TPR_MLP1_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA element modulatory factor 1 TATA binding, putative

Species:

Leishmania major

UniProt:

Q4QGA6_LEIMA

TriTrypDb:

LmjF.13.0480 , LMJLV39_130008800 , LMJSD75_130008900

Length:

522

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	57	63	PF00089	0.609
CLV_NRD_NRD_1	325	327	PF00675	0.562
CLV_NRD_NRD_1	353	355	PF00675	0.694
CLV_NRD_NRD_1	411	413	PF00675	0.551
CLV_NRD_NRD_1	435	437	PF00675	0.597
CLV_NRD_NRD_1	494	496	PF00675	0.665
CLV_PCSK_KEX2_1	301	303	PF00082	0.590
CLV_PCSK_KEX2_1	411	413	PF00082	0.590
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.590
CLV_PCSK_SKI1_1	184	188	PF00082	0.432
CLV_PCSK_SKI1_1	31	35	PF00082	0.467
CLV_Separin_Metazoa	445	449	PF03568	0.518
DEG_APCC_DBOX_1	215	223	PF00400	0.635
DEG_SPOP_SBC_1	507	511	PF00917	0.525
DOC_CDC14_PxL_1	413	421	PF14671	0.691
DOC_MAPK_gen_1	354	360	PF00069	0.690
DOC_MAPK_RevD_3	398	412	PF00069	0.541
DOC_PP4_FxxP_1	395	398	PF00568	0.665
DOC_USP7_MATH_1	255	259	PF00917	0.629
DOC_USP7_MATH_1	369	373	PF00917	0.682
DOC_USP7_MATH_1	377	381	PF00917	0.632
DOC_USP7_MATH_1	421	425	PF00917	0.711
DOC_USP7_MATH_1	5	9	PF00917	0.673
DOC_USP7_MATH_1	507	511	PF00917	0.753
DOC_USP7_MATH_1	71	75	PF00917	0.713
DOC_USP7_UBL2_3	96	100	PF12436	0.506
DOC_WW_Pin1_4	13	18	PF00397	0.592
DOC_WW_Pin1_4	3	8	PF00397	0.658
DOC_WW_Pin1_4	373	378	PF00397	0.691
LIG_14-3-3_CanoR_1	216	220	PF00244	0.635
LIG_14-3-3_CanoR_1	250	256	PF00244	0.602
LIG_14-3-3_CanoR_1	274	280	PF00244	0.644
LIG_14-3-3_CanoR_1	314	318	PF00244	0.657
LIG_14-3-3_CanoR_1	448	456	PF00244	0.632
LIG_14-3-3_CanoR_1	52	58	PF00244	0.629
LIG_14-3-3_CanoR_1	60	68	PF00244	0.593
LIG_Actin_WH2_2	171	189	PF00022	0.627
LIG_Actin_WH2_2	201	218	PF00022	0.638
LIG_Actin_WH2_2	353	370	PF00022	0.676
LIG_APCC_Cbox_2	334	340	PF00515	0.646
LIG_BIR_II_1	1	5	PF00653	0.474
LIG_EH_1	419	423	PF12763	0.781
LIG_FHA_1	164	170	PF00498	0.553
LIG_FHA_1	228	234	PF00498	0.651
LIG_FHA_1	289	295	PF00498	0.615
LIG_FHA_1	70	76	PF00498	0.698
LIG_FHA_2	123	129	PF00498	0.546
LIG_FHA_2	194	200	PF00498	0.579
LIG_FHA_2	222	228	PF00498	0.638
LIG_FHA_2	259	265	PF00498	0.600
LIG_FHA_2	290	296	PF00498	0.561
LIG_FHA_2	344	350	PF00498	0.676
LIG_GBD_Chelix_1	161	169	PF00786	0.628
LIG_LIR_Apic_2	394	398	PF02991	0.588
LIG_LIR_Gen_1	26	34	PF02991	0.618
LIG_LIR_Gen_1	289	298	PF02991	0.557
LIG_LIR_Gen_1	333	343	PF02991	0.649
LIG_LIR_Nem_3	26	30	PF02991	0.635
LIG_LIR_Nem_3	289	293	PF02991	0.628
LIG_LIR_Nem_3	295	300	PF02991	0.529
LIG_LIR_Nem_3	333	339	PF02991	0.642
LIG_MYND_1	417	421	PF01753	0.689
LIG_Pex14_1	332	336	PF04695	0.638
LIG_Pex14_1	466	470	PF04695	0.552
LIG_SH2_CRK	290	294	PF00017	0.602
LIG_SH2_CRK	297	301	PF00017	0.538
LIG_SH2_CRK	470	474	PF00017	0.560
LIG_SH2_STAP1	190	194	PF00017	0.616
LIG_SH2_STAP1	290	294	PF00017	0.629
LIG_SH2_STAT3	190	193	PF00017	0.631
LIG_SH2_STAT5	290	293	PF00017	0.610
LIG_SH2_STAT5	336	339	PF00017	0.649
LIG_SH3_1	412	418	PF00018	0.537
LIG_SH3_3	1	7	PF00018	0.661
LIG_SH3_3	12	18	PF00018	0.591
LIG_SH3_3	412	418	PF00018	0.664
LIG_TRAF2_1	125	128	PF00917	0.562
LIG_TRAF2_1	132	135	PF00917	0.539
LIG_TRAF2_1	338	341	PF00917	0.641
LIG_TRAF2_1	63	66	PF00917	0.653
LIG_UBA3_1	88	96	PF00899	0.658
MOD_CK1_1	201	207	PF00069	0.640
MOD_CK1_1	258	264	PF00069	0.635
MOD_CK1_1	272	278	PF00069	0.408
MOD_CK1_1	316	322	PF00069	0.552
MOD_CK1_1	396	402	PF00069	0.721
MOD_CK1_1	510	516	PF00069	0.777
MOD_CK2_1	122	128	PF00069	0.575
MOD_CK2_1	129	135	PF00069	0.533
MOD_CK2_1	193	199	PF00069	0.579
MOD_CK2_1	264	270	PF00069	0.621
MOD_CK2_1	289	295	PF00069	0.544
MOD_CK2_1	343	349	PF00069	0.618
MOD_CK2_1	375	381	PF00069	0.788
MOD_CK2_1	391	397	PF00069	0.633
MOD_CK2_1	59	65	PF00069	0.688
MOD_Cter_Amidation	409	412	PF01082	0.556
MOD_GlcNHglycan	131	134	PF01048	0.644
MOD_GlcNHglycan	190	193	PF01048	0.631
MOD_GlcNHglycan	20	23	PF01048	0.576
MOD_GlcNHglycan	275	278	PF01048	0.639
MOD_GlcNHglycan	322	325	PF01048	0.556
MOD_GlcNHglycan	369	372	PF01048	0.675
MOD_GlcNHglycan	400	403	PF01048	0.747
MOD_GlcNHglycan	449	452	PF01048	0.627
MOD_GlcNHglycan	488	494	PF01048	0.514
MOD_GlcNHglycan	502	505	PF01048	0.549
MOD_GlcNHglycan	512	515	PF01048	0.704
MOD_GlcNHglycan	516	519	PF01048	0.640
MOD_GlcNHglycan	61	64	PF01048	0.566
MOD_GSK3_1	13	20	PF00069	0.629
MOD_GSK3_1	163	170	PF00069	0.440
MOD_GSK3_1	193	200	PF00069	0.595
MOD_GSK3_1	221	228	PF00069	0.639
MOD_GSK3_1	269	276	PF00069	0.634
MOD_GSK3_1	296	303	PF00069	0.616
MOD_GSK3_1	316	323	PF00069	0.300
MOD_GSK3_1	339	346	PF00069	0.663
MOD_GSK3_1	369	376	PF00069	0.647
MOD_GSK3_1	506	513	PF00069	0.769
MOD_GSK3_1	71	78	PF00069	0.706
MOD_N-GLC_1	163	168	PF02516	0.394
MOD_N-GLC_1	220	225	PF02516	0.637
MOD_N-GLC_1	53	58	PF02516	0.688
MOD_NEK2_1	10	15	PF00069	0.552
MOD_NEK2_1	186	191	PF00069	0.637
MOD_NEK2_1	215	220	PF00069	0.536
MOD_NEK2_1	269	274	PF00069	0.634
MOD_NEK2_1	300	305	PF00069	0.570
MOD_NEK2_1	339	344	PF00069	0.627
MOD_NEK2_1	360	365	PF00069	0.704
MOD_NEK2_1	367	372	PF00069	0.662
MOD_PIKK_1	164	170	PF00454	0.626
MOD_PIKK_1	269	275	PF00454	0.632
MOD_PIKK_1	343	349	PF00454	0.594
MOD_PIKK_1	375	381	PF00454	0.777
MOD_PKA_2	215	221	PF00069	0.636
MOD_PKA_2	249	255	PF00069	0.551
MOD_PKA_2	273	279	PF00069	0.650
MOD_PKA_2	313	319	PF00069	0.646
MOD_PKA_2	353	359	PF00069	0.630
MOD_PKA_2	435	441	PF00069	0.630
MOD_PKA_2	447	453	PF00069	0.505
MOD_PKA_2	59	65	PF00069	0.613
MOD_Plk_1	288	294	PF00069	0.538
MOD_Plk_1	360	366	PF00069	0.712
MOD_Plk_1	489	495	PF00069	0.520
MOD_Plk_1	53	59	PF00069	0.650
MOD_Plk_2-3	264	270	PF00069	0.560
MOD_Plk_2-3	289	295	PF00069	0.552
MOD_Plk_2-3	313	319	PF00069	0.546
MOD_Plk_4	289	295	PF00069	0.552
MOD_Plk_4	353	359	PF00069	0.688
MOD_Plk_4	5	11	PF00069	0.599
MOD_ProDKin_1	13	19	PF00069	0.591
MOD_ProDKin_1	3	9	PF00069	0.664
MOD_ProDKin_1	373	379	PF00069	0.692
MOD_SUMO_rev_2	431	438	PF00179	0.723
TRG_DiLeu_BaEn_1	289	294	PF01217	0.628
TRG_DiLeu_BaEn_1	475	480	PF01217	0.617
TRG_DiLeu_BaEn_4	104	110	PF01217	0.582
TRG_ENDOCYTIC_2	290	293	PF00928	0.629
TRG_ENDOCYTIC_2	297	300	PF00928	0.508
TRG_ENDOCYTIC_2	336	339	PF00928	0.649
TRG_ENDOCYTIC_2	470	473	PF00928	0.569
TRG_ENDOCYTIC_2	484	487	PF00928	0.427
TRG_ER_diArg_1	123	126	PF00400	0.635
TRG_ER_diArg_1	411	413	PF00400	0.621
TRG_Pf-PMV_PEXEL_1	335	340	PF00026	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7L520	Trypanosoma rangeli	27%	76%
A0A3S7WSC1	Leishmania donovani	94%	69%
A4H737	Leishmania braziliensis	78%	69%
A4HVH7	Leishmania infantum	94%	100%
D0A6T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
E9AP72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	74%