD_NEK2_2	198	203	PF00069	0.419
MOD_NEK2_2	484	489	PF00069	0.428
MOD_PIKK_1	80	86	PF00454	0.450
MOD_PKA_1	520	526	PF00069	0.450
MOD_PKA_2	231	237	PF00069	0.404
MOD_PKA_2	259	265	PF00069	0.450
MOD_PKA_2	291	297	PF00069	0.508
MOD_PKA_2	371	377	PF00069	0.404
MOD_PKA_2	520	526	PF00069	0.450
MOD_Plk_1	158	164	PF00069	0.404
MOD_Plk_1	80	86	PF00069	0.515
MOD_Plk_2-3	311	317	PF00069	0.450
MOD_Plk_2-3	575	581	PF00069	0.570
MOD_Plk_4	121	127	PF00069	0.478
MOD_Plk_4	198	204	PF00069	0.419
MOD_Plk_4	231	237	PF00069	0.412
MOD_Plk_4	60	66	PF00069	0.417
MOD_ProDKin_1	237	243	PF00069	0.460
MOD_ProDKin_1	249	255	PF00069	0.361
MOD_ProDKin_1	339	345	PF00069	0.482
MOD_ProDKin_1	460	466	PF00069	0.508
MOD_ProDKin_1	536	542	PF00069	0.404
MOD_SUMO_rev_2	168	177	PF00179	0.508
MOD_SUMO_rev_2	89	99	PF00179	0.463
TRG_DiLeu_BaEn_1	153	158	PF01217	0.415
TRG_DiLeu_BaEn_2	59	65	PF01217	0.508
TRG_DiLeu_BaEn_4	153	159	PF01217	0.415
TRG_ENDOCYTIC_2	117	120	PF00928	0.415
TRG_ENDOCYTIC_2	187	190	PF00928	0.404
TRG_ENDOCYTIC_2	227	230	PF00928	0.450
TRG_ENDOCYTIC_2	33	36	PF00928	0.404
TRG_ENDOCYTIC_2	335	338	PF00928	0.415
TRG_ENDOCYTIC_2	426	429	PF00928	0.451
TRG_ER_diArg_1	190	193	PF00400	0.453
TRG_ER_diArg_1	567	569	PF00400	0.502
TRG_ER_diArg_1	90	92	PF00400	0.450
TRG_NES_CRM1_1	34	46	PF08389	0.450
TRG_NLS_MonoExtN_4	211	218	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	328	332	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDF4	Leptomonas seymouri	75%	99%
A0A0S4JGY1	Bodo saltans	49%	100%
A0A1X0NN98	Trypanosomatidae	57%	99%
A0A3Q8IE67	Leishmania donovani	24%	83%
A0A3S7WSD6	Leishmania donovani	93%	98%
A0A422NNZ6	Trypanosoma rangeli	58%	99%
A4H732	Leishmania braziliensis	88%	100%
A4HVG6	Leishmania infantum	94%	99%
A4I4B9	Leishmania infantum	24%	84%
D0A6U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AP67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	99%
Q01656	Chlamydomonas reinhardtii	27%	100%
Q9H0K4	Homo sapiens	28%	82%
V5BDZ5	Trypanosoma cruzi	58%	92%