Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitogen-activated protein kinase kinase 2

Species:

Leishmania major

UniProt:

Q4QGB0_LEIMA

TriTrypDb:

LmjF.13.0440 , LMJLV39_130008300 , LMJSD75_130008400

Length:

1090

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

Q4QGB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGB0

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	265	269	PF00656	0.532
CLV_C14_Caspase3-7	270	274	PF00656	0.536
CLV_C14_Caspase3-7	601	605	PF00656	0.541
CLV_C14_Caspase3-7	643	647	PF00656	0.523
CLV_C14_Caspase3-7	944	948	PF00656	0.491
CLV_NRD_NRD_1	1051	1053	PF00675	0.458
CLV_NRD_NRD_1	1063	1065	PF00675	0.424
CLV_NRD_NRD_1	304	306	PF00675	0.794
CLV_NRD_NRD_1	854	856	PF00675	0.383
CLV_PCSK_FUR_1	404	408	PF00082	0.662

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ62	Leptomonas seymouri	83%	100%
A0A0S4JD17	Bodo saltans	39%	89%
A0A1X0NNW0	Trypanosomatidae	53%	100%
A0A3S7WSG6	Leishmania donovani	97%	100%
A0A422NP63	Trypanosoma rangeli	52%	100%
A4H733	Leishmania braziliensis	93%	100%
A4HVG7	Leishmania infantum	97%	100%
D0A6U2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	98%
E9AP68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BIE1	Trypanosoma cruzi	51%	96%

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