C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGA8_LEIMA

TriTrypDb:

LmjF.13.0460

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QGA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.313
CLV_C14_Caspase3-7	330	334	PF00656	0.545
CLV_C14_Caspase3-7	356	360	PF00656	0.456
CLV_NRD_NRD_1	225	227	PF00675	0.755
CLV_NRD_NRD_1	257	259	PF00675	0.537
CLV_NRD_NRD_1	346	348	PF00675	0.458
CLV_NRD_NRD_1	489	491	PF00675	0.604
CLV_PCSK_KEX2_1	257	259	PF00082	0.403
CLV_PCSK_KEX2_1	307	309	PF00082	0.545
CLV_PCSK_KEX2_1	489	491	PF00082	0.583

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8U7	Bodo saltans	30%	89%
A0A1X0NN86	Trypanosomatidae	33%	91%
A0A3R7ML15	Trypanosoma rangeli	33%	96%
A0A3S5H6N3	Leishmania donovani	94%	100%
A4H735	Leishmania braziliensis	78%	100%
A4HVH5	Leishmania infantum	93%	100%
D0A6T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AP70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AVH4	Trypanosoma cruzi	35%	100%

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