C2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGA8_LEIMA

TriTrypDb:

LmjF.13.0460

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.313
CLV_C14_Caspase3-7	330	334	PF00656	0.545
CLV_C14_Caspase3-7	356	360	PF00656	0.456
CLV_NRD_NRD_1	225	227	PF00675	0.755
CLV_NRD_NRD_1	257	259	PF00675	0.537
CLV_NRD_NRD_1	346	348	PF00675	0.458
CLV_NRD_NRD_1	489	491	PF00675	0.604
CLV_PCSK_KEX2_1	257	259	PF00082	0.403
CLV_PCSK_KEX2_1	307	309	PF00082	0.545
CLV_PCSK_KEX2_1	489	491	PF00082	0.583
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.538
CLV_PCSK_SKI1_1	297	301	PF00082	0.478
CLV_PCSK_SKI1_1	453	457	PF00082	0.587
CLV_Separin_Metazoa	9	13	PF03568	0.476
DEG_APCC_DBOX_1	317	325	PF00400	0.416
DEG_APCC_DBOX_1	44	52	PF00400	0.219
DEG_SCF_FBW7_2	280	287	PF00400	0.583
DEG_SCF_FBW7_2	409	414	PF00400	0.484
DOC_CDC14_PxL_1	369	377	PF14671	0.526
DOC_MAPK_DCC_7	86	94	PF00069	0.219
DOC_MAPK_gen_1	106	115	PF00069	0.359
DOC_MAPK_gen_1	291	301	PF00069	0.407
DOC_MAPK_gen_1	86	94	PF00069	0.377
DOC_MAPK_MEF2A_6	86	94	PF00069	0.334
DOC_PP1_RVXF_1	144	150	PF00149	0.507
DOC_PP1_RVXF_1	167	174	PF00149	0.603
DOC_PP4_FxxP_1	111	114	PF00568	0.476
DOC_SPAK_OSR1_1	110	114	PF12202	0.476
DOC_USP7_MATH_1	208	212	PF00917	0.519
DOC_USP7_MATH_1	390	394	PF00917	0.403
DOC_USP7_UBL2_3	104	108	PF12436	0.476
DOC_USP7_UBL2_3	153	157	PF12436	0.638
DOC_USP7_UBL2_3	192	196	PF12436	0.580
DOC_USP7_UBL2_3	272	276	PF12436	0.587
DOC_USP7_UBL2_3	491	495	PF12436	0.647
DOC_WW_Pin1_4	280	285	PF00397	0.563
DOC_WW_Pin1_4	401	406	PF00397	0.683
DOC_WW_Pin1_4	407	412	PF00397	0.613
LIG_14-3-3_CanoR_1	190	197	PF00244	0.564
LIG_14-3-3_CanoR_1	257	263	PF00244	0.449
LIG_14-3-3_CanoR_1	265	273	PF00244	0.478
LIG_14-3-3_CanoR_1	340	345	PF00244	0.525
LIG_14-3-3_CanoR_1	418	424	PF00244	0.363
LIG_deltaCOP1_diTrp_1	194	201	PF00928	0.397
LIG_FHA_1	120	126	PF00498	0.598
LIG_FHA_1	129	135	PF00498	0.638
LIG_FHA_1	182	188	PF00498	0.570
LIG_FHA_1	25	31	PF00498	0.451
LIG_FHA_1	257	263	PF00498	0.481
LIG_FHA_2	17	23	PF00498	0.340
LIG_FHA_2	243	249	PF00498	0.467
LIG_FHA_2	281	287	PF00498	0.561
LIG_FHA_2	328	334	PF00498	0.534
LIG_FHA_2	354	360	PF00498	0.533
LIG_FHA_2	428	434	PF00498	0.442
LIG_IRF3_LxIS_1	75	80	PF10401	0.219
LIG_LIR_Gen_1	158	166	PF02991	0.642
LIG_LIR_Gen_1	184	191	PF02991	0.426
LIG_LIR_Gen_1	3	11	PF02991	0.322
LIG_LIR_Gen_1	414	424	PF02991	0.511
LIG_LIR_Nem_3	158	164	PF02991	0.624
LIG_LIR_Nem_3	184	189	PF02991	0.427
LIG_LIR_Nem_3	3	8	PF02991	0.370
LIG_LIR_Nem_3	414	419	PF02991	0.524
LIG_Pex14_1	197	201	PF04695	0.401
LIG_Pex14_2	416	420	PF04695	0.516
LIG_SH2_NCK_1	161	165	PF00017	0.623
LIG_SH2_PTP2	186	189	PF00017	0.434
LIG_SH2_STAP1	203	207	PF00017	0.490
LIG_SH2_STAT3	95	98	PF00017	0.407
LIG_SH2_STAT5	186	189	PF00017	0.414
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.364
LIG_SUMO_SIM_par_1	130	137	PF11976	0.686
LIG_SUMO_SIM_par_1	30	36	PF11976	0.476
LIG_SxIP_EBH_1	365	376	PF03271	0.515
LIG_TRAF2_1	117	120	PF00917	0.414
LIG_TRAF2_1	284	287	PF00917	0.582
LIG_TRAF2_1	411	414	PF00917	0.482
LIG_UBA3_1	368	376	PF00899	0.524
LIG_UBA3_1	99	106	PF00899	0.476
LIG_WRC_WIRS_1	368	373	PF05994	0.517
LIG_WRC_WIRS_1	420	425	PF05994	0.465
MOD_CDK_SPK_2	280	285	PF00069	0.585
MOD_CDK_SPxxK_3	401	408	PF00069	0.676
MOD_CK1_1	242	248	PF00069	0.502
MOD_CK1_1	82	88	PF00069	0.469
MOD_CK2_1	114	120	PF00069	0.439
MOD_CK2_1	280	286	PF00069	0.535
MOD_CK2_1	427	433	PF00069	0.412
MOD_CK2_1	77	83	PF00069	0.476
MOD_Cter_Amidation	487	490	PF01082	0.577
MOD_GlcNHglycan	116	119	PF01048	0.412
MOD_GlcNHglycan	135	139	PF01048	0.617
MOD_GlcNHglycan	143	146	PF01048	0.507
MOD_GlcNHglycan	165	169	PF01048	0.635
MOD_GlcNHglycan	2	5	PF01048	0.506
MOD_GlcNHglycan	236	239	PF01048	0.638
MOD_GlcNHglycan	241	244	PF01048	0.543
MOD_GlcNHglycan	38	41	PF01048	0.451
MOD_GSK3_1	155	162	PF00069	0.644
MOD_GSK3_1	222	229	PF00069	0.578
MOD_GSK3_1	24	31	PF00069	0.466
MOD_GSK3_1	327	334	PF00069	0.485
MOD_GSK3_1	367	374	PF00069	0.517
MOD_GSK3_1	419	426	PF00069	0.460
MOD_GSK3_1	457	464	PF00069	0.503
MOD_GSK3_1	75	82	PF00069	0.496
MOD_N-GLC_1	60	65	PF02516	0.434
MOD_NEK2_1	134	139	PF00069	0.649
MOD_NEK2_1	327	332	PF00069	0.491
MOD_NEK2_1	367	372	PF00069	0.418
MOD_NEK2_1	423	428	PF00069	0.440
MOD_NEK2_1	474	479	PF00069	0.640
MOD_NEK2_1	77	82	PF00069	0.456
MOD_NEK2_2	469	474	PF00069	0.628
MOD_PIKK_1	119	125	PF00454	0.355
MOD_PIKK_1	181	187	PF00454	0.519
MOD_PIKK_1	25	31	PF00454	0.460
MOD_PIKK_1	409	415	PF00454	0.521
MOD_PKA_1	195	201	PF00069	0.525
MOD_PKA_1	226	232	PF00069	0.788
MOD_PKA_2	256	262	PF00069	0.450
MOD_Plk_1	203	209	PF00069	0.566
MOD_Plk_1	278	284	PF00069	0.495
MOD_Plk_1	60	66	PF00069	0.434
MOD_Plk_2-3	159	165	PF00069	0.598
MOD_Plk_2-3	429	435	PF00069	0.442
MOD_Plk_4	30	36	PF00069	0.422
MOD_Plk_4	423	429	PF00069	0.452
MOD_Plk_4	469	475	PF00069	0.701
MOD_ProDKin_1	280	286	PF00069	0.564
MOD_ProDKin_1	401	407	PF00069	0.676
MOD_SUMO_for_1	284	287	PF00179	0.609
MOD_SUMO_for_1	375	378	PF00179	0.533
MOD_SUMO_rev_2	193	198	PF00179	0.528
MOD_SUMO_rev_2	393	397	PF00179	0.466
TRG_DiLeu_BaEn_2	295	301	PF01217	0.474
TRG_ENDOCYTIC_2	161	164	PF00928	0.600
TRG_ENDOCYTIC_2	186	189	PF00928	0.423
TRG_ER_diArg_1	209	212	PF00400	0.589
TRG_NES_CRM1_1	319	333	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8U7	Bodo saltans	30%	89%
A0A1X0NN86	Trypanosomatidae	33%	91%
A0A3R7ML15	Trypanosoma rangeli	33%	96%
A0A3S5H6N3	Leishmania donovani	94%	100%
A4H735	Leishmania braziliensis	78%	100%
A4HVH5	Leishmania infantum	93%	100%
D0A6T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AP70	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AVH4	Trypanosoma cruzi	35%	100%