Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania major

UniProt:

Q4QGA5_LEIMA

TriTrypDb:

LmjF.13.0490 , LMJLV39_130008900 , LMJSD75_130009000

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QGA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.583
CLV_NRD_NRD_1	121	123	PF00675	0.394
CLV_NRD_NRD_1	287	289	PF00675	0.649
CLV_NRD_NRD_1	322	324	PF00675	0.364
CLV_NRD_NRD_1	443	445	PF00675	0.553
CLV_PCSK_FUR_1	441	445	PF00082	0.498
CLV_PCSK_KEX2_1	126	128	PF00082	0.333
CLV_PCSK_KEX2_1	322	324	PF00082	0.364
CLV_PCSK_KEX2_1	441	443	PF00082	0.518
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.355
CLV_PCSK_PC7_1	122	128	PF00082	0.292
CLV_PCSK_SKI1_1	201	205	PF00082	0.557
CLV_PCSK_SKI1_1	289	293	PF00082	0.606
DEG_SCF_FBW7_1	475	481	PF00400	0.573
DOC_ANK_TNKS_1	190	197	PF00023	0.413
DOC_CDC14_PxL_1	176	184	PF14671	0.425
DOC_CKS1_1	475	480	PF01111	0.625
DOC_CYCLIN_yCln2_LP_2	383	386	PF00134	0.346
DOC_MAPK_DCC_7	480	489	PF00069	0.601
DOC_MAPK_gen_1	126	136	PF00069	0.353
DOC_MAPK_gen_1	480	489	PF00069	0.558
DOC_MAPK_gen_1	85	95	PF00069	0.338
DOC_PP1_RVXF_1	199	205	PF00149	0.418
DOC_PP2B_LxvP_1	383	386	PF13499	0.346
DOC_PP2B_LxvP_1	44	47	PF13499	0.481
DOC_USP7_MATH_1	17	21	PF00917	0.654
DOC_USP7_MATH_1	274	278	PF00917	0.445
DOC_USP7_MATH_1	291	295	PF00917	0.704
DOC_USP7_MATH_1	337	341	PF00917	0.438
DOC_USP7_MATH_1	419	423	PF00917	0.340
DOC_USP7_MATH_1	446	450	PF00917	0.588
DOC_USP7_MATH_1	495	499	PF00917	0.448
DOC_USP7_UBL2_3	408	412	PF12436	0.530
DOC_USP7_UBL2_3	459	463	PF12436	0.674
DOC_WW_Pin1_4	135	140	PF00397	0.271
DOC_WW_Pin1_4	294	299	PF00397	0.635
DOC_WW_Pin1_4	465	470	PF00397	0.554
DOC_WW_Pin1_4	474	479	PF00397	0.538
DOC_WW_Pin1_4	482	487	PF00397	0.707
LIG_14-3-3_CanoR_1	105	110	PF00244	0.411
LIG_14-3-3_CanoR_1	129	135	PF00244	0.368
LIG_14-3-3_CanoR_1	212	216	PF00244	0.456
LIG_14-3-3_CanoR_1	34	41	PF00244	0.537
LIG_APCC_ABBA_1	159	164	PF00400	0.271
LIG_APCC_ABBAyCdc20_2	158	164	PF00400	0.271
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	328	332	PF00533	0.477
LIG_deltaCOP1_diTrp_1	169	176	PF00928	0.353
LIG_DLG_GKlike_1	105	113	PF00625	0.406
LIG_FHA_1	129	135	PF00498	0.353
LIG_FHA_1	144	150	PF00498	0.230
LIG_FHA_1	176	182	PF00498	0.463
LIG_FHA_1	225	231	PF00498	0.512
LIG_FHA_1	264	270	PF00498	0.411
LIG_FHA_1	328	334	PF00498	0.408
LIG_FHA_1	355	361	PF00498	0.560
LIG_FHA_1	479	485	PF00498	0.683
LIG_FHA_1	497	503	PF00498	0.495
LIG_FHA_2	243	249	PF00498	0.498
LIG_FHA_2	391	397	PF00498	0.319
LIG_FHA_2	398	404	PF00498	0.321
LIG_FHA_2	435	441	PF00498	0.461
LIG_LIR_Gen_1	131	140	PF02991	0.350
LIG_LIR_Gen_1	241	251	PF02991	0.345
LIG_LIR_Gen_1	417	426	PF02991	0.364
LIG_LIR_Nem_3	131	135	PF02991	0.350
LIG_LIR_Nem_3	241	246	PF02991	0.391
LIG_LIR_Nem_3	417	423	PF02991	0.389
LIG_MYND_1	381	385	PF01753	0.495
LIG_Pex14_2	166	170	PF04695	0.204
LIG_Rb_pABgroove_1	90	98	PF01858	0.371
LIG_SH2_CRK	416	420	PF00017	0.429
LIG_SH2_CRK	433	437	PF00017	0.472
LIG_SH2_CRK	96	100	PF00017	0.394
LIG_SH2_NCK_1	416	420	PF00017	0.515
LIG_SH2_PTP2	162	165	PF00017	0.404
LIG_SH2_SRC	162	165	PF00017	0.404
LIG_SH2_SRC	96	99	PF00017	0.394
LIG_SH2_STAT5	115	118	PF00017	0.335
LIG_SH2_STAT5	162	165	PF00017	0.424
LIG_SH2_STAT5	186	189	PF00017	0.384
LIG_SH2_STAT5	363	366	PF00017	0.448
LIG_SH2_STAT5	420	423	PF00017	0.338
LIG_SH3_1	480	486	PF00018	0.526
LIG_SH3_2	14	19	PF14604	0.584
LIG_SH3_3	11	17	PF00018	0.585
LIG_SH3_3	189	195	PF00018	0.587
LIG_SH3_3	308	314	PF00018	0.434
LIG_SH3_3	401	407	PF00018	0.468
LIG_SH3_3	480	486	PF00018	0.570
LIG_SUMO_SIM_anti_2	39	45	PF11976	0.388
LIG_SUMO_SIM_anti_2	68	75	PF11976	0.198
LIG_SUMO_SIM_par_1	344	350	PF11976	0.423
LIG_SUMO_SIM_par_1	485	490	PF11976	0.490
LIG_SxIP_EBH_1	212	222	PF03271	0.398
LIG_TRAF2_1	223	226	PF00917	0.494
LIG_TRAF2_1	437	440	PF00917	0.500
LIG_TYR_ITIM	113	118	PF00017	0.404
LIG_TYR_ITIM	418	423	PF00017	0.361
LIG_UBA3_1	215	220	PF00899	0.396
LIG_WRC_WIRS_1	106	111	PF05994	0.292
MOD_CDK_SPK_2	294	299	PF00069	0.591
MOD_CDK_SPxK_1	474	480	PF00069	0.584
MOD_CDK_SPxxK_3	135	142	PF00069	0.271
MOD_CDK_SPxxK_3	465	472	PF00069	0.543
MOD_CK1_1	108	114	PF00069	0.435
MOD_CK1_1	185	191	PF00069	0.456
MOD_CK1_1	241	247	PF00069	0.251
MOD_CK1_1	294	300	PF00069	0.773
MOD_CK1_1	422	428	PF00069	0.390
MOD_CK1_1	447	453	PF00069	0.550
MOD_CK1_1	485	491	PF00069	0.412
MOD_CK2_1	18	24	PF00069	0.589
MOD_CK2_1	242	248	PF00069	0.391
MOD_CK2_1	397	403	PF00069	0.415
MOD_CK2_1	434	440	PF00069	0.540
MOD_DYRK1A_RPxSP_1	482	486	PF00069	0.560
MOD_GlcNHglycan	188	191	PF01048	0.479
MOD_GlcNHglycan	240	243	PF01048	0.481
MOD_GlcNHglycan	35	38	PF01048	0.697
MOD_GlcNHglycan	376	379	PF01048	0.542
MOD_GlcNHglycan	445	449	PF01048	0.549
MOD_GSK3_1	18	25	PF00069	0.585
MOD_GSK3_1	182	189	PF00069	0.476
MOD_GSK3_1	238	245	PF00069	0.425
MOD_GSK3_1	274	281	PF00069	0.558
MOD_GSK3_1	4	11	PF00069	0.621
MOD_GSK3_1	474	481	PF00069	0.766
MOD_GSK3_1	49	56	PF00069	0.516
MOD_N-GLC_1	17	22	PF02516	0.579
MOD_N-GLC_1	30	35	PF02516	0.451
MOD_NEK2_1	182	187	PF00069	0.473
MOD_NEK2_1	211	216	PF00069	0.323
MOD_NEK2_1	218	223	PF00069	0.329
MOD_NEK2_1	390	395	PF00069	0.317
MOD_NEK2_1	49	54	PF00069	0.570
MOD_NEK2_1	501	506	PF00069	0.618
MOD_NEK2_2	130	135	PF00069	0.404
MOD_PIKK_1	291	297	PF00454	0.791
MOD_PKA_2	128	134	PF00069	0.313
MOD_PKA_2	18	24	PF00069	0.579
MOD_PKA_2	190	196	PF00069	0.425
MOD_PKA_2	211	217	PF00069	0.457
MOD_PKA_2	283	289	PF00069	0.692
MOD_PKA_2	33	39	PF00069	0.573
MOD_PKA_2	355	361	PF00069	0.440
MOD_PKA_2	374	380	PF00069	0.515
MOD_PKA_2	56	62	PF00069	0.458
MOD_PKB_1	442	450	PF00069	0.581
MOD_Plk_1	17	23	PF00069	0.578
MOD_Plk_1	39	45	PF00069	0.464
MOD_Plk_4	211	217	PF00069	0.330
MOD_Plk_4	339	345	PF00069	0.466
MOD_Plk_4	39	45	PF00069	0.532
MOD_Plk_4	397	403	PF00069	0.446
MOD_ProDKin_1	135	141	PF00069	0.271
MOD_ProDKin_1	294	300	PF00069	0.629
MOD_ProDKin_1	465	471	PF00069	0.555
MOD_ProDKin_1	474	480	PF00069	0.537
MOD_ProDKin_1	482	488	PF00069	0.706
MOD_SUMO_rev_2	226	235	PF00179	0.377
TRG_DiLeu_BaEn_1	225	230	PF01217	0.521
TRG_DiLeu_BaEn_4	225	231	PF01217	0.523
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.455
TRG_ENDOCYTIC_2	115	118	PF00928	0.404
TRG_ENDOCYTIC_2	363	366	PF00928	0.426
TRG_ENDOCYTIC_2	420	423	PF00928	0.406
TRG_ENDOCYTIC_2	432	435	PF00928	0.465
TRG_ER_diArg_1	321	323	PF00400	0.406
TRG_ER_diArg_1	441	444	PF00400	0.554
TRG_ER_diArg_1	479	482	PF00400	0.552
TRG_ER_diArg_1	502	505	PF00400	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P925	Leptomonas seymouri	65%	100%
A0A1X0NN77	Trypanosomatidae	33%	100%
A0A3Q8I8G2	Leishmania donovani	94%	100%
A0A3R7KJL2	Trypanosoma rangeli	32%	100%
A4H738	Leishmania braziliensis	83%	100%
A4HVH8	Leishmania infantum	94%	100%
D0A6T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AP73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BFH7	Trypanosoma cruzi	38%	100%