Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QGA0_LEIMA

TriTrypDb:

LmjF.13.0540 , LMJLV39_130009400 , LMJSD75_130009500

Length:

198

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8
GO:0016020	membrane	2	6

Expansion

Sequence features

Q4QGA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QGA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.519
CLV_NRD_NRD_1	54	56	PF00675	0.432
CLV_PCSK_FUR_1	45	49	PF00082	0.457
CLV_PCSK_KEX2_1	178	180	PF00082	0.457
CLV_PCSK_KEX2_1	47	49	PF00082	0.436
CLV_PCSK_KEX2_1	53	55	PF00082	0.417
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.452
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.434
CLV_PCSK_SKI1_1	128	132	PF00082	0.437
CLV_PCSK_SKI1_1	33	37	PF00082	0.456
CLV_PCSK_SKI1_1	86	90	PF00082	0.476
DEG_APCC_DBOX_1	127	135	PF00400	0.339
DEG_CRL4_CDT2_1	38	49	PF00400	0.691
DEG_CRL4_CDT2_2	38	49	PF00400	0.691
DEG_Nend_UBRbox_3	1	3	PF02207	0.662
DOC_CKS1_1	1	6	PF01111	0.763
DOC_CYCLIN_yCln2_LP_2	129	135	PF00134	0.417
DOC_MAPK_DCC_7	128	136	PF00069	0.339
DOC_MAPK_gen_1	45	52	PF00069	0.705
DOC_MAPK_MEF2A_6	128	136	PF00069	0.339
DOC_PP2B_LxvP_1	129	132	PF13499	0.417
DOC_USP7_MATH_1	35	39	PF00917	0.696
DOC_USP7_MATH_1	67	71	PF00917	0.732
DOC_USP7_MATH_1	7	11	PF00917	0.702
DOC_USP7_MATH_1	82	86	PF00917	0.639
DOC_USP7_UBL2_3	178	182	PF12436	0.741
DOC_WW_Pin1_4	188	193	PF00397	0.679
DOC_WW_Pin1_4	73	78	PF00397	0.717
DOC_WW_Pin1_4	9	14	PF00397	0.662
LIG_14-3-3_CanoR_1	24	29	PF00244	0.645
LIG_14-3-3_CanoR_1	81	88	PF00244	0.691
LIG_FHA_1	139	145	PF00498	0.308
LIG_FHA_1	82	88	PF00498	0.630
LIG_FHA_2	184	190	PF00498	0.674
LIG_LIR_Gen_1	25	35	PF02991	0.595
LIG_LIR_Gen_1	46	57	PF02991	0.692
LIG_LIR_Nem_3	25	31	PF02991	0.599
LIG_LIR_Nem_3	46	52	PF02991	0.686
LIG_SH2_GRB2like	125	128	PF00017	0.390
LIG_SH2_SRC	28	31	PF00017	0.600
LIG_SH2_STAP1	28	32	PF00017	0.656
LIG_SH2_STAT5	121	124	PF00017	0.452
LIG_SH2_STAT5	157	160	PF00017	0.634
LIG_SH2_STAT5	49	52	PF00017	0.622
LIG_SH3_3	129	135	PF00018	0.274
LIG_TRAF2_1	27	30	PF00917	0.587
LIG_TYR_ITIM	26	31	PF00017	0.590
MOD_CK1_1	113	119	PF00069	0.277
MOD_CK1_1	38	44	PF00069	0.699
MOD_CK2_1	183	189	PF00069	0.659
MOD_CK2_1	24	30	PF00069	0.602
MOD_CMANNOS	142	145	PF00535	0.289
MOD_GlcNHglycan	102	105	PF01048	0.404
MOD_GlcNHglycan	69	72	PF01048	0.432
MOD_GlcNHglycan	9	12	PF01048	0.470
MOD_GlcNHglycan	92	95	PF01048	0.436
MOD_GlcNHglycan	96	99	PF01048	0.427
MOD_GSK3_1	106	113	PF00069	0.236
MOD_GSK3_1	90	97	PF00069	0.638
MOD_N-GLC_1	7	12	PF02516	0.491
MOD_NEK2_1	100	105	PF00069	0.615
MOD_NEK2_1	183	188	PF00069	0.771
MOD_NEK2_2	96	101	PF00069	0.621
MOD_PKA_2	80	86	PF00069	0.690
MOD_Plk_4	35	41	PF00069	0.666
MOD_Plk_4	96	102	PF00069	0.691
MOD_ProDKin_1	188	194	PF00069	0.680
MOD_ProDKin_1	73	79	PF00069	0.721
MOD_ProDKin_1	9	15	PF00069	0.663
TRG_DiLeu_BaEn_1	61	66	PF01217	0.640
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.623
TRG_ENDOCYTIC_2	121	124	PF00928	0.452
TRG_ENDOCYTIC_2	28	31	PF00928	0.589
TRG_ENDOCYTIC_2	49	52	PF00928	0.587
TRG_ER_diArg_1	179	181	PF00400	0.747
TRG_ER_diArg_1	52	55	PF00400	0.626
TRG_NLS_MonoCore_2	177	182	PF00514	0.733
TRG_NLS_MonoExtC_3	177	182	PF00514	0.733
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE47	Leptomonas seymouri	76%	100%
A0A0S4J5J9	Bodo saltans	40%	100%
A0A1X0NNT8	Trypanosomatidae	44%	96%
A0A3Q8IHY4	Leishmania donovani	96%	100%
A0A3R7MTA4	Trypanosoma rangeli	46%	100%
A4H743	Leishmania braziliensis	84%	100%
A4HVI3	Leishmania infantum	96%	100%
D0A6S6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AP78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5DBH6	Trypanosoma cruzi	46%	100%