Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGA3_LEIMA

TriTrypDb:

LmjF.13.0510 , LMJLV39_130009100 , LMJSD75_130009200

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QGA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.654
CLV_NRD_NRD_1	175	177	PF00675	0.554
CLV_NRD_NRD_1	32	34	PF00675	0.468
CLV_NRD_NRD_1	41	43	PF00675	0.658
CLV_PCSK_KEX2_1	16	18	PF00082	0.667
CLV_PCSK_KEX2_1	175	177	PF00082	0.535
CLV_PCSK_KEX2_1	247	249	PF00082	0.663
CLV_PCSK_KEX2_1	32	34	PF00082	0.453
CLV_PCSK_KEX2_1	41	43	PF00082	0.639
CLV_PCSK_KEX2_1	75	77	PF00082	0.523
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.634
DEG_Nend_UBRbox_2	1	3	PF02207	0.620
DEG_SCF_FBW7_1	4	11	PF00400	0.631
DOC_CYCLIN_RxL_1	172	182	PF00134	0.626
DOC_CYCLIN_yCln2_LP_2	164	170	PF00134	0.412
DOC_MAPK_MEF2A_6	162	171	PF00069	0.563
DOC_MAPK_MEF2A_6	55	63	PF00069	0.550
DOC_MAPK_RevD_3	61	76	PF00069	0.568
DOC_PP1_RVXF_1	173	180	PF00149	0.638
DOC_PP2B_LxvP_1	236	239	PF13499	0.665
DOC_USP7_MATH_1	140	144	PF00917	0.622
DOC_USP7_MATH_1	25	29	PF00917	0.713
DOC_USP7_MATH_1	8	12	PF00917	0.691
DOC_WW_Pin1_4	134	139	PF00397	0.658
DOC_WW_Pin1_4	4	9	PF00397	0.680
LIG_14-3-3_CanoR_1	155	164	PF00244	0.614
LIG_14-3-3_CanoR_1	175	180	PF00244	0.499
LIG_BRCT_BRCA1_1	140	144	PF00533	0.443
LIG_FHA_1	105	111	PF00498	0.662
LIG_FHA_1	172	178	PF00498	0.553
LIG_FHA_1	186	192	PF00498	0.575
LIG_FHA_2	5	11	PF00498	0.701
LIG_FHA_2	98	104	PF00498	0.650
LIG_HP1_1	167	171	PF01393	0.406
LIG_IBAR_NPY_1	166	168	PF08397	0.407
LIG_Integrin_RGD_1	121	123	PF01839	0.667
LIG_LIR_Gen_1	165	172	PF02991	0.415
LIG_LIR_Gen_1	85	92	PF02991	0.591
LIG_LIR_Nem_3	165	171	PF02991	0.412
LIG_LIR_Nem_3	85	90	PF02991	0.587
LIG_NRP_CendR_1	247	249	PF00754	0.719
LIG_SH2_PTP2	135	138	PF00017	0.555
LIG_SH2_PTP2	168	171	PF00017	0.413
LIG_SH2_STAP1	30	34	PF00017	0.497
LIG_SH2_STAT3	34	37	PF00017	0.585
LIG_SH2_STAT5	135	138	PF00017	0.622
LIG_SH2_STAT5	168	171	PF00017	0.413
LIG_SH3_3	218	224	PF00018	0.621
LIG_SUMO_SIM_par_1	76	81	PF11976	0.527
LIG_TRAF2_1	100	103	PF00917	0.656
LIG_WRC_WIRS_1	192	197	PF05994	0.524
LIG_WW_3	237	241	PF00397	0.535
MOD_CK1_1	178	184	PF00069	0.579
MOD_CK1_1	194	200	PF00069	0.389
MOD_CK2_1	178	184	PF00069	0.562
MOD_CK2_1	4	10	PF00069	0.770
MOD_CK2_1	97	103	PF00069	0.652
MOD_GlcNHglycan	10	13	PF01048	0.609
MOD_GlcNHglycan	158	161	PF01048	0.545
MOD_GlcNHglycan	217	220	PF01048	0.575
MOD_GlcNHglycan	55	58	PF01048	0.567
MOD_GlcNHglycan	65	68	PF01048	0.512
MOD_GSK3_1	134	141	PF00069	0.577
MOD_GSK3_1	171	178	PF00069	0.626
MOD_GSK3_1	33	40	PF00069	0.554
MOD_GSK3_1	4	11	PF00069	0.646
MOD_GSK3_1	41	48	PF00069	0.656
MOD_GSK3_1	78	85	PF00069	0.548
MOD_GSK3_1	88	95	PF00069	0.651
MOD_N-GLC_1	88	93	PF02516	0.561
MOD_NEK2_1	171	176	PF00069	0.693
MOD_NEK2_1	63	68	PF00069	0.615
MOD_NEK2_2	104	109	PF00069	0.592
MOD_PIKK_1	33	39	PF00454	0.652
MOD_PKA_1	175	181	PF00069	0.556
MOD_PKA_1	32	38	PF00069	0.669
MOD_PKA_1	41	47	PF00069	0.688
MOD_PKA_2	175	181	PF00069	0.557
MOD_PKA_2	239	245	PF00069	0.553
MOD_PKA_2	32	38	PF00069	0.644
MOD_PKA_2	41	47	PF00069	0.678
MOD_PKA_2	92	98	PF00069	0.673
MOD_Plk_4	191	197	PF00069	0.573
MOD_Plk_4	25	31	PF00069	0.519
MOD_ProDKin_1	134	140	PF00069	0.664
MOD_ProDKin_1	4	10	PF00069	0.677
TRG_ENDOCYTIC_2	168	171	PF00928	0.413
TRG_ER_diArg_1	175	177	PF00400	0.645
TRG_ER_diArg_1	247	249	PF00400	0.659
TRG_ER_diArg_1	32	34	PF00400	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q3	Leptomonas seymouri	57%	85%
A0A1X0NN61	Trypanosomatidae	36%	100%
A0A3S5H6N4	Leishmania donovani	93%	100%
A0A422NQK2	Trypanosoma rangeli	33%	100%
A4H740	Leishmania braziliensis	79%	84%
A4HVI0	Leishmania infantum	92%	100%
D0A6T1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AP75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5AVG9	Trypanosoma cruzi	37%	86%