Coiled-coil domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1014), putative

Species:

Leishmania major

UniProt:

Q4QGA2_LEIMA

TriTrypDb:

LmjF.13.0520 , LMJLV39_130009200 , LMJSD75_130009300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QGA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006351	DNA-templated transcription	7	2
GO:0006366	transcription by RNA polymerase II	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0032774	RNA biosynthetic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:0097659	nucleic acid-templated transcription	6	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	2
GO:0003713	transcription coactivator activity	3	2
GO:0140110	transcription regulator activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.534
CLV_NRD_NRD_1	216	218	PF00675	0.248
CLV_NRD_NRD_1	25	27	PF00675	0.623
CLV_NRD_NRD_1	252	254	PF00675	0.514
CLV_PCSK_KEX2_1	128	130	PF00082	0.524
CLV_PCSK_KEX2_1	191	193	PF00082	0.248
CLV_PCSK_KEX2_1	216	218	PF00082	0.239
CLV_PCSK_KEX2_1	25	27	PF00082	0.595
CLV_PCSK_KEX2_1	252	254	PF00082	0.519
CLV_PCSK_KEX2_1	56	58	PF00082	0.531
CLV_PCSK_KEX2_1	73	75	PF00082	0.503
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.524
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.259
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.576
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.424
CLV_PCSK_PC7_1	187	193	PF00082	0.248
CLV_PCSK_PC7_1	21	27	PF00082	0.619
CLV_PCSK_PC7_1	69	75	PF00082	0.635
CLV_PCSK_SKI1_1	112	116	PF00082	0.625
CLV_PCSK_SKI1_1	191	195	PF00082	0.353
CLV_PCSK_SKI1_1	48	52	PF00082	0.510
DOC_USP7_MATH_1	133	137	PF00917	0.674
DOC_USP7_UBL2_3	194	198	PF12436	0.553
DOC_USP7_UBL2_3	270	274	PF12436	0.689
DOC_USP7_UBL2_3	48	52	PF12436	0.499
DOC_USP7_UBL2_3	62	66	PF12436	0.508
DOC_USP7_UBL2_3	87	91	PF12436	0.575
DOC_USP7_UBL2_3	99	103	PF12436	0.471
DOC_WW_Pin1_4	228	233	PF00397	0.473
LIG_14-3-3_CanoR_1	13	20	PF00244	0.587
LIG_14-3-3_CanoR_1	216	224	PF00244	0.474
LIG_14-3-3_CanoR_1	41	49	PF00244	0.635
LIG_Actin_WH2_2	201	218	PF00022	0.553
LIG_deltaCOP1_diTrp_1	222	228	PF00928	0.449
LIG_EH_1	233	237	PF12763	0.459
LIG_FHA_2	161	167	PF00498	0.470
LIG_LIR_Gen_1	218	227	PF02991	0.485
LIG_LIR_Nem_3	218	223	PF02991	0.485
LIG_PCNA_yPIPBox_3	216	228	PF02747	0.459
LIG_PCNA_yPIPBox_3	91	105	PF02747	0.494
LIG_SH2_GRB2like	10	13	PF00017	0.614
LIG_SH2_STAT5	10	13	PF00017	0.614
LIG_SH3_3	229	235	PF00018	0.473
LIG_SH3_3	83	89	PF00018	0.570
LIG_TRAF2_1	151	154	PF00917	0.623
LIG_TYR_ITSM	216	223	PF00017	0.553
LIG_UBA3_1	223	230	PF00899	0.473
MOD_CK2_1	256	262	PF00069	0.716
MOD_CMANNOS	225	228	PF00535	0.248
MOD_Cter_Amidation	189	192	PF01082	0.248
MOD_GlcNHglycan	135	138	PF01048	0.645
MOD_GlcNHglycan	160	163	PF01048	0.275
MOD_GlcNHglycan	177	180	PF01048	0.307
MOD_GlcNHglycan	2	5	PF01048	0.576
MOD_GSK3_1	154	161	PF00069	0.352
MOD_GSK3_1	8	15	PF00069	0.562
MOD_N-GLC_1	175	180	PF02516	0.270
MOD_NEK2_1	215	220	PF00069	0.459
MOD_PIKK_1	215	221	PF00454	0.450
MOD_PKA_2	12	18	PF00069	0.594
MOD_PKA_2	215	221	PF00069	0.471
MOD_PKA_2	40	46	PF00069	0.583
MOD_Plk_2-3	256	262	PF00069	0.643
MOD_ProDKin_1	228	234	PF00069	0.473
MOD_SUMO_for_1	124	127	PF00179	0.735
MOD_SUMO_for_1	208	211	PF00179	0.509
MOD_SUMO_rev_2	206	213	PF00179	0.414
MOD_SUMO_rev_2	43	50	PF00179	0.501
MOD_SUMO_rev_2	58	68	PF00179	0.420
TRG_DiLeu_BaEn_4	210	216	PF01217	0.421
TRG_ENDOCYTIC_2	197	200	PF00928	0.448
TRG_ENDOCYTIC_2	220	223	PF00928	0.469
TRG_ER_diArg_1	215	217	PF00400	0.473
TRG_ER_diArg_1	25	27	PF00400	0.619
TRG_ER_diArg_1	252	254	PF00400	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1R4	Leptomonas seymouri	68%	100%
A0A0S4JL95	Bodo saltans	46%	100%
A0A1X0NNI4	Trypanosomatidae	54%	100%
A0A3R7NKC3	Trypanosoma rangeli	53%	100%
A0A3S7WSF4	Leishmania donovani	94%	100%
A4H741	Leishmania braziliensis	83%	100%
A4HVI1	Leishmania infantum	94%	100%
D0A6T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AP76	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q28HN4	Xenopus tropicalis	29%	100%
Q54GW3	Dictyostelium discoideum	28%	100%
Q68EY7	Xenopus laevis	29%	100%
Q6PHE8	Danio rerio	28%	100%
V5BAV6	Trypanosoma cruzi	54%	91%