Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGA7_LEIMA

TriTrypDb:

LmjF.13.0470 , LMJLV39_130008700 , LMJSD75_130008800

Length:

492

Annotations

LeishMANIAdb annotations

A putative 7TM transporter or receptor protein limited to Kinetoplastids. Very little similarity to animal GPCRs

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 6
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QGA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	245	247	PF00675	0.437
CLV_NRD_NRD_1	367	369	PF00675	0.386
CLV_PCSK_KEX2_1	245	247	PF00082	0.437
CLV_PCSK_KEX2_1	367	369	PF00082	0.405
DEG_Nend_UBRbox_2	1	3	PF02207	0.439
DEG_SCF_FBW7_2	429	435	PF00400	0.482
DEG_SPOP_SBC_1	469	473	PF00917	0.553
DOC_CDC14_PxL_1	175	183	PF14671	0.374
DOC_CKS1_1	268	273	PF01111	0.286
DOC_CKS1_1	429	434	PF01111	0.480
DOC_CYCLIN_yCln2_LP_2	176	182	PF00134	0.402
DOC_CYCLIN_yCln2_LP_2	310	316	PF00134	0.380
DOC_MAPK_gen_1	116	123	PF00069	0.618
DOC_MAPK_gen_1	298	305	PF00069	0.318
DOC_MAPK_gen_1	364	374	PF00069	0.578
DOC_MAPK_MEF2A_6	116	123	PF00069	0.618
DOC_PP1_RVXF_1	194	201	PF00149	0.510
DOC_PP1_RVXF_1	368	375	PF00149	0.475
DOC_PP1_RVXF_1	8	14	PF00149	0.414
DOC_PP2B_LxvP_1	176	179	PF13499	0.405
DOC_PP2B_LxvP_1	310	313	PF13499	0.379
DOC_USP7_MATH_1	23	27	PF00917	0.427
DOC_USP7_MATH_1	238	242	PF00917	0.374
DOC_USP7_MATH_1	394	398	PF00917	0.505
DOC_USP7_MATH_1	468	472	PF00917	0.546
DOC_WW_Pin1_4	267	272	PF00397	0.286
DOC_WW_Pin1_4	400	405	PF00397	0.538
DOC_WW_Pin1_4	428	433	PF00397	0.546
DOC_WW_Pin1_4	440	445	PF00397	0.469
LIG_14-3-3_CanoR_1	10	14	PF00244	0.382
LIG_14-3-3_CanoR_1	249	255	PF00244	0.562
LIG_14-3-3_CanoR_1	367	373	PF00244	0.614
LIG_14-3-3_CanoR_1	398	403	PF00244	0.555
LIG_APCC_ABBA_1	156	161	PF00400	0.426
LIG_BRCT_BRCA1_1	257	261	PF00533	0.634
LIG_BRCT_BRCA1_1	370	374	PF00533	0.581
LIG_Clathr_ClatBox_1	387	391	PF01394	0.374
LIG_CSL_BTD_1	94	97	PF09270	0.286
LIG_deltaCOP1_diTrp_1	361	365	PF00928	0.596
LIG_deltaCOP1_diTrp_1	90	95	PF00928	0.426
LIG_EH1_1	225	233	PF00400	0.199
LIG_eIF4E_1	166	172	PF01652	0.429
LIG_eIF4E_1	226	232	PF01652	0.199
LIG_eIF4E_1	279	285	PF01652	0.398
LIG_FHA_1	100	106	PF00498	0.300
LIG_FHA_1	193	199	PF00498	0.553
LIG_FHA_1	227	233	PF00498	0.402
LIG_FHA_1	249	255	PF00498	0.623
LIG_FHA_1	383	389	PF00498	0.452
LIG_FHA_1	397	403	PF00498	0.447
LIG_FHA_1	474	480	PF00498	0.575
LIG_HP1_1	111	115	PF01393	0.402
LIG_LIR_Gen_1	164	173	PF02991	0.286
LIG_LIR_Gen_1	234	244	PF02991	0.286
LIG_LIR_Gen_1	258	269	PF02991	0.530
LIG_LIR_Gen_1	338	349	PF02991	0.439
LIG_LIR_Gen_1	40	49	PF02991	0.451
LIG_LIR_Gen_1	90	101	PF02991	0.352
LIG_LIR_Nem_3	164	169	PF02991	0.286
LIG_LIR_Nem_3	174	180	PF02991	0.286
LIG_LIR_Nem_3	188	194	PF02991	0.608
LIG_LIR_Nem_3	234	240	PF02991	0.286
LIG_LIR_Nem_3	258	264	PF02991	0.530
LIG_LIR_Nem_3	338	344	PF02991	0.439
LIG_LIR_Nem_3	40	44	PF02991	0.363
LIG_LIR_Nem_3	84	89	PF02991	0.423
LIG_LIR_Nem_3	90	96	PF02991	0.335
LIG_LYPXL_SIV_4	331	339	PF13949	0.185
LIG_NRBOX	171	177	PF00104	0.353
LIG_NRBOX	78	84	PF00104	0.420
LIG_PCNA_PIPBox_1	150	159	PF02747	0.413
LIG_Pex14_1	211	215	PF04695	0.346
LIG_Pex14_2	132	136	PF04695	0.363
LIG_Pex14_2	257	261	PF04695	0.634
LIG_PTB_Apo_2	12	19	PF02174	0.304
LIG_SH2_CRK	166	170	PF00017	0.286
LIG_SH2_CRK	173	177	PF00017	0.286
LIG_SH2_CRK	237	241	PF00017	0.402
LIG_SH2_GRB2like	51	54	PF00017	0.336
LIG_SH2_PTP2	239	242	PF00017	0.402
LIG_SH2_SRC	237	240	PF00017	0.402
LIG_SH2_STAP1	173	177	PF00017	0.374
LIG_SH2_STAP1	280	284	PF00017	0.317
LIG_SH2_STAP1	392	396	PF00017	0.436
LIG_SH2_STAP1	51	55	PF00017	0.402
LIG_SH2_STAT3	306	309	PF00017	0.380
LIG_SH2_STAT5	101	104	PF00017	0.355
LIG_SH2_STAT5	166	169	PF00017	0.311
LIG_SH2_STAT5	173	176	PF00017	0.311
LIG_SH2_STAT5	226	229	PF00017	0.365
LIG_SH2_STAT5	239	242	PF00017	0.214
LIG_SH2_STAT5	243	246	PF00017	0.467
LIG_SH2_STAT5	263	266	PF00017	0.150
LIG_SH2_STAT5	283	286	PF00017	0.222
LIG_SH2_STAT5	43	46	PF00017	0.439
LIG_SH2_STAT5	430	433	PF00017	0.480
LIG_SH3_3	265	271	PF00018	0.308
LIG_SH3_3	438	444	PF00018	0.535
LIG_SH3_3	91	97	PF00018	0.265
LIG_SUMO_SIM_anti_2	220	225	PF11976	0.290
LIG_SUMO_SIM_anti_2	54	59	PF11976	0.410
LIG_SUMO_SIM_par_1	111	117	PF11976	0.370
LIG_SUMO_SIM_par_1	385	391	PF11976	0.374
LIG_SUMO_SIM_par_1	78	84	PF11976	0.316
LIG_TYR_ITIM	171	176	PF00017	0.311
LIG_TYR_ITIM	277	282	PF00017	0.378
MOD_CK1_1	379	385	PF00069	0.374
MOD_CK1_1	403	409	PF00069	0.568
MOD_CK1_1	449	455	PF00069	0.592
MOD_CK1_1	61	67	PF00069	0.402
MOD_CK2_1	285	291	PF00069	0.417
MOD_CMANNOS	362	365	PF00535	0.401
MOD_CMANNOS	92	95	PF00535	0.447
MOD_GlcNHglycan	150	153	PF01048	0.617
MOD_GlcNHglycan	25	28	PF01048	0.701
MOD_GlcNHglycan	432	435	PF01048	0.621
MOD_GlcNHglycan	451	454	PF01048	0.743
MOD_GlcNHglycan	457	460	PF01048	0.677
MOD_GlcNHglycan	58	61	PF01048	0.636
MOD_GSK3_1	18	25	PF00069	0.452
MOD_GSK3_1	378	385	PF00069	0.473
MOD_GSK3_1	394	401	PF00069	0.391
MOD_GSK3_1	436	443	PF00069	0.502
MOD_GSK3_1	445	452	PF00069	0.441
MOD_GSK3_1	469	476	PF00069	0.543
MOD_GSK3_1	49	56	PF00069	0.427
MOD_GSK3_1	61	68	PF00069	0.427
MOD_GSK3_1	95	102	PF00069	0.402
MOD_LATS_1	366	372	PF00433	0.696
MOD_N-GLC_1	185	190	PF02516	0.390
MOD_N-GLC_1	28	33	PF02516	0.604
MOD_N-GLC_1	37	42	PF02516	0.649
MOD_N-GLC_1	394	399	PF02516	0.709
MOD_N-GLC_1	435	440	PF02516	0.734
MOD_NEK2_1	114	119	PF00069	0.515
MOD_NEK2_1	135	140	PF00069	0.368
MOD_NEK2_1	171	176	PF00069	0.412
MOD_NEK2_1	192	197	PF00069	0.587
MOD_NEK2_1	231	236	PF00069	0.373
MOD_NEK2_1	28	33	PF00069	0.422
MOD_NEK2_1	285	290	PF00069	0.430
MOD_NEK2_1	325	330	PF00069	0.402
MOD_NEK2_1	378	383	PF00069	0.339
MOD_NEK2_1	457	462	PF00069	0.523
MOD_NEK2_1	49	54	PF00069	0.434
MOD_NEK2_1	67	72	PF00069	0.400
MOD_NEK2_2	238	243	PF00069	0.402
MOD_PIKK_1	457	463	PF00454	0.562
MOD_PKA_2	248	254	PF00069	0.503
MOD_PKA_2	9	15	PF00069	0.416
MOD_Plk_1	185	191	PF00069	0.610
MOD_Plk_1	28	34	PF00069	0.387
MOD_Plk_1	37	43	PF00069	0.396
MOD_Plk_4	161	167	PF00069	0.264
MOD_Plk_4	171	177	PF00069	0.333
MOD_Plk_4	185	191	PF00069	0.525
MOD_Plk_4	231	237	PF00069	0.365
MOD_Plk_4	238	244	PF00069	0.372
MOD_Plk_4	335	341	PF00069	0.321
MOD_Plk_4	37	43	PF00069	0.402
MOD_Plk_4	9	15	PF00069	0.416
MOD_ProDKin_1	267	273	PF00069	0.286
MOD_ProDKin_1	400	406	PF00069	0.541
MOD_ProDKin_1	428	434	PF00069	0.546
MOD_ProDKin_1	440	446	PF00069	0.465
TRG_DiLeu_BaLyEn_6	193	198	PF01217	0.556
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.329
TRG_ENDOCYTIC_2	166	169	PF00928	0.286
TRG_ENDOCYTIC_2	173	176	PF00928	0.286
TRG_ENDOCYTIC_2	210	213	PF00928	0.370
TRG_ENDOCYTIC_2	237	240	PF00928	0.286
TRG_ENDOCYTIC_2	279	282	PF00928	0.315
TRG_ENDOCYTIC_2	86	89	PF00928	0.399
TRG_ER_diArg_1	115	118	PF00400	0.635
TRG_ER_diArg_1	244	246	PF00400	0.625
TRG_ER_diArg_1	367	370	PF00400	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8F6	Leptomonas seymouri	55%	93%
A0A1X0NN68	Trypanosomatidae	40%	84%
A0A3Q8ICT8	Leishmania donovani	94%	100%
A0A3R7NUA8	Trypanosoma rangeli	41%	88%
A4HVH6	Leishmania infantum	94%	100%
E9AP71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BAW0	Trypanosoma cruzi	39%	82%