UPF0301 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

UPF0301 protein

Gene product:

Uncharacterized ACR, COG1678, putative

Species:

Leishmania major

UniProt:

Q4QG99_LEIMA

TriTrypDb:

LmjF.13.0550 , LMJLV39_130009500 , LMJSD75_130009600

Length:

670

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QG99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QG99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.594
CLV_C14_Caspase3-7	59	63	PF00656	0.493
CLV_NRD_NRD_1	17	19	PF00675	0.503
CLV_NRD_NRD_1	252	254	PF00675	0.657
CLV_NRD_NRD_1	328	330	PF00675	0.800
CLV_NRD_NRD_1	374	376	PF00675	0.513
CLV_NRD_NRD_1	421	423	PF00675	0.513
CLV_NRD_NRD_1	623	625	PF00675	0.693
CLV_NRD_NRD_1	66	68	PF00675	0.484
CLV_NRD_NRD_1	9	11	PF00675	0.507
CLV_PCSK_FUR_1	620	624	PF00082	0.699
CLV_PCSK_KEX2_1	17	19	PF00082	0.495
CLV_PCSK_KEX2_1	252	254	PF00082	0.648
CLV_PCSK_KEX2_1	328	330	PF00082	0.800
CLV_PCSK_KEX2_1	374	376	PF00082	0.513
CLV_PCSK_KEX2_1	421	423	PF00082	0.513
CLV_PCSK_KEX2_1	619	621	PF00082	0.702
CLV_PCSK_KEX2_1	622	624	PF00082	0.688
CLV_PCSK_KEX2_1	66	68	PF00082	0.484
CLV_PCSK_PC1ET2_1	619	621	PF00082	0.795
CLV_PCSK_PC7_1	370	376	PF00082	0.513
CLV_PCSK_PC7_1	616	622	PF00082	0.562
CLV_PCSK_SKI1_1	200	204	PF00082	0.764
CLV_PCSK_SKI1_1	3	7	PF00082	0.510
CLV_PCSK_SKI1_1	370	374	PF00082	0.411
CLV_PCSK_SKI1_1	375	379	PF00082	0.411
CLV_PCSK_SKI1_1	382	386	PF00082	0.411
CLV_PCSK_SKI1_1	58	62	PF00082	0.592
CLV_PCSK_SKI1_1	616	620	PF00082	0.628
CLV_Separin_Metazoa	597	601	PF03568	0.534
DEG_APCC_DBOX_1	374	382	PF00400	0.513
DEG_APCC_DBOX_1	57	65	PF00400	0.490
DEG_COP1_1	330	340	PF00400	0.617
DEG_Nend_UBRbox_2	1	3	PF02207	0.560
DEG_SPOP_SBC_1	116	120	PF00917	0.711
DEG_SPOP_SBC_1	206	210	PF00917	0.718
DEG_SPOP_SBC_1	553	557	PF00917	0.683
DOC_ANK_TNKS_1	328	335	PF00023	0.625
DOC_MAPK_gen_1	221	231	PF00069	0.450
DOC_MAPK_gen_1	355	364	PF00069	0.590
DOC_MAPK_gen_1	374	381	PF00069	0.273
DOC_MAPK_MEF2A_6	145	153	PF00069	0.536
DOC_MAPK_MEF2A_6	262	271	PF00069	0.744
DOC_MAPK_MEF2A_6	355	364	PF00069	0.671
DOC_MAPK_MEF2A_6	374	381	PF00069	0.302
DOC_USP7_MATH_1	108	112	PF00917	0.781
DOC_USP7_MATH_1	117	121	PF00917	0.679
DOC_USP7_MATH_1	131	135	PF00917	0.574
DOC_USP7_MATH_1	206	210	PF00917	0.718
DOC_USP7_MATH_1	277	281	PF00917	0.765
DOC_USP7_MATH_1	320	324	PF00917	0.826
DOC_USP7_MATH_1	332	336	PF00917	0.662
DOC_USP7_MATH_1	434	438	PF00917	0.411
DOC_USP7_MATH_1	459	463	PF00917	0.411
DOC_USP7_MATH_1	519	523	PF00917	0.547
DOC_USP7_MATH_1	552	556	PF00917	0.823
DOC_USP7_MATH_1	644	648	PF00917	0.496
DOC_WW_Pin1_4	167	172	PF00397	0.560
DOC_WW_Pin1_4	282	287	PF00397	0.710
DOC_WW_Pin1_4	327	332	PF00397	0.663
DOC_WW_Pin1_4	609	614	PF00397	0.685
DOC_WW_Pin1_4	69	74	PF00397	0.513
LIG_14-3-3_CanoR_1	145	150	PF00244	0.545
LIG_14-3-3_CanoR_1	244	248	PF00244	0.723
LIG_14-3-3_CanoR_1	374	378	PF00244	0.411
LIG_14-3-3_CanoR_1	382	391	PF00244	0.411
LIG_14-3-3_CanoR_1	643	649	PF00244	0.502
LIG_BRCT_BRCA1_1	56	60	PF00533	0.609
LIG_deltaCOP1_diTrp_1	43	47	PF00928	0.535
LIG_deltaCOP1_diTrp_1	51	60	PF00928	0.531
LIG_FAT_LD_1	470	478	PF03623	0.411
LIG_FHA_1	136	142	PF00498	0.803
LIG_FHA_1	146	152	PF00498	0.549
LIG_FHA_1	158	164	PF00498	0.402
LIG_FHA_1	197	203	PF00498	0.732
LIG_FHA_1	374	380	PF00498	0.411
LIG_FHA_1	408	414	PF00498	0.411
LIG_FHA_1	426	432	PF00498	0.411
LIG_FHA_1	82	88	PF00498	0.556
LIG_FHA_2	290	296	PF00498	0.748
LIG_FHA_2	531	537	PF00498	0.515
LIG_FHA_2	57	63	PF00498	0.537
LIG_IRF3_LxIS_1	360	365	PF10401	0.369
LIG_LIR_Apic_2	72	78	PF02991	0.517
LIG_LIR_Gen_1	178	189	PF02991	0.611
LIG_LIR_Nem_3	178	184	PF02991	0.607
LIG_LIR_Nem_3	43	47	PF02991	0.535
LIG_LIR_Nem_3	627	631	PF02991	0.681
LIG_LIR_Nem_3	7	12	PF02991	0.484
LIG_Pex14_1	641	645	PF04695	0.502
LIG_REV1ctd_RIR_1	370	379	PF16727	0.411
LIG_SH2_CRK	156	160	PF00017	0.570
LIG_SH2_CRK	645	649	PF00017	0.499
LIG_SH2_CRK	9	13	PF00017	0.485
LIG_SH2_NCK_1	645	649	PF00017	0.601
LIG_SH2_PTP2	75	78	PF00017	0.522
LIG_SH2_SRC	75	78	PF00017	0.602
LIG_SH2_STAP1	37	41	PF00017	0.533
LIG_SH2_STAP1	652	656	PF00017	0.516
LIG_SH2_STAT3	90	93	PF00017	0.523
LIG_SH2_STAT5	189	192	PF00017	0.504
LIG_SH2_STAT5	75	78	PF00017	0.602
LIG_SH3_3	449	455	PF00018	0.513
LIG_SH3_3	645	651	PF00018	0.614
LIG_SH3_3	74	80	PF00018	0.535
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.411
LIG_SUMO_SIM_anti_2	469	474	PF11976	0.515
LIG_SUMO_SIM_anti_2	485	492	PF11976	0.286
LIG_SUMO_SIM_par_1	267	272	PF11976	0.586
LIG_TRAF2_1	121	124	PF00917	0.719
LIG_TRAF2_1	339	342	PF00917	0.723
LIG_TRAF2_1	483	486	PF00917	0.513
LIG_TRAF2_1	579	582	PF00917	0.794
LIG_TRAF2_2	33	38	PF00917	0.518
LIG_TYR_ITIM	154	159	PF00017	0.570
LIG_WW_2	77	80	PF00397	0.550
MOD_CDK_SPxxK_3	609	616	PF00069	0.537
MOD_CK1_1	134	140	PF00069	0.700
MOD_CK1_1	157	163	PF00069	0.469
MOD_CK1_1	175	181	PF00069	0.523
MOD_CK1_1	208	214	PF00069	0.697
MOD_CK1_1	258	264	PF00069	0.753
MOD_CK1_1	323	329	PF00069	0.666
MOD_CK1_1	365	371	PF00069	0.613
MOD_CK1_1	437	443	PF00069	0.411
MOD_CK1_1	515	521	PF00069	0.411
MOD_CK1_1	96	102	PF00069	0.633
MOD_CK2_1	117	123	PF00069	0.829
MOD_CK2_1	209	215	PF00069	0.692
MOD_CK2_1	289	295	PF00069	0.743
MOD_CK2_1	327	333	PF00069	0.869
MOD_CK2_1	336	342	PF00069	0.765
MOD_CK2_1	480	486	PF00069	0.513
MOD_CK2_1	552	558	PF00069	0.728
MOD_GlcNHglycan	119	122	PF01048	0.732
MOD_GlcNHglycan	133	136	PF01048	0.804
MOD_GlcNHglycan	156	159	PF01048	0.473
MOD_GlcNHglycan	212	215	PF01048	0.677
MOD_GlcNHglycan	258	261	PF01048	0.727
MOD_GlcNHglycan	292	295	PF01048	0.771
MOD_GlcNHglycan	387	390	PF01048	0.411
MOD_GlcNHglycan	436	439	PF01048	0.411
MOD_GlcNHglycan	480	485	PF01048	0.523
MOD_GlcNHglycan	514	517	PF01048	0.411
MOD_GlcNHglycan	570	573	PF01048	0.730
MOD_GlcNHglycan	575	578	PF01048	0.721
MOD_GlcNHglycan	632	635	PF01048	0.643
MOD_GSK3_1	131	138	PF00069	0.703
MOD_GSK3_1	196	203	PF00069	0.682
MOD_GSK3_1	205	212	PF00069	0.675
MOD_GSK3_1	323	330	PF00069	0.726
MOD_GSK3_1	332	339	PF00069	0.766
MOD_GSK3_1	403	410	PF00069	0.411
MOD_GSK3_1	437	444	PF00069	0.411
MOD_GSK3_1	515	522	PF00069	0.372
MOD_GSK3_1	526	533	PF00069	0.412
MOD_N-GLC_1	175	180	PF02516	0.621
MOD_N-GLC_1	69	74	PF02516	0.513
MOD_NEK2_1	172	177	PF00069	0.650
MOD_NEK2_1	362	367	PF00069	0.597
MOD_NEK2_1	373	378	PF00069	0.411
MOD_NEK2_1	436	441	PF00069	0.411
MOD_NEK2_1	526	531	PF00069	0.434
MOD_NEK2_1	589	594	PF00069	0.693
MOD_PIKK_1	24	30	PF00454	0.473
MOD_PIKK_1	535	541	PF00454	0.737
MOD_PK_1	336	342	PF00069	0.613
MOD_PKA_1	255	261	PF00069	0.733
MOD_PKA_2	144	150	PF00069	0.560
MOD_PKA_2	243	249	PF00069	0.664
MOD_PKA_2	373	379	PF00069	0.411
MOD_PKA_2	531	537	PF00069	0.697
MOD_PKB_1	253	261	PF00069	0.697
MOD_Plk_1	19	25	PF00069	0.479
MOD_Plk_1	403	409	PF00069	0.411
MOD_Plk_1	441	447	PF00069	0.411
MOD_Plk_1	519	525	PF00069	0.620
MOD_Plk_2-3	56	62	PF00069	0.565
MOD_Plk_4	425	431	PF00069	0.499
MOD_Plk_4	441	447	PF00069	0.279
MOD_Plk_4	637	643	PF00069	0.517
MOD_Plk_4	93	99	PF00069	0.599
MOD_ProDKin_1	167	173	PF00069	0.558
MOD_ProDKin_1	282	288	PF00069	0.710
MOD_ProDKin_1	327	333	PF00069	0.665
MOD_ProDKin_1	609	615	PF00069	0.688
MOD_ProDKin_1	69	75	PF00069	0.513
MOD_SUMO_for_1	502	505	PF00179	0.436
MOD_SUMO_rev_2	352	360	PF00179	0.732
MOD_SUMO_rev_2	48	55	PF00179	0.634
TRG_DiLeu_BaEn_1	359	364	PF01217	0.622
TRG_DiLeu_BaEn_1	387	392	PF01217	0.513
TRG_DiLeu_BaEn_2	55	61	PF01217	0.610
TRG_ENDOCYTIC_2	156	159	PF00928	0.570
TRG_ENDOCYTIC_2	510	513	PF00928	0.411
TRG_ENDOCYTIC_2	645	648	PF00928	0.499
TRG_ENDOCYTIC_2	652	655	PF00928	0.514
TRG_ENDOCYTIC_2	9	12	PF00928	0.484
TRG_ER_diArg_1	17	19	PF00400	0.495
TRG_ER_diArg_1	252	255	PF00400	0.620
TRG_ER_diArg_1	373	375	PF00400	0.513
TRG_ER_diArg_1	420	422	PF00400	0.513
TRG_ER_diArg_1	620	623	PF00400	0.698
TRG_ER_diArg_1	65	67	PF00400	0.486
TRG_NLS_MonoCore_2	618	623	PF00514	0.794
TRG_NLS_MonoExtC_3	618	623	PF00514	0.794
TRG_NLS_MonoExtN_4	616	623	PF00514	0.640
TRG_Pf-PMV_PEXEL_1	164	168	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.513

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM6	Leptomonas seymouri	58%	100%
A0A3S7WSH5	Leishmania donovani	93%	100%
A4H744	Leishmania braziliensis	80%	100%
A4HVI4	Leishmania infantum	93%	100%
E9AP79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%